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The map label for this gene is murC

Identifier: 189423738

GI number: 189423738

Start: 675634

End: 677004

Strand: Reverse

Name: murC

Synonym: Glov_0669

Alternate gene names: 189423738

Gene position: 677004-675634 (Counterclockwise)

Preceding gene: 189423739

Following gene: 189423737

Centisome position: 17.28

GC content: 58.21

Gene sequence:

>1371_bases
ATGTACGGAAACATAGAAAAGATCCACTTTGTAGGTATTGGCGGCATCGGCATGAGCGGTATTGCCGAAGTGCTGCTGAA
CCTGGGGTACCAGGTATCCGGTTCCGACCTGCGGGAGAGCGATACCACTGAACGGTTGCGCAGCCTGGGTGGTGAGATCT
GCATCGGCCACGCCGCAGAAAATCTGACCAACGTGGATGTGGTGGTCACCTCAACAGCGGTGCAGAGTGACAATCCGGAG
GTGATCGAGGCCAAGCATCGCATGGTACCGGTCATCCCGCGGGCAGAGATGCTGGCAGAGCTGATGCGGATGAAGTACGG
CATTGCCATTGCCGGTACCCACGGCAAGACCACCACCACCTCCATGGTGGCCACGGTGCTGACCCATGCCGGGATCGACC
CGACCATCGTGATCGGCGGCAAACTGAACACCCTGGGCAGCAATGCCAAGCTGGGACAGGGCAAATTTCTGGTGGCTGAG
GCCGATGAGTCGGATGGTTCATTCCTGACCCTCTCCCCCACCATTGCCGTGGTAACCAACATCGATGCCGACCATCTGGA
TTACTACACCGGCGGGTTGGAGCAGATTAAAGACACCTTTGTCTCCTTTATCAACAAGGTGCCGTTCTATGGTCTGGCGG
TGCTTTGCCAGGAAGACCGCAATATTAACGAGATCATCCCCCGGATCAAGAAACGGTTCATGACCTACGGACTCTCGTCC
CAGGCCGACCTGCGGGCGACCCATGTCAAGCTGGACGGTTTTCAAACCACCTTTACCGCCCACTACAAGGGCTATCGTCT
GGGTGAAATCAGCTTCAATATGCCGGGTGCCCATAACGTACTGAACGCCCTGGCCTGTACCGCTGTGGCGCTGGAGCTGG
ATGTGCCGTTCGACAAGATCCAGGAAGGTTTTGCCCAGTTTGGTGGTGTTGGTCGTCGTTTCACGGTCAAAGGAGAGAAA
AACGGGATCATGGTGGTGGATGACTATGGCCACCACCCTGCCGAGATCCGGGCCACCCTGGGGGCGGCACGTAATGGCTG
GCCCGAGCGTCGCCTGGTGGTGGCGTTCCAGCCCCACCGCTACAGTCGCACCAAGGAGTTGTTTAACGAGTTTGTCACCT
GTTTCTATGATGCCGACGTATTGGTACTGACCGATATCTACGCTGCCAGCGAGCAGCCGATCCCCGGTGTTTCAGCCGAG
CGTCTGGCCGAAGAGACCCGCCGCCATGGCCAGCGGGACGTGACCTACATTGCCGATCGGAACGACCTGCCTGATTACCT
GGCCGGGATCGTCAAAGAAGGCGACATCGTGATCACCCTGGGGGCCGGCAATATCTGGCAAGCCGGCGAAGCTCTGGTGA
AGAGGCTCTGA

Upstream 100 bases:

>100_bases
ACCGCGACGCACTGAAACTGATTGGTGAAAATGCCGCTGCCCTGGCCCGGCTGGATGCAGCCAGGGTTATTGTTGACCAG
ATGCTGGAAGGGGTACAGCC

Downstream 100 bases:

>100_bases
TGCATGCCGGTCTTGAACATATCAGGGACTGGTTCAAGGGAGAGCTGCTGTTTCATGAGCCGCTTGCCAGACATGTCTCG
CTGAAGGTGGGGGGGCCGGT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MYGNIEKIHFVGIGGIGMSGIAEVLLNLGYQVSGSDLRESDTTERLRSLGGEICIGHAAENLTNVDVVVTSTAVQSDNPE
VIEAKHRMVPVIPRAEMLAELMRMKYGIAIAGTHGKTTTTSMVATVLTHAGIDPTIVIGGKLNTLGSNAKLGQGKFLVAE
ADESDGSFLTLSPTIAVVTNIDADHLDYYTGGLEQIKDTFVSFINKVPFYGLAVLCQEDRNINEIIPRIKKRFMTYGLSS
QADLRATHVKLDGFQTTFTAHYKGYRLGEISFNMPGAHNVLNALACTAVALELDVPFDKIQEGFAQFGGVGRRFTVKGEK
NGIMVVDDYGHHPAEIRATLGAARNGWPERRLVVAFQPHRYSRTKELFNEFVTCFYDADVLVLTDIYAASEQPIPGVSAE
RLAEETRRHGQRDVTYIADRNDLPDYLAGIVKEGDIVITLGAGNIWQAGEALVKRL

Sequences:

>Translated_456_residues
MYGNIEKIHFVGIGGIGMSGIAEVLLNLGYQVSGSDLRESDTTERLRSLGGEICIGHAAENLTNVDVVVTSTAVQSDNPE
VIEAKHRMVPVIPRAEMLAELMRMKYGIAIAGTHGKTTTTSMVATVLTHAGIDPTIVIGGKLNTLGSNAKLGQGKFLVAE
ADESDGSFLTLSPTIAVVTNIDADHLDYYTGGLEQIKDTFVSFINKVPFYGLAVLCQEDRNINEIIPRIKKRFMTYGLSS
QADLRATHVKLDGFQTTFTAHYKGYRLGEISFNMPGAHNVLNALACTAVALELDVPFDKIQEGFAQFGGVGRRFTVKGEK
NGIMVVDDYGHHPAEIRATLGAARNGWPERRLVVAFQPHRYSRTKELFNEFVTCFYDADVLVLTDIYAASEQPIPGVSAE
RLAEETRRHGQRDVTYIADRNDLPDYLAGIVKEGDIVITLGAGNIWQAGEALVKRL
>Mature_456_residues
MYGNIEKIHFVGIGGIGMSGIAEVLLNLGYQVSGSDLRESDTTERLRSLGGEICIGHAAENLTNVDVVVTSTAVQSDNPE
VIEAKHRMVPVIPRAEMLAELMRMKYGIAIAGTHGKTTTTSMVATVLTHAGIDPTIVIGGKLNTLGSNAKLGQGKFLVAE
ADESDGSFLTLSPTIAVVTNIDADHLDYYTGGLEQIKDTFVSFINKVPFYGLAVLCQEDRNINEIIPRIKKRFMTYGLSS
QADLRATHVKLDGFQTTFTAHYKGYRLGEISFNMPGAHNVLNALACTAVALELDVPFDKIQEGFAQFGGVGRRFTVKGEK
NGIMVVDDYGHHPAEIRATLGAARNGWPERRLVVAFQPHRYSRTKELFNEFVTCFYDADVLVLTDIYAASEQPIPGVSAE
RLAEETRRHGQRDVTYIADRNDLPDYLAGIVKEGDIVITLGAGNIWQAGEALVKRL

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=459, Percent_Identity=46.4052287581699, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1790680, Length=353, Percent_Identity=30.5949008498584, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_GEOLS (B3E3Y1)

Other databases:

- EMBL:   CP001089
- RefSeq:   YP_001950915.1
- ProteinModelPortal:   B3E3Y1
- SMR:   B3E3Y1
- GeneID:   6369083
- GenomeReviews:   CP001089_GR
- KEGG:   glo:Glov_0669
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49749; Mature: 49749

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGNIEKIHFVGIGGIGMSGIAEVLLNLGYQVSGSDLRESDTTERLRSLGGEICIGHAAE
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCCCCEEEECCCC
NLTNVDVVVTSTAVQSDNPEVIEAKHRMVPVIPRAEMLAELMRMKYGIAIAGTHGKTTTT
CCCCEEEEEEEEEECCCCCHHEECCCCEEECCCHHHHHHHHHHHHCCEEEEECCCCCHHH
SMVATVLTHAGIDPTIVIGGKLNTLGSNAKLGQGKFLVAEADESDGSFLTLSPTIAVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCEEEEEEE
IDADHLDYYTGGLEQIKDTFVSFINKVPFYGLAVLCQEDRNINEIIPRIKKRFMTYGLSS
CCHHHHHHHCCCHHHHHHHHHHHHHCCCHHHEEEEEECCCCHHHHHHHHHHHHHHCCCCC
QADLRATHVKLDGFQTTFTAHYKGYRLGEISFNMPGAHNVLNALACTAVALELDVPFDKI
CCCCEEEEEEECCCEEEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHEEEEECCCHHHH
QEGFAQFGGVGRRFTVKGEKNGIMVVDDYGHHPAEIRATLGAARNGWPERRLVVAFQPHR
HHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCC
YSRTKELFNEFVTCFYDADVLVLTDIYAASEQPIPGVSAERLAEETRRHGQRDVTYIADR
CHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECC
NDLPDYLAGIVKEGDIVITLGAGNIWQAGEALVKRL
CCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MYGNIEKIHFVGIGGIGMSGIAEVLLNLGYQVSGSDLRESDTTERLRSLGGEICIGHAAE
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHCCCCEEEECCCC
NLTNVDVVVTSTAVQSDNPEVIEAKHRMVPVIPRAEMLAELMRMKYGIAIAGTHGKTTTT
CCCCEEEEEEEEEECCCCCHHEECCCCEEECCCHHHHHHHHHHHHCCEEEEECCCCCHHH
SMVATVLTHAGIDPTIVIGGKLNTLGSNAKLGQGKFLVAEADESDGSFLTLSPTIAVVTN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEECCEEEEEEE
IDADHLDYYTGGLEQIKDTFVSFINKVPFYGLAVLCQEDRNINEIIPRIKKRFMTYGLSS
CCHHHHHHHCCCHHHHHHHHHHHHHCCCHHHEEEEEECCCCHHHHHHHHHHHHHHCCCCC
QADLRATHVKLDGFQTTFTAHYKGYRLGEISFNMPGAHNVLNALACTAVALELDVPFDKI
CCCCEEEEEEECCCEEEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHEEEEECCCHHHH
QEGFAQFGGVGRRFTVKGEKNGIMVVDDYGHHPAEIRATLGAARNGWPERRLVVAFQPHR
HHHHHHHCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCC
YSRTKELFNEFVTCFYDADVLVLTDIYAASEQPIPGVSAERLAEETRRHGQRDVTYIADR
CHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECC
NDLPDYLAGIVKEGDIVITLGAGNIWQAGEALVKRL
CCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA