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The map label for this gene is hisB [H]

Identifier: 188586610

GI number: 188586610

Start: 2108253

End: 2108843

Strand: Reverse

Name: hisB [H]

Synonym: Nther_2000

Alternate gene names: 188586610

Gene position: 2108843-2108253 (Counterclockwise)

Preceding gene: 188586611

Following gene: 188586609

Centisome position: 66.62

GC content: 37.39

Gene sequence:

>591_bases
ATGGAAAGAAGGGTTGCCACAGTAGAAAGAAAAACTTCAGAAACGGAAATTCAACTTTCCGTCAACTTGGATGGGCAAGC
CAATTTTAGCATTGACACTCCGGTTTATTTTCTAAATCATATGCTCGAACTCTTCAGTTACCATTCAGGTTTTGATTTGG
AAATTGAAGCTTCCGGGGATACGGAAATTGATAATCATCATATAGTGGAAGATATTGCCTTGGTATTGGGAGAAGCTTTT
AGAAAGGCGATAGGAGATAAAGGTGGTATTAATAGATATGCCAATATACACCTTCCTATGGATGAAACTTTAATTTTAGT
AGTTGTAGATATTTCCGGAAGGCCTCATTTAAGTTATGGTTTGGAATTTCAAAATGAGAGGGTGGGTCAATTTGAAACTG
CATTATTCCGAGAGTTTTTTAAGTCTTTTGTAAATGAAAGTAAAATAACTCTTCATTTAAGACAATTATCTGGAACTGAT
CCTCACCATATAGCCGAGGCGACTTTTAAAGGACTAGCACGCAGCCTTCGAGAAGCAGTTCGCATATCCGGAGATACAGC
TAAAATTCCCTCGTCAAAGGGCAAATTATAA

Upstream 100 bases:

>100_bases
GAGCTATCAATTGAAACAGAATCGCATTGGCCAACTAGTGGAAAATTTAAAAGATTTAGTTTAATTAGGATAATTAAATA
GTATAAGAGAGGTGTTATCA

Downstream 100 bases:

>100_bases
ACCGGACGCAAATGTAAATGGGGTGGTACAATGATTGGAATTATTGATTACGGTGTCGGGAATTTATTTAGTGTAAAAAA
TGCTTTGGATTATTTGGAAA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MERRVATVERKTSETEIQLSVNLDGQANFSIDTPVYFLNHMLELFSYHSGFDLEIEASGDTEIDNHHIVEDIALVLGEAF
RKAIGDKGGINRYANIHLPMDETLILVVVDISGRPHLSYGLEFQNERVGQFETALFREFFKSFVNESKITLHLRQLSGTD
PHHIAEATFKGLARSLREAVRISGDTAKIPSSKGKL

Sequences:

>Translated_196_residues
MERRVATVERKTSETEIQLSVNLDGQANFSIDTPVYFLNHMLELFSYHSGFDLEIEASGDTEIDNHHIVEDIALVLGEAF
RKAIGDKGGINRYANIHLPMDETLILVVVDISGRPHLSYGLEFQNERVGQFETALFREFFKSFVNESKITLHLRQLSGTD
PHHIAEATFKGLARSLREAVRISGDTAKIPSSKGKL
>Mature_196_residues
MERRVATVERKTSETEIQLSVNLDGQANFSIDTPVYFLNHMLELFSYHSGFDLEIEASGDTEIDNHHIVEDIALVLGEAF
RKAIGDKGGINRYANIHLPMDETLILVVVDISGRPHLSYGLEFQNERVGQFETALFREFFKSFVNESKITLHLRQLSGTD
PHHIAEATFKGLARSLREAVRISGDTAKIPSSKGKL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=193, Percent_Identity=47.6683937823834, Blast_Score=174, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324776, Length=220, Percent_Identity=37.2727272727273, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22013; Mature: 22013

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRVATVERKTSETEIQLSVNLDGQANFSIDTPVYFLNHMLELFSYHSGFDLEIEASGD
CCCCHHHHHHCCCCEEEEEEEEECCCCCCEECCHHHHHHHHHHHHHCCCCCCEEEECCCC
TEIDNHHIVEDIALVLGEAFRKAIGDKGGINRYANIHLPMDETLILVVVDISGRPHLSYG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCEEEC
LEFQNERVGQFETALFREFFKSFVNESKITLHLRQLSGTDPHHIAEATFKGLARSLREAV
CEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
RISGDTAKIPSSKGKL
HCCCCCCCCCCCCCCC
>Mature Secondary Structure
MERRVATVERKTSETEIQLSVNLDGQANFSIDTPVYFLNHMLELFSYHSGFDLEIEASGD
CCCCHHHHHHCCCCEEEEEEEEECCCCCCEECCHHHHHHHHHHHHHCCCCCCEEEECCCC
TEIDNHHIVEDIALVLGEAFRKAIGDKGGINRYANIHLPMDETLILVVVDISGRPHLSYG
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCEEEC
LEFQNERVGQFETALFREFFKSFVNESKITLHLRQLSGTDPHHIAEATFKGLARSLREAV
CEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
RISGDTAKIPSSKGKL
HCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA