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The map label for this gene is iorA [H]

Identifier: 189353658

GI number: 189353658

Start: 1919522

End: 1920016

Strand: Reverse

Name: iorA [H]

Synonym: BMULJ_04903

Alternate gene names: 189353658

Gene position: 1920016-1919522 (Counterclockwise)

Preceding gene: 189353660

Following gene: 189353657

Centisome position: 77.63

GC content: 68.48

Gene sequence:

>495_bases
ATGATCGACATCGTCGTGAACGATACACGCCATTCGCTCGACCAGGTACCGGACGATATGCCGTTGCTCTGGGTGCTGCG
TGACCGGCTCAAGCTCACCGGCACGAAGTTCGGCTGCGGCAAGGGATTGTGCGGCGCATGCACGGTGCATGTCGACGGGC
AGGCCGTGCGGTCGTGCGTGATGCCGGCCGTCGCGGTGCAGGGCCGCAAGGTGACGACGATCGAGGGATTGTCGCCGGAC
GGACGGCATCCGTTGCAGCTCGCATGGGTCGCCGAAGACGTGCCGCAATGCGGCTATTGCCAGCCGGGCCAGGTGATGCA
GGCCGCCGCGCTGCTGAACGGCGGCCGGCCCGTCGACGACGCGGCGATCGTGTCCGCGATGTCGGGCAATGTGTGCCGGT
GCGGCACCTATGCGGGCATCCATCGCGCGATCAAGCGCGCGGCGTCGGGCGATCCCGCGCTCGACGCGGTGGCCGGCGAC
GCCAAGGAGGCATGA

Upstream 100 bases:

>100_bases
TCGACGAAATGATCGCTGGCGCGCGAGCGCGCCGCGTTTCGATAATGCGATACCGCGCACGGCGATGCGCGACCCCACGA
CCCGACTCAGGAGACCGCGC

Downstream 100 bases:

>100_bases
GATGCGACACGATCGAACCGCACCGATGCCGCCCATCGACGACGCCCCGCGGCGCCGCTTTCTGAAGCAGAGTGCCGCGC
TGCTCACTGCCGGCGTCGCC

Product: isoquinoline 1-oxidoreductase, alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MIDIVVNDTRHSLDQVPDDMPLLWVLRDRLKLTGTKFGCGKGLCGACTVHVDGQAVRSCVMPAVAVQGRKVTTIEGLSPD
GRHPLQLAWVAEDVPQCGYCQPGQVMQAAALLNGGRPVDDAAIVSAMSGNVCRCGTYAGIHRAIKRAASGDPALDAVAGD
AKEA

Sequences:

>Translated_164_residues
MIDIVVNDTRHSLDQVPDDMPLLWVLRDRLKLTGTKFGCGKGLCGACTVHVDGQAVRSCVMPAVAVQGRKVTTIEGLSPD
GRHPLQLAWVAEDVPQCGYCQPGQVMQAAALLNGGRPVDDAAIVSAMSGNVCRCGTYAGIHRAIKRAASGDPALDAVAGD
AKEA
>Mature_164_residues
MIDIVVNDTRHSLDQVPDDMPLLWVLRDRLKLTGTKFGCGKGLCGACTVHVDGQAVRSCVMPAVAVQGRKVTTIEGLSPD
GRHPLQLAWVAEDVPQCGYCQPGQVMQAAALLNGGRPVDDAAIVSAMSGNVCRCGTYAGIHRAIKRAASGDPALDAVAGD
AKEA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786480, Length=143, Percent_Identity=47.5524475524476, Blast_Score=113, Evalue=5e-27,
Organism=Escherichia coli, GI1789232, Length=142, Percent_Identity=36.6197183098592, Blast_Score=84, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=149, Percent_Identity=39.5973154362416, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17539860, Length=142, Percent_Identity=36.6197183098592, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32566215, Length=155, Percent_Identity=36.1290322580645, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737937, Length=142, Percent_Identity=39.4366197183099, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647193, Length=160, Percent_Identity=36.25, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24647201, Length=145, Percent_Identity=36.551724137931, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647199, Length=161, Percent_Identity=35.4037267080745, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647197, Length=145, Percent_Identity=35.8620689655172, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24647195, Length=145, Percent_Identity=35.8620689655172, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 17149; Mature: 17149

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDIVVNDTRHSLDQVPDDMPLLWVLRDRLKLTGTKFGCGKGLCGACTVHVDGQAVRSCV
CEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECHHHHHHHH
MPAVAVQGRKVTTIEGLSPDGRHPLQLAWVAEDVPQCGYCQPGQVMQAAALLNGGRPVDD
HHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCH
AAIVSAMSGNVCRCGTYAGIHRAIKRAASGDPALDAVAGDAKEA
HHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MIDIVVNDTRHSLDQVPDDMPLLWVLRDRLKLTGTKFGCGKGLCGACTVHVDGQAVRSCV
CEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECHHHHHHHH
MPAVAVQGRKVTTIEGLSPDGRHPLQLAWVAEDVPQCGYCQPGQVMQAAALLNGGRPVDD
HHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCH
AAIVSAMSGNVCRCGTYAGIHRAIKRAASGDPALDAVAGDAKEA
HHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]