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The map label for this gene is fabF [H]

Identifier: 190571161

GI number: 190571161

Start: 824543

End: 825805

Strand: Direct

Name: fabF [H]

Synonym: WPa_0759

Alternate gene names: 190571161

Gene position: 824543-825805 (Clockwise)

Preceding gene: 190571160

Following gene: 190571162

Centisome position: 55.62

GC content: 39.98

Gene sequence:

>1263_bases
ATGAGCAAAAGAGTAGTAGTTACCGGTGTTGGCTTAATTACTCCACTAGCACCAGATGTTAATAACACCTGGTTAAAGCT
GAAAGAAGGTAAATCTGGCATAAAAGCAATCAGTACAGATAGGTTCAACTCTTCTGATCTTGCTTGCAGGGTTGCAGGAC
AGGTATCCTACAACGCTGAAAGCTGTTTTAATCCGCTAGATTATATTTCTGAAAAAGACCTAAAAAGAACAGATCGTTTT
ATTCACTACGGAATTGCAGCAGCTGTTCAGGCAGTAGAAGATTCACTAATTTTGGAAAATAAAAATATTAATAAAGAGCG
AATAGGTGTAGCTATTGGTTCTGGTATAGGTGGTCTTCCATCAATTCAGGAAAATGTAATTACCATGCAGGAGAAGGGGC
CTAGACGTGTTAGCCCATTTTTTGTTCCTGCAAGTCTAATAAATTTGATATCTGGTCATATTTCTATTAAATACGAATTT
ATAGGTCCAAATGACTCAGCGGTTACTGCATGTGCAACAGGTGCGCATGCGATTATAAACTCAGCAAGAGCTATAAAACT
CGGTGAAGCTGACATTATGATTGCAGGCGGAGCAGAAAGTGCGTTATGCAGAGTTGGAATTGCAGGTTTTGCATCGATGA
AGGCGCTATCAACTAAATTCAATGATAAGCCTGAAGAGGCCTCAAGGCCATGGGACGAAGAACGCGATGGATTTGTCATG
GGCGAAGGGGCCGGTATATTAGTTCTGGAAGAATATGAACATGCAAAAAAAAGGGAAGCAAAAATATATGCAGAACTCAC
TGGATATGGACTCACAGGAGATGCGCACCACATTACAGCACCACATCCAGAAGGAAGAGGCGCACTTAAGGCAATGGAAC
TTGCTTTAAGGAGTGCACAAGTAAGCCCAAGTCAAATTGGGTATATCAATGCACATGGAACTTCAACAAAACTTGGGGAT
AAAGTTGAAGTAATAGCAATGAAGCAGTTATTCGGTGACTATGCCTATAAAATACCTGTTTCCTCGACTAAATCTTCTAT
AGGACATTTACTTGGTGCCGCAGGAAGTGTTGAAGCAATATTTAGTATCCTTGCATTAAACAATGGAATTGTTCCACCAA
CTTTAAACCTACACAAACCTTCAGAAGGGTGTGATTTAAATTTTGTACCACTTAAAGCTCAAGAGCATAAAATTCAATAT
GCGCTTTCTAATTCATTTGGTTTTGGTGGTACCAACGCGTCTCTCATCTTTGGAAAGGTGTAG

Upstream 100 bases:

>100_bases
AGAATTTGGTATAGAGATTCCTGATGAAGATGCGCAAAAAATGGAAACTATGGAACAGATAGTTGAATATGTAGTAAACA
AAGCAAACAATTGATGTTGA

Downstream 100 bases:

>100_bases
TTAATTATGCTATTTTGAATCGACTACGAAAATGTCATTCGAGTAGCTGAAACTGGAATGGCTTTGTTGCATCGCTACCT
ATGAAAGGCTAACTATACAA

Product: 3-oxoacyl-(acyl-carrier-protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSKRVVVTGVGLITPLAPDVNNTWLKLKEGKSGIKAISTDRFNSSDLACRVAGQVSYNAESCFNPLDYISEKDLKRTDRF
IHYGIAAAVQAVEDSLILENKNINKERIGVAIGSGIGGLPSIQENVITMQEKGPRRVSPFFVPASLINLISGHISIKYEF
IGPNDSAVTACATGAHAIINSARAIKLGEADIMIAGGAESALCRVGIAGFASMKALSTKFNDKPEEASRPWDEERDGFVM
GEGAGILVLEEYEHAKKREAKIYAELTGYGLTGDAHHITAPHPEGRGALKAMELALRSAQVSPSQIGYINAHGTSTKLGD
KVEVIAMKQLFGDYAYKIPVSSTKSSIGHLLGAAGSVEAIFSILALNNGIVPPTLNLHKPSEGCDLNFVPLKAQEHKIQY
ALSNSFGFGGTNASLIFGKV

Sequences:

>Translated_420_residues
MSKRVVVTGVGLITPLAPDVNNTWLKLKEGKSGIKAISTDRFNSSDLACRVAGQVSYNAESCFNPLDYISEKDLKRTDRF
IHYGIAAAVQAVEDSLILENKNINKERIGVAIGSGIGGLPSIQENVITMQEKGPRRVSPFFVPASLINLISGHISIKYEF
IGPNDSAVTACATGAHAIINSARAIKLGEADIMIAGGAESALCRVGIAGFASMKALSTKFNDKPEEASRPWDEERDGFVM
GEGAGILVLEEYEHAKKREAKIYAELTGYGLTGDAHHITAPHPEGRGALKAMELALRSAQVSPSQIGYINAHGTSTKLGD
KVEVIAMKQLFGDYAYKIPVSSTKSSIGHLLGAAGSVEAIFSILALNNGIVPPTLNLHKPSEGCDLNFVPLKAQEHKIQY
ALSNSFGFGGTNASLIFGKV
>Mature_419_residues
SKRVVVTGVGLITPLAPDVNNTWLKLKEGKSGIKAISTDRFNSSDLACRVAGQVSYNAESCFNPLDYISEKDLKRTDRFI
HYGIAAAVQAVEDSLILENKNINKERIGVAIGSGIGGLPSIQENVITMQEKGPRRVSPFFVPASLINLISGHISIKYEFI
GPNDSAVTACATGAHAIINSARAIKLGEADIMIAGGAESALCRVGIAGFASMKALSTKFNDKPEEASRPWDEERDGFVMG
EGAGILVLEEYEHAKKREAKIYAELTGYGLTGDAHHITAPHPEGRGALKAMELALRSAQVSPSQIGYINAHGTSTKLGDK
VEVIAMKQLFGDYAYKIPVSSTKSSIGHLLGAAGSVEAIFSILALNNGIVPPTLNLHKPSEGCDLNFVPLKAQEHKIQYA
LSNSFGFGGTNASLIFGKV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=49.6420047732697, Blast_Score=388, Evalue=1e-108,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=60.2739726027397, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI41872631, Length=279, Percent_Identity=27.5985663082437, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1787337, Length=422, Percent_Identity=55.6872037914692, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1788663, Length=427, Percent_Identity=37.4707259953162, Blast_Score=252, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=39.618138424821, Blast_Score=274, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI71983535, Length=258, Percent_Identity=46.1240310077519, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17550940, Length=258, Percent_Identity=28.6821705426357, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI212642053, Length=303, Percent_Identity=26.0726072607261, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=39.0625, Blast_Score=292, Evalue=6e-80,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=42.9928741092637, Blast_Score=325, Evalue=5e-89,
Organism=Drosophila melanogaster, GI221330659, Length=280, Percent_Identity=26.7857142857143, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19920632, Length=278, Percent_Identity=26.2589928057554, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24581345, Length=282, Percent_Identity=23.0496453900709, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44724; Mature: 44592

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRVVVTGVGLITPLAPDVNNTWLKLKEGKSGIKAISTDRFNSSDLACRVAGQVSYNAE
CCCEEEEEECCEECCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCEEEEEECCEEECHH
SCFNPLDYISEKDLKRTDRFIHYGIAAAVQAVEDSLILENKNINKERIGVAIGSGIGGLP
HHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHEEEEEECCCCCCC
SIQENVITMQEKGPRRVSPFFVPASLINLISGHISIKYEFIGPNDSAVTACATGAHAIIN
CCHHHEEEECCCCCCCCCCEEEHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCHHHHHC
SARAIKLGEADIMIAGGAESALCRVGIAGFASMKALSTKFNDKPEEASRPWDEERDGFVM
CCCEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEE
GEGAGILVLEEYEHAKKREAKIYAELTGYGLTGDAHHITAPHPEGRGALKAMELALRSAQ
ECCCCEEEECCHHHHHHHCEEEEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHHHCC
VSPSQIGYINAHGTSTKLGDKVEVIAMKQLFGDYAYKIPVSSTKSSIGHLLGAAGSVEAI
CCHHHEEEEECCCCCCCCCCCEEEEEHHHHHCCEEEEECCCCCHHHHHHHHCCCCCHHHH
FSILALNNGIVPPTLNLHKPSEGCDLNFVPLKAQEHKIQYALSNSFGFGGTNASLIFGKV
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEECC
>Mature Secondary Structure 
SKRVVVTGVGLITPLAPDVNNTWLKLKEGKSGIKAISTDRFNSSDLACRVAGQVSYNAE
CCEEEEEECCEECCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCEEEEEECCEEECHH
SCFNPLDYISEKDLKRTDRFIHYGIAAAVQAVEDSLILENKNINKERIGVAIGSGIGGLP
HHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHEEEEEECCCCCCC
SIQENVITMQEKGPRRVSPFFVPASLINLISGHISIKYEFIGPNDSAVTACATGAHAIIN
CCHHHEEEECCCCCCCCCCEEEHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCHHHHHC
SARAIKLGEADIMIAGGAESALCRVGIAGFASMKALSTKFNDKPEEASRPWDEERDGFVM
CCCEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEE
GEGAGILVLEEYEHAKKREAKIYAELTGYGLTGDAHHITAPHPEGRGALKAMELALRSAQ
ECCCCEEEECCHHHHHHHCEEEEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHHHCC
VSPSQIGYINAHGTSTKLGDKVEVIAMKQLFGDYAYKIPVSSTKSSIGHLLGAAGSVEAI
CCHHHEEEEECCCCCCCCCCCEEEEEHHHHHCCEEEEECCCCCHHHHHHHHCCCCCHHHH
FSILALNNGIVPPTLNLHKPSEGCDLNFVPLKAQEHKIQYALSNSFGFGGTNASLIFGKV
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]