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The map label for this gene is xapR [H]

Identifier: 189353660

GI number: 189353660

Start: 1921035

End: 1921925

Strand: Reverse

Name: xapR [H]

Synonym: BMULJ_04905

Alternate gene names: 189353660

Gene position: 1921925-1921035 (Counterclockwise)

Preceding gene: 189353669

Following gene: 189353658

Centisome position: 77.71

GC content: 68.69

Gene sequence:

>891_bases
ATGGACATGCGTGTGTTGCGTTACTTTGCGGTGCTGGCCGACGAACTGCATTTCGGGCGCGCGGCCGCGCGGCTCCATAT
CTCGCAGCCGCCGCTGAGCCAGCAGATCCGGCTGCTCGAGGAACAGCTCGGCACCGCGTTGTTCGTGCGCTCGCAGCATC
GCGTCGAGCTGACCGAGGCAGGGAAAACACTGAAGGAGCAGGTGCCGCTGATCGTCGCGCAGTTCGACCGTGCGATCGAC
CTGACGCGCTGTGCGGGGCGCGGCGAGAAAGGCCGCGTCGCGGTCGGCATCATCAGCTCCGCGATGGTCGCGCCGATTCC
GCGCGCGCTGCGCGTGTTCGCTGAGCGGCACCCGCACGTGCAGTGGTCGCTGCACGAGATGACGCCGGCCGCGCAGATCG
ATGCGCTCAAGGAGAAGCGGCTCGACGTCTGTTTCTTCCGGCTGTTCCAGGACGATCCGGCGATCCGCAGCGAAGTCGTC
GTGCGCGAAACGGCGGTGGCCGCGCTGCCGCTCGATCATCGGCTCGCGTCGCGCGATGCGATCGCGCTCGGCGAGCTCGC
GAACGAGCACTTCGTGTCGTTCGGGTTGCGCCATTCGCAGCTCGCGCGCTTCCTGCAACAGTGTTGCGTGGACGCGCGCT
TCACGCCGCGGATCGAGCACGAGGTCGTCGAGGTGCACACGCTGCTGTCGCTCGTGCGCGAGGGGCTCGGCGTCGCGTTG
CTGCCCGCGTCGGCGCGGCAGATCTCGACGGGCGGCGTGTCGTTCGTGCCGCTGCTCGCGCCCGAACTCGAAGTGTCGCT
GCAGGCGCGCTACCGCGCGGACGACACGTCCGCCGTGCTCGGCGCGTTTCTCGATACGGTGCGCGAAGTCGCGGCCGAAT
ACCGTGCGTGA

Upstream 100 bases:

>100_bases
GTGACACACTGCGACGTGCACTGCTGCTTGGGACCGAGTGTCACAAGCCAAATGCGCTCTGTACAATATTTTTTACTGAC
GCTCTTGATACGTTTCCGAT

Downstream 100 bases:

>100_bases
CTCAGCGCGCGAGCGTTTGCGCGACCAGCGCGCCGATCGCATCGAGCAGCGGCTTCACGCGCGCGTGCCGCTCGCGCGGC
CAGATCGCATGGAGGTTGTA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MDMRVLRYFAVLADELHFGRAAARLHISQPPLSQQIRLLEEQLGTALFVRSQHRVELTEAGKTLKEQVPLIVAQFDRAID
LTRCAGRGEKGRVAVGIISSAMVAPIPRALRVFAERHPHVQWSLHEMTPAAQIDALKEKRLDVCFFRLFQDDPAIRSEVV
VRETAVAALPLDHRLASRDAIALGELANEHFVSFGLRHSQLARFLQQCCVDARFTPRIEHEVVEVHTLLSLVREGLGVAL
LPASARQISTGGVSFVPLLAPELEVSLQARYRADDTSAVLGAFLDTVREVAAEYRA

Sequences:

>Translated_296_residues
MDMRVLRYFAVLADELHFGRAAARLHISQPPLSQQIRLLEEQLGTALFVRSQHRVELTEAGKTLKEQVPLIVAQFDRAID
LTRCAGRGEKGRVAVGIISSAMVAPIPRALRVFAERHPHVQWSLHEMTPAAQIDALKEKRLDVCFFRLFQDDPAIRSEVV
VRETAVAALPLDHRLASRDAIALGELANEHFVSFGLRHSQLARFLQQCCVDARFTPRIEHEVVEVHTLLSLVREGLGVAL
LPASARQISTGGVSFVPLLAPELEVSLQARYRADDTSAVLGAFLDTVREVAAEYRA
>Mature_296_residues
MDMRVLRYFAVLADELHFGRAAARLHISQPPLSQQIRLLEEQLGTALFVRSQHRVELTEAGKTLKEQVPLIVAQFDRAID
LTRCAGRGEKGRVAVGIISSAMVAPIPRALRVFAERHPHVQWSLHEMTPAAQIDALKEKRLDVCFFRLFQDDPAIRSEVV
VRETAVAALPLDHRLASRDAIALGELANEHFVSFGLRHSQLARFLQQCCVDARFTPRIEHEVVEVHTLLSLVREGLGVAL
LPASARQISTGGVSFVPLLAPELEVSLQARYRADDTSAVLGAFLDTVREVAAEYRA

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=258, Percent_Identity=37.5968992248062, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1787879, Length=261, Percent_Identity=38.3141762452107, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1788887, Length=290, Percent_Identity=31.3793103448276, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790399, Length=277, Percent_Identity=27.7978339350181, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI145693105, Length=275, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI157672245, Length=297, Percent_Identity=30.3030303030303, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=26.2948207171315, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787806, Length=244, Percent_Identity=27.4590163934426, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788297, Length=258, Percent_Identity=27.5193798449612, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788748, Length=297, Percent_Identity=24.9158249158249, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790208, Length=65, Percent_Identity=52.3076923076923, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87082132, Length=298, Percent_Identity=24.496644295302, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1787601, Length=227, Percent_Identity=25.1101321585903, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI1790783, Length=290, Percent_Identity=23.7931034482759, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32886; Mature: 32886

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMRVLRYFAVLADELHFGRAAARLHISQPPLSQQIRLLEEQLGTALFVRSQHRVELTEA
CCHHHHHHHHHHHHHHHHCHHHHEEECCCCCHHHHHHHHHHHHCCEEEECCCCCEEHHHH
GKTLKEQVPLIVAQFDRAIDLTRCAGRGEKGRVAVGIISSAMVAPIPRALRVFAERHPHV
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHCCHHHHHHHHHHCCCC
QWSLHEMTPAAQIDALKEKRLDVCFFRLFQDDPAIRSEVVVRETAVAALPLDHRLASRDA
EEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCH
IALGELANEHFVSFGLRHSQLARFLQQCCVDARFTPRIEHEVVEVHTLLSLVREGLGVAL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEE
LPASARQISTGGVSFVPLLAPELEVSLQARYRADDTSAVLGAFLDTVREVAAEYRA
ECCCCCEECCCCCEEEEHCCCCHHHEEHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDMRVLRYFAVLADELHFGRAAARLHISQPPLSQQIRLLEEQLGTALFVRSQHRVELTEA
CCHHHHHHHHHHHHHHHHCHHHHEEECCCCCHHHHHHHHHHHHCCEEEECCCCCEEHHHH
GKTLKEQVPLIVAQFDRAIDLTRCAGRGEKGRVAVGIISSAMVAPIPRALRVFAERHPHV
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHCCHHHHHHHHHHCCCC
QWSLHEMTPAAQIDALKEKRLDVCFFRLFQDDPAIRSEVVVRETAVAALPLDHRLASRDA
EEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCH
IALGELANEHFVSFGLRHSQLARFLQQCCVDARFTPRIEHEVVEVHTLLSLVREGLGVAL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEE
LPASARQISTGGVSFVPLLAPELEVSLQARYRADDTSAVLGAFLDTVREVAAEYRA
ECCCCCEECCCCCEEEEHCCCCHHHEEHHHCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]