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The map label for this gene is fnr [H]

Identifier: 188586644

GI number: 188586644

Start: 2146206

End: 2146937

Strand: Reverse

Name: fnr [H]

Synonym: Nther_2034

Alternate gene names: 188586644

Gene position: 2146937-2146206 (Counterclockwise)

Preceding gene: 188586645

Following gene: 188586643

Centisome position: 67.82

GC content: 35.11

Gene sequence:

>732_bases
ATGACTAATATAAATAAATTAACTGAAAGTCAGGATGATAATTACAGGTCTTTGATGGAAAGTTTGCGTAAACTGGAAAT
ATTTTCGCATTTAACTGAGGATGAGCTTAATAGTATTTCCAAGCTGGCATATTTGAGGGAATTCCCCGGGGGAAGTGTTA
TCTTTTATCATGGTGATCCTGGTGAAGCAATGTATTATGTAAAAGATGGCAAAGTGAAAATTGTAAAAGATGACTTTGAT
GGTAGAGAACAAATTTTGCATATAATGAAACCTGGAGATATTTTTGCCGAAGTAGTTGTCTTTGATGATGGTCCTTATCC
AGCAACGGCTGAGGTGATGGAAGATACTGTGGTCGGTGTAATTACTAAGGAAAGGTTAGAAAATCACTTGCATGAACATC
CCACTATCGCTATTAAAATAATGAAATTAATGGGAAAACGTCTGAGAAAAGCGCAAAGCAAAGTGGCTGATTTGGCATTA
AGGGATACTTATCAAAGAACTATCAATATTATATACAACTTAATGGAAGAAGATGATTGTGCCTTTTGTAGTGAAAAACA
AGAAATTGCCATAACTGCTACTCATCAAGAATTGGCTAGTATGGCTGGGACTTCTAGAGAAACTGTCACTAGGGTACTTT
CTACATTAAAAAAAGAGGGCATTATAAAAACTGATAAAGGTTATATTGCTGTTACTGATCCTGTGAAACTTAAAGATAAG
GTGATTGAGTGA

Upstream 100 bases:

>100_bases
GTGACCTATCTGAAAGGTGCTAATTATAATAATACAGGGTCAGAATCCAAACAAGAGATAAATTCGGATACAAAAATTGA
ATCTGAGGAGAGGGAGAAAG

Downstream 100 bases:

>100_bases
CATGAAAAAAATATATAAAGGATTAATTGCCTTGGCGGCAGTATTTCTGTTAACTATTTTTGGGGGGGCAAGATTGCTTG
AAGTTTTAATTACTTATCCA

Product: Crp/Fnr family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MTNINKLTESQDDNYRSLMESLRKLEIFSHLTEDELNSISKLAYLREFPGGSVIFYHGDPGEAMYYVKDGKVKIVKDDFD
GREQILHIMKPGDIFAEVVVFDDGPYPATAEVMEDTVVGVITKERLENHLHEHPTIAIKIMKLMGKRLRKAQSKVADLAL
RDTYQRTINIIYNLMEEDDCAFCSEKQEIAITATHQELASMAGTSRETVTRVLSTLKKEGIIKTDKGYIAVTDPVKLKDK
VIE

Sequences:

>Translated_243_residues
MTNINKLTESQDDNYRSLMESLRKLEIFSHLTEDELNSISKLAYLREFPGGSVIFYHGDPGEAMYYVKDGKVKIVKDDFD
GREQILHIMKPGDIFAEVVVFDDGPYPATAEVMEDTVVGVITKERLENHLHEHPTIAIKIMKLMGKRLRKAQSKVADLAL
RDTYQRTINIIYNLMEEDDCAFCSEKQEIAITATHQELASMAGTSRETVTRVLSTLKKEGIIKTDKGYIAVTDPVKLKDK
VIE
>Mature_242_residues
TNINKLTESQDDNYRSLMESLRKLEIFSHLTEDELNSISKLAYLREFPGGSVIFYHGDPGEAMYYVKDGKVKIVKDDFDG
REQILHIMKPGDIFAEVVVFDDGPYPATAEVMEDTVVGVITKERLENHLHEHPTIAIKIMKLMGKRLRKAQSKVADLALR
DTYQRTINIIYNLMEEDDCAFCSEKQEIAITATHQELASMAGTSRETVTRVLSTLKKEGIIKTDKGYIAVTDPVKLKDKV
IE

Specific function: It is involved in the activation of genes necessary for anaerobic respiration [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=191, Percent_Identity=28.2722513089005, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787595, Length=217, Percent_Identity=25.3456221198157, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27573; Mature: 27442

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNINKLTESQDDNYRSLMESLRKLEIFSHLTEDELNSISKLAYLREFPGGSVIFYHGDP
CCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCC
GEAMYYVKDGKVKIVKDDFDGREQILHIMKPGDIFAEVVVFDDGPYPATAEVMEDTVVGV
CCEEEEEECCEEEEEECCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHH
ITKERLENHLHEHPTIAIKIMKLMGKRLRKAQSKVADLALRDTYQRTINIIYNLMEEDDC
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AFCSEKQEIAITATHQELASMAGTSRETVTRVLSTLKKEGIIKTDKGYIAVTDPVKLKDK
HHCCCCCCEEEEECHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECCCEEEEECCHHHHHH
VIE
CCC
>Mature Secondary Structure 
TNINKLTESQDDNYRSLMESLRKLEIFSHLTEDELNSISKLAYLREFPGGSVIFYHGDP
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCC
GEAMYYVKDGKVKIVKDDFDGREQILHIMKPGDIFAEVVVFDDGPYPATAEVMEDTVVGV
CCEEEEEECCEEEEEECCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHH
ITKERLENHLHEHPTIAIKIMKLMGKRLRKAQSKVADLALRDTYQRTINIIYNLMEEDDC
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AFCSEKQEIAITATHQELASMAGTSRETVTRVLSTLKKEGIIKTDKGYIAVTDPVKLKDK
HHCCCCCCEEEEECHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECCCEEEEECCHHHHHH
VIE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8846791; 9384377 [H]