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The map label for this gene is clpP

Identifier: 189025737

GI number: 189025737

Start: 543884

End: 544495

Strand: Direct

Name: clpP

Synonym: TPASS_0507

Alternate gene names: 189025737

Gene position: 543884-544495 (Clockwise)

Preceding gene: 189025736

Following gene: 189025738

Centisome position: 47.73

GC content: 52.78

Gene sequence:

>612_bases
GTGCGTGAACGTATGCATAATCTGGTTCCCTACGTGATTGAACAGTCGGGGGGTGGAGAGCGGAGCTATGACATTTTTTC
CCGCTTGTTGAAGGACCGTATTATTTTCGTAGACGGGGAGATCACTGACGCGGTGGCGGATTTAGTTGTAGCGCAGTTAC
TTTTTCTAGAGTCTCAGAATCCAGATAAGGATATCAGCCTGTACATTAATAGTCCTGGCGGGGCGGTTACTGCAGGGCTT
GCAGTGTACGATACGATGCAGCACATTTGCCCTGAGGTGCAGACCATTTGCTTAGGACAGGCTTCGAGTATGGCAGCAGT
GTTACTGGCAGGAGGTGCGCCTGGCAAGCGTTTTGCGCTTCCGTCTTCTCGGGTGATGATCCATCAACCATGGGGTGGCG
TACAGGGGCAGGCAAGTGATGTGTGCATCCAGGCGCAGGAGATCCTGCGCCTAAAGACGCTGACGATTGCGTATTTCGCG
TTGCACACTGGGCAGTCAGAGGAGCAGGTGCGGGAGGATATGGAGCGAGATTTCTTCCTTTCCGCGGAGCAGGCGTGTTC
GTATGGTATCGTAGATACGGTAATGAAGAGGAGAAAGCATGCTCAGGTCTAA

Upstream 100 bases:

>100_bases
GGAATACGAGAACGGAAGCTGTGCCAGAAATTGCTCGGACGATGTGTGACTGAGTGTGGGCCGGAGCAGTCTTTGACTGA
CTTTCTTCAGGAGCAGTCCC

Downstream 100 bases:

>100_bases
GGGGGATCTGGTATTGGGCTGCTCTTTCTGTGGAAAAAAAGAAGATGAGCGACGCCGGATTGTGACCGGTCATGGGGTTT
CTATTTGCAATTATTGTGTG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MRERMHNLVPYVIEQSGGGERSYDIFSRLLKDRIIFVDGEITDAVADLVVAQLLFLESQNPDKDISLYINSPGGAVTAGL
AVYDTMQHICPEVQTICLGQASSMAAVLLAGGAPGKRFALPSSRVMIHQPWGGVQGQASDVCIQAQEILRLKTLTIAYFA
LHTGQSEEQVREDMERDFFLSAEQACSYGIVDTVMKRRKHAQV

Sequences:

>Translated_203_residues
MRERMHNLVPYVIEQSGGGERSYDIFSRLLKDRIIFVDGEITDAVADLVVAQLLFLESQNPDKDISLYINSPGGAVTAGL
AVYDTMQHICPEVQTICLGQASSMAAVLLAGGAPGKRFALPSSRVMIHQPWGGVQGQASDVCIQAQEILRLKTLTIAYFA
LHTGQSEEQVREDMERDFFLSAEQACSYGIVDTVMKRRKHAQV
>Mature_203_residues
MRERMHNLVPYVIEQSGGGERSYDIFSRLLKDRIIFVDGEITDAVADLVVAQLLFLESQNPDKDISLYINSPGGAVTAGL
AVYDTMQHICPEVQTICLGQASSMAAVLLAGGAPGKRFALPSSRVMIHQPWGGVQGQASDVCIQAQEILRLKTLTIAYFA
LHTGQSEEQVREDMERDFFLSAEQACSYGIVDTVMKRRKHAQV

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=55.2083333333333, Blast_Score=222, Evalue=2e-58,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=61.9791666666667, Blast_Score=258, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=50.5376344086022, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI20129427, Length=193, Percent_Identity=55.440414507772, Blast_Score=231, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_TREPA (O83520)

Other databases:

- EMBL:   AE000520
- PIR:   B71314
- RefSeq:   NP_218948.1
- ProteinModelPortal:   O83520
- SMR:   O83520
- IntAct:   O83520
- MEROPS:   S14.001
- GeneID:   2611746
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0507
- NMPDR:   fig|243276.1.peg.507
- TIGR:   TP_0507
- HOGENOM:   HBG558421
- OMA:   HANGEAS
- ProtClustDB:   PRK00277
- BioCyc:   TPAL243276:TP_0507-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22346; Mature: 22346

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 103-103 ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRERMHNLVPYVIEQSGGGERSYDIFSRLLKDRIIFVDGEITDAVADLVVAQLLFLESQN
CCHHHHHHCCEEEECCCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCC
PDKDISLYINSPGGAVTAGLAVYDTMQHICPEVQTICLGQASSMAAVLLAGGAPGKRFAL
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCEEEC
PSSRVMIHQPWGGVQGQASDVCIQAQEILRLKTLTIAYFALHTGQSEEQVREDMERDFFL
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
SAEQACSYGIVDTVMKRRKHAQV
CHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRERMHNLVPYVIEQSGGGERSYDIFSRLLKDRIIFVDGEITDAVADLVVAQLLFLESQN
CCHHHHHHCCEEEECCCCCCCHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCC
PDKDISLYINSPGGAVTAGLAVYDTMQHICPEVQTICLGQASSMAAVLLAGGAPGKRFAL
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCEEEC
PSSRVMIHQPWGGVQGQASDVCIQAQEILRLKTLTIAYFALHTGQSEEQVREDMERDFFL
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
SAEQACSYGIVDTVMKRRKHAQV
CHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876