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The map label for this gene is murB

Identifier: 189423737

GI number: 189423737

Start: 674726

End: 675634

Strand: Reverse

Name: murB

Synonym: Glov_0668

Alternate gene names: 189423737

Gene position: 675634-674726 (Counterclockwise)

Preceding gene: 189423738

Following gene: 189423736

Centisome position: 17.25

GC content: 57.1

Gene sequence:

>909_bases
ATGCATGCCGGTCTTGAACATATCAGGGACTGGTTCAAGGGAGAGCTGCTGTTTCATGAGCCGCTTGCCAGACATGTCTC
GCTGAAGGTGGGGGGGCCGGTGGATCTGCTGGCGACCCCCGATTCGCGGGAAGAGCTGCAACAGCTGGTGACACTGCTGG
ATCAGCAGCAAATTCCACGTTTCGTACTGGGAGGCGGTTTTAACCTGCTACCAAGTGATGTTGGCTACCGCGGTTGTGCC
ATCTCCTTGAAGCAGATCAACCGGCTGCAGCTTGACGACACCGTTGTGGCCATTGAGGCAGGGGCCAGCAACCAATCCCT
GGCGCGGGCTGTGGCAGAACTCGGCCTGAGCGGTATTGAGTTTCTGATCGGTATTCCGGGCAGCGTGGGGGGGGCGGTGC
GGATGAACGCCGGCGCCCATGGCAGTGATATCTTCAGTGTCGTGAAAACCGTGACACTGCTGGATCAGGGACAGTTCAGA
GAACTGCCGCGTGAGCAGCTGACCTACGGTTACCGCTGTTTTGAGATTCCTGACAATAGCGTGATCGTCGCGGTCACGTT
ACAGCTGTCCGAAGACTCGCTTCAGGCGGTGCGCAGCAGGATGGAAGAGCAGCTGGGGCTGCGCTGGGCTACACAAAATG
TGAAGTTTCCCAATGCCGGTTCGTTTTTTAAAAATCCGCCCGGCGAGTCTGCCTGGCGCCTGATTGACCAGGCCGGTTTA
CGTGGGTTCAGTATCGGGAATGCCCAGGTAAGTGAAGTACATACCAACTTCCTGATAAATCGCGGCAATGCAACTGCTGC
AGATTTTCGGGCACTGGCGGCAGCAGTCAAGGAACGGGTTAAGGCAACGTGTGGTATCGAGCTTGAGGAAGAAGTGCAAC
TGCTTGACAGCGGGGAGTGCGGGCAATGA

Upstream 100 bases:

>100_bases
CTGATTACCTGGCCGGGATCGTCAAAGAAGGCGACATCGTGATCACCCTGGGGGCCGGCAATATCTGGCAAGCCGGCGAA
GCTCTGGTGAAGAGGCTCTG

Downstream 100 bases:

>100_bases
CGCGTGACGAACTGAAACAGAAACGGATCGGTGTGTTGATGGGGGGGCTGTCGGCTGAACGGGATGTCTCGCTCAAAAGC
GGCATGGCAGTCCATCAGGC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MHAGLEHIRDWFKGELLFHEPLARHVSLKVGGPVDLLATPDSREELQQLVTLLDQQQIPRFVLGGGFNLLPSDVGYRGCA
ISLKQINRLQLDDTVVAIEAGASNQSLARAVAELGLSGIEFLIGIPGSVGGAVRMNAGAHGSDIFSVVKTVTLLDQGQFR
ELPREQLTYGYRCFEIPDNSVIVAVTLQLSEDSLQAVRSRMEEQLGLRWATQNVKFPNAGSFFKNPPGESAWRLIDQAGL
RGFSIGNAQVSEVHTNFLINRGNATAADFRALAAAVKERVKATCGIELEEEVQLLDSGECGQ

Sequences:

>Translated_302_residues
MHAGLEHIRDWFKGELLFHEPLARHVSLKVGGPVDLLATPDSREELQQLVTLLDQQQIPRFVLGGGFNLLPSDVGYRGCA
ISLKQINRLQLDDTVVAIEAGASNQSLARAVAELGLSGIEFLIGIPGSVGGAVRMNAGAHGSDIFSVVKTVTLLDQGQFR
ELPREQLTYGYRCFEIPDNSVIVAVTLQLSEDSLQAVRSRMEEQLGLRWATQNVKFPNAGSFFKNPPGESAWRLIDQAGL
RGFSIGNAQVSEVHTNFLINRGNATAADFRALAAAVKERVKATCGIELEEEVQLLDSGECGQ
>Mature_302_residues
MHAGLEHIRDWFKGELLFHEPLARHVSLKVGGPVDLLATPDSREELQQLVTLLDQQQIPRFVLGGGFNLLPSDVGYRGCA
ISLKQINRLQLDDTVVAIEAGASNQSLARAVAELGLSGIEFLIGIPGSVGGAVRMNAGAHGSDIFSVVKTVTLLDQGQFR
ELPREQLTYGYRCFEIPDNSVIVAVTLQLSEDSLQAVRSRMEEQLGLRWATQNVKFPNAGSFFKNPPGESAWRLIDQAGL
RGFSIGNAQVSEVHTNFLINRGNATAADFRALAAAVKERVKATCGIELEEEVQLLDSGECGQ

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_GEOLS (B3E3Y0)

Other databases:

- EMBL:   CP001089
- RefSeq:   YP_001950914.1
- ProteinModelPortal:   B3E3Y0
- SMR:   B3E3Y0
- GeneID:   6369079
- GenomeReviews:   CP001089_GR
- KEGG:   glo:Glov_0668
- HOGENOM:   HBG686573
- OMA:   SKKHAGF
- ProtClustDB:   PRK13905
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 32805; Mature: 32805

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 172-172 ACT_SITE 221-221 ACT_SITE 291-291

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAGLEHIRDWFKGELLFHEPLARHVSLKVGGPVDLLATPDSREELQQLVTLLDQQQIPR
CCCCHHHHHHHHCCCEEECCHHHHHEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCC
FVLGGGFNLLPSDVGYRGCAISLKQINRLQLDDTVVAIEAGASNQSLARAVAELGLSGIE
EEECCCCCCCCCCCCCCCEEEEHHHCCCEEECCEEEEEECCCCCHHHHHHHHHHCCCHHH
FLIGIPGSVGGAVRMNAGAHGSDIFSVVKTVTLLDQGQFRELPREQLTYGYRCFEIPDNS
EEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCEEEEECCCCC
VIVAVTLQLSEDSLQAVRSRMEEQLGLRWATQNVKFPNAGSFFKNPPGESAWRLIDQAGL
EEEEEEEEECHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
RGFSIGNAQVSEVHTNFLINRGNATAADFRALAAAVKERVKATCGIELEEEVQLLDSGEC
CEEECCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
GQ
CC
>Mature Secondary Structure
MHAGLEHIRDWFKGELLFHEPLARHVSLKVGGPVDLLATPDSREELQQLVTLLDQQQIPR
CCCCHHHHHHHHCCCEEECCHHHHHEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHCCC
FVLGGGFNLLPSDVGYRGCAISLKQINRLQLDDTVVAIEAGASNQSLARAVAELGLSGIE
EEECCCCCCCCCCCCCCCEEEEHHHCCCEEECCEEEEEECCCCCHHHHHHHHHHCCCHHH
FLIGIPGSVGGAVRMNAGAHGSDIFSVVKTVTLLDQGQFRELPREQLTYGYRCFEIPDNS
EEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCEEEEECCCCC
VIVAVTLQLSEDSLQAVRSRMEEQLGLRWATQNVKFPNAGSFFKNPPGESAWRLIDQAGL
EEEEEEEEECHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
RGFSIGNAQVSEVHTNFLINRGNATAADFRALAAAVKERVKATCGIELEEEVQLLDSGEC
CEEECCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
GQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA