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The map label for this gene is bhbA [H]

Identifier: 188586112

GI number: 188586112

Start: 1558021

End: 1559700

Strand: Direct

Name: bhbA [H]

Synonym: Nther_1486

Alternate gene names: 188586112

Gene position: 1558021-1559700 (Clockwise)

Preceding gene: 188586111

Following gene: 188586113

Centisome position: 49.22

GC content: 39.4

Gene sequence:

>1680_bases
TTGACCACTAATAAGAGGGATCAAAAAGAACTTGAACAACAGTACCAAAACTGGAAAGACGGAACCTTAAAAAAAGCTTT
GGATCGTTTTCCTGAACGAAAAGAAGAATTCACCACTGTCTCCAATATACCAGTTGACCCAGTTTATACCCCTTTAAATG
AAGATACAGATTATTCAGAAGATCTAGGTTTCCCAGGCGAGTATCCCTTTACAAGAGGTGTCCAGCCAACAATGTACAGG
GGACGTTTCTGGACCATGCGCCAGTACGCAGGTTTTGCCTCAGCCCGGGAAACTAATAAACGTTTTAGATATTTATTAGA
TCAGGGGCAAACTGGATTGAGCGTGGCCTTTGATTTGCCAACACAGATCGGTTATGATTCTGATCATGCCATGGCGCAAG
GTGAAGTGGGTAAAGTTGGAGTTGCCGTAGATTCTCTTGAAGATATGGAAATACTTTTAGATCAGATACCCCTAGACAAA
GTCAGTACATCAATGACTATTAACGCACCGGCTGCGGTCTTATTAGCAATGTATATAGCCATTGGTGAAAAACAAGGTAT
TCCTAAGGAAAAATTAGCAGGTACCATTCAAAATGACATTTTAAAGGAATATGTGGCCCGAGGGACATATATATTCCCGC
CAGAACCTTCAATGCGGCTAATTACAGATATTATTAAATATTGCAGTAAAGAAGTTCCAAGATGGAATACCATTAGTATT
AGCGGTTACCATATAAGGGAAGCGGGAAGTAATGCTATACAGGAGATCGCCTTTACTATCGCAAATGGCTTGGCTTATGT
AGATGCCGCCTTAGAGAGTGGTTTGGATATTGATGAATTTGCCCCTAGATTGTCATTTTTCTTCAACTCTCACCTGGACT
TCTTTGAAGAAATTGCTAAGTTCCGTGCTGCAAGAAGACTATGGGCCAAGCTAATGAAAGAACGATATGGCGCCCAAAAC
CCCAAGAGTATGAAAATGAGATTTCACACTCAAACGGCTGGTTGTACTTTAACAGCTCAGCAACCAAATAACAATATTGT
TAGAGTAACTCTACAGGCTCTAGCTGCAGTATTAGGTGGCACTCAATCACTACATACCAATTCAAGGGATGAAGCTCTAT
CACTTCCCACAGAAGAATCTGTGCAAATAGCTTTAAGAACTCAGCAGATTATCGCAAATGAAAGTGGTGTAGCAGATACT
GTTGATCCAATAGGTGGTAGTTACTATGTTGAATCCCTTACTAATCAATTAGAAGAAGAAGCTCAAAAATTAATTGATAA
GATAGATGATTTAGGTGGTGCTCCTAAAGCCATTGAACAAGGATTTATCCAGAAAGAAATACAATACAGCGCCTATGAAT
GGCAAAAATCTGTCGAAGAAGAAGAACAGATAATTGTGGGACTTAACAAATATCAGGTTGAAGAAGAGTTTGACCTGACA
ACTCATAAAGTTGATCAAAGTGTGGCAGATGATCAGCGTAAAAGATTAAAAGATCTGCGCGATAAACGAGATAATGATAC
AGTTGAAAACAAATTGAGTGAATTAAAGAAAGCTGCCAATGGTGATGACAATCTAATGCCGTATATCATCGATGCAGTTA
AAGAATATGCTACCCTTGGCGAAATTTGTGGAGCTTTACGAGAAGTATTTGGAGAATATGAAGCTGACAGCTATATCTAA

Upstream 100 bases:

>100_bases
AAACTAATTTTGTTTAATCTTGGTAGACTGAAATTAGGTTAATTTAAGAAATTTTTTGTAATTGAACTTTCGTAAAATCA
TCTAAACAGGAGGGATCTTT

Downstream 100 bases:

>100_bases
AATTACCAGTTTAATTAAAACATAACATAAAAGGAGGTTATGTTAACTTGTCTCCCAAAAGAGTGGTTGTGGCAAAACCA
GGTTTAGATGGACATGATAG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MTTNKRDQKELEQQYQNWKDGTLKKALDRFPERKEEFTTVSNIPVDPVYTPLNEDTDYSEDLGFPGEYPFTRGVQPTMYR
GRFWTMRQYAGFASARETNKRFRYLLDQGQTGLSVAFDLPTQIGYDSDHAMAQGEVGKVGVAVDSLEDMEILLDQIPLDK
VSTSMTINAPAAVLLAMYIAIGEKQGIPKEKLAGTIQNDILKEYVARGTYIFPPEPSMRLITDIIKYCSKEVPRWNTISI
SGYHIREAGSNAIQEIAFTIANGLAYVDAALESGLDIDEFAPRLSFFFNSHLDFFEEIAKFRAARRLWAKLMKERYGAQN
PKSMKMRFHTQTAGCTLTAQQPNNNIVRVTLQALAAVLGGTQSLHTNSRDEALSLPTEESVQIALRTQQIIANESGVADT
VDPIGGSYYVESLTNQLEEEAQKLIDKIDDLGGAPKAIEQGFIQKEIQYSAYEWQKSVEEEEQIIVGLNKYQVEEEFDLT
THKVDQSVADDQRKRLKDLRDKRDNDTVENKLSELKKAANGDDNLMPYIIDAVKEYATLGEICGALREVFGEYEADSYI

Sequences:

>Translated_559_residues
MTTNKRDQKELEQQYQNWKDGTLKKALDRFPERKEEFTTVSNIPVDPVYTPLNEDTDYSEDLGFPGEYPFTRGVQPTMYR
GRFWTMRQYAGFASARETNKRFRYLLDQGQTGLSVAFDLPTQIGYDSDHAMAQGEVGKVGVAVDSLEDMEILLDQIPLDK
VSTSMTINAPAAVLLAMYIAIGEKQGIPKEKLAGTIQNDILKEYVARGTYIFPPEPSMRLITDIIKYCSKEVPRWNTISI
SGYHIREAGSNAIQEIAFTIANGLAYVDAALESGLDIDEFAPRLSFFFNSHLDFFEEIAKFRAARRLWAKLMKERYGAQN
PKSMKMRFHTQTAGCTLTAQQPNNNIVRVTLQALAAVLGGTQSLHTNSRDEALSLPTEESVQIALRTQQIIANESGVADT
VDPIGGSYYVESLTNQLEEEAQKLIDKIDDLGGAPKAIEQGFIQKEIQYSAYEWQKSVEEEEQIIVGLNKYQVEEEFDLT
THKVDQSVADDQRKRLKDLRDKRDNDTVENKLSELKKAANGDDNLMPYIIDAVKEYATLGEICGALREVFGEYEADSYI
>Mature_558_residues
TTNKRDQKELEQQYQNWKDGTLKKALDRFPERKEEFTTVSNIPVDPVYTPLNEDTDYSEDLGFPGEYPFTRGVQPTMYRG
RFWTMRQYAGFASARETNKRFRYLLDQGQTGLSVAFDLPTQIGYDSDHAMAQGEVGKVGVAVDSLEDMEILLDQIPLDKV
STSMTINAPAAVLLAMYIAIGEKQGIPKEKLAGTIQNDILKEYVARGTYIFPPEPSMRLITDIIKYCSKEVPRWNTISIS
GYHIREAGSNAIQEIAFTIANGLAYVDAALESGLDIDEFAPRLSFFFNSHLDFFEEIAKFRAARRLWAKLMKERYGAQNP
KSMKMRFHTQTAGCTLTAQQPNNNIVRVTLQALAAVLGGTQSLHTNSRDEALSLPTEESVQIALRTQQIIANESGVADTV
DPIGGSYYVESLTNQLEEEAQKLIDKIDDLGGAPKAIEQGFIQKEIQYSAYEWQKSVEEEEQIIVGLNKYQVEEEFDLTT
HKVDQSVADDQRKRLKDLRDKRDNDTVENKLSELKKAANGDDNLMPYIIDAVKEYATLGEICGALREVFGEYEADSYI

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=554, Percent_Identity=48.7364620938628, Blast_Score=525, Evalue=1e-149,
Organism=Escherichia coli, GI1789284, Length=517, Percent_Identity=50.0967117988395, Blast_Score=509, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI25144500, Length=541, Percent_Identity=48.2439926062847, Blast_Score=530, Evalue=1e-151,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 63052; Mature: 62920

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNKRDQKELEQQYQNWKDGTLKKALDRFPERKEEFTTVSNIPVDPVYTPLNEDTDYSE
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHH
DLGFPGEYPFTRGVQPTMYRGRFWTMRQYAGFASARETNKRFRYLLDQGQTGLSVAFDLP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
TQIGYDSDHAMAQGEVGKVGVAVDSLEDMEILLDQIPLDKVSTSMTINAPAAVLLAMYIA
HHCCCCCCCHHCCCCCCCEEEEHHHHHHHHHHHHHCCHHHHCCCEEECCHHHHHHHHHHH
IGEKQGIPKEKLAGTIQNDILKEYVARGTYIFPPEPSMRLITDIIKYCSKEVPRWNTISI
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEE
SGYHIREAGSNAIQEIAFTIANGLAYVDAALESGLDIDEFAPRLSFFFNSHLDFFEEIAK
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FRAARRLWAKLMKERYGAQNPKSMKMRFHTQTAGCTLTAQQPNNNIVRVTLQALAAVLGG
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEHHHHHHHHHHCC
TQSLHTNSRDEALSLPTEESVQIALRTQQIIANESGVADTVDPIGGSYYVESLTNQLEEE
CHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AQKLIDKIDDLGGAPKAIEQGFIQKEIQYSAYEWQKSVEEEEQIIVGLNKYQVEEEFDLT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHCHHHHCHH
THKVDQSVADDQRKRLKDLRDKRDNDTVENKLSELKKAANGDDNLMPYIIDAVKEYATLG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
EICGALREVFGEYEADSYI
HHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TTNKRDQKELEQQYQNWKDGTLKKALDRFPERKEEFTTVSNIPVDPVYTPLNEDTDYSE
CCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHH
DLGFPGEYPFTRGVQPTMYRGRFWTMRQYAGFASARETNKRFRYLLDQGQTGLSVAFDLP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
TQIGYDSDHAMAQGEVGKVGVAVDSLEDMEILLDQIPLDKVSTSMTINAPAAVLLAMYIA
HHCCCCCCCHHCCCCCCCEEEEHHHHHHHHHHHHHCCHHHHCCCEEECCHHHHHHHHHHH
IGEKQGIPKEKLAGTIQNDILKEYVARGTYIFPPEPSMRLITDIIKYCSKEVPRWNTISI
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEE
SGYHIREAGSNAIQEIAFTIANGLAYVDAALESGLDIDEFAPRLSFFFNSHLDFFEEIAK
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FRAARRLWAKLMKERYGAQNPKSMKMRFHTQTAGCTLTAQQPNNNIVRVTLQALAAVLGG
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCEEEHHHHHHHHHHCC
TQSLHTNSRDEALSLPTEESVQIALRTQQIIANESGVADTVDPIGGSYYVESLTNQLEEE
CHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
AQKLIDKIDDLGGAPKAIEQGFIQKEIQYSAYEWQKSVEEEEQIIVGLNKYQVEEEFDLT
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHCHHHHCHH
THKVDQSVADDQRKRLKDLRDKRDNDTVENKLSELKKAANGDDNLMPYIIDAVKEYATLG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
EICGALREVFGEYEADSYI
HHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]