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The map label for this gene is ahpF [C]

Identifier: 188586743

GI number: 188586743

Start: 2253729

End: 2254601

Strand: Direct

Name: ahpF [C]

Synonym: Nther_2134

Alternate gene names: 188586743

Gene position: 2253729-2254601 (Clockwise)

Preceding gene: 188586742

Following gene: 188586748

Centisome position: 71.2

GC content: 39.52

Gene sequence:

>873_bases
ATGTCAAATACGAACACAGAAATTGCCATAGTAGGCTGTGGCCCTGCCGGGTTGTCTGCAGCTATAAACGTTAAAGCTCG
TAATAAAACAAGTTTGATTTTTGGCACTGAGGTATGTAGCCCCAAACTTCAAAAAGCTCCTCATTTACATAATTATCTAG
GTTTTTTTGACATTACAGGCGAAGAATTTCAAAAACGTGCCTTAAAACAAGTTGAACACTATGGAATTGAAATGTTGAGG
TCTAGTGTTGACAGTATTTTTCCTCTAGGCGATGGTTTTGATCTCATGGTTAAAGACGAAGTCTATCATGCAAAAGTCGT
CATCTTAGCTACTGGAGTTACCCAAGGTCATGTACTACCAGGAGAAAACGAATTTTTAGGTAAAGGGGTCAGTTACTGCG
CTTCTTGTGATGCTCCAATATTTAAAAATAAAACGACTGCTATCATAGCTGAAGTAAAAGAAGCTGAACAAGAAGCGGAA
CTGTTATCCGAATTATGCGAACATGTGTATTATATTCCCCAGTATCGAGAAGAAATCCAAGTAAACGATGGAGTAGAAAT
AATCCAAGACAAACCCAAAGCAATCCTTGGCAAAAATCAAGTTACTCACCTACAATTGAAAAATCAACGAATAGAATGTG
ACGGTATTTTTATAATTCGCGAAACTGTTCCCGCAAGCCAGCTAGTTCAAGGCCTAGAAACAAGTGGCTCTGCAATAAAG
GTCAACCGAGATATGAGTACGAATATTGAGGGTCTATATGCAGCTGGTGATATTACCGGTTGGCCCTATCAACTCGGCAA
AGCAGTAGGAGAGGGCCAGGTTGCAGCACTCAATGCAGTGGATTTCATTTCACAACAAAAGAAAAATGATTAG

Upstream 100 bases:

>100_bases
TACAAAAGCTAATGTCAGTTAATTTTATAATGTTTCTGTTTATTTAATAGATCCTTTATAATATAAGTTTTAACCGATAC
ATTCAGGAGGATGATAGTTT

Downstream 100 bases:

>100_bases
GGAAAGATGATTAAGATGTATCAATTAATAAATTTTTAAATCATCAAAAGGATAATATCTCATGAGTACATTTCCTTTGA
CATTATCCATAGGGACAGGC

Product: Thioredoxin-disulfide reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSNTNTEIAIVGCGPAGLSAAINVKARNKTSLIFGTEVCSPKLQKAPHLHNYLGFFDITGEEFQKRALKQVEHYGIEMLR
SSVDSIFPLGDGFDLMVKDEVYHAKVVILATGVTQGHVLPGENEFLGKGVSYCASCDAPIFKNKTTAIIAEVKEAEQEAE
LLSELCEHVYYIPQYREEIQVNDGVEIIQDKPKAILGKNQVTHLQLKNQRIECDGIFIIRETVPASQLVQGLETSGSAIK
VNRDMSTNIEGLYAAGDITGWPYQLGKAVGEGQVAALNAVDFISQQKKND

Sequences:

>Translated_290_residues
MSNTNTEIAIVGCGPAGLSAAINVKARNKTSLIFGTEVCSPKLQKAPHLHNYLGFFDITGEEFQKRALKQVEHYGIEMLR
SSVDSIFPLGDGFDLMVKDEVYHAKVVILATGVTQGHVLPGENEFLGKGVSYCASCDAPIFKNKTTAIIAEVKEAEQEAE
LLSELCEHVYYIPQYREEIQVNDGVEIIQDKPKAILGKNQVTHLQLKNQRIECDGIFIIRETVPASQLVQGLETSGSAIK
VNRDMSTNIEGLYAAGDITGWPYQLGKAVGEGQVAALNAVDFISQQKKND
>Mature_289_residues
SNTNTEIAIVGCGPAGLSAAINVKARNKTSLIFGTEVCSPKLQKAPHLHNYLGFFDITGEEFQKRALKQVEHYGIEMLRS
SVDSIFPLGDGFDLMVKDEVYHAKVVILATGVTQGHVLPGENEFLGKGVSYCASCDAPIFKNKTTAIIAEVKEAEQEAEL
LSELCEHVYYIPQYREEIQVNDGVEIIQDKPKAILGKNQVTHLQLKNQRIECDGIFIIRETVPASQLVQGLETSGSAIKV
NRDMSTNIEGLYAAGDITGWPYQLGKAVGEGQVAALNAVDFISQQKKND

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081763, Length=271, Percent_Identity=26.5682656826568, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787114, Length=314, Percent_Identity=26.4331210191083, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321898, Length=318, Percent_Identity=28.3018867924528, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320560, Length=314, Percent_Identity=27.3885350318471, Blast_Score=93, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 31699; Mature: 31568

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTNTEIAIVGCGPAGLSAAINVKARNKTSLIFGTEVCSPKLQKAPHLHNYLGFFDITG
CCCCCCEEEEEECCCCCCCEEEEEEECCCEEEEEECHHCCCHHHCCCCHHHHHEEEECCH
EEFQKRALKQVEHYGIEMLRSSVDSIFPLGDGFDLMVKDEVYHAKVVILATGVTQGHVLP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEEEEECCCCCCCCC
GENEFLGKGVSYCASCDAPIFKNKTTAIIAEVKEAEQEAELLSELCEHVYYIPQYREEIQ
CCCHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHEE
VNDGVEIIQDKPKAILGKNQVTHLQLKNQRIECDGIFIIRETVPASQLVQGLETSGSAIK
CCCCHHEECCCCCHHHCCCCEEEEEEECCEEEECEEEEEECCCCHHHHHHHHCCCCCEEE
VNRDMSTNIEGLYAAGDITGWPYQLGKAVGEGQVAALNAVDFISQQKKND
EECCCCCCCCEEEEECCCCCCHHHHHHHCCCCCEEEHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNTNTEIAIVGCGPAGLSAAINVKARNKTSLIFGTEVCSPKLQKAPHLHNYLGFFDITG
CCCCCEEEEEECCCCCCCEEEEEEECCCEEEEEECHHCCCHHHCCCCHHHHHEEEECCH
EEFQKRALKQVEHYGIEMLRSSVDSIFPLGDGFDLMVKDEVYHAKVVILATGVTQGHVLP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEEEEEECCCCCCCCC
GENEFLGKGVSYCASCDAPIFKNKTTAIIAEVKEAEQEAELLSELCEHVYYIPQYREEIQ
CCCHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHEE
VNDGVEIIQDKPKAILGKNQVTHLQLKNQRIECDGIFIIRETVPASQLVQGLETSGSAIK
CCCCHHEECCCCCHHHCCCCEEEEEEECCEEEECEEEEEECCCCHHHHHHHHCCCCCEEE
VNRDMSTNIEGLYAAGDITGWPYQLGKAVGEGQVAALNAVDFISQQKKND
EECCCCCCCCEEEEECCCCCCHHHHHHHCCCCCEEEHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]