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The map label for this gene is paaH [H]

Identifier: 189353144

GI number: 189353144

Start: 1341026

End: 1342582

Strand: Reverse

Name: paaH [H]

Synonym: BMULJ_04380

Alternate gene names: 189353144

Gene position: 1342582-1341026 (Counterclockwise)

Preceding gene: 189353146

Following gene: 189353143

Centisome position: 54.29

GC content: 71.8

Gene sequence:

>1557_bases
ATGGCTGTTTCTTCTGCACATTCGACGAACCCCGGCGCGTTGCCGCTGTCGGCCGTCGTCGGCGTGATCGGCGCCGGCGC
GATGGGCGCGGGTATCGCGCAGGTCGCGGCCGCGGCCGGCCACACGGTCTTGCTGTACGACCTGAACGAAGCCGCCTGCG
ACAAGGCGCTGGCCGGCATTCGCGCGCAGTTCGCGCGGCTCGCGGAGAAAGGGCGGCTCGAGCCGGCCGAGGCCGATGCC
GCCGGCAGCCGCCTCCGCGCCGTGCGCGCGCTCGCCGATTTCGCGCCCGCCGCGCTGATCGTCGAGGCGGCTGCGGAGCG
GCTCGACGTGAAGCGCGAGATTTTCGCGACGCTCGAACGTCATGTCGACGATGCGTGTCTGCTCGCGACCAACACGTCGT
CGATCTCGATCACGTCGATTGCGGCCGGGCTGCGCGCGCCGCAGCGCGTCGCCGGCCTGCATTTCTTCAACCCGGCGCCG
TTGATGGCGCTCGTCGAGGTCGTCAGCGGGCTCGCGACCGCGCCCGAGGTCGCGCAGGCGCTCTACGCGACCGCGGCCGC
GTGGGGCAAGAAGCCCGTGATGGCGAAGTCGACGCCCGGCTTCATCGTCAATCGCGTCGCGCGGCCGTACTACGCGGAGG
CGCTGCGCGTGCTGAACGAACAGGGCGGCACGCCCGCGTCGATCGACGCGGTGCTGCGCGACGCCGGCGGCTTCCGGATG
GGGCCGTTCGAACTGATGGACCTGATCGGCCACGACGTGAACTTCGCGGTGACCGAATCGGTGTTCCGCGCGTACTTTAA
CGATCCACGCTACACGCCGTCGCTGATTCAGCAAGAGCTCGTGAACGCGGGCTTCCTCGGCCGCAAGTCGGGGCGCGGCT
TCTATTCCTATGCGGACGGCGCCGCGCCGCCCGTCGCCGATGTCGAACCGCCGCGCGATGCGCCGGCCGACGTCGTGCTG
TTCGCCGTCGACGGCCCGGCCGCCGCGCTGCATGCGCGCCTGGCCGAGCGCATCGCGGGCGCGCGCGTGCAGGATGCGCA
TCCGCACGAGCTGATCGCGACGGCCGGCCGCGCGTCGATCGCGCTGACGGACGGCCGCACCGCGACCGAGCGTGCCGCGC
AAACCGGCATGACCGATCTCGTGCTCGTCGATCTCGCGCGCGATTACACGCAGGCCGGCGTCGTCGCGCTTGCGCGCGCG
CTGCAATGCAGCGACGCCGCCTACGCGGACGCGGTCGGCCTGTTCCAGCAGGCCGGTTTCCGCGTGATCGGCCTCGGCGA
CGTGCCGGGGATGATCGCGATGCGCACGGTCGCGATGCTCGCGAACGAGGCGGCCGACGCCGTGAACCAGGGCGTTTGCT
CGCCCGCCGATCTCGATCTCGCGATGGAGAAGGGCGTCAACTACCCGTGCGGCCCGCTCGCGTGGGCCGATGCGATCGGC
GTCGGCCGCGTGTACCGCGTGCTGTCGAATCTCGCCGCGAGCTATGGCGAGGACCGCTATCGCGTCTCGCCGCGCATCGC
CGCGCGGCACGCGGCCGGCCGGTCGTTGCGCGCGTAG

Upstream 100 bases:

>100_bases
CGCTCTGTTGCCCGACAAATTCGGGCTCGCCCTGACATAAATCTACCGACCGGTCGGTTTATAATCGCTCGCACTTCCAC
TTGATGACGGATCGCAAGCG

Downstream 100 bases:

>100_bases
CCGCGATCCCGATCACGACAACGACATATTCCCTTGGAGGAGCACCCCGATGACTTACCCGACGCACCCCGCCGCCGCGC
TCGAGCCGATCGAGACCGCC

Product: 3-hydroxy-acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MAVSSAHSTNPGALPLSAVVGVIGAGAMGAGIAQVAAAAGHTVLLYDLNEAACDKALAGIRAQFARLAEKGRLEPAEADA
AGSRLRAVRALADFAPAALIVEAAAERLDVKREIFATLERHVDDACLLATNTSSISITSIAAGLRAPQRVAGLHFFNPAP
LMALVEVVSGLATAPEVAQALYATAAAWGKKPVMAKSTPGFIVNRVARPYYAEALRVLNEQGGTPASIDAVLRDAGGFRM
GPFELMDLIGHDVNFAVTESVFRAYFNDPRYTPSLIQQELVNAGFLGRKSGRGFYSYADGAAPPVADVEPPRDAPADVVL
FAVDGPAAALHARLAERIAGARVQDAHPHELIATAGRASIALTDGRTATERAAQTGMTDLVLVDLARDYTQAGVVALARA
LQCSDAAYADAVGLFQQAGFRVIGLGDVPGMIAMRTVAMLANEAADAVNQGVCSPADLDLAMEKGVNYPCGPLAWADAIG
VGRVYRVLSNLAASYGEDRYRVSPRIAARHAAGRSLRA

Sequences:

>Translated_518_residues
MAVSSAHSTNPGALPLSAVVGVIGAGAMGAGIAQVAAAAGHTVLLYDLNEAACDKALAGIRAQFARLAEKGRLEPAEADA
AGSRLRAVRALADFAPAALIVEAAAERLDVKREIFATLERHVDDACLLATNTSSISITSIAAGLRAPQRVAGLHFFNPAP
LMALVEVVSGLATAPEVAQALYATAAAWGKKPVMAKSTPGFIVNRVARPYYAEALRVLNEQGGTPASIDAVLRDAGGFRM
GPFELMDLIGHDVNFAVTESVFRAYFNDPRYTPSLIQQELVNAGFLGRKSGRGFYSYADGAAPPVADVEPPRDAPADVVL
FAVDGPAAALHARLAERIAGARVQDAHPHELIATAGRASIALTDGRTATERAAQTGMTDLVLVDLARDYTQAGVVALARA
LQCSDAAYADAVGLFQQAGFRVIGLGDVPGMIAMRTVAMLANEAADAVNQGVCSPADLDLAMEKGVNYPCGPLAWADAIG
VGRVYRVLSNLAASYGEDRYRVSPRIAARHAAGRSLRA
>Mature_517_residues
AVSSAHSTNPGALPLSAVVGVIGAGAMGAGIAQVAAAAGHTVLLYDLNEAACDKALAGIRAQFARLAEKGRLEPAEADAA
GSRLRAVRALADFAPAALIVEAAAERLDVKREIFATLERHVDDACLLATNTSSISITSIAAGLRAPQRVAGLHFFNPAPL
MALVEVVSGLATAPEVAQALYATAAAWGKKPVMAKSTPGFIVNRVARPYYAEALRVLNEQGGTPASIDAVLRDAGGFRMG
PFELMDLIGHDVNFAVTESVFRAYFNDPRYTPSLIQQELVNAGFLGRKSGRGFYSYADGAAPPVADVEPPRDAPADVVLF
AVDGPAAALHARLAERIAGARVQDAHPHELIATAGRASIALTDGRTATERAAQTGMTDLVLVDLARDYTQAGVVALARAL
QCSDAAYADAVGLFQQAGFRVIGLGDVPGMIAMRTVAMLANEAADAVNQGVCSPADLDLAMEKGVNYPCGPLAWADAIGV
GRVYRVLSNLAASYGEDRYRVSPRIAARHAAGRSLRA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=40.418118466899, Blast_Score=202, Evalue=8e-52,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=38.4868421052632, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=33.6879432624113, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI68989263, Length=306, Percent_Identity=30.3921568627451, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI261878539, Length=306, Percent_Identity=30.3921568627451, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=29.3617021276596, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1787661, Length=487, Percent_Identity=47.6386036960986, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788682, Length=275, Percent_Identity=32.3636363636364, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790281, Length=271, Percent_Identity=30.2583025830258, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17563036, Length=301, Percent_Identity=39.5348837209302, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17553560, Length=283, Percent_Identity=39.2226148409894, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17549919, Length=284, Percent_Identity=39.0845070422535, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI71985930, Length=301, Percent_Identity=29.5681063122924, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71985923, Length=300, Percent_Identity=28.3333333333333, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25144276, Length=290, Percent_Identity=32.4137931034483, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17508951, Length=290, Percent_Identity=32.4137931034483, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17508953, Length=290, Percent_Identity=32.4137931034483, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17558304, Length=290, Percent_Identity=31.0344827586207, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24583077, Length=280, Percent_Identity=34.2857142857143, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24583079, Length=280, Percent_Identity=34.2857142857143, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI19921000, Length=280, Percent_Identity=34.2857142857143, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45549573, Length=233, Percent_Identity=27.8969957081545, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI20129993, Length=231, Percent_Identity=26.8398268398268, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 53858; Mature: 53727

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSSAHSTNPGALPLSAVVGVIGAGAMGAGIAQVAAAAGHTVLLYDLNEAACDKALAGI
CCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHH
RAQFARLAEKGRLEPAEADAAGSRLRAVRALADFAPAALIVEAAAERLDVKREIFATLER
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVDDACLLATNTSSISITSIAAGLRAPQRVAGLHFFNPAPLMALVEVVSGLATAPEVAQA
CCCCEEEEEECCCCEEHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
LYATAAAWGKKPVMAKSTPGFIVNRVARPYYAEALRVLNEQGGTPASIDAVLRDAGGFRM
HHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
GPFELMDLIGHDVNFAVTESVFRAYFNDPRYTPSLIQQELVNAGFLGRKSGRGFYSYADG
CHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCC
AAPPVADVEPPRDAPADVVLFAVDGPAAALHARLAERIAGARVQDAHPHELIATAGRASI
CCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEE
ALTDGRTATERAAQTGMTDLVLVDLARDYTQAGVVALARALQCSDAAYADAVGLFQQAGF
EEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
RVIGLGDVPGMIAMRTVAMLANEAADAVNQGVCSPADLDLAMEKGVNYPCGPLAWADAIG
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHH
VGRVYRVLSNLAASYGEDRYRVSPRIAARHAAGRSLRA
HHHHHHHHHHHHHHCCCCCEEECHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVSSAHSTNPGALPLSAVVGVIGAGAMGAGIAQVAAAAGHTVLLYDLNEAACDKALAGI
CCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHH
RAQFARLAEKGRLEPAEADAAGSRLRAVRALADFAPAALIVEAAAERLDVKREIFATLER
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVDDACLLATNTSSISITSIAAGLRAPQRVAGLHFFNPAPLMALVEVVSGLATAPEVAQA
CCCCEEEEEECCCCEEHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
LYATAAAWGKKPVMAKSTPGFIVNRVARPYYAEALRVLNEQGGTPASIDAVLRDAGGFRM
HHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
GPFELMDLIGHDVNFAVTESVFRAYFNDPRYTPSLIQQELVNAGFLGRKSGRGFYSYADG
CHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECCC
AAPPVADVEPPRDAPADVVLFAVDGPAAALHARLAERIAGARVQDAHPHELIATAGRASI
CCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCEE
ALTDGRTATERAAQTGMTDLVLVDLARDYTQAGVVALARALQCSDAAYADAVGLFQQAGF
EEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
RVIGLGDVPGMIAMRTVAMLANEAADAVNQGVCSPADLDLAMEKGVNYPCGPLAWADAIG
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHH
VGRVYRVLSNLAASYGEDRYRVSPRIAARHAAGRSLRA
HHHHHHHHHHHHHHCCCCCEEECHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]