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The map label for this gene is thiJ [H]

Identifier: 189025677

GI number: 189025677

Start: 473076

End: 473705

Strand: Direct

Name: thiJ [H]

Synonym: TPASS_0445

Alternate gene names: 189025677

Gene position: 473076-473705 (Clockwise)

Preceding gene: 189025676

Following gene: 189025678

Centisome position: 41.52

GC content: 59.52

Gene sequence:

>630_bases
GTGAGCGTACGGGTATACCTTTTTGTTGCACACGGATTTGAGGAAGTGGAGACTATCACCCCGTTGGATTATCTCAGACG
TGCGGGGATAGCGTTAACGCTCGTGGGTGTTGGGGCAGAGCAGGTTGTTTCTACGCGTGGCTTGCGTGTGAGCTGCGACT
GCAGTCTTGAGGCGCTTTGTGCTTCTCCGGGCATCGCGGATGCCGCGTGCGCCGCAGATGCGGTTCTTCTTCCCGGGGGG
TTGGAAAACTGTCATACGCTTGCCGCCTGTGCGGCGGTGCGTGATTTTGTCATGCGCGTGCACCTGCGCGGAGGACTCGT
CGCTGCGCTGTGTGCTGCCCCGGCGCGAGTGCTCTCTGCGTGGAATCTCCTGGGGTCACGTCGCTATACCTGCTATCCGG
GTATGGAGCCGGCGGTGTTCTCCGCACATGACGATGGGGTTGGGAAAAGGACGGAAGAGGAGAAATCGCGTGCGCTTCGT
AAACCTGAGCGCGCGCGGGTGGTACGTGATGGAAATCTTTTGACCGCGTGTGCGGCAGGTGCGGCAGAAGAGTTTTCTTT
CGCAGTTATCGAAGCACTCTGTGGAGTGGAAGTTGCGCAAAGTGTGCGTGCGCAAGTGGTGGCCCGGTGA

Upstream 100 bases:

>100_bases
CGCACGGCTAGTACGTCGCTTTTGAACGGAGGACGATTATCCGTAGTCTGTGTGCGCGGGGTTGCACTGTTGCTGTAAGA
ACAGGTACGGGGGTGTTGCG

Downstream 100 bases:

>100_bases
ATCAGAGGGACGAGCGTGCTGCGCGGCAGCCAGAGGAAAAGGTGGATTCATCTGCCGGTGTGTCTCCCTGCAATAGTCCG
TATGGGAGTGGACTTTTGGA

Product: 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSVRVYLFVAHGFEEVETITPLDYLRRAGIALTLVGVGAEQVVSTRGLRVSCDCSLEALCASPGIADAACAADAVLLPGG
LENCHTLAACAAVRDFVMRVHLRGGLVAALCAAPARVLSAWNLLGSRRYTCYPGMEPAVFSAHDDGVGKRTEEEKSRALR
KPERARVVRDGNLLTACAAGAAEEFSFAVIEALCGVEVAQSVRAQVVAR

Sequences:

>Translated_209_residues
MSVRVYLFVAHGFEEVETITPLDYLRRAGIALTLVGVGAEQVVSTRGLRVSCDCSLEALCASPGIADAACAADAVLLPGG
LENCHTLAACAAVRDFVMRVHLRGGLVAALCAAPARVLSAWNLLGSRRYTCYPGMEPAVFSAHDDGVGKRTEEEKSRALR
KPERARVVRDGNLLTACAAGAAEEFSFAVIEALCGVEVAQSVRAQVVAR
>Mature_208_residues
SVRVYLFVAHGFEEVETITPLDYLRRAGIALTLVGVGAEQVVSTRGLRVSCDCSLEALCASPGIADAACAADAVLLPGGL
ENCHTLAACAAVRDFVMRVHLRGGLVAALCAAPARVLSAWNLLGSRRYTCYPGMEPAVFSAHDDGVGKRTEEEKSRALRK
PERARVVRDGNLLTACAAGAAEEFSFAVIEALCGVEVAQSVRAQVVAR

Specific function: Involved in biogenesis of ribosomal proteins, probably as a ribosomal protein-folding chaperone. Interacts with ribosomal subunits, ribosomes and polysomes. Confers resistance to oxidative stress [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C56 family [H]

Homologues:

Organism=Homo sapiens, GI183227678, Length=209, Percent_Identity=33.9712918660287, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI31543380, Length=209, Percent_Identity=33.9712918660287, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI87081736, Length=207, Percent_Identity=28.9855072463768, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17531319, Length=206, Percent_Identity=29.6116504854369, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28571932, Length=206, Percent_Identity=33.9805825242718, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24653499, Length=200, Percent_Identity=31, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006287
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: NA

Molecular weight: Translated: 22046; Mature: 21914

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
4.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRVYLFVAHGFEEVETITPLDYLRRAGIALTLVGVGAEQVVSTRGLRVSCDCSLEALC
CCEEEEEEEECCHHHHHHCCHHHHHHHCCEEEEEEECCHHHHHHHCCCEEEECCCHHHHH
ASPGIADAACAADAVLLPGGLENCHTLAACAAVRDFVMRVHLRGGLVAALCAAPARVLSA
CCCCCCHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
WNLLGSRRYTCYPGMEPAVFSAHDDGVGKRTEEEKSRALRKPERARVVRDGNLLTACAAG
HHHHCCCCEEECCCCCCCEEECCCCCCCCCCHHHHHHHHCCCHHHHEEECCCEEEHHHCC
AAEEFSFAVIEALCGVEVAQSVRAQVVAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVRVYLFVAHGFEEVETITPLDYLRRAGIALTLVGVGAEQVVSTRGLRVSCDCSLEALC
CEEEEEEEECCHHHHHHCCHHHHHHHCCEEEEEEECCHHHHHHHCCCEEEECCCHHHHH
ASPGIADAACAADAVLLPGGLENCHTLAACAAVRDFVMRVHLRGGLVAALCAAPARVLSA
CCCCCCHHHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
WNLLGSRRYTCYPGMEPAVFSAHDDGVGKRTEEEKSRALRKPERARVVRDGNLLTACAAG
HHHHCCCCEEECCCCCCCEEECCCCCCCCCCHHHHHHHHCCCHHHHEEECCCEEEHHHCC
AAEEFSFAVIEALCGVEVAQSVRAQVVAR
CHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9592144 [H]