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The map label for this gene is hisA [H]

Identifier: 188586608

GI number: 188586608

Start: 2106865

End: 2107605

Strand: Reverse

Name: hisA [H]

Synonym: Nther_1998

Alternate gene names: 188586608

Gene position: 2107605-2106865 (Counterclockwise)

Preceding gene: 188586609

Following gene: 188586607

Centisome position: 66.58

GC content: 36.84

Gene sequence:

>741_bases
TTGAGTTTAGAATTGATACCTGCAATTGATTTATACGAAGGAGAATGTGTCAGGTTAACTGAAGGGGAATTGGGCTCGAA
AAAAGTGTATAGTGATAACCCTTCAGACATGGCCAGACATTTTCAAGAACAAGGCGCCTCTAGATTGCACCTGGTAGACT
TAGAAGGAGCCTTTCAAGGAAGTGTTAAAAATTCCACTATTATCGAAAAAATAGCAAATAAAGTATCGATTCCAGTCCAA
GTAGGTGGAGGAATTAGATCAATTGAAGCTATAGAAAGACTGGTTAATATGGGCGTTGACCAAGTTATACTTGGTACTAA
AGCTTACAATGACAGGGACTTTTTACAATCAGCTTTAGAGTTATTTCATAAAAATATAATAGTTGGAGTGGATATTAAAG
GTGGTAAAGTGGCTACAGAAGGTTGGGTCAATGTTTCGGACACAAAAACTTACGATTATTTAAGTGAATTGACCGAACTG
GGTGTACCACGAGTTATTTTAACGGATATCTCTAAAGATGGAAAACTTCAAGGGCCGAACCTGGAGTTATTTAAAGAACT
AGCGATTTTTACTGAACTGGATTTAGTTTTATCCGGAGGGATGTCTTCTTTAGAAGATATAAATCGAATCCAAAAGCTAC
AAAATGAAATTGCACACAACTTAGCAGGAGTGATCCTGGGAAAAGCTTTATATGAAGGGAAAATAGATTTACAAGGGGCA
CTGGAAACCATTAGAAAATGA

Upstream 100 bases:

>100_bases
GTATTGTGGGCCAAGATAATATATTGGGTGTACAGTTTCACCCGGAAAAAAGCAGTCATGCCGGGTTATCTATCTTGAAA
GTGTTTGGAGGGATGATGGG

Downstream 100 bases:

>100_bases
GGTGATTTTATTGCTAGCTAAAAGAATAATACCTTGTCTTGATGTCAAAGATGGACAAGTAGTCAAGGGTGTAAAATTTA
ATGAATTAAAATTAGCCGGT

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSLELIPAIDLYEGECVRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHLVDLEGAFQGSVKNSTIIEKIANKVSIPVQ
VGGGIRSIEAIERLVNMGVDQVILGTKAYNDRDFLQSALELFHKNIIVGVDIKGGKVATEGWVNVSDTKTYDYLSELTEL
GVPRVILTDISKDGKLQGPNLELFKELAIFTELDLVLSGGMSSLEDINRIQKLQNEIAHNLAGVILGKALYEGKIDLQGA
LETIRK

Sequences:

>Translated_246_residues
MSLELIPAIDLYEGECVRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHLVDLEGAFQGSVKNSTIIEKIANKVSIPVQ
VGGGIRSIEAIERLVNMGVDQVILGTKAYNDRDFLQSALELFHKNIIVGVDIKGGKVATEGWVNVSDTKTYDYLSELTEL
GVPRVILTDISKDGKLQGPNLELFKELAIFTELDLVLSGGMSSLEDINRIQKLQNEIAHNLAGVILGKALYEGKIDLQGA
LETIRK
>Mature_245_residues
SLELIPAIDLYEGECVRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHLVDLEGAFQGSVKNSTIIEKIANKVSIPVQV
GGGIRSIEAIERLVNMGVDQVILGTKAYNDRDFLQSALELFHKNIIVGVDIKGGKVATEGWVNVSDTKTYDYLSELTELG
VPRVILTDISKDGKLQGPNLELFKELAIFTELDLVLSGGMSSLEDINRIQKLQNEIAHNLAGVILGKALYEGKIDLQGAL
ETIRK

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=33.6065573770492, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1788336, Length=216, Percent_Identity=24.0740740740741, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26937; Mature: 26806

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLELIPAIDLYEGECVRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHLVDLEGAFQG
CCCEEECCEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCC
SVKNSTIIEKIANKVSIPVQVGGGIRSIEAIERLVNMGVDQVILGTKAYNDRDFLQSALE
CCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHH
LFHKNIIVGVDIKGGKVATEGWVNVSDTKTYDYLSELTELGVPRVILTDISKDGKLQGPN
HHHCCEEEEEECCCCEEECCCCEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
LELFKELAIFTELDLVLSGGMSSLEDINRIQKLQNEIAHNLAGVILGKALYEGKIDLQGA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LETIRK
HHHHCC
>Mature Secondary Structure 
SLELIPAIDLYEGECVRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHLVDLEGAFQG
CCEEECCEECCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCC
SVKNSTIIEKIANKVSIPVQVGGGIRSIEAIERLVNMGVDQVILGTKAYNDRDFLQSALE
CCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHH
LFHKNIIVGVDIKGGKVATEGWVNVSDTKTYDYLSELTELGVPRVILTDISKDGKLQGPN
HHHCCEEEEEECCCCEEECCCCEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
LELFKELAIFTELDLVLSGGMSSLEDINRIQKLQNEIAHNLAGVILGKALYEGKIDLQGA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LETIRK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA