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The map label for this gene is mraY

Identifier: 189025578

GI number: 189025578

Start: 371214

End: 372305

Strand: Direct

Name: mraY

Synonym: TPASS_0345

Alternate gene names: 189025578

Gene position: 371214-372305 (Clockwise)

Preceding gene: 189025576

Following gene: 189025579

Centisome position: 32.58

GC content: 50.73

Gene sequence:

>1092_bases
ATGGGGTTAATTTTTTTCCGTTATGATCGCTGCTATATGTTGTCGGTGTTGTCGTATCTTCACGTGTACTTTGGGCCGTT
TCGTCTGTTGCAATCTTATGCGGTGTTGATGGGGATTGCCCTGTATGCGGGATTCTTTTTTACGTATGGGGTGTTGCCCA
GTGCGTATCGCTTTTTGCCCCAAGACAGGGGGCGTGCGTTTGCGCCGTGTGCACAGGAAGCAGCGGGTAAACCCACAGGG
GCAGGAGTGATTTTTGTGTCCGTCTTTGTGTTGTTAGTGTACCTGCTTATGCGTCCGAGTTTTGTGCATGCGCTTATATT
GCTGCTGACGTGGGGGGTGATGCTCACCGGATACTTAGACGATTGCGCGCAGGTGTGCTGGGGGGAGTATCGCAAAGGCG
CGTTGGACTTTTTGTTTGCGGTGCTGACAGCAGCGCTGTTGGGTCATTTTTATTTTCACGATCAGGTGTTCTGGTGGTTT
CCTTTTTTTTCAGATCCGGTGTTCGTCTCTCCTTTTTTATTTTTTGCCGGTTCGGTGGTGATTTTGTGGATGTCAATTAA
CGCAACCAATTGCACAGACGGGGTTGACGGGCTTTCGGGAGCGTTGGTGTTGATGGCGCTTCTTTCGATGGGTACGATTT
TTTACTTTTTGTTGGGAAATGTGCGTGCGGCGCAGTACCTACTGGTGCCGTTTGTAGTGGATGGTGCGCAATGGGCACTG
ATGAGTTTTGCACTTGCCGGGGCGCTGATGGGGTATGTGTGGCGTAATGCACACCCTAGTACGGTGTTGATGGGAGACGC
AGGCTCCCGTGCGCTGGGGTTTTTCATTGGGGTGTTGGTGTTGATCTCGGGCAATCCATTTTTGCTGTTGATGACAAGCG
GTGTTATTTTGGTGAATGGGGGTACGGGGCTTCTAAAAGTGGTGTTGTTGCGTTTTTTTCATGTGCGGATCCTGAGCCGG
GTGCGCTTTCCGCTCCATGATCACATGCGTGAGAATTGGCACTGGTCTACGGCGCAGGTATTGCTGAGGTTTATGATTTT
ACAGGGACTGCTCACGATTGGTCTTTTGGGGGTTTTGTTCAAACTGCGGTAG

Upstream 100 bases:

>100_bases
AGTGTAACGGAGCACTGTGCCTTGTGCTAGTCCCTGAGCGAGAAGGATGCAGCAGGAGAGGGCAAGGGAGGAGAACAGGA
AGGAGCACCGGTAGTAGTTG

Downstream 100 bases:

>100_bases
AGGGAGGGCACCCCTTGCGGGGCACGCCGGGCCGAGCGAGGGCGACGGTGCGGAGTATCCGGCGCCTTGACGTGCGTTTA
TTTCTTTTGCTAGCCTGCCC

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MGLIFFRYDRCYMLSVLSYLHVYFGPFRLLQSYAVLMGIALYAGFFFTYGVLPSAYRFLPQDRGRAFAPCAQEAAGKPTG
AGVIFVSVFVLLVYLLMRPSFVHALILLLTWGVMLTGYLDDCAQVCWGEYRKGALDFLFAVLTAALLGHFYFHDQVFWWF
PFFSDPVFVSPFLFFAGSVVILWMSINATNCTDGVDGLSGALVLMALLSMGTIFYFLLGNVRAAQYLLVPFVVDGAQWAL
MSFALAGALMGYVWRNAHPSTVLMGDAGSRALGFFIGVLVLISGNPFLLLMTSGVILVNGGTGLLKVVLLRFFHVRILSR
VRFPLHDHMRENWHWSTAQVLLRFMILQGLLTIGLLGVLFKLR

Sequences:

>Translated_363_residues
MGLIFFRYDRCYMLSVLSYLHVYFGPFRLLQSYAVLMGIALYAGFFFTYGVLPSAYRFLPQDRGRAFAPCAQEAAGKPTG
AGVIFVSVFVLLVYLLMRPSFVHALILLLTWGVMLTGYLDDCAQVCWGEYRKGALDFLFAVLTAALLGHFYFHDQVFWWF
PFFSDPVFVSPFLFFAGSVVILWMSINATNCTDGVDGLSGALVLMALLSMGTIFYFLLGNVRAAQYLLVPFVVDGAQWAL
MSFALAGALMGYVWRNAHPSTVLMGDAGSRALGFFIGVLVLISGNPFLLLMTSGVILVNGGTGLLKVVLLRFFHVRILSR
VRFPLHDHMRENWHWSTAQVLLRFMILQGLLTIGLLGVLFKLR
>Mature_362_residues
GLIFFRYDRCYMLSVLSYLHVYFGPFRLLQSYAVLMGIALYAGFFFTYGVLPSAYRFLPQDRGRAFAPCAQEAAGKPTGA
GVIFVSVFVLLVYLLMRPSFVHALILLLTWGVMLTGYLDDCAQVCWGEYRKGALDFLFAVLTAALLGHFYFHDQVFWWFP
FFSDPVFVSPFLFFAGSVVILWMSINATNCTDGVDGLSGALVLMALLSMGTIFYFLLGNVRAAQYLLVPFVVDGAQWALM
SFALAGALMGYVWRNAHPSTVLMGDAGSRALGFFIGVLVLISGNPFLLLMTSGVILVNGGTGLLKVVLLRFFHVRILSRV
RFPLHDHMRENWHWSTAQVLLRFMILQGLLTIGLLGVLFKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=168, Percent_Identity=32.1428571428571, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_TREPA (O83365)

Other databases:

- EMBL:   AE000520
- PIR:   H71335
- RefSeq:   NP_218785.1
- ProteinModelPortal:   O83365
- IntAct:   O83365
- GeneID:   2611676
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0345
- NMPDR:   fig|243276.1.peg.344
- TIGR:   TP_0345
- HOGENOM:   HBG427783
- OMA:   CEKLEML
- ProtClustDB:   CLSK873804
- BioCyc:   TPAL243276:TP_0345-MONOMER
- BRENDA:   2.7.8.13
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926

Pfam domain/function: PF00953 Glycos_transf_4

EC number: =2.7.8.13

Molecular weight: Translated: 40559; Mature: 40428

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x207aa8b0)-; HASH(0x20b916b0)-; HASH(0x1fe1e154)-; HASH(0x1fa223e0)-; HASH(0x1e1a4bcc)-; HASH(0x208be194)-; HASH(0x1f97ea98)-; HASH(0x20e43204)-; HASH(0x20723154)-; HASH(0x2072416c)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLIFFRYDRCYMLSVLSYLHVYFGPFRLLQSYAVLMGIALYAGFFFTYGVLPSAYRFLP
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QDRGRAFAPCAQEAAGKPTGAGVIFVSVFVLLVYLLMRPSFVHALILLLTWGVMLTGYLD
CCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
DCAQVCWGEYRKGALDFLFAVLTAALLGHFYFHDQVFWWFPFFSDPVFVSPFLFFAGSVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCE
ILWMSINATNCTDGVDGLSGALVLMALLSMGTIFYFLLGNVRAAQYLLVPFVVDGAQWAL
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHH
MSFALAGALMGYVWRNAHPSTVLMGDAGSRALGFFIGVLVLISGNPFLLLMTSGVILVNG
HHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEEEC
GTGLLKVVLLRFFHVRILSRVRFPLHDHMRENWHWSTAQVLLRFMILQGLLTIGLLGVLF
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KLR
HCH
>Mature Secondary Structure 
GLIFFRYDRCYMLSVLSYLHVYFGPFRLLQSYAVLMGIALYAGFFFTYGVLPSAYRFLP
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QDRGRAFAPCAQEAAGKPTGAGVIFVSVFVLLVYLLMRPSFVHALILLLTWGVMLTGYLD
CCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
DCAQVCWGEYRKGALDFLFAVLTAALLGHFYFHDQVFWWFPFFSDPVFVSPFLFFAGSVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCE
ILWMSINATNCTDGVDGLSGALVLMALLSMGTIFYFLLGNVRAAQYLLVPFVVDGAQWAL
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHH
MSFALAGALMGYVWRNAHPSTVLMGDAGSRALGFFIGVLVLISGNPFLLLMTSGVILVNG
HHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEEEC
GTGLLKVVLLRFFHVRILSRVRFPLHDHMRENWHWSTAQVLLRFMILQGLLTIGLLGVLF
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KLR
HCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9665876