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The map label for this gene is pyrD

Identifier: 188587355

GI number: 188587355

Start: 2982627

End: 2983538

Strand: Reverse

Name: pyrD

Synonym: Nther_2762

Alternate gene names: 188587355

Gene position: 2983538-2982627 (Counterclockwise)

Preceding gene: 188587356

Following gene: 188587354

Centisome position: 94.25

GC content: 42.32

Gene sequence:

>912_bases
ATGGCTGATCTTAAGGTGAATTTTGCAGGAATACCAATGAAAAATCCTGTAGCATCGGCATCGGGAACTTTTGGATTTGG
TTTTGAATATCAATCGGTCATAAGTCCACACGAGCTTGGTGCTTTAGTAGTTAAGGGATTAACTTTGTCTCCCAAAAGGG
GTAATCAAGGAACCAGGCTGCACGAAACAGCTTCGGGCTTGTTGAATTCCATTGGTCTGGAAAATCCCGGCATTGACAAC
TTTATTAATGAAATATTACCTGATTTACGTCAATGTGATGCTACTACCTTAATTAACATTTCAGGTGGTAACGACGAAGA
ATATGTAGAAATTACACAAAAGCTCAATAATTGCCAAGGGATAGCGGGCTTGGAAGTTAATATTTCGTGTCCTAATATCC
GAGAAGGGGGATTGGTATACGGGGTAGATCCCGAACTGACATATCGCTTGGTTTCTAAAGTTCGGCAATCCACTTCCTTT
CCAGTTATTGTGAAATTATCCCCCAATGTCACAGATATAACTGAAATAGCCAAAGCTTGTGAACGAGCGGGTGCCGACGG
CCTTTCTCTCATAAATACTGTTGCAGGTATGGCTATTGACATTGACCAAAAAGAGCCTGTTTTTGATAATATTTCGGCCG
GCCTATCTGGCCCAGCCATTAAACCTATTGCCTTAAAAGCAGTTTACCAGGTGAGCCAAGCAGTTGACTTACCGGTGATG
GGCATGGGTGGAATTTATAATTACCAGGATGCCATTGAATTTATCCTGGCTGGCGCGACTTCAGTAGCTTTGGGAACGGT
TAATTTTGCTGAACCTACAGCCGCCAAATCAATAATTCAGGGGATTGACAACTACTTGGAGCGAGAAGGGTATCTTTCAG
TAAATGATATCAGAGGTTTGGCATGGAAATAG

Upstream 100 bases:

>100_bases
GGTGCCTGTCTTGGTTGCACCTGTGAATCTGTGGATAATCAATCCTACAAGCATGCATGCATCGATGGTCCTGTCTTCTG
GGGAAATGAGGTGAAACTAA

Downstream 100 bases:

>100_bases
AAATCAGTACTGAATCTGGAGGGATCTGGTATATGAAGGATAAAGGAGATAATAATCGAAATGATCAGCCAGCAAGGGAA
AAGTCAACTGACCTAGAGGA

Product: dihydroorotate oxidase B, catalytic subunit

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MADLKVNFAGIPMKNPVASASGTFGFGFEYQSVISPHELGALVVKGLTLSPKRGNQGTRLHETASGLLNSIGLENPGIDN
FINEILPDLRQCDATTLINISGGNDEEYVEITQKLNNCQGIAGLEVNISCPNIREGGLVYGVDPELTYRLVSKVRQSTSF
PVIVKLSPNVTDITEIAKACERAGADGLSLINTVAGMAIDIDQKEPVFDNISAGLSGPAIKPIALKAVYQVSQAVDLPVM
GMGGIYNYQDAIEFILAGATSVALGTVNFAEPTAAKSIIQGIDNYLEREGYLSVNDIRGLAWK

Sequences:

>Translated_303_residues
MADLKVNFAGIPMKNPVASASGTFGFGFEYQSVISPHELGALVVKGLTLSPKRGNQGTRLHETASGLLNSIGLENPGIDN
FINEILPDLRQCDATTLINISGGNDEEYVEITQKLNNCQGIAGLEVNISCPNIREGGLVYGVDPELTYRLVSKVRQSTSF
PVIVKLSPNVTDITEIAKACERAGADGLSLINTVAGMAIDIDQKEPVFDNISAGLSGPAIKPIALKAVYQVSQAVDLPVM
GMGGIYNYQDAIEFILAGATSVALGTVNFAEPTAAKSIIQGIDNYLEREGYLSVNDIRGLAWK
>Mature_302_residues
ADLKVNFAGIPMKNPVASASGTFGFGFEYQSVISPHELGALVVKGLTLSPKRGNQGTRLHETASGLLNSIGLENPGIDNF
INEILPDLRQCDATTLINISGGNDEEYVEITQKLNNCQGIAGLEVNISCPNIREGGLVYGVDPELTYRLVSKVRQSTSFP
VIVKLSPNVTDITEIAKACERAGADGLSLINTVAGMAIDIDQKEPVFDNISAGLSGPAIKPIALKAVYQVSQAVDLPVMG
MGGIYNYQDAIEFILAGATSVALGTVNFAEPTAAKSIIQGIDNYLEREGYLSVNDIRGLAWK

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=304, Percent_Identity=28.9473684210526, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI45006951, Length=320, Percent_Identity=25, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI87082059, Length=318, Percent_Identity=29.2452830188679, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787177, Length=312, Percent_Identity=27.5641025641026, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71984108, Length=296, Percent_Identity=28.0405405405405, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322633, Length=308, Percent_Identity=27.2727272727273, Blast_Score=92, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24640763, Length=303, Percent_Identity=32.3432343234323, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18858217, Length=303, Percent_Identity=32.3432343234323, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_NATTJ (B2A2U4)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001918900.1
- ProteinModelPortal:   B2A2U4
- SMR:   B2A2U4
- GeneID:   6315747
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_2762
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32174; Mature: 32043

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLKVNFAGIPMKNPVASASGTFGFGFEYQSVISPHELGALVVKGLTLSPKRGNQGTRL
CCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCEECCCCCCCCCHH
HETASGLLNSIGLENPGIDNFINEILPDLRQCDATTLINISGGNDEEYVEITQKLNNCQG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCC
IAGLEVNISCPNIREGGLVYGVDPELTYRLVSKVRQSTSFPVIVKLSPNVTDITEIAKAC
EECEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHH
ERAGADGLSLINTVAGMAIDIDQKEPVFDNISAGLSGPAIKPIALKAVYQVSQAVDLPVM
HHCCCCHHHHHHHHHCCEEECCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCC
GMGGIYNYQDAIEFILAGATSVALGTVNFAEPTAAKSIIQGIDNYLEREGYLSVNDIRGL
CCCCCCCHHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHCCCC
AWK
CCC
>Mature Secondary Structure 
ADLKVNFAGIPMKNPVASASGTFGFGFEYQSVISPHELGALVVKGLTLSPKRGNQGTRL
CCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCEECCCCCCCCCHH
HETASGLLNSIGLENPGIDNFINEILPDLRQCDATTLINISGGNDEEYVEITQKLNNCQG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCC
IAGLEVNISCPNIREGGLVYGVDPELTYRLVSKVRQSTSFPVIVKLSPNVTDITEIAKAC
EECEEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHH
ERAGADGLSLINTVAGMAIDIDQKEPVFDNISAGLSGPAIKPIALKAVYQVSQAVDLPVM
HHCCCCHHHHHHHHHCCEEECCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCC
GMGGIYNYQDAIEFILAGATSVALGTVNFAEPTAAKSIIQGIDNYLEREGYLSVNDIRGL
CCCCCCCHHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEHHHCCCC
AWK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA