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The map label for this gene is dtd

Identifier: 188585915

GI number: 188585915

Start: 1361224

End: 1361676

Strand: Direct

Name: dtd

Synonym: Nther_1289

Alternate gene names: 188585915

Gene position: 1361224-1361676 (Clockwise)

Preceding gene: 188585914

Following gene: 188585916

Centisome position: 43.0

GC content: 33.33

Gene sequence:

>453_bases
ATGAGAGCAGTGGTTCAAAGAGTTAGCAAATCTTACGTTAATGTTAATGGAGAAAAAGTCGGAGAAATTAATCAAGGTTT
AAATGTACTACTAGGTGTTGAAGATGGTGATGGGGAAGACGATATCAAATATTTAGTTGATAAAATTGTCAATCTAAGAA
TTTTTGAGGATGACCAAGGAAAAATGAACTTATCGGTAAATGATATCGGAGGAGAATTATTAGTTATTAGTCAGTTTACC
TTGCTGGGAGATTGTCGAAAAGGTAGAAGGCCAAATTTTATGAAAGCAGCTTCTCCGGAAATTGCCGATGAGCTATATCA
AAAGTTTGTAGAAAAAGTGAGCAAAGATTATGGATTATCATTAGCCACAGGAAGCTTTAAAGAACATATGGAAGTAGATA
TTTTAAATGACGGTCCTGTGACTATTTTATTAGATAGTAACAAAAAGTTTTGA

Upstream 100 bases:

>100_bases
ATTTGTGATTGACAAACTACAGAATATTCAGGATGTATTGAAAGTACAAAGGGATAACCCCTAGATTAAGTGGCAGTGGT
TTTATGAAAGGAGAGATACC

Downstream 100 bases:

>100_bases
TTACAGATAGAAGGAGGCGATAAAACATTGATTATTGAGCAATTAGTTGTAGGTGAATTAGGTGCTAACTGTTATATTGT
CGGTTGTCAGGAAACCGGTG

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MRAVVQRVSKSYVNVNGEKVGEINQGLNVLLGVEDGDGEDDIKYLVDKIVNLRIFEDDQGKMNLSVNDIGGELLVISQFT
LLGDCRKGRRPNFMKAASPEIADELYQKFVEKVSKDYGLSLATGSFKEHMEVDILNDGPVTILLDSNKKF

Sequences:

>Translated_150_residues
MRAVVQRVSKSYVNVNGEKVGEINQGLNVLLGVEDGDGEDDIKYLVDKIVNLRIFEDDQGKMNLSVNDIGGELLVISQFT
LLGDCRKGRRPNFMKAASPEIADELYQKFVEKVSKDYGLSLATGSFKEHMEVDILNDGPVTILLDSNKKF
>Mature_150_residues
MRAVVQRVSKSYVNVNGEKVGEINQGLNVLLGVEDGDGEDDIKYLVDKIVNLRIFEDDQGKMNLSVNDIGGELLVISQFT
LLGDCRKGRRPNFMKAASPEIADELYQKFVEKVSKDYGLSLATGSFKEHMEVDILNDGPVTILLDSNKKF

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=149, Percent_Identity=44.9664429530201, Blast_Score=117, Evalue=4e-27,
Organism=Escherichia coli, GI1790320, Length=144, Percent_Identity=47.9166666666667, Blast_Score=136, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI115533292, Length=151, Percent_Identity=43.7086092715232, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319982, Length=150, Percent_Identity=36, Blast_Score=100, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281361569, Length=147, Percent_Identity=44.2176870748299, Blast_Score=116, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_NATTJ (B2A2F7)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917460.1
- ProteinModelPortal:   B2A2F7
- SMR:   B2A2F7
- GeneID:   6315182
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1289
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16683; Mature: 16683

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVQRVSKSYVNVNGEKVGEINQGLNVLLGVEDGDGEDDIKYLVDKIVNLRIFEDDQG
CHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHEEEEEECCCC
KMNLSVNDIGGELLVISQFTLLGDCRKGRRPNFMKAASPEIADELYQKFVEKVSKDYGLS
EEEEEEECCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
LATGSFKEHMEVDILNDGPVTILLDSNKKF
EECCCCCCCCEEEEECCCCEEEEECCCCCC
>Mature Secondary Structure
MRAVVQRVSKSYVNVNGEKVGEINQGLNVLLGVEDGDGEDDIKYLVDKIVNLRIFEDDQG
CHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHEEEEEECCCC
KMNLSVNDIGGELLVISQFTLLGDCRKGRRPNFMKAASPEIADELYQKFVEKVSKDYGLS
EEEEEEECCCCEEEEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCE
LATGSFKEHMEVDILNDGPVTILLDSNKKF
EECCCCCCCCEEEEECCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA