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The map label for this gene is adh [H]

Identifier: 189352496

GI number: 189352496

Start: 551226

End: 552275

Strand: Reverse

Name: adh [H]

Synonym: BMULJ_03716

Alternate gene names: 189352496

Gene position: 552275-551226 (Counterclockwise)

Preceding gene: 189352497

Following gene: 189352495

Centisome position: 22.33

GC content: 60.86

Gene sequence:

>1050_bases
ATGACGGTCAAAGCATACGGAGCCTATGCCGGCGACAAAGCTCTTGAATCGATGGACATCGTCCGCCGCGCGCCGGGCGC
GCACGACGTGAAAATCGACATCGCGTTCTGTGGTGTCTGCCATTCCGACATCCATCAGGTACGCGCCGAGTGGGCTGGCA
CGCTGTTTCCCTGTGTGCCGGGACACGAAATCGTCGGGCGTGTTTCGGCGGTCGGCGCAAATGTGTCGGGCTTCAAGGTG
GGCGAGCTCGTCGGAGTTGGCTGCATCGTTGACAGTTGCAGGCACTGCGCAGATTGCGACGAAGGGCTGGAGAACTATTG
CGACCACATGGTCGGCACGTATAACGGGCCGACGGCTGACGCGCCCGGTCACACTCTGGGCGGCTATTCGCAAGAGATCG
TGGTGCATGAGCGCTATGTTCTGCGCATCCGGCACGACGAAGCGCAACTCGCCGCAGTCGCACCGTTGCTCTGCGCAGGG
ATTACGACGTATTCCCCGCTGCGTCACTGGAAGGTGGGGCCTGGACACAAGGTCGGCATCGTGGGTATCGGCGGGCTGGG
CCATATGGGCATCAAGCTGGCCAATGCAATGGGCGCATATGTGGTGGCGTTCACGACCTCCGGGTCGAAGCGCGAAGCAG
CCAAAGCGCTGGGGGCGCATGAGGTGGTAGTGTCGCGTAACGCCGATGAAATGTCCGCGCATGCAAAGAGCCTCGACTTC
ATTCTCAACACGGTAGCGGCTCCGCATGATCTTGATGCGTTCTTCACCCTTCTCAAGCGCGACGGCACCATGACCCTGGT
GGGCGCGCCCGCTTCGCCGCATCCTTCACCGCAGGTCTTCAACCTGATCATGAAGCGGCGCAGCCTGGCCGGTTCGATGA
TTGGCGGCATTCCGGAGACACAGGAGATGCTCGATTTCTGTGCCGAGCATGGCATCGTCTCCGACATTGAGATGATCCGC
GCCGACCAGATCAACGACGCGTACGAACGCATGCTGAAGGGCGATGTGAAATACCGCTTCGTCATTGACAGCTCGTCGCT
GGCTCAGTGA

Upstream 100 bases:

>100_bases
AGTGTCGTGCTGTTGCTGATTGCGGCTTTCCTGACTTTCCTGACGTCCCGCTCCGACACCGCGTCGGCGAGTTGATCAAC
CAATTACGAGGGTTCAAATC

Downstream 100 bases:

>100_bases
CCCATCGATTCAGACCGCGGATTCGTTTTGAAACATCGGAGCTTGAGCTATGGAATACAAGCATCTTGGACGAACAGGCC
TGAAAATCAGCCGGCTCGCG

Product: alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MTVKAYGAYAGDKALESMDIVRRAPGAHDVKIDIAFCGVCHSDIHQVRAEWAGTLFPCVPGHEIVGRVSAVGANVSGFKV
GELVGVGCIVDSCRHCADCDEGLENYCDHMVGTYNGPTADAPGHTLGGYSQEIVVHERYVLRIRHDEAQLAAVAPLLCAG
ITTYSPLRHWKVGPGHKVGIVGIGGLGHMGIKLANAMGAYVVAFTTSGSKREAAKALGAHEVVVSRNADEMSAHAKSLDF
ILNTVAAPHDLDAFFTLLKRDGTMTLVGAPASPHPSPQVFNLIMKRRSLAGSMIGGIPETQEMLDFCAEHGIVSDIEMIR
ADQINDAYERMLKGDVKYRFVIDSSSLAQ

Sequences:

>Translated_349_residues
MTVKAYGAYAGDKALESMDIVRRAPGAHDVKIDIAFCGVCHSDIHQVRAEWAGTLFPCVPGHEIVGRVSAVGANVSGFKV
GELVGVGCIVDSCRHCADCDEGLENYCDHMVGTYNGPTADAPGHTLGGYSQEIVVHERYVLRIRHDEAQLAAVAPLLCAG
ITTYSPLRHWKVGPGHKVGIVGIGGLGHMGIKLANAMGAYVVAFTTSGSKREAAKALGAHEVVVSRNADEMSAHAKSLDF
ILNTVAAPHDLDAFFTLLKRDGTMTLVGAPASPHPSPQVFNLIMKRRSLAGSMIGGIPETQEMLDFCAEHGIVSDIEMIR
ADQINDAYERMLKGDVKYRFVIDSSSLAQ
>Mature_348_residues
TVKAYGAYAGDKALESMDIVRRAPGAHDVKIDIAFCGVCHSDIHQVRAEWAGTLFPCVPGHEIVGRVSAVGANVSGFKVG
ELVGVGCIVDSCRHCADCDEGLENYCDHMVGTYNGPTADAPGHTLGGYSQEIVVHERYVLRIRHDEAQLAAVAPLLCAGI
TTYSPLRHWKVGPGHKVGIVGIGGLGHMGIKLANAMGAYVVAFTTSGSKREAAKALGAHEVVVSRNADEMSAHAKSLDFI
LNTVAAPHDLDAFFTLLKRDGTMTLVGAPASPHPSPQVFNLIMKRRSLAGSMIGGIPETQEMLDFCAEHGIVSDIEMIRA
DQINDAYERMLKGDVKYRFVIDSSSLAQ

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=369, Percent_Identity=23.8482384823848, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4501933, Length=347, Percent_Identity=27.3775216138329, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI34577061, Length=366, Percent_Identity=26.5027322404372, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4501929, Length=345, Percent_Identity=26.9565217391304, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI71743840, Length=309, Percent_Identity=25.8899676375405, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI262073058, Length=309, Percent_Identity=25.8899676375405, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1786518, Length=347, Percent_Identity=80.4034582132565, Blast_Score=569, Evalue=1e-164,
Organism=Escherichia coli, GI87082401, Length=342, Percent_Identity=33.9181286549708, Blast_Score=174, Evalue=6e-45,
Organism=Escherichia coli, GI87081918, Length=311, Percent_Identity=27.3311897106109, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI226510992, Length=257, Percent_Identity=27.2373540856031, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786552, Length=368, Percent_Identity=26.9021739130435, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790045, Length=282, Percent_Identity=26.241134751773, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788407, Length=249, Percent_Identity=27.710843373494, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787863, Length=140, Percent_Identity=33.5714285714286, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788075, Length=287, Percent_Identity=26.1324041811847, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1788073, Length=263, Percent_Identity=27.7566539923954, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=338, Percent_Identity=28.1065088757396, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562582, Length=346, Percent_Identity=29.1907514450867, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI71988145, Length=348, Percent_Identity=26.1494252873563, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI25146526, Length=368, Percent_Identity=26.3586956521739, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=370, Percent_Identity=26.4864864864865, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=362, Percent_Identity=25.6906077348066, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=232, Percent_Identity=29.3103448275862, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=351, Percent_Identity=33.3333333333333, Blast_Score=175, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6319621, Length=350, Percent_Identity=32.2857142857143, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324486, Length=344, Percent_Identity=32.2674418604651, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323980, Length=325, Percent_Identity=38.1538461538462, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6323729, Length=344, Percent_Identity=30.5232558139535, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6319949, Length=331, Percent_Identity=35.6495468277946, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=28.686327077748, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=346, Percent_Identity=23.9884393063584, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=26.9021739130435, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 37252; Mature: 37121

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKAYGAYAGDKALESMDIVRRAPGAHDVKIDIAFCGVCHSDIHQVRAEWAGTLFPCVP
CEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCC
GHEIVGRVSAVGANVSGFKVGELVGVGCIVDSCRHCADCDEGLENYCDHMVGTYNGPTAD
CHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
APGHTLGGYSQEIVVHERYVLRIRHDEAQLAAVAPLLCAGITTYSPLRHWKVGPGHKVGI
CCCCCCCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEEE
VGIGGLGHMGIKLANAMGAYVVAFTTSGSKREAAKALGAHEVVVSRNADEMSAHAKSLDF
EEECCCCHHHHHHHHHCCEEEEEEECCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
ILNTVAAPHDLDAFFTLLKRDGTMTLVGAPASPHPSPQVFNLIMKRRSLAGSMIGGIPET
HHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
QEMLDFCAEHGIVSDIEMIRADQINDAYERMLKGDVKYRFVIDSSSLAQ
HHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
TVKAYGAYAGDKALESMDIVRRAPGAHDVKIDIAFCGVCHSDIHQVRAEWAGTLFPCVP
EEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHHHHCCCCCCCCC
GHEIVGRVSAVGANVSGFKVGELVGVGCIVDSCRHCADCDEGLENYCDHMVGTYNGPTAD
CHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
APGHTLGGYSQEIVVHERYVLRIRHDEAQLAAVAPLLCAGITTYSPLRHWKVGPGHKVGI
CCCCCCCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEEE
VGIGGLGHMGIKLANAMGAYVVAFTTSGSKREAAKALGAHEVVVSRNADEMSAHAKSLDF
EEECCCCHHHHHHHHHCCEEEEEEECCCCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHH
ILNTVAAPHDLDAFFTLLKRDGTMTLVGAPASPHPSPQVFNLIMKRRSLAGSMIGGIPET
HHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
QEMLDFCAEHGIVSDIEMIRADQINDAYERMLKGDVKYRFVIDSSSLAQ
HHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]