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The map label for this gene is hisH [H]

Identifier: 188586609

GI number: 188586609

Start: 2107602

End: 2108222

Strand: Reverse

Name: hisH [H]

Synonym: Nther_1999

Alternate gene names: 188586609

Gene position: 2108222-2107602 (Counterclockwise)

Preceding gene: 188586610

Following gene: 188586608

Centisome position: 66.6

GC content: 40.74

Gene sequence:

>621_bases
ATGATTGGAATTATTGATTACGGTGTCGGGAATTTATTTAGTGTAAAAAATGCTTTGGATTATTTGGAAATAAACAGTGA
AATCACTGATTCACCTGAGAAATTAACTAACTATTCCGCCCTGATATTACCTGGAGTAGGTTCCTTCAAAGAAGGTATGA
GCATGCTGAAAGAGCAAGGCTTTCAAGATATTATCAGGGAACGGGTTAAGGCTGGTGTCCCCTTGCTGGGGATATGCCTG
GGGATGCAGTTATTGTTCACAGAAGGTGAAGAAGGGGATGCAGAGAGAAATGCGACCCCTGGACTGGCTTTGATTGATGG
TCGGATAACTAAATTCCCCCAGGACGTGATGGTTCCACATGTTGGCTGGAATCAAGTTAATATTTCTAATTCCCATCCCG
TTTTTGATCATATTGATGGAGAATATTTTTATTTTGTACATTCTTATAGAGCCGAATTAGATCAGCTATCAGAAGATGTG
CTGATTGGACAGACGAGTTACTATGAATCTTTTCCCAGTATTGTGGGCCAAGATAATATATTGGGTGTACAGTTTCACCC
GGAAAAAAGCAGTCATGCCGGGTTATCTATCTTGAAAGTGTTTGGAGGGATGATGGGTTGA

Upstream 100 bases:

>100_bases
CAGCCTTCGAGAAGCAGTTCGCATATCCGGAGATACAGCTAAAATTCCCTCGTCAAAGGGCAAATTATAAACCGGACGCA
AATGTAAATGGGGTGGTACA

Downstream 100 bases:

>100_bases
GTTTAGAATTGATACCTGCAATTGATTTATACGAAGGAGAATGTGTCAGGTTAACTGAAGGGGAATTGGGCTCGAAAAAA
GTGTATAGTGATAACCCTTC

Product: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit

Products: NA

Alternate protein names: IGP synthase glutamine amidotransferase subunit; IGP synthase subunit hisH; ImGP synthase subunit hisH; IGPS subunit hisH [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MIGIIDYGVGNLFSVKNALDYLEINSEITDSPEKLTNYSALILPGVGSFKEGMSMLKEQGFQDIIRERVKAGVPLLGICL
GMQLLFTEGEEGDAERNATPGLALIDGRITKFPQDVMVPHVGWNQVNISNSHPVFDHIDGEYFYFVHSYRAELDQLSEDV
LIGQTSYYESFPSIVGQDNILGVQFHPEKSSHAGLSILKVFGGMMG

Sequences:

>Translated_206_residues
MIGIIDYGVGNLFSVKNALDYLEINSEITDSPEKLTNYSALILPGVGSFKEGMSMLKEQGFQDIIRERVKAGVPLLGICL
GMQLLFTEGEEGDAERNATPGLALIDGRITKFPQDVMVPHVGWNQVNISNSHPVFDHIDGEYFYFVHSYRAELDQLSEDV
LIGQTSYYESFPSIVGQDNILGVQFHPEKSSHAGLSILKVFGGMMG
>Mature_206_residues
MIGIIDYGVGNLFSVKNALDYLEINSEITDSPEKLTNYSALILPGVGSFKEGMSMLKEQGFQDIIRERVKAGVPLLGICL
GMQLLFTEGEEGDAERNATPGLALIDGRITKFPQDVMVPHVGWNQVNISNSHPVFDHIDGEYFYFVHSYRAELDQLSEDV
LIGQTSYYESFPSIVGQDNILGVQFHPEKSSHAGLSILKVFGGMMG

Specific function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR [H]

COG id: COG0118

COG function: function code E; Glutamine amidotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788334, Length=200, Percent_Identity=38.5, Blast_Score=125, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319725, Length=211, Percent_Identity=35.0710900473934, Blast_Score=119, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010139
- InterPro:   IPR016226 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 22706; Mature: 22706

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIIDYGVGNLFSVKNALDYLEINSEITDSPEKLTNYSALILPGVGSFKEGMSMLKEQG
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCCCCHHHHHHHHHHCC
FQDIIRERVKAGVPLLGICLGMQLLFTEGEEGDAERNATPGLALIDGRITKFPQDVMVPH
HHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCEEEECCCHHHCCHHHCCCC
VGWNQVNISNSHPVFDHIDGEYFYFVHSYRAELDQLSEDVLIGQTSYYESFPSIVGQDNI
CCCCEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCCCE
LGVQFHPEKSSHAGLSILKVFGGMMG
EEEEECCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MIGIIDYGVGNLFSVKNALDYLEINSEITDSPEKLTNYSALILPGVGSFKEGMSMLKEQG
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCCCCHHHHHHHHHHCC
FQDIIRERVKAGVPLLGICLGMQLLFTEGEEGDAERNATPGLALIDGRITKFPQDVMVPH
HHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCEEEECCCHHHCCHHHCCCC
VGWNQVNISNSHPVFDHIDGEYFYFVHSYRAELDQLSEDVLIGQTSYYESFPSIVGQDNI
CCCCEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHEECCHHHHHHHHHHHCCCCE
LGVQFHPEKSSHAGLSILKVFGGMMG
EEEEECCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Glycosyltransferases; Pentosyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]