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The map label for this gene is htrA [H]

Identifier: 188587485

GI number: 188587485

Start: 3126803

End: 3127972

Strand: Reverse

Name: htrA [H]

Synonym: Nther_2895

Alternate gene names: 188587485

Gene position: 3127972-3126803 (Counterclockwise)

Preceding gene: 188587486

Following gene: 188587484

Centisome position: 98.81

GC content: 40.34

Gene sequence:

>1170_bases
ATGTCTTTTTATAAACGACAAGGACCTAGTTTTGTCTCCATAATTATAGTTGCCTTACTAAGTGCTATCATCGGAGGGGT
ATTAACTGCTATTATACTTCCTCCTGCCGTTGCAGGTAGATTAGAAACAGAAATGAAAGAATCCCCTCAAAAAGAGGCGG
AACAGTCAGAGCCAAATAGCGATGAAGAGGATCACTTATTTTGGGAAGATATTGACCCCGAAGAATATCAAGATACTCCT
GTAGTTCGTGCTGCCCAAGAGGTGATGCCAGCAGTGGTTGGTGTCACTAACAGGGCTCAAGCTTGGGATCAAACTATGGA
TCGAGGTACAGGTTCAGGTGTTGTCATTGAACCTGAAGGTTTAATCGTAACTAATTATCATGTTATTGAAGCTGCTGAAG
AAGTGGTCGTCACAATAGAAGAAGGGAAAAGTGCAGAGGCAGAAATAGTTGGTGAAGACCCTGAAACAGATCTGGCAGTT
TTAGAAGTTGATCCACAAAACTTTGATAAAGAAGAACTTCATAGTGCAGAATTTGGTGATTCTGATGAGTTAGTTGCCGG
TGAGATGACTATTGCCATTGGTAACCCATTGGGATTGGCTTTCCAGCAATCAGTCACTGCTGGAGTGATTAGTGCTACGG
ATCGGAAAGTAAGAGTTGGTGAAGACTACATTAGCCTAATTCAAACAGATGCAGCTATTAATCCCGGAAATAGTGGAGGC
CCCCTGGTAAACGCTTTAGGTGAAGTTATAGGTATAAACAGTGTAAAAATTAGGGATGCTGGAGTAGAAGGTATGGGATT
TGCAATACCAAGTAACCGTGTTTCGGAAATAGTTGAGGATTTAATTGAATACGGCTTTGTGGAACGACCTTGGATAGGAA
TTTACATCCAAGAAATAGACCCCTATATTGCTGAAATATATAATTTACCAGTGAACTACGGTATATTTATCCAGGAAATA
GAACCAAACAGCCCTGCTGCTGAAGCCGGTATGCAAAGAGGGGATATTTTAATTGAGTTTGCAGGAGAACAAATAGATAG
TCAAGCGAAATTGCGAAATGTTCGTAATGATTATGATGTTGGCGACAATGTAGAAGTGACTGTATTAAGAGAAGGAGAAG
AAATTACTTTAGATATGACTTTAGAAGGTGATCCTAGACTAGATCAATAG

Upstream 100 bases:

>100_bases
CCCTATAACATTCACTCTTTAATTAATAAACCATTTGAAGCTCGTAAAATGGCTGTGCTATAATTTTATCACAGCTATCA
AAACTAGAGGGGGTAATAAC

Downstream 100 bases:

>100_bases
TAGAAATTGTAATAAATACCGGGCAATTCTTCTGTCCGGTATTTATTTTTATCAAACTCGCATGATGCGTTCAATTGAAA
ATTCTACAGTACCAATAAAT

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSFYKRQGPSFVSIIIVALLSAIIGGVLTAIILPPAVAGRLETEMKESPQKEAEQSEPNSDEEDHLFWEDIDPEEYQDTP
VVRAAQEVMPAVVGVTNRAQAWDQTMDRGTGSGVVIEPEGLIVTNYHVIEAAEEVVVTIEEGKSAEAEIVGEDPETDLAV
LEVDPQNFDKEELHSAEFGDSDELVAGEMTIAIGNPLGLAFQQSVTAGVISATDRKVRVGEDYISLIQTDAAINPGNSGG
PLVNALGEVIGINSVKIRDAGVEGMGFAIPSNRVSEIVEDLIEYGFVERPWIGIYIQEIDPYIAEIYNLPVNYGIFIQEI
EPNSPAAEAGMQRGDILIEFAGEQIDSQAKLRNVRNDYDVGDNVEVTVLREGEEITLDMTLEGDPRLDQ

Sequences:

>Translated_389_residues
MSFYKRQGPSFVSIIIVALLSAIIGGVLTAIILPPAVAGRLETEMKESPQKEAEQSEPNSDEEDHLFWEDIDPEEYQDTP
VVRAAQEVMPAVVGVTNRAQAWDQTMDRGTGSGVVIEPEGLIVTNYHVIEAAEEVVVTIEEGKSAEAEIVGEDPETDLAV
LEVDPQNFDKEELHSAEFGDSDELVAGEMTIAIGNPLGLAFQQSVTAGVISATDRKVRVGEDYISLIQTDAAINPGNSGG
PLVNALGEVIGINSVKIRDAGVEGMGFAIPSNRVSEIVEDLIEYGFVERPWIGIYIQEIDPYIAEIYNLPVNYGIFIQEI
EPNSPAAEAGMQRGDILIEFAGEQIDSQAKLRNVRNDYDVGDNVEVTVLREGEEITLDMTLEGDPRLDQ
>Mature_388_residues
SFYKRQGPSFVSIIIVALLSAIIGGVLTAIILPPAVAGRLETEMKESPQKEAEQSEPNSDEEDHLFWEDIDPEEYQDTPV
VRAAQEVMPAVVGVTNRAQAWDQTMDRGTGSGVVIEPEGLIVTNYHVIEAAEEVVVTIEEGKSAEAEIVGEDPETDLAVL
EVDPQNFDKEELHSAEFGDSDELVAGEMTIAIGNPLGLAFQQSVTAGVISATDRKVRVGEDYISLIQTDAAINPGNSGGP
LVNALGEVIGINSVKIRDAGVEGMGFAIPSNRVSEIVEDLIEYGFVERPWIGIYIQEIDPYIAEIYNLPVNYGIFIQEIE
PNSPAAEAGMQRGDILIEFAGEQIDSQAKLRNVRNDYDVGDNVEVTVLREGEEITLDMTLEGDPRLDQ

Specific function: May be involved in processing, maturation, or secretion of extracellular enzymes [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=306, Percent_Identity=32.6797385620915, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4506141, Length=309, Percent_Identity=31.7152103559871, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI7019477, Length=287, Percent_Identity=34.8432055749129, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI24308541, Length=312, Percent_Identity=28.525641025641, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1786356, Length=275, Percent_Identity=40, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789629, Length=276, Percent_Identity=38.4057971014493, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1789630, Length=344, Percent_Identity=36.3372093023256, Blast_Score=168, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24646839, Length=307, Percent_Identity=33.8762214983713, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 42286; Mature: 42154

Theoretical pI: Translated: 3.76; Mature: 3.76

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFYKRQGPSFVSIIIVALLSAIIGGVLTAIILPPAVAGRLETEMKESPQKEAEQSEPNS
CCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCCCC
DEEDHLFWEDIDPEEYQDTPVVRAAQEVMPAVVGVTNRAQAWDQTMDRGTGSGVVIEPEG
CCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCCC
LIVTNYHVIEAAEEVVVTIEEGKSAEAEIVGEDPETDLAVLEVDPQNFDKEELHSAEFGD
EEEEEEHHHCCCCEEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCCCHHHHHCCCCCC
SDELVAGEMTIAIGNPLGLAFQQSVTAGVISATDRKVRVGEDYISLIQTDAAINPGNSGG
CCCEEECEEEEEECCCCCHHHHHHHHHHEEECCCCEEEECHHHHHHHHHCCCCCCCCCCC
PLVNALGEVIGINSVKIRDAGVEGMGFAIPSNRVSEIVEDLIEYGFVERPWIGIYIQEID
HHHHHHHHHHCCCCEEEEECCCCCCEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHC
PYIAEIYNLPVNYGIFIQEIEPNSPAAEAGMQRGDILIEFAGEQIDSQAKLRNVRNDYDV
HHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCCCEEEEECCCHHCHHHHHHHCCCCCCC
GDNVEVTVLREGEEITLDMTLEGDPRLDQ
CCCEEEEEEECCCEEEEEEEECCCCCCCC
>Mature Secondary Structure 
SFYKRQGPSFVSIIIVALLSAIIGGVLTAIILPPAVAGRLETEMKESPQKEAEQSEPNS
CCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCCCC
DEEDHLFWEDIDPEEYQDTPVVRAAQEVMPAVVGVTNRAQAWDQTMDRGTGSGVVIEPEG
CCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCCC
LIVTNYHVIEAAEEVVVTIEEGKSAEAEIVGEDPETDLAVLEVDPQNFDKEELHSAEFGD
EEEEEEHHHCCCCEEEEEEECCCCCCEEEECCCCCCCEEEEEECCCCCCHHHHHCCCCCC
SDELVAGEMTIAIGNPLGLAFQQSVTAGVISATDRKVRVGEDYISLIQTDAAINPGNSGG
CCCEEECEEEEEECCCCCHHHHHHHHHHEEECCCCEEEECHHHHHHHHHCCCCCCCCCCC
PLVNALGEVIGINSVKIRDAGVEGMGFAIPSNRVSEIVEDLIEYGFVERPWIGIYIQEID
HHHHHHHHHHCCCCEEEEECCCCCCEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHC
PYIAEIYNLPVNYGIFIQEIEPNSPAAEAGMQRGDILIEFAGEQIDSQAKLRNVRNDYDV
HHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCCCEEEEECCCHHCHHHHHHHCCCCCCC
GDNVEVTVLREGEEITLDMTLEGDPRLDQ
CCCEEEEEEECCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10692364; 11133960; 11555295 [H]