Click here to switch to the map view.

The map label for this gene is clpX

Identifier: 189025738

GI number: 189025738

Start: 544482

End: 545729

Strand: Direct

Name: clpX

Synonym: TPASS_0508

Alternate gene names: 189025738

Gene position: 544482-545729 (Clockwise)

Preceding gene: 189025737

Following gene: 189025739

Centisome position: 47.78

GC content: 48.56

Gene sequence:

>1248_bases
ATGCTCAGGTCTAAGGGGGATCTGGTATTGGGCTGCTCTTTCTGTGGAAAAAAAGAAGATGAGCGACGCCGGATTGTGAC
CGGTCATGGGGTTTCTATTTGCAATTATTGTGTGGAGCGGTGTGCAGAATACTTGCGTGATCGCAAGCCGTCGGCACTTG
CGCTCATGACCAAAGAGGAGATTCCAACTCCTTTAGAGTTGAAAGCTTACCTTGATCAGTACGTTATTGGGCAGGATTTG
GCCAAGCGGGTGCTATCGGTTGCGGTGTACAACCACTACAAACGGGTGGCAGGTAGGTCTTTGGATATTGATTCGGTATT
GATTGAAAAATCTAACGTGCTGCTTATTGGGCCGACAGGTTCAGGCAAAACGCTGTTGGCTAAGACACTTTCTCAGAAAA
TGAAGGTCCCCTTTGCGATAGCAGATGCTACTACGCTCACCGAGGCCGGTTATGTGGGTGAGGACGTAGAGAATATCTTA
TTAAAGCTCGTTCAGAATGCGAACGGAGATGTTGCCCTCGCAGAACGGGGGATTATCTTCATTGATGAAATCGATAAGAT
TTCGCGTAAGAGCGAGAACGTGTCTATTACGCGTGATGTGTCGGGTGAAGGGGTTCAGCAGGCGCTTTTGAAAATAATTG
AGGGAACGATAGCATCGGTGCCTCCGCAGGGGGGTCGCAAGCATCCAAACCAAGACATGCTCAGGGTGGATACATCGAAC
ATTTTGTTCATCTGTGGTGGTGCGTTCGTTGGGTTAGATGGTATTGTCGGTACGAGAGTGTGTAAGAATCCGGTTGGCTT
TGGAGCAGATGTAAAAACGGTAAAGGAGCGAGGTCTGCAACTGATGCACGAGGACGTCATTCCGGATGATTTGGTGAAAT
TTGGATTAATCCCAGAGATTATCGGCCGTCTGCCGGTGACGGTCGCCTTGGATGCTCTTTCTAAAGAGGATCTGCGCAAT
ATCTTGGTACGACCGCGAAATGCTATTGTCCGTCAGTTTGAAGCGTTATTCGCGTTGGATGACGTGCGTCTTGTCTTTGA
TGAGGACGCTTTGGACGCAATAGCTCAGCAGGCAATTGATCAAAAAACGGGGGCGCGGGGTTTGCGCTCTATTGTGGAAA
GATTAATGCTTGATGCTATGTTTGAGGCACCGTCTCTGAAAGGGAAAAAGGAGCTATGCATTACGAAGAAGGTAGTTACA
CAAGAGGAAAAAGCCAGCGTTCGCCTTGTTTCTGAACGTACTGCGTGA

Upstream 100 bases:

>100_bases
GAGGAGCAGGTGCGGGAGGATATGGAGCGAGATTTCTTCCTTTCCGCGGAGCAGGCGTGTTCGTATGGTATCGTAGATAC
GGTAATGAAGAGGAGAAAGC

Downstream 100 bases:

>100_bases
TGGTGTGGTGACCCGGGGGATACGTGTGAAAGACTTTACTTTTCCCCGTTTGTTTCCTATAGTTTGCGCTAGAGTGCGAA
CGTTTGGGAGGTTGCTATGG

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MLRSKGDLVLGCSFCGKKEDERRRIVTGHGVSICNYCVERCAEYLRDRKPSALALMTKEEIPTPLELKAYLDQYVIGQDL
AKRVLSVAVYNHYKRVAGRSLDIDSVLIEKSNVLLIGPTGSGKTLLAKTLSQKMKVPFAIADATTLTEAGYVGEDVENIL
LKLVQNANGDVALAERGIIFIDEIDKISRKSENVSITRDVSGEGVQQALLKIIEGTIASVPPQGGRKHPNQDMLRVDTSN
ILFICGGAFVGLDGIVGTRVCKNPVGFGADVKTVKERGLQLMHEDVIPDDLVKFGLIPEIIGRLPVTVALDALSKEDLRN
ILVRPRNAIVRQFEALFALDDVRLVFDEDALDAIAQQAIDQKTGARGLRSIVERLMLDAMFEAPSLKGKKELCITKKVVT
QEEKASVRLVSERTA

Sequences:

>Translated_415_residues
MLRSKGDLVLGCSFCGKKEDERRRIVTGHGVSICNYCVERCAEYLRDRKPSALALMTKEEIPTPLELKAYLDQYVIGQDL
AKRVLSVAVYNHYKRVAGRSLDIDSVLIEKSNVLLIGPTGSGKTLLAKTLSQKMKVPFAIADATTLTEAGYVGEDVENIL
LKLVQNANGDVALAERGIIFIDEIDKISRKSENVSITRDVSGEGVQQALLKIIEGTIASVPPQGGRKHPNQDMLRVDTSN
ILFICGGAFVGLDGIVGTRVCKNPVGFGADVKTVKERGLQLMHEDVIPDDLVKFGLIPEIIGRLPVTVALDALSKEDLRN
ILVRPRNAIVRQFEALFALDDVRLVFDEDALDAIAQQAIDQKTGARGLRSIVERLMLDAMFEAPSLKGKKELCITKKVVT
QEEKASVRLVSERTA
>Mature_415_residues
MLRSKGDLVLGCSFCGKKEDERRRIVTGHGVSICNYCVERCAEYLRDRKPSALALMTKEEIPTPLELKAYLDQYVIGQDL
AKRVLSVAVYNHYKRVAGRSLDIDSVLIEKSNVLLIGPTGSGKTLLAKTLSQKMKVPFAIADATTLTEAGYVGEDVENIL
LKLVQNANGDVALAERGIIFIDEIDKISRKSENVSITRDVSGEGVQQALLKIIEGTIASVPPQGGRKHPNQDMLRVDTSN
ILFICGGAFVGLDGIVGTRVCKNPVGFGADVKTVKERGLQLMHEDVIPDDLVKFGLIPEIIGRLPVTVALDALSKEDLRN
ILVRPRNAIVRQFEALFALDDVRLVFDEDALDAIAQQAIDQKTGARGLRSIVERLMLDAMFEAPSLKGKKELCITKKVVT
QEEKASVRLVSERTA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=304, Percent_Identity=49.0131578947368, Blast_Score=280, Evalue=2e-75,
Organism=Escherichia coli, GI1786642, Length=399, Percent_Identity=56.6416040100251, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1790366, Length=223, Percent_Identity=34.5291479820628, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71982908, Length=295, Percent_Identity=45.7627118644068, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71982905, Length=295, Percent_Identity=45.7627118644068, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI71988663, Length=395, Percent_Identity=36.2025316455696, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI71988660, Length=255, Percent_Identity=38.0392156862745, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319704, Length=410, Percent_Identity=40.9756097560976, Blast_Score=271, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24648289, Length=294, Percent_Identity=46.5986394557823, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI24648291, Length=294, Percent_Identity=46.5986394557823, Blast_Score=265, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_TREPA (O83521)

Other databases:

- EMBL:   AE000520
- PIR:   C71314
- RefSeq:   NP_218949.1
- ProteinModelPortal:   O83521
- IntAct:   O83521
- GeneID:   2611767
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0508
- NMPDR:   fig|243276.1.peg.508
- TIGR:   TP_0508
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- BioCyc:   TPAL243276:TP_0508-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 45478; Mature: 45478

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSKGDLVLGCSFCGKKEDERRRIVTGHGVSICNYCVERCAEYLRDRKPSALALMTKEE
CCCCCCCEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHH
IPTPLELKAYLDQYVIGQDLAKRVLSVAVYNHYKRVAGRSLDIDSVLIEKSNVLLIGPTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCEEEEECCC
SGKTLLAKTLSQKMKVPFAIADATTLTEAGYVGEDVENILLKLVQNANGDVALAERGIIF
CCHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEE
IDEIDKISRKSENVSITRDVSGEGVQQALLKIIEGTIASVPPQGGRKHPNQDMLRVDTSN
EECHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCC
ILFICGGAFVGLDGIVGTRVCKNPVGFGADVKTVKERGLQLMHEDVIPDDLVKFGLIPEI
EEEEECCHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCHHHH
IGRLPVTVALDALSKEDLRNILVRPRNAIVRQFEALFALDDVRLVFDEDALDAIAQQAID
HCCCCHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHH
QKTGARGLRSIVERLMLDAMFEAPSLKGKKELCITKKVVTQEEKASVRLVSERTA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHEEECCCCCC
>Mature Secondary Structure
MLRSKGDLVLGCSFCGKKEDERRRIVTGHGVSICNYCVERCAEYLRDRKPSALALMTKEE
CCCCCCCEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHH
IPTPLELKAYLDQYVIGQDLAKRVLSVAVYNHYKRVAGRSLDIDSVLIEKSNVLLIGPTG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCEEEEECCC
SGKTLLAKTLSQKMKVPFAIADATTLTEAGYVGEDVENILLKLVQNANGDVALAERGIIF
CCHHHHHHHHHHHHCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECCCEEE
IDEIDKISRKSENVSITRDVSGEGVQQALLKIIEGTIASVPPQGGRKHPNQDMLRVDTSN
EECHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCC
ILFICGGAFVGLDGIVGTRVCKNPVGFGADVKTVKERGLQLMHEDVIPDDLVKFGLIPEI
EEEEECCHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCHHHH
IGRLPVTVALDALSKEDLRNILVRPRNAIVRQFEALFALDDVRLVFDEDALDAIAQQAID
HCCCCHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHH
QKTGARGLRSIVERLMLDAMFEAPSLKGKKELCITKKVVTQEEKASVRLVSERTA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876