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The map label for this gene is uvrC [H]

Identifier: 188586645

GI number: 188586645

Start: 2146930

End: 2148987

Strand: Reverse

Name: uvrC [H]

Synonym: Nther_2035

Alternate gene names: 188586645

Gene position: 2148987-2146930 (Counterclockwise)

Preceding gene: 188586646

Following gene: 188586644

Centisome position: 67.89

GC content: 37.51

Gene sequence:

>2058_bases
GTGACCAGAGAAGACTTACAAGAAAAACTAGCAAATCTACCGGAAAAACCTGGCGTATACTTAATGAAAAGCAAGCAAGG
TCGCGTGATATACGTGGGAAAAGCAATTAATCTAAAAAACAGAGTCCGTTCATATTTTAATTCCGGTAATAAAGCTGTCA
AAGTACAGGTGATGACCCCTAAGATTTCTGATATAGAAACCATTGTTACTGATTCCGAGTTAGAAGCGCTAATATTGGAA
AATAATTTAATTAAAAAGTATCGCCCTAAATATAACGTGAGCTTAAGGGATGATAAAAATTATCCTTACCTAAAAATAAC
TACAGAAGAAGATTACCCGCGCTTGATCATTGCCAGGCGAATGGGTAAACATGGTCGTTATTTTGGACCTTATCCCAATG
CGGGAGCAGTTAGGGAGACAATAAAGCTTTTGCGCAAATTGTTTCCAGTTAGAACATGTAAAGGAGAAACTCCCAAAAAT
CAAGGGAAACGACCCTGTTTAAATTATTTCATTAATAGATGTTTAGCGCCATGTAATGAAAAGGTTTCCCGAGATGAGTA
CCGAGAAATGATTCAAGATATTATTTCTGTATTAGAAGGGAAAGAGGAAGAACTTTTGAACGAATTGGAACGCAAAATGA
ATCTGGCTGCAGAGGAAATGGAGTTTGAAAAAGCTGCCGAATACAGGAATCAAAAAGCTGCTCTAGAAAAGATCAGACAG
AAACAAAAAATCGTTTCTGAACGAAGAGAAGATTATGATATCATCGCTTTAGGATTTGAAGAAAAGATTGATGATACTAG
CGATACTGATGATAGTACTGAAGAAGCTTGTGTCCAAATTTTCTACATTAGAGGTGGAAAATTAATGGGGCGCAATAATT
TTCGGGTTTCAACTGGCGCCTTAGAAGGAGCGGAAGACATGTTGACCTCTTTTATAAAACAATACTACGCCCAGGCTCTT
CATGTGCCTAAACAGATTTTAGTATCTCATCCTTTGACAGAGAAAGAACTTATTGAAAGTTGGTTGGCAGAGAAGCGGGA
AGGCAAAGTTGAAGTTAAGGTTCCCCAAAGAGGAGAAAAATACCAACTGATGAATATGGCTATTAAAAATGCTGAACTGG
AACTAAAGCAACAGGAACTAGAAAGCGAAAAAGAACGTAAAATGACAGAGGGTGCATTAAAGGAATTGGCATTAAAACTG
TCTCTTTCGGAAATTCCCTTTCGAGTGGAGGGTTATGATATTTCTCATACCCAGGGTGAAGAGACTGTAGCTTCCATGGT
GGTATTCGAAGGTGGAAAATCTAAGAAAAAAGATTATCGAAAATTTCGGATTAGAACTACCGCGGGTCCAGATGACTTTA
AAGCCATGGAAGAAGTATTAAGGAGACGTTTTCATCGAGCAAAAAAGGAAGAGCAAGAATATTTGATGGCTGCAGAAACC
AAGCAAGACAGTGAATACGATGCTCGGGAAGGGAATAAAGACAATATTAGCCAATATAATTCAGGAACTGAATACTCTGA
ATACGATTTCAAATTTGCTGTACTACCTGATTTAATAGTTATTGATGGTGGCAAAGGACAATTGAGTAGTGCAGTTAAGG
TCATGGAAGAGGTCGGTTATTCTCAAATACCCGTGATATCTTTGGCCAAAAGAGAAGAGGAAATATTTGTTCCTGAAAGG
TCAACATCTTTAAAGTTTCCATCTAATTCCGAAGCATTGAAATTACTCCAACGGATTAGGGATGAAGCTCATAGATTTGC
AGTTAGCTATCATAGGAAAAGCAGGGGAAAAGCCACTTTGACCTCGCTATTGGATGAAGTCCCTGAAATAGGTTCTAGAA
GAAAGAAAGAATTATTTGAACATTATTCTTCTTTGAACGAAATAAAACAGGCCAGTATAGATGAGCTGGCAAACTTGCCT
TCTATGAATAAAAAGGCAGCTAAAAATTTAGTGACCTATCTGAAAGGTGCTAATTATAATAATACAGGGTCAGAATCCAA
ACAAGAGATAAATTCGGATACAAAAATTGAATCTGAGGAGAGGGAGAAAGATGACTAA

Upstream 100 bases:

>100_bases
GCTTTTTTAAATACGGTTAAACCAATAACAGTGTTATGATATAATATAACTTTAAGAATATATTTTAAATCCAATATAAT
AGCTGTAGGGGGAAGTAACA

Downstream 100 bases:

>100_bases
TATAAATAAATTAACTGAAAGTCAGGATGATAATTACAGGTCTTTGATGGAAAGTTTGCGTAAACTGGAAATATTTTCGC
ATTTAACTGAGGATGAGCTT

Product: excinuclease ABC, C subunit

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 685; Mature: 684

Protein sequence:

>685_residues
MTREDLQEKLANLPEKPGVYLMKSKQGRVIYVGKAINLKNRVRSYFNSGNKAVKVQVMTPKISDIETIVTDSELEALILE
NNLIKKYRPKYNVSLRDDKNYPYLKITTEEDYPRLIIARRMGKHGRYFGPYPNAGAVRETIKLLRKLFPVRTCKGETPKN
QGKRPCLNYFINRCLAPCNEKVSRDEYREMIQDIISVLEGKEEELLNELERKMNLAAEEMEFEKAAEYRNQKAALEKIRQ
KQKIVSERREDYDIIALGFEEKIDDTSDTDDSTEEACVQIFYIRGGKLMGRNNFRVSTGALEGAEDMLTSFIKQYYAQAL
HVPKQILVSHPLTEKELIESWLAEKREGKVEVKVPQRGEKYQLMNMAIKNAELELKQQELESEKERKMTEGALKELALKL
SLSEIPFRVEGYDISHTQGEETVASMVVFEGGKSKKKDYRKFRIRTTAGPDDFKAMEEVLRRRFHRAKKEEQEYLMAAET
KQDSEYDAREGNKDNISQYNSGTEYSEYDFKFAVLPDLIVIDGGKGQLSSAVKVMEEVGYSQIPVISLAKREEEIFVPER
STSLKFPSNSEALKLLQRIRDEAHRFAVSYHRKSRGKATLTSLLDEVPEIGSRRKKELFEHYSSLNEIKQASIDELANLP
SMNKKAAKNLVTYLKGANYNNTGSESKQEINSDTKIESEEREKDD

Sequences:

>Translated_685_residues
MTREDLQEKLANLPEKPGVYLMKSKQGRVIYVGKAINLKNRVRSYFNSGNKAVKVQVMTPKISDIETIVTDSELEALILE
NNLIKKYRPKYNVSLRDDKNYPYLKITTEEDYPRLIIARRMGKHGRYFGPYPNAGAVRETIKLLRKLFPVRTCKGETPKN
QGKRPCLNYFINRCLAPCNEKVSRDEYREMIQDIISVLEGKEEELLNELERKMNLAAEEMEFEKAAEYRNQKAALEKIRQ
KQKIVSERREDYDIIALGFEEKIDDTSDTDDSTEEACVQIFYIRGGKLMGRNNFRVSTGALEGAEDMLTSFIKQYYAQAL
HVPKQILVSHPLTEKELIESWLAEKREGKVEVKVPQRGEKYQLMNMAIKNAELELKQQELESEKERKMTEGALKELALKL
SLSEIPFRVEGYDISHTQGEETVASMVVFEGGKSKKKDYRKFRIRTTAGPDDFKAMEEVLRRRFHRAKKEEQEYLMAAET
KQDSEYDAREGNKDNISQYNSGTEYSEYDFKFAVLPDLIVIDGGKGQLSSAVKVMEEVGYSQIPVISLAKREEEIFVPER
STSLKFPSNSEALKLLQRIRDEAHRFAVSYHRKSRGKATLTSLLDEVPEIGSRRKKELFEHYSSLNEIKQASIDELANLP
SMNKKAAKNLVTYLKGANYNNTGSESKQEINSDTKIESEEREKDD
>Mature_684_residues
TREDLQEKLANLPEKPGVYLMKSKQGRVIYVGKAINLKNRVRSYFNSGNKAVKVQVMTPKISDIETIVTDSELEALILEN
NLIKKYRPKYNVSLRDDKNYPYLKITTEEDYPRLIIARRMGKHGRYFGPYPNAGAVRETIKLLRKLFPVRTCKGETPKNQ
GKRPCLNYFINRCLAPCNEKVSRDEYREMIQDIISVLEGKEEELLNELERKMNLAAEEMEFEKAAEYRNQKAALEKIRQK
QKIVSERREDYDIIALGFEEKIDDTSDTDDSTEEACVQIFYIRGGKLMGRNNFRVSTGALEGAEDMLTSFIKQYYAQALH
VPKQILVSHPLTEKELIESWLAEKREGKVEVKVPQRGEKYQLMNMAIKNAELELKQQELESEKERKMTEGALKELALKLS
LSEIPFRVEGYDISHTQGEETVASMVVFEGGKSKKKDYRKFRIRTTAGPDDFKAMEEVLRRRFHRAKKEEQEYLMAAETK
QDSEYDAREGNKDNISQYNSGTEYSEYDFKFAVLPDLIVIDGGKGQLSSAVKVMEEVGYSQIPVISLAKREEEIFVPERS
TSLKFPSNSEALKLLQRIRDEAHRFAVSYHRKSRGKATLTSLLDEVPEIGSRRKKELFEHYSSLNEIKQASIDELANLPS
MNKKAAKNLVTYLKGANYNNTGSESKQEINSDTKIESEEREKDD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=668, Percent_Identity=34.7305389221557, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1788037, Length=190, Percent_Identity=28.4210526315789, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 78931; Mature: 78800

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTREDLQEKLANLPEKPGVYLMKSKQGRVIYVGKAINLKNRVRSYFNSGNKAVKVQVMTP
CCHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEEECC
KISDIETIVTDSELEALILENNLIKKYRPKYNVSLRDDKNYPYLKITTEEDYPRLIIARR
CCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCHHHHHHH
MGKHGRYFGPYPNAGAVRETIKLLRKLFPVRTCKGETPKNQGKRPCLNYFINRCLAPCNE
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KVSRDEYREMIQDIISVLEGKEEELLNELERKMNLAAEEMEFEKAAEYRNQKAALEKIRQ
HCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQKIVSERREDYDIIALGFEEKIDDTSDTDDSTEEACVQIFYIRGGKLMGRNNFRVSTGA
HHHHHHHHCCCCCEEEECCHHHCCCCCCCCCCHHHHHHEEEEEECCEEECCCCCEEECCC
LEGAEDMLTSFIKQYYAQALHVPKQILVSHPLTEKELIESWLAEKREGKVEVKVPQRGEK
CCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCH
YQLMNMAIKNAELELKQQELESEKERKMTEGALKELALKLSLSEIPFRVEGYDISHTQGE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCH
ETVASMVVFEGGKSKKKDYRKFRIRTTAGPDDFKAMEEVLRRRFHRAKKEEQEYLMAAET
HHHHHHHHCCCCCCCHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KQDSEYDAREGNKDNISQYNSGTEYSEYDFKFAVLPDLIVIDGGKGQLSSAVKVMEEVGY
CCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHCCC
SQIPVISLAKREEEIFVPERSTSLKFPSNSEALKLLQRIRDEAHRFAVSYHRKSRGKATL
CCCCHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
TSLLDEVPEIGSRRKKELFEHYSSLNEIKQASIDELANLPSMNKKAAKNLVTYLKGANYN
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
NTGSESKQEINSDTKIESEEREKDD
CCCCHHHHHCCCCCCCCCHHHCCCC
>Mature Secondary Structure 
TREDLQEKLANLPEKPGVYLMKSKQGRVIYVGKAINLKNRVRSYFNSGNKAVKVQVMTP
CHHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEEECC
KISDIETIVTDSELEALILENNLIKKYRPKYNVSLRDDKNYPYLKITTEEDYPRLIIARR
CCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCHHHHHHH
MGKHGRYFGPYPNAGAVRETIKLLRKLFPVRTCKGETPKNQGKRPCLNYFINRCLAPCNE
HCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KVSRDEYREMIQDIISVLEGKEEELLNELERKMNLAAEEMEFEKAAEYRNQKAALEKIRQ
HCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQKIVSERREDYDIIALGFEEKIDDTSDTDDSTEEACVQIFYIRGGKLMGRNNFRVSTGA
HHHHHHHHCCCCCEEEECCHHHCCCCCCCCCCHHHHHHEEEEEECCEEECCCCCEEECCC
LEGAEDMLTSFIKQYYAQALHVPKQILVSHPLTEKELIESWLAEKREGKVEVKVPQRGEK
CCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCH
YQLMNMAIKNAELELKQQELESEKERKMTEGALKELALKLSLSEIPFRVEGYDISHTQGE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCH
ETVASMVVFEGGKSKKKDYRKFRIRTTAGPDDFKAMEEVLRRRFHRAKKEEQEYLMAAET
HHHHHHHHCCCCCCCHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KQDSEYDAREGNKDNISQYNSGTEYSEYDFKFAVLPDLIVIDGGKGQLSSAVKVMEEVGY
CCCCCCCCCCCCCCCHHHCCCCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHCCC
SQIPVISLAKREEEIFVPERSTSLKFPSNSEALKLLQRIRDEAHRFAVSYHRKSRGKATL
CCCCHHHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
TSLLDEVPEIGSRRKKELFEHYSSLNEIKQASIDELANLPSMNKKAAKNLVTYLKGANYN
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
NTGSESKQEINSDTKIESEEREKDD
CCCCHHHHHCCCCCCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA