Click here to switch to the map view.

The map label for this gene is phr [H]

Identifier: 188586748

GI number: 188586748

Start: 2260956

End: 2262326

Strand: Direct

Name: phr [H]

Synonym: Nther_2139

Alternate gene names: 188586748

Gene position: 2260956-2262326 (Clockwise)

Preceding gene: 188586743

Following gene: 188586750

Centisome position: 71.42

GC content: 36.54

Gene sequence:

>1371_bases
ATGATTCATAAAGAAAGAATAGAAATCCTCCAAGAAGTACAAACACCAGCTCAAGAAGGAAAATACGTACTCTACTGGAT
GCAAAAAGCACAACGAACTCATTACAATCATGCACTTGAATATGCTATCGAACAGGCCAACAAGCTCAACTTACCCCTGA
TCGTTTATTTTGGCTTGTACGAACAATTTCCTTATGCTAGTTCAAGACATTTTCAGTTCATGCTTCAAGGATTACAGGAT
GTCGCCGAAAACTTGGCGAAAAGAAATATCAAAATGATTATAAAGAGAACTTTTCCTCCTTATGGGGCAATTGAATTAGC
AAAAGATGCTTCTATGATTGTAGTTGACAAGGGGTATCTTAAATTTGAAAAGGACTGGAAAGAAATACTCTCACATCAGT
TAAGCTGTCCTATTCACCAAATTGAAACCGACGCCGTTATACCGGTGAATACAGCCTCTTCGAAAGAAGAGTATGCTGCC
TATACATTGCGAAAAAAGCTCTTAAAAATGCTTGACATTTTCCTCACTCCTTTGATTTCAAGGAATCCAAATTTTAATTC
CTTTGAGATAACAAATCTAGAACAATATAATGATATAGATATTTATACTAAAAGTGCTTCCGAAATTCTAGAGGAATTAG
ACATCCATCGAGAAGTACAACCCGTAACAGATATTAAAGGAGGAGAAAATCAAGCTCTAGAACAATTATCCGGGTTTTTG
AACCAAGGAAAAGGTTTGGAGCTCTATATTCAAAAAAAGAATGACCCTAGTGTTCAGGCCACTTCAAAATTAAGCCCTTA
TTTACATTTTGGCCAAATTTCACCTTTATTTATCGCACTAGAAGTACTTAAATTTACCCAAGATTATAATCATGAATTTC
TAGAACAATTAATAGTCAGAAGAGAGTTGAGCCTTAACCTGATTGAGAAAAATATTAATTATCTTACTTTATCACCACTG
CCTCAGTGGTCTATAAAAACTCTAAATGAACACCGCAATGACCCGCGAAATAACTTTTATACCTTAGAAGAAATAGAAGC
CGCTAACACACATGATAAATACTTTAATGCAGCCCAAAAAGAACTTATGTCCAGGGGAACAATTCATAATTATATCCGTA
TGTACTGGGGGAAAAAGATCATAGAGTGGTCCCAAACGCCAGAAGAAGCTCATAATACCCTCTGTCACTTGAATGACAAA
TATGCCCTAGACGGTCGTGATCCCAATGGTTACGCCAATATATTATGGTGTTTTGGCAAACACGACCGACCATTCCAAGA
GAGGCAAATTTTTGGGAAAGTAAGGTATATGGGAGTTAATGCATTAAAGAGAAATGGCAAACCTGACCAATATGTGGCTA
CTTGGGTCTAG

Upstream 100 bases:

>100_bases
CAATTATCAACGAGGGTTTGTTAAACTTTTGCTAGAACATATAACATATATACAAAATGCCAAAACTAGTAAATTTTTAT
TAATTTAAGGAGTGAGCTTA

Downstream 100 bases:

>100_bases
AAGACTTGCCAGAGTCCTCCAAACTAATCAATTCTTCTGGAAAAGGGGCAAAAAAATACTGACTCAAGAGATAGCTTTGC
TCGTATTTAATAGCCCAAGA

Product: Deoxyribodipyrimidine photo-lyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MIHKERIEILQEVQTPAQEGKYVLYWMQKAQRTHYNHALEYAIEQANKLNLPLIVYFGLYEQFPYASSRHFQFMLQGLQD
VAENLAKRNIKMIIKRTFPPYGAIELAKDASMIVVDKGYLKFEKDWKEILSHQLSCPIHQIETDAVIPVNTASSKEEYAA
YTLRKKLLKMLDIFLTPLISRNPNFNSFEITNLEQYNDIDIYTKSASEILEELDIHREVQPVTDIKGGENQALEQLSGFL
NQGKGLELYIQKKNDPSVQATSKLSPYLHFGQISPLFIALEVLKFTQDYNHEFLEQLIVRRELSLNLIEKNINYLTLSPL
PQWSIKTLNEHRNDPRNNFYTLEEIEAANTHDKYFNAAQKELMSRGTIHNYIRMYWGKKIIEWSQTPEEAHNTLCHLNDK
YALDGRDPNGYANILWCFGKHDRPFQERQIFGKVRYMGVNALKRNGKPDQYVATWV

Sequences:

>Translated_456_residues
MIHKERIEILQEVQTPAQEGKYVLYWMQKAQRTHYNHALEYAIEQANKLNLPLIVYFGLYEQFPYASSRHFQFMLQGLQD
VAENLAKRNIKMIIKRTFPPYGAIELAKDASMIVVDKGYLKFEKDWKEILSHQLSCPIHQIETDAVIPVNTASSKEEYAA
YTLRKKLLKMLDIFLTPLISRNPNFNSFEITNLEQYNDIDIYTKSASEILEELDIHREVQPVTDIKGGENQALEQLSGFL
NQGKGLELYIQKKNDPSVQATSKLSPYLHFGQISPLFIALEVLKFTQDYNHEFLEQLIVRRELSLNLIEKNINYLTLSPL
PQWSIKTLNEHRNDPRNNFYTLEEIEAANTHDKYFNAAQKELMSRGTIHNYIRMYWGKKIIEWSQTPEEAHNTLCHLNDK
YALDGRDPNGYANILWCFGKHDRPFQERQIFGKVRYMGVNALKRNGKPDQYVATWV
>Mature_456_residues
MIHKERIEILQEVQTPAQEGKYVLYWMQKAQRTHYNHALEYAIEQANKLNLPLIVYFGLYEQFPYASSRHFQFMLQGLQD
VAENLAKRNIKMIIKRTFPPYGAIELAKDASMIVVDKGYLKFEKDWKEILSHQLSCPIHQIETDAVIPVNTASSKEEYAA
YTLRKKLLKMLDIFLTPLISRNPNFNSFEITNLEQYNDIDIYTKSASEILEELDIHREVQPVTDIKGGENQALEQLSGFL
NQGKGLELYIQKKNDPSVQATSKLSPYLHFGQISPLFIALEVLKFTQDYNHEFLEQLIVRRELSLNLIEKNINYLTLSPL
PQWSIKTLNEHRNDPRNNFYTLEEIEAANTHDKYFNAAQKELMSRGTIHNYIRMYWGKKIIEWSQTPEEAHNTLCHLNDK
YALDGRDPNGYANILWCFGKHDRPFQERQIFGKVRYMGVNALKRNGKPDQYVATWV

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586396, Length=464, Percent_Identity=37.5, Blast_Score=284, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24586398, Length=462, Percent_Identity=37.2294372294372, Blast_Score=284, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24586404, Length=148, Percent_Identity=45.945945945946, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 53331; Mature: 53331

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHKERIEILQEVQTPAQEGKYVLYWMQKAQRTHYNHALEYAIEQANKLNLPLIVYFGLY
CCCHHHHHHHHHHHCHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHH
EQFPYASSRHFQFMLQGLQDVAENLAKRNIKMIIKRTFPPYGAIELAKDASMIVVDKGYL
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEECCCCCEEEEECCCC
KFEKDWKEILSHQLSCPIHQIETDAVIPVNTASSKEEYAAYTLRKKLLKMLDIFLTPLIS
EEHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RNPNFNSFEITNLEQYNDIDIYTKSASEILEELDIHREVQPVTDIKGGENQALEQLSGFL
CCCCCCCEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHH
NQGKGLELYIQKKNDPSVQATSKLSPYLHFGQISPLFIALEVLKFTQDYNHEFLEQLIVR
HCCCCEEEEEEECCCCCCEEHHCCCCCEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
RELSLNLIEKNINYLTLSPLPQWSIKTLNEHRNDPRNNFYTLEEIEAANTHDKYFNAAQK
HHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEEHHHHHCCCCHHHHHHHHHH
ELMSRGTIHNYIRMYWGKKIIEWSQTPEEAHNTLCHLNDKYALDGRDPNGYANILWCFGK
HHHHCCHHHHHHHHHHCHHHHCCCCCHHHHHCCEEECCCCEEECCCCCCCCEEEEEEECC
HDRPFQERQIFGKVRYMGVNALKRNGKPDQYVATWV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
>Mature Secondary Structure
MIHKERIEILQEVQTPAQEGKYVLYWMQKAQRTHYNHALEYAIEQANKLNLPLIVYFGLY
CCCHHHHHHHHHHHCHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHH
EQFPYASSRHFQFMLQGLQDVAENLAKRNIKMIIKRTFPPYGAIELAKDASMIVVDKGYL
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEECCCCCEEEEECCCC
KFEKDWKEILSHQLSCPIHQIETDAVIPVNTASSKEEYAAYTLRKKLLKMLDIFLTPLIS
EEHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RNPNFNSFEITNLEQYNDIDIYTKSASEILEELDIHREVQPVTDIKGGENQALEQLSGFL
CCCCCCCEEECCCCCCCCCEEEECCHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHH
NQGKGLELYIQKKNDPSVQATSKLSPYLHFGQISPLFIALEVLKFTQDYNHEFLEQLIVR
HCCCCEEEEEEECCCCCCEEHHCCCCCEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
RELSLNLIEKNINYLTLSPLPQWSIKTLNEHRNDPRNNFYTLEEIEAANTHDKYFNAAQK
HHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEEHHHHHCCCCHHHHHHHHHH
ELMSRGTIHNYIRMYWGKKIIEWSQTPEEAHNTLCHLNDKYALDGRDPNGYANILWCFGK
HHHHCCHHHHHHHHHHCHHHHCCCCCHHHHHCCEEECCCCEEECCCCCCCCEEEEEEECC
HDRPFQERQIFGKVRYMGVNALKRNGKPDQYVATWV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]