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The map label for this gene is alsR [H]

Identifier: 189353334

GI number: 189353334

Start: 1574998

End: 1575909

Strand: Direct

Name: alsR [H]

Synonym: BMULJ_04574

Alternate gene names: 189353334

Gene position: 1574998-1575909 (Clockwise)

Preceding gene: 189353332

Following gene: 189353336

Centisome position: 63.68

GC content: 72.04

Gene sequence:

>912_bases
ATGATCGATCTGCGCCAGTTCCGGCAATTCATCGCCGTCGCCGAGACGCTCAGCTTCCGGCGCGCCGCCGAGCGCCTGCA
CATGGCGCAGCCGCCGCTCAGCGCGGCGATCCGCAAACTCGAGGACGAACTCGGCGTCATGCTCCTCGCCCGCGACAACC
GCGGCACGGCGCTCACGCCGGCCGGCGACGCGTTCCTGCTCGAAGCGCGGCGCGCGCTGGAGCAGGCCGAGCGCGCGATG
ATCGCGGCCCGCCGTGCCGGTGCGGGCCTCGGCGGCACGTTGCGGTTGCGGTTCGTCGACAGCACCGTCAATGCACTGCT
GCCGCCGATCCTGCGCGCGTTCCAGGAGCGGCATCCGCACGTCGATTTCCAGCTCGAGGAAGGCACGACCGCCGAGCAGG
TGCTGGCGCTGCGTCAGGACCGCACCGATGTCGGGCTCGTCGTGCTGCCGGTGCCGGATGCCGGCGACGTTCACATCGAG
CCGCTCTTGCGCGACCGCATGGTTGCCGCGCTGCCCGATGGACACCGGCTGGCGCGCCGCCGGCGCATCGCGCTCGCGGA
GCTGGCGGACGAACCGTGGGTGCTGTTTGCCGCGCATCACGGCCCCGGCATGCATGCGCGGATCGTCACCGCGTGCGCGC
AGGCCGGTTTCACGCCGCGCGTCGTGCAGCAGCCGCGTCAGATGCAGACGACGGCCGGGCTCGTCGCCGGCGGTATCGGT
GTTGCGCTGATGCCGCGCCTGTTCGTGCCGGTGCAGCCGCCCGGCATGACGTTTTGCGAACTGAAGGGCGCCGGCTGCCC
GCTTGCGTACGAACTGGCGCTCGCCTATCGCACGCCGTCGCCGCTCGTCGACGCGTTGCGCGACACGGCGCGGCACGCGG
TGCGCGAACTGGGGCTCAACGCGGCAACGTGA

Upstream 100 bases:

>100_bases
CTCCCGAATGTCGACAATGAATGACACCGGAAGTCTGGTCGACGCCGCGCGATAGATAAAATACGAATTCGATGATCAAC
TGATACATGGAAGGTATCGC

Downstream 100 bases:

>100_bases
GCGCGCGCGTGGCGCGCGTCACGCTCAATCGCCGAGCAGATTCAGCGCGACTTCGAGCACGGTCCGTTTGAACTCGGCCT
GTCGCGTCGGCAGCGACGTG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MIDLRQFRQFIAVAETLSFRRAAERLHMAQPPLSAAIRKLEDELGVMLLARDNRGTALTPAGDAFLLEARRALEQAERAM
IAARRAGAGLGGTLRLRFVDSTVNALLPPILRAFQERHPHVDFQLEEGTTAEQVLALRQDRTDVGLVVLPVPDAGDVHIE
PLLRDRMVAALPDGHRLARRRRIALAELADEPWVLFAAHHGPGMHARIVTACAQAGFTPRVVQQPRQMQTTAGLVAGGIG
VALMPRLFVPVQPPGMTFCELKGAGCPLAYELALAYRTPSPLVDALRDTARHAVRELGLNAAT

Sequences:

>Translated_303_residues
MIDLRQFRQFIAVAETLSFRRAAERLHMAQPPLSAAIRKLEDELGVMLLARDNRGTALTPAGDAFLLEARRALEQAERAM
IAARRAGAGLGGTLRLRFVDSTVNALLPPILRAFQERHPHVDFQLEEGTTAEQVLALRQDRTDVGLVVLPVPDAGDVHIE
PLLRDRMVAALPDGHRLARRRRIALAELADEPWVLFAAHHGPGMHARIVTACAQAGFTPRVVQQPRQMQTTAGLVAGGIG
VALMPRLFVPVQPPGMTFCELKGAGCPLAYELALAYRTPSPLVDALRDTARHAVRELGLNAAT
>Mature_303_residues
MIDLRQFRQFIAVAETLSFRRAAERLHMAQPPLSAAIRKLEDELGVMLLARDNRGTALTPAGDAFLLEARRALEQAERAM
IAARRAGAGLGGTLRLRFVDSTVNALLPPILRAFQERHPHVDFQLEEGTTAEQVLALRQDRTDVGLVVLPVPDAGDVHIE
PLLRDRMVAALPDGHRLARRRRIALAELADEPWVLFAAHHGPGMHARIVTACAQAGFTPRVVQQPRQMQTTAGLVAGGIG
VALMPRLFVPVQPPGMTFCELKGAGCPLAYELALAYRTPSPLVDALRDTARHAVRELGLNAAT

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=270, Percent_Identity=38.5185185185185, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1788887, Length=245, Percent_Identity=39.5918367346939, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI2367136, Length=273, Percent_Identity=32.6007326007326, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790399, Length=250, Percent_Identity=32, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI157672245, Length=231, Percent_Identity=32.4675324675325, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI145693105, Length=254, Percent_Identity=27.9527559055118, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787530, Length=259, Percent_Identity=27.4131274131274, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788748, Length=254, Percent_Identity=29.1338582677165, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787601, Length=199, Percent_Identity=29.1457286432161, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=27.2357723577236, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787806, Length=254, Percent_Identity=25.9842519685039, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790208, Length=260, Percent_Identity=27.3076923076923, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787589, Length=131, Percent_Identity=35.8778625954198, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786401, Length=168, Percent_Identity=32.1428571428571, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788296, Length=234, Percent_Identity=26.0683760683761, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790262, Length=196, Percent_Identity=27.0408163265306, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788481, Length=194, Percent_Identity=27.8350515463918, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789173, Length=145, Percent_Identity=33.7931034482759, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081904, Length=206, Percent_Identity=24.2718446601942, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33010; Mature: 33010

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLRQFRQFIAVAETLSFRRAAERLHMAQPPLSAAIRKLEDELGVMLLARDNRGTALTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCEEEEEECCCCCEECC
AGDAFLLEARRALEQAERAMIAARRAGAGLGGTLRLRFVDSTVNALLPPILRAFQERHPH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCC
VDFQLEEGTTAEQVLALRQDRTDVGLVVLPVPDAGDVHIEPLLRDRMVAALPDGHRLARR
CEEEECCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHCCCCHHHHHHH
RRIALAELADEPWVLFAAHHGPGMHARIVTACAQAGFTPRVVQQPRQMQTTAGLVAGGIG
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHH
VALMPRLFVPVQPPGMTFCELKGAGCPLAYELALAYRTPSPLVDALRDTARHAVRELGLN
HHHHHHHEECCCCCCCEEEEECCCCCCHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
AAT
CCC
>Mature Secondary Structure
MIDLRQFRQFIAVAETLSFRRAAERLHMAQPPLSAAIRKLEDELGVMLLARDNRGTALTP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCEEEEEECCCCCEECC
AGDAFLLEARRALEQAERAMIAARRAGAGLGGTLRLRFVDSTVNALLPPILRAFQERHPH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCC
VDFQLEEGTTAEQVLALRQDRTDVGLVVLPVPDAGDVHIEPLLRDRMVAALPDGHRLARR
CEEEECCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCEEHHHHHHHHHHCCCCHHHHHHH
RRIALAELADEPWVLFAAHHGPGMHARIVTACAQAGFTPRVVQQPRQMQTTAGLVAGGIG
HHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHH
VALMPRLFVPVQPPGMTFCELKGAGCPLAYELALAYRTPSPLVDALRDTARHAVRELGLN
HHHHHHHEECCCCCCCEEEEECCCCCCHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
AAT
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]