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The map label for this gene is yfhQ [H]

Identifier: 189025576

GI number: 189025576

Start: 366801

End: 367634

Strand: Direct

Name: yfhQ [H]

Synonym: TPASS_0343

Alternate gene names: 189025576

Gene position: 366801-367634 (Clockwise)

Preceding gene: 189025575

Following gene: 189025578

Centisome position: 32.19

GC content: 49.52

Gene sequence:

>834_bases
TTGGTAGGGCTGAGCCAATCTGCGGGTGATATAGAAAAGTTTCAAAACGCCATATTGGATTTTTATGCACAGCAGGGCAG
GGATTTTCCGTGGAGAAGTACTTGCGACGCGTATGCGATACTGGTGTCTGAGTTTATGTTACAACAGACACAGACGGAGC
GGGTGTGTCCGAAGTATGCAGAATGGCTTCATCGTTTTCCTTCTTTGGAGTCTCTTGCGTGCGCTCCATTTGCGCACGTG
CTCCAAGCGTGGATTGGATTAGGATACAACAGGCGCGCTCGTTTTTTGCATCAGTCGGCAAAACTCATTGTTGAAAGGTA
TTGTGCAGTAGTTCCTGATGACCCGAGTGAACTAAAGAAGCTCCCCGGTGTCGGTGACTATACTGCCGCTGCAGTTGCTT
GCTTTGCGTACAATAAGGCCACCGTGTTTTTAGAAACAAACATCCGTGCAGTGTTTATACGCTTTTTCTTTCCCGATACG
CACCAGGTCAGTGATCGGGAGTTGCTCTCGCTGGTCCGGTGCACCCTGTATGAGGAAAATCCTCGGCGTTGGTACTACGC
ACTGATGGATTATGGGGCAGTTCTAAAAAGGAAGATTACAAATCCTAATCGTCGCAGCAAGCATTACGTGAAGCAGTCAC
CGTTTGAAGGTTCTCTGAGGCAGGTGCGTGGAGCGGTTTTAAGAGAGATAAGCGGCATGCAACACGCGGTGCGCGAGAAA
ACGCTTTTCGCAAAGCTGTCCTTTGAGCACGAAAGATTGAGCCGCGCTCTAGACTCGCTGGTAAGCGAGGGACTGGTAGT
AAAAACAGAGGCTGGGTATTCCATCGCTGATTGA

Upstream 100 bases:

>100_bases
CGAATTACAGTTTTGCAGATCTTGTTCTAAACACAGAAGGGTGCGATCAAGAAACAGTGGTGAGTATTATTATTGAAATG
TTACGCGCTAGAGGGATAGC

Downstream 100 bases:

>100_bases
TTCTTTATGACTCAAGACGCTTGAGTATTTCACAAATAAAGATGCCTTTCTCTTTTATTTCAATGGCATCTGATGTGAGG
ATCAGCATGTTGGGCTGCTT

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MVGLSQSAGDIEKFQNAILDFYAQQGRDFPWRSTCDAYAILVSEFMLQQTQTERVCPKYAEWLHRFPSLESLACAPFAHV
LQAWIGLGYNRRARFLHQSAKLIVERYCAVVPDDPSELKKLPGVGDYTAAAVACFAYNKATVFLETNIRAVFIRFFFPDT
HQVSDRELLSLVRCTLYEENPRRWYYALMDYGAVLKRKITNPNRRSKHYVKQSPFEGSLRQVRGAVLREISGMQHAVREK
TLFAKLSFEHERLSRALDSLVSEGLVVKTEAGYSIAD

Sequences:

>Translated_277_residues
MVGLSQSAGDIEKFQNAILDFYAQQGRDFPWRSTCDAYAILVSEFMLQQTQTERVCPKYAEWLHRFPSLESLACAPFAHV
LQAWIGLGYNRRARFLHQSAKLIVERYCAVVPDDPSELKKLPGVGDYTAAAVACFAYNKATVFLETNIRAVFIRFFFPDT
HQVSDRELLSLVRCTLYEENPRRWYYALMDYGAVLKRKITNPNRRSKHYVKQSPFEGSLRQVRGAVLREISGMQHAVREK
TLFAKLSFEHERLSRALDSLVSEGLVVKTEAGYSIAD
>Mature_277_residues
MVGLSQSAGDIEKFQNAILDFYAQQGRDFPWRSTCDAYAILVSEFMLQQTQTERVCPKYAEWLHRFPSLESLACAPFAHV
LQAWIGLGYNRRARFLHQSAKLIVERYCAVVPDDPSELKKLPGVGDYTAAAVACFAYNKATVFLETNIRAVFIRFFFPDT
HQVSDRELLSLVRCTLYEENPRRWYYALMDYGAVLKRKITNPNRRSKHYVKQSPFEGSLRQVRGAVLREISGMQHAVREK
TLFAKLSFEHERLSRALDSLVSEGLVVKTEAGYSIAD

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=199, Percent_Identity=35.1758793969849, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI115298654, Length=199, Percent_Identity=35.1758793969849, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI115298652, Length=199, Percent_Identity=35.1758793969849, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI115298648, Length=199, Percent_Identity=35.1758793969849, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI115298650, Length=199, Percent_Identity=35.1758793969849, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI190358497, Length=199, Percent_Identity=35.1758793969849, Blast_Score=117, Evalue=9e-27,
Organism=Escherichia coli, GI1789331, Length=188, Percent_Identity=34.5744680851064, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 31720; Mature: 31720

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGLSQSAGDIEKFQNAILDFYAQQGRDFPWRSTCDAYAILVSEFMLQQTQTERVCPKYA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
EWLHRFPSLESLACAPFAHVLQAWIGLGYNRRARFLHQSAKLIVERYCAVVPDDPSELKK
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LPGVGDYTAAAVACFAYNKATVFLETNIRAVFIRFFFPDTHQVSDRELLSLVRCTLYEEN
CCCCCCHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCC
PRRWYYALMDYGAVLKRKITNPNRRSKHYVKQSPFEGSLRQVRGAVLREISGMQHAVREK
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TLFAKLSFEHERLSRALDSLVSEGLVVKTEAGYSIAD
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCC
>Mature Secondary Structure
MVGLSQSAGDIEKFQNAILDFYAQQGRDFPWRSTCDAYAILVSEFMLQQTQTERVCPKYA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
EWLHRFPSLESLACAPFAHVLQAWIGLGYNRRARFLHQSAKLIVERYCAVVPDDPSELKK
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
LPGVGDYTAAAVACFAYNKATVFLETNIRAVFIRFFFPDTHQVSDRELLSLVRCTLYEEN
CCCCCCHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCC
PRRWYYALMDYGAVLKRKITNPNRRSKHYVKQSPFEGSLRQVRGAVLREISGMQHAVREK
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TLFAKLSFEHERLSRALDSLVSEGLVVKTEAGYSIAD
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]