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The map label for this gene is comEC [H]

Identifier: 189183210

GI number: 189183210

Start: 316464

End: 318512

Strand: Reverse

Name: comEC [H]

Synonym: OTT_0303

Alternate gene names: 189183210

Gene position: 318512-316464 (Counterclockwise)

Preceding gene: 189183211

Following gene: 189183209

Centisome position: 15.85

GC content: 28.7

Gene sequence:

>2049_bases
ATGATTATATCTTCAGTTAATAAATTAATAGCAGAAGAGTATCATAATATTAGTTTATGGTTTATTGTTAGTTTTATATT
TGGTATAGCGCTATATTTTGCCTTGCCTTTTGAACCGCAAATTTGTCAAATTTTGCTTATATTACCAATCTTCATAGTTA
TTTTCATAATTACAAGAAAGAGCTTTTTAAGCAAAACATTGCTGTTAATTCTGTTTTGTTGCTATTTAGGTGTTATAGTT
GGTAAAATAAGATATTTAACAGCAAATACATACCATATTGATACGATTATAAAATCTAAAATTTATGGAACAATAAAAAA
AATTCATCCTACTTCTAGAGGAGTGATACTAGTTATTGATAACTGCCATGTCGAAACATCTGATAGTTACAATATACTAA
CAAGTATAAAAATATCAGCTTTTAGAAAACAAGTGCATAACATTACAATTGGAGATCAAGTTGCTTTCAATGCAACATTA
TATCCTCTAACAAGTAATAAACTAATGATTAATGAATTGCCATTCAATATACTTGCATATTTTAACAATATCAGCGCAAT
AGGTTATGCAACATCATCAGTGAAATTAGTTCAAAGTAATAATCAAAACAATGGATTACTAAGCCATAAATTAATTGCTA
CTATTGAGCATATTAGAATTAAGATACATGATAGAGTTATAGACGCTTTAGATAGTTATTTAGGTGGTTTTATTAATGCG
ATTTTATTAGGAGAAAATCATGCACTTAATAAAGATATTATTATCAGTATGAGGCAAGCTGGAGTATCGCACATATTGTG
CATATCAGGATTACACCTTTCTATGGTTGCAATTGCATTATTTATTGGATGTAGATTTATCTTAAATTTATCAACCACTG
TTGCTTTTAATTGCGATGTAAGAACTATAGCAATAATAATATCTTTAATAGGTAGTTTTTGCTATCTAGTATTAGCTGGA
GGGCATATTGCTACAATTAGAGCTTTTATAATGACTTCAACTACTATGGTAGTTGTGCTAATAAAGCGTGGAGTAGTCCC
ATTACGATTAGTTGGCTTAGCTGCTATTATAATTCTGTTATTTAATCCAGAATATATTATGCATCCAAGTTTTCAGCTAT
CATTTATAGCTGTGATATCATTAATTAGTTGCTACGAGCTTCAGAGTATTACTCAGCAACATAAATTCAATGTAGATCAA
AAAGATATATTATCTAAAATACAGCTATTTTTTGAGTCAAACATATATTCAAGTGCTATTGCTAGCATAGCAACTGCTCC
AATTGTAATATATCACTTTTACAGTTTTCCTAACTACTCAGTATTAGCAAATCTATTGATAGTGCCATTAACAGCATTTT
GGGTTATGCCATTAACTCTGATATCTTTATTACTAATGCCTTTTAACATAGAAAACTATTTCTTGTTATTAGCAGGGCAA
GGAGTTGATGTTATAATTAAAATAGCTAAGATAATTTCAACACTTCCATATGCAGTAACTTACTTTGGGCATATTGACGA
TGTTAGCTTATTAATTTATTTGTTTGGATTCTTATGGCTAGTTATTTGGCATAAACCCTGGAGGATGATTGGAGTAGTAA
TAATTATTATAGCTATTATACGAACAGCATTAGTTTCTAAACCAGATCTTGTTTTCAATGGTGAACTTACAGCTCTTGGT
ATTAAGAATTCTAATAGTAAATTTGAGATACATGCTTCTTCTAATATGCCAGAATTTTTTTTAAATTATTGGAGTAATTG
GTATGGTCAGAACGAAATATTATTTCGTAATAGTGCAATAAAAACATTCAACCATAGAATTATTACCAACTCAGGTAAAA
TAGTAGCTATTAGATTTAAAAATACTGATGAATGCGTACCAGCTGATTTGATAATTAGTGTAATACCAAATGATAAATGC
AAATATACTACAGCAAAGATAATTGATGCTGCTATATTGAATAAGTCCAATATAGTAGAAGTATATTGTCATAAACAAAA
ATGTGAATATAAGACTAAATTGAAGAGTGATAGGTTCAAGCTAAGTTAA

Upstream 100 bases:

>100_bases
AACATAGAAGAAATGCAAGAAGTATAATTTCTGTGTTTCTATAATATTTTATCTAGTCAGATCAAATTTTGATTTTACAA
CACAACCTAATAACAAATTA

Downstream 100 bases:

>100_bases
TAAATTCAAAAGTACTTAAAGCAGCATGAGTAAATATGGTGGCTTGAGCCGGGATTGAACCGGCGACGCAAGGATTTTCA
GTCCTACGCTCTACCACTGA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MIISSVNKLIAEEYHNISLWFIVSFIFGIALYFALPFEPQICQILLILPIFIVIFIITRKSFLSKTLLLILFCCYLGVIV
GKIRYLTANTYHIDTIIKSKIYGTIKKIHPTSRGVILVIDNCHVETSDSYNILTSIKISAFRKQVHNITIGDQVAFNATL
YPLTSNKLMINELPFNILAYFNNISAIGYATSSVKLVQSNNQNNGLLSHKLIATIEHIRIKIHDRVIDALDSYLGGFINA
ILLGENHALNKDIIISMRQAGVSHILCISGLHLSMVAIALFIGCRFILNLSTTVAFNCDVRTIAIIISLIGSFCYLVLAG
GHIATIRAFIMTSTTMVVVLIKRGVVPLRLVGLAAIIILLFNPEYIMHPSFQLSFIAVISLISCYELQSITQQHKFNVDQ
KDILSKIQLFFESNIYSSAIASIATAPIVIYHFYSFPNYSVLANLLIVPLTAFWVMPLTLISLLLMPFNIENYFLLLAGQ
GVDVIIKIAKIISTLPYAVTYFGHIDDVSLLIYLFGFLWLVIWHKPWRMIGVVIIIIAIIRTALVSKPDLVFNGELTALG
IKNSNSKFEIHASSNMPEFFLNYWSNWYGQNEILFRNSAIKTFNHRIITNSGKIVAIRFKNTDECVPADLIISVIPNDKC
KYTTAKIIDAAILNKSNIVEVYCHKQKCEYKTKLKSDRFKLS

Sequences:

>Translated_682_residues
MIISSVNKLIAEEYHNISLWFIVSFIFGIALYFALPFEPQICQILLILPIFIVIFIITRKSFLSKTLLLILFCCYLGVIV
GKIRYLTANTYHIDTIIKSKIYGTIKKIHPTSRGVILVIDNCHVETSDSYNILTSIKISAFRKQVHNITIGDQVAFNATL
YPLTSNKLMINELPFNILAYFNNISAIGYATSSVKLVQSNNQNNGLLSHKLIATIEHIRIKIHDRVIDALDSYLGGFINA
ILLGENHALNKDIIISMRQAGVSHILCISGLHLSMVAIALFIGCRFILNLSTTVAFNCDVRTIAIIISLIGSFCYLVLAG
GHIATIRAFIMTSTTMVVVLIKRGVVPLRLVGLAAIIILLFNPEYIMHPSFQLSFIAVISLISCYELQSITQQHKFNVDQ
KDILSKIQLFFESNIYSSAIASIATAPIVIYHFYSFPNYSVLANLLIVPLTAFWVMPLTLISLLLMPFNIENYFLLLAGQ
GVDVIIKIAKIISTLPYAVTYFGHIDDVSLLIYLFGFLWLVIWHKPWRMIGVVIIIIAIIRTALVSKPDLVFNGELTALG
IKNSNSKFEIHASSNMPEFFLNYWSNWYGQNEILFRNSAIKTFNHRIITNSGKIVAIRFKNTDECVPADLIISVIPNDKC
KYTTAKIIDAAILNKSNIVEVYCHKQKCEYKTKLKSDRFKLS
>Mature_682_residues
MIISSVNKLIAEEYHNISLWFIVSFIFGIALYFALPFEPQICQILLILPIFIVIFIITRKSFLSKTLLLILFCCYLGVIV
GKIRYLTANTYHIDTIIKSKIYGTIKKIHPTSRGVILVIDNCHVETSDSYNILTSIKISAFRKQVHNITIGDQVAFNATL
YPLTSNKLMINELPFNILAYFNNISAIGYATSSVKLVQSNNQNNGLLSHKLIATIEHIRIKIHDRVIDALDSYLGGFINA
ILLGENHALNKDIIISMRQAGVSHILCISGLHLSMVAIALFIGCRFILNLSTTVAFNCDVRTIAIIISLIGSFCYLVLAG
GHIATIRAFIMTSTTMVVVLIKRGVVPLRLVGLAAIIILLFNPEYIMHPSFQLSFIAVISLISCYELQSITQQHKFNVDQ
KDILSKIQLFFESNIYSSAIASIATAPIVIYHFYSFPNYSVLANLLIVPLTAFWVMPLTLISLLLMPFNIENYFLLLAGQ
GVDVIIKIAKIISTLPYAVTYFGHIDDVSLLIYLFGFLWLVIWHKPWRMIGVVIIIIAIIRTALVSKPDLVFNGELTALG
IKNSNSKFEIHASSNMPEFFLNYWSNWYGQNEILFRNSAIKTFNHRIITNSGKIVAIRFKNTDECVPADLIISVIPNDKC
KYTTAKIIDAAILNKSNIVEVYCHKQKCEYKTKLKSDRFKLS

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 76757; Mature: 76757

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISSVNKLIAEEYHNISLWFIVSFIFGIALYFALPFEPQICQILLILPIFIVIFIITRK
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
SFLSKTLLLILFCCYLGVIVGKIRYLTANTYHIDTIIKSKIYGTIKKIHPTSRGVILVID
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEHHHHHHHHHHHHHHCCCCCCCEEEEEE
NCHVETSDSYNILTSIKISAFRKQVHNITIGDQVAFNATLYPLTSNKLMINELPFNILAY
CCEEECCCCCEEEEHHHHHHHHHHHHCCEECCCEEEEEEEEEECCCCEEEECCCHHHHHH
FNNISAIGYATSSVKLVQSNNQNNGLLSHKLIATIEHIRIKIHDRVIDALDSYLGGFINA
HCCCCEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHE
ILLGENHALNKDIIISMRQAGVSHILCISGLHLSMVAIALFIGCRFILNLSTTVAFNCDV
EEECCCCCCCHHHEEEEHHCCCCEEHHHCCHHHHHHHHHHHHHHHHHEECCCEEEEECCH
RTIAIIISLIGSFCYLVLAGGHIATIRAFIMTSTTMVVVLIKRGVVPLRLVGLAAIIILL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FNPEYIMHPSFQLSFIAVISLISCYELQSITQQHKFNVDQKDILSKIQLFFESNIYSSAI
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHH
ASIATAPIVIYHFYSFPNYSVLANLLIVPLTAFWVMPLTLISLLLMPFNIENYFLLLAGQ
HHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
GVDVIIKIAKIISTLPYAVTYFGHIDDVSLLIYLFGFLWLVIWHKPWRMIGVVIIIIAII
CHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RTALVSKPDLVFNGELTALGIKNSNSKFEIHASSNMPEFFLNYWSNWYGQNEILFRNSAI
HHHHCCCCCEEECCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCHH
KTFNHRIITNSGKIVAIRFKNTDECVPADLIISVIPNDKCKYTTAKIIDAAILNKSNIVE
HHHCCEEEECCCCEEEEEECCCCCCCCHHHEEEECCCCCCCCHHHHHHHHHHCCCCCEEE
VYCHKQKCEYKTKLKSDRFKLS
EEEECCCCCHHHHCCCCCCCCC
>Mature Secondary Structure
MIISSVNKLIAEEYHNISLWFIVSFIFGIALYFALPFEPQICQILLILPIFIVIFIITRK
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
SFLSKTLLLILFCCYLGVIVGKIRYLTANTYHIDTIIKSKIYGTIKKIHPTSRGVILVID
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEHHHHHHHHHHHHHHCCCCCCCEEEEEE
NCHVETSDSYNILTSIKISAFRKQVHNITIGDQVAFNATLYPLTSNKLMINELPFNILAY
CCEEECCCCCEEEEHHHHHHHHHHHHCCEECCCEEEEEEEEEECCCCEEEECCCHHHHHH
FNNISAIGYATSSVKLVQSNNQNNGLLSHKLIATIEHIRIKIHDRVIDALDSYLGGFINA
HCCCCEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHE
ILLGENHALNKDIIISMRQAGVSHILCISGLHLSMVAIALFIGCRFILNLSTTVAFNCDV
EEECCCCCCCHHHEEEEHHCCCCEEHHHCCHHHHHHHHHHHHHHHHHEECCCEEEEECCH
RTIAIIISLIGSFCYLVLAGGHIATIRAFIMTSTTMVVVLIKRGVVPLRLVGLAAIIILL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FNPEYIMHPSFQLSFIAVISLISCYELQSITQQHKFNVDQKDILSKIQLFFESNIYSSAI
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHH
ASIATAPIVIYHFYSFPNYSVLANLLIVPLTAFWVMPLTLISLLLMPFNIENYFLLLAGQ
HHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
GVDVIIKIAKIISTLPYAVTYFGHIDDVSLLIYLFGFLWLVIWHKPWRMIGVVIIIIAII
CHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
RTALVSKPDLVFNGELTALGIKNSNSKFEIHASSNMPEFFLNYWSNWYGQNEILFRNSAI
HHHHCCCCCEEECCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCHH
KTFNHRIITNSGKIVAIRFKNTDECVPADLIISVIPNDKCKYTTAKIIDAAILNKSNIVE
HHHCCEEEECCCCEEEEEECCCCCCCCHHHEEEECCCCCCCCHHHHHHHHHHCCCCCEEE
VYCHKQKCEYKTKLKSDRFKLS
EEEECCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]