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The map label for this gene is pdh [H]

Identifier: 188586957

GI number: 188586957

Start: 2499424

End: 2500500

Strand: Reverse

Name: pdh [H]

Synonym: Nther_2349

Alternate gene names: 188586957

Gene position: 2500500-2499424 (Counterclockwise)

Preceding gene: 188586958

Following gene: 188586956

Centisome position: 78.99

GC content: 40.2

Gene sequence:

>1077_bases
ATGAGTGTGAAAATTTTTGAAGAGATGGAGAAGCACGGTCATGAGCAGGTAATCTTTAATTACGACAAGACTACCGGGTT
AAAAGCCATCATTGCAGTACATGATACTACTCTAGGTCCCGCTTTAGGTGGTTGCAGAATGCTTCCATACGAAACCGAGG
AAGAAGCTCTAGACGATGTGTTACGCCTTTCCAAAGGGATGACTTATAAGTGCAGTATTTCCGAAGTAGATTACGGTGGT
GGTAAAACTGTTATAATCGGCGACCCTGAAAAGGACAAGTCTGAAGGTATGTTTAGGGCCTTGGGGCGATTTGTTGGAAC
TATGAAAGGCCGCTACTATACCGGTACCGATGTTGGAACAGTACCCGATGATTTTGTGCACTCATATCGCGAATCGGATT
ATTTTGTGGGTTTACCTGAAGAGTTCGGAGGCAGTGGCAACTCAGCTATAAATACAGCTTTTGGAACTTTGATGGGCATT
AAAGCCTGTGTTAAAGAACATTTTGGCCAGGTTAATCTAGAAGGAAAGAAAATTGCCATTCAGGGCTTGGGTAAGGTTGG
TCAAAATTTGGTTGATTTCCTAATGGAAGAAGGAGCTCATATAATTGCCACTGACATCAGCAAAGATAATATTAATCAAG
TCAAAGAGCGACATTCAAGTGTCGAAATGGTAGAACCTGATGCGATATACGAAGTTGACTGTGATATATTTAGCCCTAAT
GCTCTGGGAGCTGTCATCAATGATTTTACTGTGGAAAAATTAAAATGTTCAATTATAGCAGGGGCAGCCAATAACCAGTT
AAAAGAAGAAAAACATGGCCGCATGTTGTTTGATAAAGGTATTCTTTATGCTCCAGATTATATTGTTAATGCTGGTGGGC
TAATACAGGTTTCGGATGAGATTGGTGGTCATAATAAAGACAGGATCAGAAAAAAGACAGAACGTATTTATGATATTTTA
TTGCAGGTATTCAAAATCTCCCGGGAAGAAAACATCACTCCACAAGAAGCTTCCGATAAACTGGTTGAGGAGCGAATAGC
AACAGTTAAAGGATTGCAATCTAATTACATGGGTTAA

Upstream 100 bases:

>100_bases
TTATTGGTCCAAAAAGCGTGAAGGTGGAAAATAGTCAAAAAGTTTGGTATTCTTTTCCATGAAGGGACTAATATTTACCA
AAATATAAGGAGGTACTCTA

Downstream 100 bases:

>100_bases
TATAATTAGCGGTAAAATTTGGCTTGAAGGAGGGAGTTAATTTGAAAATACTAGTAATCAATCCGGGATCAACTTCTACG
AAGATTGCCCTTTATGAAAA

Product: leucine dehydrogenase

Products: NA

Alternate protein names: PheDH [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSVKIFEEMEKHGHEQVIFNYDKTTGLKAIIAVHDTTLGPALGGCRMLPYETEEEALDDVLRLSKGMTYKCSISEVDYGG
GKTVIIGDPEKDKSEGMFRALGRFVGTMKGRYYTGTDVGTVPDDFVHSYRESDYFVGLPEEFGGSGNSAINTAFGTLMGI
KACVKEHFGQVNLEGKKIAIQGLGKVGQNLVDFLMEEGAHIIATDISKDNINQVKERHSSVEMVEPDAIYEVDCDIFSPN
ALGAVINDFTVEKLKCSIIAGAANNQLKEEKHGRMLFDKGILYAPDYIVNAGGLIQVSDEIGGHNKDRIRKKTERIYDIL
LQVFKISREENITPQEASDKLVEERIATVKGLQSNYMG

Sequences:

>Translated_358_residues
MSVKIFEEMEKHGHEQVIFNYDKTTGLKAIIAVHDTTLGPALGGCRMLPYETEEEALDDVLRLSKGMTYKCSISEVDYGG
GKTVIIGDPEKDKSEGMFRALGRFVGTMKGRYYTGTDVGTVPDDFVHSYRESDYFVGLPEEFGGSGNSAINTAFGTLMGI
KACVKEHFGQVNLEGKKIAIQGLGKVGQNLVDFLMEEGAHIIATDISKDNINQVKERHSSVEMVEPDAIYEVDCDIFSPN
ALGAVINDFTVEKLKCSIIAGAANNQLKEEKHGRMLFDKGILYAPDYIVNAGGLIQVSDEIGGHNKDRIRKKTERIYDIL
LQVFKISREENITPQEASDKLVEERIATVKGLQSNYMG
>Mature_357_residues
SVKIFEEMEKHGHEQVIFNYDKTTGLKAIIAVHDTTLGPALGGCRMLPYETEEEALDDVLRLSKGMTYKCSISEVDYGGG
KTVIIGDPEKDKSEGMFRALGRFVGTMKGRYYTGTDVGTVPDDFVHSYRESDYFVGLPEEFGGSGNSAINTAFGTLMGIK
ACVKEHFGQVNLEGKKIAIQGLGKVGQNLVDFLMEEGAHIIATDISKDNINQVKERHSSVEMVEPDAIYEVDCDIFSPNA
LGAVINDFTVEKLKCSIIAGAANNQLKEEKHGRMLFDKGILYAPDYIVNAGGLIQVSDEIGGHNKDRIRKKTERIYDILL
QVFKISREENITPQEASDKLVEERIATVKGLQSNYMG

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=304, Percent_Identity=25.6578947368421, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4885281, Length=304, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45553475, Length=374, Percent_Identity=24.8663101604278, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45549226, Length=317, Percent_Identity=25.2365930599369, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24649460, Length=270, Percent_Identity=24.0740740740741, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.20 [H]

Molecular weight: Translated: 39509; Mature: 39378

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKIFEEMEKHGHEQVIFNYDKTTGLKAIIAVHDTTLGPALGGCRMLPYETEEEALDDV
CCCHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCEECCCCCHHHHHHHH
LRLSKGMTYKCSISEVDYGGGKTVIIGDPEKDKSEGMFRALGRFVGTMKGRYYTGTDVGT
HHHHCCCEEEEECCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCC
VPDDFVHSYRESDYFVGLPEEFGGSGNSAINTAFGTLMGIKACVKEHFGQVNLEGKKIAI
CCHHHHHHHCCCCEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
QGLGKVGQNLVDFLMEEGAHIIATDISKDNINQVKERHSSVEMVEPDAIYEVDCDIFSPN
EHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCEEECCCCEEEEECCEECCC
ALGAVINDFTVEKLKCSIIAGAANNQLKEEKHGRMLFDKGILYAPDYIVNAGGLIQVSDE
HHHHHHHHHHHHHEEEEEEECCCCCHHHHHHCCCEEEECCCEECCCCEECCCCEEEECHH
IGGHNKDRIRKKTERIYDILLQVFKISREENITPQEASDKLVEERIATVKGLQSNYMG
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVKIFEEMEKHGHEQVIFNYDKTTGLKAIIAVHDTTLGPALGGCRMLPYETEEEALDDV
CCHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCEECCCCCHHHHHHHH
LRLSKGMTYKCSISEVDYGGGKTVIIGDPEKDKSEGMFRALGRFVGTMKGRYYTGTDVGT
HHHHCCCEEEEECCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEECCCCCC
VPDDFVHSYRESDYFVGLPEEFGGSGNSAINTAFGTLMGIKACVKEHFGQVNLEGKKIAI
CCHHHHHHHCCCCEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
QGLGKVGQNLVDFLMEEGAHIIATDISKDNINQVKERHSSVEMVEPDAIYEVDCDIFSPN
EHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCEEECCCCEEEEECCEECCC
ALGAVINDFTVEKLKCSIIAGAANNQLKEEKHGRMLFDKGILYAPDYIVNAGGLIQVSDE
HHHHHHHHHHHHHEEEEEEECCCCCHHHHHHCCCEEEECCCEECCCCEECCCCEEEECHH
IGGHNKDRIRKKTERIYDILLQVFKISREENITPQEASDKLVEERIATVKGLQSNYMG
HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1880121 [H]