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The map label for this gene is pyrF [H]

Identifier: 188587354

GI number: 188587354

Start: 2981803

End: 2982636

Strand: Reverse

Name: pyrF [H]

Synonym: Nther_2761

Alternate gene names: 188587354

Gene position: 2982636-2981803 (Counterclockwise)

Preceding gene: 188587355

Following gene: 188587353

Centisome position: 94.22

GC content: 40.41

Gene sequence:

>834_bases
ATGGAAATAGAAATCAGTACTGAATCTGGAGGGATCTGGTATATGAAGGATAAAGGAGATAATAATCGAAATGATCAGCC
AGCAAGGGAAAAGTCAACTGACCTAGAGGATAAATTGATTGTAGCCCTGGATATGCCTGACCGAACACAAGCCCTTTCCC
TGGTTGATGAGTTGGGAGAACAAATTAAGTGGTATAAAATCGGTTTAGAGTTATTTTGTTCCCAGGGACCAGAAATCATA
TCTGAATTGGTGGATAGAGATAAAAAAGTATTTTTGGATTTAAAACTTCACGATATTCCCAATACTGTTTCCAGAACAGC
TAAAGAATTAGTACGAAGAGGCGCATCTATGATAAATGTTCATACAGCGGGCGGTAAGGACATGATGGCTAGAACTGTGG
AAGAGGTACACACAGAGGCAAGTGGTAGAGGAATCACACCACCTAAAATAGTTGGTGTGACGGTATTGACTAGTTTGGGA
CAGAATGAATTTAATAATCAATTGGGGTTTAATGGTCACATAGAAGATAAAGTTGTCGAATGGGCTCAAATGGCCCGAAA
TAGTGGGTTAGATGGAGTGGTAGCTTCAGCTAAAGAAGCAGCCCAGATCAAAGAAAAGTTGGGAGCAGAGTTTTTAATAG
TTACACCGGGAATTCGGTTGGCTTCTGATGATAAAAGTGACCAAAAACGGGTGTTGACTCCAGATAAGGCTTTAAATAAA
GGTGCTACCCATATAGTGGTAGGACGATCAATTACTGGCAAAGAAGGGCCAGGGCAAAAGAAAACAGCGGTTCAAGAGAT
ATATAACTGTATGAGGAGTGAGCAAAATGACTAA

Upstream 100 bases:

>100_bases
ATTTTGCTGAACCTACAGCCGCCAAATCAATAATTCAGGGGATTGACAACTACTTGGAGCGAGAAGGGTATCTTTCAGTA
AATGATATCAGAGGTTTGGC

Downstream 100 bases:

>100_bases
AGATAATCGTATTATGGAAATTTTTGAACAAACAGGTGCAATAACTCATGGACATTTCTTATTAACATCAGGCAGACACA
GTGATTGTTATGTTCAATGT

Product: orotidine 5'-phosphate decarboxylase

Products: NA

Alternate protein names: OMP decarboxylase; OMPDCase; OMPdecase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MEIEISTESGGIWYMKDKGDNNRNDQPAREKSTDLEDKLIVALDMPDRTQALSLVDELGEQIKWYKIGLELFCSQGPEII
SELVDRDKKVFLDLKLHDIPNTVSRTAKELVRRGASMINVHTAGGKDMMARTVEEVHTEASGRGITPPKIVGVTVLTSLG
QNEFNNQLGFNGHIEDKVVEWAQMARNSGLDGVVASAKEAAQIKEKLGAEFLIVTPGIRLASDDKSDQKRVLTPDKALNK
GATHIVVGRSITGKEGPGQKKTAVQEIYNCMRSEQND

Sequences:

>Translated_277_residues
MEIEISTESGGIWYMKDKGDNNRNDQPAREKSTDLEDKLIVALDMPDRTQALSLVDELGEQIKWYKIGLELFCSQGPEII
SELVDRDKKVFLDLKLHDIPNTVSRTAKELVRRGASMINVHTAGGKDMMARTVEEVHTEASGRGITPPKIVGVTVLTSLG
QNEFNNQLGFNGHIEDKVVEWAQMARNSGLDGVVASAKEAAQIKEKLGAEFLIVTPGIRLASDDKSDQKRVLTPDKALNK
GATHIVVGRSITGKEGPGQKKTAVQEIYNCMRSEQND
>Mature_277_residues
MEIEISTESGGIWYMKDKGDNNRNDQPAREKSTDLEDKLIVALDMPDRTQALSLVDELGEQIKWYKIGLELFCSQGPEII
SELVDRDKKVFLDLKLHDIPNTVSRTAKELVRRGASMINVHTAGGKDMMARTVEEVHTEASGRGITPPKIVGVTVLTSLG
QNEFNNQLGFNGHIEDKVVEWAQMARNSGLDGVVASAKEAAQIKEKLGAEFLIVTPGIRLASDDKSDQKRVLTPDKALNK
GATHIVVGRSITGKEGPGQKKTAVQEIYNCMRSEQND

Specific function: Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) [H]

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the OMP decarboxylase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787537, Length=226, Percent_Identity=38.0530973451327, Blast_Score=155, Evalue=3e-39,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR014732
- InterPro:   IPR018089
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.1.23 [H]

Molecular weight: Translated: 30497; Mature: 30497

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00156 OMPDECASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIEISTESGGIWYMKDKGDNNRNDQPAREKSTDLEDKLIVALDMPDRTQALSLVDELGE
CEEEEEECCCCEEEEECCCCCCCCCCCCHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHH
QIKWYKIGLELFCSQGPEIISELVDRDKKVFLDLKLHDIPNTVSRTAKELVRRGASMINV
HHEEHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEE
HTAGGKDMMARTVEEVHTEASGRGITPPKIVGVTVLTSLGQNEFNNQLGFNGHIEDKVVE
ECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHH
WAQMARNSGLDGVVASAKEAAQIKEKLGAEFLIVTPGIRLASDDKSDQKRVLTPDKALNK
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCCEECCCHHHHCC
GATHIVVGRSITGKEGPGQKKTAVQEIYNCMRSEQND
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEIEISTESGGIWYMKDKGDNNRNDQPAREKSTDLEDKLIVALDMPDRTQALSLVDELGE
CEEEEEECCCCEEEEECCCCCCCCCCCCHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHH
QIKWYKIGLELFCSQGPEIISELVDRDKKVFLDLKLHDIPNTVSRTAKELVRRGASMINV
HHEEHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEE
HTAGGKDMMARTVEEVHTEASGRGITPPKIVGVTVLTSLGQNEFNNQLGFNGHIEDKVVE
ECCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHH
WAQMARNSGLDGVVASAKEAAQIKEKLGAEFLIVTPGIRLASDDKSDQKRVLTPDKALNK
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCEECCCCCCCCCEECCCHHHHCC
GATHIVVGRSITGKEGPGQKKTAVQEIYNCMRSEQND
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA