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The map label for this gene is hom [H]

Identifier: 189424279

GI number: 189424279

Start: 1260564

End: 1261883

Strand: Reverse

Name: hom [H]

Synonym: Glov_1214

Alternate gene names: 189424279

Gene position: 1261883-1260564 (Counterclockwise)

Preceding gene: 189424280

Following gene: 189424278

Centisome position: 32.21

GC content: 57.2

Gene sequence:

>1320_bases
ATGAATGAGATCAAGGTTGGCCTGATCGGCTTTGGCAATATCGGTGCAGGCGTGGTCCGGCTGCTGCAGGAGAATGCGCA
AACGGTACAACAGAAGGTGGGTAGCGGCATTATCCTGAAACGGATTGCCGACCTGGATATCACCAGTGATCGCGGAGTTT
CCGTTGATCCAGCCATGCTGACCACCGATGTGAATGAGATTTTCAATGATCCCGAGATCAGCATCGTGATTGAGCTGATC
GGCGGCTATGAACCGGCCAAGACCTTTGTACTGAAGGCGATTGAAGCCGGCAAACATGTGGTCACCGCCAACAAGGCCCT
GCTGGCCCTGCATGGTGATGAGATCTACGCCGCTGCCGCCCGTAAAGGTGTTGAGGTCCAGTTTGAGGCAGCGGTAGGGG
GCGGCATTCCGGTCCTGTCAGCCATCAAGGGCAATCTGTCCGGCAACCGCTTCAGCTCGGTCTTCGGTATCATGAACGGT
ACCTGCAACTACATCCTGACCCGCATGACCCAGGAAGGTGCTGATTTTGAGGATGTACTCAAAAGTGCCATGGAACTTGG
CTACGCCGAACCGGACCCCACCTTTGACATCGAAGGGGTTGATACGGCCCACAAGCTGGCGGTGCTGGCCTCGCTCTGTT
TCGGCACTAAAATCGATTTCAACGCCATTCACACCGAAGGGATCACCGCCATTTCAGGCATTGATATCCGCTTTGCCGAG
CAGTTCGGCTACCGGATCAAGCTGCTGGCCATCGGCAAACTGACCGACGACAGGCAACTTGAAGTACGGGTACACCCCAC
CATGATCCCGCTGCGCAATCCTCTGGCCGACGTGAACGGCGTCTTCAACGCCATCCACCTGACCGGTGACTTTGTCGGAC
CGGTACTGTTCTACGGCCGGGGAGCGGGCCAAAACCCCACTGCCAGCGCCATTGTGGGAGACCTTGTCGCCCTTTCCCGC
AGCATCGCTGCCGGTGTTCAAAACCGCAGATCCGCGCCGTTGGGTTTTCTGGACAACACCATCACCACCCTGCCGCTCAA
GCCGATGGAAGAGATCATCACCAGCTTCATGCTGCGCTTTACCGCCCAGGATCAACCGGGCGTACTGGCCGGCATCGCCG
GTGTACTGGGTAAAAACGGTATCAGCATTGAATCGATGGTACAGACCGCCCGACACAACGGCGGGCAGGCCGTACCGATT
GTGATCAAGACCCACGAAGCCCGCGAAGGGGCGATTCGCACGGCCCTGGCCGAGATCGACAGCTTTGACTTTATCAGCGA
GAAGAGCCGCCTGATTCGTATTGAGGACAATCTGGAGTAA

Upstream 100 bases:

>100_bases
TCGCCAAGAAATATGGAGACAAGGAGTCTCCCGCCTTTGTGAACGGCATCCTGGATGAGCTGGAGGCCTGCCCCAAGGAT
GAGGAGCGGAGTGATACGGA

Downstream 100 bases:

>100_bases
GTTAAAATAACTTTATTGTTGCGGGAACGTGGAGTTTTTCGTTCTGGGTGCGACAGGCACGACATGGCGCGGAGGCGTAC
CGAACAGTACGCCGCACAAG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MNEIKVGLIGFGNIGAGVVRLLQENAQTVQQKVGSGIILKRIADLDITSDRGVSVDPAMLTTDVNEIFNDPEISIVIELI
GGYEPAKTFVLKAIEAGKHVVTANKALLALHGDEIYAAAARKGVEVQFEAAVGGGIPVLSAIKGNLSGNRFSSVFGIMNG
TCNYILTRMTQEGADFEDVLKSAMELGYAEPDPTFDIEGVDTAHKLAVLASLCFGTKIDFNAIHTEGITAISGIDIRFAE
QFGYRIKLLAIGKLTDDRQLEVRVHPTMIPLRNPLADVNGVFNAIHLTGDFVGPVLFYGRGAGQNPTASAIVGDLVALSR
SIAAGVQNRRSAPLGFLDNTITTLPLKPMEEIITSFMLRFTAQDQPGVLAGIAGVLGKNGISIESMVQTARHNGGQAVPI
VIKTHEAREGAIRTALAEIDSFDFISEKSRLIRIEDNLE

Sequences:

>Translated_439_residues
MNEIKVGLIGFGNIGAGVVRLLQENAQTVQQKVGSGIILKRIADLDITSDRGVSVDPAMLTTDVNEIFNDPEISIVIELI
GGYEPAKTFVLKAIEAGKHVVTANKALLALHGDEIYAAAARKGVEVQFEAAVGGGIPVLSAIKGNLSGNRFSSVFGIMNG
TCNYILTRMTQEGADFEDVLKSAMELGYAEPDPTFDIEGVDTAHKLAVLASLCFGTKIDFNAIHTEGITAISGIDIRFAE
QFGYRIKLLAIGKLTDDRQLEVRVHPTMIPLRNPLADVNGVFNAIHLTGDFVGPVLFYGRGAGQNPTASAIVGDLVALSR
SIAAGVQNRRSAPLGFLDNTITTLPLKPMEEIITSFMLRFTAQDQPGVLAGIAGVLGKNGISIESMVQTARHNGGQAVPI
VIKTHEAREGAIRTALAEIDSFDFISEKSRLIRIEDNLE
>Mature_439_residues
MNEIKVGLIGFGNIGAGVVRLLQENAQTVQQKVGSGIILKRIADLDITSDRGVSVDPAMLTTDVNEIFNDPEISIVIELI
GGYEPAKTFVLKAIEAGKHVVTANKALLALHGDEIYAAAARKGVEVQFEAAVGGGIPVLSAIKGNLSGNRFSSVFGIMNG
TCNYILTRMTQEGADFEDVLKSAMELGYAEPDPTFDIEGVDTAHKLAVLASLCFGTKIDFNAIHTEGITAISGIDIRFAE
QFGYRIKLLAIGKLTDDRQLEVRVHPTMIPLRNPLADVNGVFNAIHLTGDFVGPVLFYGRGAGQNPTASAIVGDLVALSR
SIAAGVQNRRSAPLGFLDNTITTLPLKPMEEIITSFMLRFTAQDQPGVLAGIAGVLGKNGISIESMVQTARHNGGQAVPI
VIKTHEAREGAIRTALAEIDSFDFISEKSRLIRIEDNLE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=248, Percent_Identity=26.6129032258064, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790376, Length=361, Percent_Identity=22.9916897506925, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=131, Percent_Identity=32.0610687022901, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46876; Mature: 46876

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIKVGLIGFGNIGAGVVRLLQENAQTVQQKVGSGIILKRIADLDITSDRGVSVDPAML
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCCHHH
TTDVNEIFNDPEISIVIELIGGYEPAKTFVLKAIEAGKHVVTANKALLALHGDEIYAAAA
HCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCHHHHHHH
RKGVEVQFEAAVGGGIPVLSAIKGNLSGNRFSSVFGIMNGTCNYILTRMTQEGADFEDVL
CCCCEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHH
KSAMELGYAEPDPTFDIEGVDTAHKLAVLASLCFGTKIDFNAIHTEGITAISGIDIRFAE
HHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCEEEEHH
QFGYRIKLLAIGKLTDDRQLEVRVHPTMIPLRNPLADVNGVFNAIHLTGDFVGPVLFYGR
HCCCEEEEEEEECCCCCCEEEEEECCEEECCCCCHHHHHHHHEEEEECCHHHHHHHHCCC
GAGQNPTASAIVGDLVALSRSIAAGVQNRRSAPLGFLDNTITTLPLKPMEEIITSFMLRF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCEEECCCCHHHHHHHHHHHHH
TAQDQPGVLAGIAGVLGKNGISIESMVQTARHNGGQAVPIVIKTHEAREGAIRTALAEID
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHC
SFDFISEKSRLIRIEDNLE
CHHHHCCCCCEEEEECCCC
>Mature Secondary Structure
MNEIKVGLIGFGNIGAGVVRLLQENAQTVQQKVGSGIILKRIADLDITSDRGVSVDPAML
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCCCCCCCCCCCHHH
TTDVNEIFNDPEISIVIELIGGYEPAKTFVLKAIEAGKHVVTANKALLALHGDEIYAAAA
HCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCEEEEEECCHHHHHHH
RKGVEVQFEAAVGGGIPVLSAIKGNLSGNRFSSVFGIMNGTCNYILTRMTQEGADFEDVL
CCCCEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHH
KSAMELGYAEPDPTFDIEGVDTAHKLAVLASLCFGTKIDFNAIHTEGITAISGIDIRFAE
HHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCEEEEHH
QFGYRIKLLAIGKLTDDRQLEVRVHPTMIPLRNPLADVNGVFNAIHLTGDFVGPVLFYGR
HCCCEEEEEEEECCCCCCEEEEEECCEEECCCCCHHHHHHHHEEEEECCHHHHHHHHCCC
GAGQNPTASAIVGDLVALSRSIAAGVQNRRSAPLGFLDNTITTLPLKPMEEIITSFMLRF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCEEECCCCHHHHHHHHHHHHH
TAQDQPGVLAGIAGVLGKNGISIESMVQTARHNGGQAVPIVIKTHEAREGAIRTALAEID
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHC
SFDFISEKSRLIRIEDNLE
CHHHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]