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The map label for this gene is mutS [H]

Identifier: 188586750

GI number: 188586750

Start: 2263527

End: 2265401

Strand: Direct

Name: mutS [H]

Synonym: Nther_2141

Alternate gene names: 188586750

Gene position: 2263527-2265401 (Clockwise)

Preceding gene: 188586748

Following gene: 188586752

Centisome position: 71.5

GC content: 35.15

Gene sequence:

>1875_bases
ATGTCAGCTAATTACAGCAGTGTCAATAACAGATCCGAAGCCAATAGTATTAAAAGTAGATACAAAGCACGTAAAGAACA
ATTCGCAAGTGAATCAAAAGCACTTTCTAACAAAATGAATCTAATATCTAATTTAAGGTTACTAACCGTTGTTTTAGGTA
TTGGGTTAACTGGCTATTTGTTTTATATTGGGAATTATGTAGTCAGTTTTTTCTCTCTAATCATTTTTACAACAATTTTC
ATATTTCTGGTCATCAGATATCGTGTATTAACAAATAAGCGAAATTATGCCTGGGCCCTTGCCGATATTAATGAGCGTTC
TCTTATCAGATTAAAGGGGAGTTGGAATAGTTTTGAGGATACTGGTAATGAATTTTTAGACCATGATCATCCCTATGCAG
AAGATCTAGATATCTTCGGACAAAATTCCCTTTTCCAGTGGATAAATACCACTACTACCTTTTCGGGAAGGCATAAATTA
AAGACCATGTTAACACAACCATGTAATAAGATAGAAGAGATACAAGCAAGGCAAAGGTCCATTCAGGAATTAGCCGAGAA
ACTCCATTGGCGTCAACATTTAGAAGCTTTAGGGAAACAACCCGAATACGAACACCGCAATAACAAAGAACTCCAAGTTG
ATCCCCTTAATTTAATATCATGGGCAAAAACACAAAACCCCTTTTATTTAAAAACTTGGCTTAAGGTGATCGTGAATCTA
CTACCCTTAATAACTCTAAGTTTTATAATCGCAGCAATTATGACTGGAGTCACTTATATTTTTCCTATAATTATGATTGC
ACTACACATATTGATCCTTACTTATGATTACTCTAATCGCATTAGCGAGTTCAGCTTGATCTCAGGCTTTAATGAAAAAT
TGTCGGCTTACAAAGATATTTTAACAGCCATAGAAACAGAACAATTTCATGGAAGTATGTTAACAAAACTACAGGATACA
ATATTAAATTCCAAAACGGGGACAAATGCTTCGGATCGTCTAAAGCTCCTTGACGAGATAATGGAATTCATTTCGCATCG
CTCAGGCCAGTTTTATATTATATTTAATATCTTATTTCTATTGGATTATCGATGGCAAATTTCTTTAGAACATTGGAAAC
ATCAATCAGGAGATGAGCTTGAACAATGGTTTGATATTTTGGGAGATTTTGAAGCCCTGAGTAGTTTAGCGATAATTCCA
TGTGATCATCCTGATTGGGCTCAACCTGAGATCACAGCAGAACCTGGTCTATTTCAGGCCGAACAAATAGGCCACCCTTT
ATTAACAGAACATCGAGTTTGCAACGATATTGATATGGGTTCAAGTACAAATAGTTTACTAATTACGGGTTCCAATATGT
CTGGTAAAAGTACTTTACTCAGAACAGCTGGAATCAATCTGGTACTAGCATATTTGGGTGCTCCCGTTTGTGCAAATACT
ATGCAGGCGTCATTAATGAAAATTTATACATGTATGAGAGTTAGCGATAATTTAGAAAAGAATTTATCTTCTTTTTATGC
CGAACTACTTAGAATTAAACATATAGTTAAAAGTGCTGAACAGATACCAGTTTTTTATTTATTAGACGAGATTTTTAAAG
GGACTAATTCTCGTGACCGACATACTGGTGCTAGAGCTGTAATTAAAAAATTACAATCAGAAGGTGCCCTGGGCCTTGTT
TCAACACACGATCTAGAATTAGGTGCCCTGGAGAGTCAAAACACAAGTATAAAAAATTACCATTTCAGAGAGTACTATCA
AAATGGTGAAATTTACTTTGATTATATTTTGAGACCTGGGTTGGCTCCTACTACTAATGCTATTTATCTAATGAAAATGG
CAGGCATCGATCCAGATGAAGAAGATTTGGGTTAA

Upstream 100 bases:

>100_bases
CTGGTATTTTTTTGGACAAACTAGTAGAATTAAGGGAAGGAAAAGAAAAAGCATACTATTTAGATTAATTTTTAGATTAT
CTAACAGAAAGGAAGGTCTT

Downstream 100 bases:

>100_bases
ATATGATACCATAAAAAAACCGGGGAGCCCCGGTTTTTTTATGGTCTAAGTCTCTGACAAGCTTTTCTTTAATAGATCTA
ATCTGTAACGGCTTACCAAA

Product: DNA mismatch repair protein MutS domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MSANYSSVNNRSEANSIKSRYKARKEQFASESKALSNKMNLISNLRLLTVVLGIGLTGYLFYIGNYVVSFFSLIIFTTIF
IFLVIRYRVLTNKRNYAWALADINERSLIRLKGSWNSFEDTGNEFLDHDHPYAEDLDIFGQNSLFQWINTTTTFSGRHKL
KTMLTQPCNKIEEIQARQRSIQELAEKLHWRQHLEALGKQPEYEHRNNKELQVDPLNLISWAKTQNPFYLKTWLKVIVNL
LPLITLSFIIAAIMTGVTYIFPIIMIALHILILTYDYSNRISEFSLISGFNEKLSAYKDILTAIETEQFHGSMLTKLQDT
ILNSKTGTNASDRLKLLDEIMEFISHRSGQFYIIFNILFLLDYRWQISLEHWKHQSGDELEQWFDILGDFEALSSLAIIP
CDHPDWAQPEITAEPGLFQAEQIGHPLLTEHRVCNDIDMGSSTNSLLITGSNMSGKSTLLRTAGINLVLAYLGAPVCANT
MQASLMKIYTCMRVSDNLEKNLSSFYAELLRIKHIVKSAEQIPVFYLLDEIFKGTNSRDRHTGARAVIKKLQSEGALGLV
STHDLELGALESQNTSIKNYHFREYYQNGEIYFDYILRPGLAPTTNAIYLMKMAGIDPDEEDLG

Sequences:

>Translated_624_residues
MSANYSSVNNRSEANSIKSRYKARKEQFASESKALSNKMNLISNLRLLTVVLGIGLTGYLFYIGNYVVSFFSLIIFTTIF
IFLVIRYRVLTNKRNYAWALADINERSLIRLKGSWNSFEDTGNEFLDHDHPYAEDLDIFGQNSLFQWINTTTTFSGRHKL
KTMLTQPCNKIEEIQARQRSIQELAEKLHWRQHLEALGKQPEYEHRNNKELQVDPLNLISWAKTQNPFYLKTWLKVIVNL
LPLITLSFIIAAIMTGVTYIFPIIMIALHILILTYDYSNRISEFSLISGFNEKLSAYKDILTAIETEQFHGSMLTKLQDT
ILNSKTGTNASDRLKLLDEIMEFISHRSGQFYIIFNILFLLDYRWQISLEHWKHQSGDELEQWFDILGDFEALSSLAIIP
CDHPDWAQPEITAEPGLFQAEQIGHPLLTEHRVCNDIDMGSSTNSLLITGSNMSGKSTLLRTAGINLVLAYLGAPVCANT
MQASLMKIYTCMRVSDNLEKNLSSFYAELLRIKHIVKSAEQIPVFYLLDEIFKGTNSRDRHTGARAVIKKLQSEGALGLV
STHDLELGALESQNTSIKNYHFREYYQNGEIYFDYILRPGLAPTTNAIYLMKMAGIDPDEEDLG
>Mature_623_residues
SANYSSVNNRSEANSIKSRYKARKEQFASESKALSNKMNLISNLRLLTVVLGIGLTGYLFYIGNYVVSFFSLIIFTTIFI
FLVIRYRVLTNKRNYAWALADINERSLIRLKGSWNSFEDTGNEFLDHDHPYAEDLDIFGQNSLFQWINTTTTFSGRHKLK
TMLTQPCNKIEEIQARQRSIQELAEKLHWRQHLEALGKQPEYEHRNNKELQVDPLNLISWAKTQNPFYLKTWLKVIVNLL
PLITLSFIIAAIMTGVTYIFPIIMIALHILILTYDYSNRISEFSLISGFNEKLSAYKDILTAIETEQFHGSMLTKLQDTI
LNSKTGTNASDRLKLLDEIMEFISHRSGQFYIIFNILFLLDYRWQISLEHWKHQSGDELEQWFDILGDFEALSSLAIIPC
DHPDWAQPEITAEPGLFQAEQIGHPLLTEHRVCNDIDMGSSTNSLLITGSNMSGKSTLLRTAGINLVLAYLGAPVCANTM
QASLMKIYTCMRVSDNLEKNLSSFYAELLRIKHIVKSAEQIPVFYLLDEIFKGTNSRDRHTGARAVIKKLQSEGALGLVS
THDLELGALESQNTSIKNYHFREYYQNGEIYFDYILRPGLAPTTNAIYLMKMAGIDPDEEDLG

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=227, Percent_Identity=31.2775330396476, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4557761, Length=245, Percent_Identity=25.3061224489796, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI4504191, Length=287, Percent_Identity=27.1777003484321, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789089, Length=222, Percent_Identity=27.9279279279279, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508445, Length=206, Percent_Identity=28.6407766990291, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508447, Length=257, Percent_Identity=28.0155642023346, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17534743, Length=517, Percent_Identity=22.4371373307544, Blast_Score=76, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319935, Length=246, Percent_Identity=29.6747967479675, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324482, Length=537, Percent_Identity=22.1601489757914, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321912, Length=255, Percent_Identity=25.4901960784314, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320302, Length=157, Percent_Identity=29.2993630573248, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24584320, Length=237, Percent_Identity=27.0042194092827, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664545, Length=253, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 71365; Mature: 71234

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANYSSVNNRSEANSIKSRYKARKEQFASESKALSNKMNLISNLRLLTVVLGIGLTGYL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYIGNYVVSFFSLIIFTTIFIFLVIRYRVLTNKRNYAWALADINERSLIRLKGSWNSFED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCHHH
TGNEFLDHDHPYAEDLDIFGQNSLFQWINTTTTFSGRHKLKTMLTQPCNKIEEIQARQRS
CCHHHHCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IQELAEKLHWRQHLEALGKQPEYEHRNNKELQVDPLNLISWAKTQNPFYLKTWLKVIVNL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHH
LPLITLSFIIAAIMTGVTYIFPIIMIALHILILTYDYSNRISEFSLISGFNEKLSAYKDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHH
LTAIETEQFHGSMLTKLQDTILNSKTGTNASDRLKLLDEIMEFISHRSGQFYIIFNILFL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHH
LDYRWQISLEHWKHQSGDELEQWFDILGDFEALSSLAIIPCDHPDWAQPEITAEPGLFQA
HHCCCEEEHHHHCCCCCHHHHHHHHHHHCHHHHHCEEEEECCCCCCCCCCCCCCCCCCCH
EQIGHPLLTEHRVCNDIDMGSSTNSLLITGSNMSGKSTLLRTAGINLVLAYLGAPVCANT
HHCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
MQASLMKIYTCMRVSDNLEKNLSSFYAELLRIKHIVKSAEQIPVFYLLDEIFKGTNSRDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCH
HTGARAVIKKLQSEGALGLVSTHDLELGALESQNTSIKNYHFREYYQNGEIYFDYILRPG
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCC
LAPTTNAIYLMKMAGIDPDEEDLG
CCCCCCCEEEEEECCCCCCHHCCC
>Mature Secondary Structure 
SANYSSVNNRSEANSIKSRYKARKEQFASESKALSNKMNLISNLRLLTVVLGIGLTGYL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYIGNYVVSFFSLIIFTTIFIFLVIRYRVLTNKRNYAWALADINERSLIRLKGSWNSFED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCHHH
TGNEFLDHDHPYAEDLDIFGQNSLFQWINTTTTFSGRHKLKTMLTQPCNKIEEIQARQRS
CCHHHHCCCCCCHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IQELAEKLHWRQHLEALGKQPEYEHRNNKELQVDPLNLISWAKTQNPFYLKTWLKVIVNL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHH
LPLITLSFIIAAIMTGVTYIFPIIMIALHILILTYDYSNRISEFSLISGFNEKLSAYKDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHH
LTAIETEQFHGSMLTKLQDTILNSKTGTNASDRLKLLDEIMEFISHRSGQFYIIFNILFL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHH
LDYRWQISLEHWKHQSGDELEQWFDILGDFEALSSLAIIPCDHPDWAQPEITAEPGLFQA
HHCCCEEEHHHHCCCCCHHHHHHHHHHHCHHHHHCEEEEECCCCCCCCCCCCCCCCCCCH
EQIGHPLLTEHRVCNDIDMGSSTNSLLITGSNMSGKSTLLRTAGINLVLAYLGAPVCANT
HHCCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
MQASLMKIYTCMRVSDNLEKNLSSFYAELLRIKHIVKSAEQIPVFYLLDEIFKGTNSRDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCH
HTGARAVIKKLQSEGALGLVSTHDLELGALESQNTSIKNYHFREYYQNGEIYFDYILRPG
HHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCC
LAPTTNAIYLMKMAGIDPDEEDLG
CCCCCCCEEEEEECCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA