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The map label for this gene is phoR [H]

Identifier: 188585847

GI number: 188585847

Start: 1295715

End: 1297292

Strand: Direct

Name: phoR [H]

Synonym: Nther_1221

Alternate gene names: 188585847

Gene position: 1295715-1297292 (Clockwise)

Preceding gene: 188585846

Following gene: 188585850

Centisome position: 40.93

GC content: 35.42

Gene sequence:

>1578_bases
ATGATTAAAAAATTTAAGCCCAAGACCTTATTTTTAAAACTGATGCTGAGTTATTTGGTTGTCATACTAGTAACTTTGCT
AGTATTAAGTGGCATTATGTCCTATTTAGTAGAAGAATATTTTTATGGTGCCAGAGAATGGGAAGTGAATACTCAAGCCC
GTGAAGTTGCTAGTATGTTACAAGAGCCTATCCAAAATAGTGAATTACAGGATATTATGCAAAAAGCTCAAACTCTTTCA
CGTTCATTTGAAGCAGAAATAGCAGTTTTTGACGAAAATGGAAGAAATATTACAATCGCAAATTACTATTCCGATGAAGA
TACCGGGACAGTAGAATTTGAAAATCATGAGCTTGACCATGTATTAGAAGGTAATTCCCTTACGAAAAAACTAGTCGGTC
CACAAGCGGAGCGATTATTGATTGCCATACCAGTATATGAAAAAGAAGAAGAGAATGATGAAAAACAGAACACAGATGAA
ACTAGAGAGAGTGATAATGAAAGTGAAAGTAATCAGCAGGAAGATGATCAAAATGAAGAAGAACAAAAAGAAGTTATAGG
TGTAGTAAGTTTAAATGTGCCTTTAGCAGGTATTGAGGACACTTTGGCTAATATTAGTCGGTTGACTTTAATTTCAGGAG
GAATTGCAATTCTTGTAGCAAGTGCCTTTGCCCTGTCTCTTTCAAAGAATATTACTAGACCGTTGAGTTCAATCAATGAG
TCTGCACAAGCCCTGGCTAAAGGTGAATTTACCCAGAAAATTGGTCGCGAGGTGCTTGAGGAAACCGATGATGAATTGGG
TAAAGTTTCCCGCACTTTTCATTTAGCTGCCCAGGAAATTGAAAACAATATTGAAGAACAAAAAAGGTTAGCTGTTTTTA
GAAAAAATTTAGTAGATAATGCATCCCACGAATTCCGGGCTCCCTTAAGTGCCATAAGGGGTTATAGCGAATTGATTATT
GATGGTATTGTTCCTGAACAAGATCAAACCCACTATTTGAACCTAATATGGAAACATGCCGTTGAATTAAATGAAATGGT
CGATACGTTATTAGACCTGTCGAGTTTAGAAACGGGTACTATAAACTTAAACAAAGAGAAGATGACAGCCAAGGAAGTTT
TAATTGATGCCATGGATATGGTATTACCTGATGCTGAAAAGAAAAATCAAACTATAACCATAGATAAGAGTGAAAGTAAA
ACATTCTTTAAAGGAGACCCTCCGAGGGTAAAACAGATTATTGTTAATTTGTTAAAGAATGCTATCCAGTATACTTCTGA
AAAAGGTACAATAAGGTTAAGGGCATTTGATACAGAACAATACGTTGCCTTGCAAGTGGTTGATAACGGCATTGGCATCC
CAAAATCAGAGCTTGATAGTATTTTCCAAAGGTTTTACAAGGTAGATAAAGCAAGAAATCAAAATAAAAAAAGCGGAAGC
TCTGGATTAGGTTTGGCTATTGTCAATGAATTAGTAAAAATTCATAACGGCAAAATAGAAGTGGATAGTGAAGAAGGAAA
GGGCAGTACATTTACTGTTTATTTTCCGAGATCTTATAATGTTGATGGAACTGAATAA

Upstream 100 bases:

>100_bases
ATGTAAAACGAATTAGAAAAAAGCTAGAACCTGAAAGTGGTTTTGATAGTTTGATCCAGACGGTTTGGGGCGTTGGCTAC
AAATTTGAGGTGAAAAATGA

Downstream 100 bases:

>100_bases
TTGAGAAATAATAATAACCCACGGCTATAGTCGTGGGTTATTTATACTTAAAAATGTAAGATGTTAAAGAAGTTAATATA
GGATTTTTACTTTCCTTCTG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MIKKFKPKTLFLKLMLSYLVVILVTLLVLSGIMSYLVEEYFYGAREWEVNTQAREVASMLQEPIQNSELQDIMQKAQTLS
RSFEAEIAVFDENGRNITIANYYSDEDTGTVEFENHELDHVLEGNSLTKKLVGPQAERLLIAIPVYEKEEENDEKQNTDE
TRESDNESESNQQEDDQNEEEQKEVIGVVSLNVPLAGIEDTLANISRLTLISGGIAILVASAFALSLSKNITRPLSSINE
SAQALAKGEFTQKIGREVLEETDDELGKVSRTFHLAAQEIENNIEEQKRLAVFRKNLVDNASHEFRAPLSAIRGYSELII
DGIVPEQDQTHYLNLIWKHAVELNEMVDTLLDLSSLETGTINLNKEKMTAKEVLIDAMDMVLPDAEKKNQTITIDKSESK
TFFKGDPPRVKQIIVNLLKNAIQYTSEKGTIRLRAFDTEQYVALQVVDNGIGIPKSELDSIFQRFYKVDKARNQNKKSGS
SGLGLAIVNELVKIHNGKIEVDSEEGKGSTFTVYFPRSYNVDGTE

Sequences:

>Translated_525_residues
MIKKFKPKTLFLKLMLSYLVVILVTLLVLSGIMSYLVEEYFYGAREWEVNTQAREVASMLQEPIQNSELQDIMQKAQTLS
RSFEAEIAVFDENGRNITIANYYSDEDTGTVEFENHELDHVLEGNSLTKKLVGPQAERLLIAIPVYEKEEENDEKQNTDE
TRESDNESESNQQEDDQNEEEQKEVIGVVSLNVPLAGIEDTLANISRLTLISGGIAILVASAFALSLSKNITRPLSSINE
SAQALAKGEFTQKIGREVLEETDDELGKVSRTFHLAAQEIENNIEEQKRLAVFRKNLVDNASHEFRAPLSAIRGYSELII
DGIVPEQDQTHYLNLIWKHAVELNEMVDTLLDLSSLETGTINLNKEKMTAKEVLIDAMDMVLPDAEKKNQTITIDKSESK
TFFKGDPPRVKQIIVNLLKNAIQYTSEKGTIRLRAFDTEQYVALQVVDNGIGIPKSELDSIFQRFYKVDKARNQNKKSGS
SGLGLAIVNELVKIHNGKIEVDSEEGKGSTFTVYFPRSYNVDGTE
>Mature_525_residues
MIKKFKPKTLFLKLMLSYLVVILVTLLVLSGIMSYLVEEYFYGAREWEVNTQAREVASMLQEPIQNSELQDIMQKAQTLS
RSFEAEIAVFDENGRNITIANYYSDEDTGTVEFENHELDHVLEGNSLTKKLVGPQAERLLIAIPVYEKEEENDEKQNTDE
TRESDNESESNQQEDDQNEEEQKEVIGVVSLNVPLAGIEDTLANISRLTLISGGIAILVASAFALSLSKNITRPLSSINE
SAQALAKGEFTQKIGREVLEETDDELGKVSRTFHLAAQEIENNIEEQKRLAVFRKNLVDNASHEFRAPLSAIRGYSELII
DGIVPEQDQTHYLNLIWKHAVELNEMVDTLLDLSSLETGTINLNKEKMTAKEVLIDAMDMVLPDAEKKNQTITIDKSESK
TFFKGDPPRVKQIIVNLLKNAIQYTSEKGTIRLRAFDTEQYVALQVVDNGIGIPKSELDSIFQRFYKVDKARNQNKKSGS
SGLGLAIVNELVKIHNGKIEVDSEEGKGSTFTVYFPRSYNVDGTE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=288, Percent_Identity=29.1666666666667, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1789149, Length=552, Percent_Identity=24.4565217391304, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1790436, Length=250, Percent_Identity=29.6, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=32.2869955156951, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=29.4117647058824, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1786600, Length=248, Percent_Identity=30.241935483871, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790861, Length=341, Percent_Identity=26.6862170087977, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI145693157, Length=224, Percent_Identity=31.25, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788713, Length=246, Percent_Identity=25.609756097561, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87081816, Length=325, Percent_Identity=27.6923076923077, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788549, Length=247, Percent_Identity=27.5303643724696, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1790346, Length=302, Percent_Identity=23.841059602649, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790300, Length=253, Percent_Identity=30.4347826086957, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=315, Percent_Identity=23.1746031746032, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87082128, Length=312, Percent_Identity=25.9615384615385, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1789808, Length=332, Percent_Identity=26.8072289156627, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1787894, Length=318, Percent_Identity=24.8427672955975, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790551, Length=304, Percent_Identity=23.3552631578947, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788279, Length=299, Percent_Identity=22.742474916388, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59051; Mature: 59051

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKFKPKTLFLKLMLSYLVVILVTLLVLSGIMSYLVEEYFYGAREWEVNTQAREVASML
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHH
QEPIQNSELQDIMQKAQTLSRSFEAEIAVFDENGRNITIANYYSDEDTGTVEFENHELDH
HHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCEEEECCCCCHH
VLEGNSLTKKLVGPQAERLLIAIPVYEKEEENDEKQNTDETRESDNESESNQQEDDQNEE
HHCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCHH
EQKEVIGVVSLNVPLAGIEDTLANISRLTLISGGIAILVASAFALSLSKNITRPLSSINE
HHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SAQALAKGEFTQKIGREVLEETDDELGKVSRTFHLAAQEIENNIEEQKRLAVFRKNLVDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ASHEFRAPLSAIRGYSELIIDGIVPEQDQTHYLNLIWKHAVELNEMVDTLLDLSSLETGT
CCHHHHCHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
INLNKEKMTAKEVLIDAMDMVLPDAEKKNQTITIDKSESKTFFKGDPPRVKQIIVNLLKN
EECCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
AIQYTSEKGTIRLRAFDTEQYVALQVVDNGIGIPKSELDSIFQRFYKVDKARNQNKKSGS
HHHHCCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
SGLGLAIVNELVKIHNGKIEVDSEEGKGSTFTVYFPRSYNVDGTE
CCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MIKKFKPKTLFLKLMLSYLVVILVTLLVLSGIMSYLVEEYFYGAREWEVNTQAREVASML
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHH
QEPIQNSELQDIMQKAQTLSRSFEAEIAVFDENGRNITIANYYSDEDTGTVEFENHELDH
HHHHCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCEEEECCCCCHH
VLEGNSLTKKLVGPQAERLLIAIPVYEKEEENDEKQNTDETRESDNESESNQQEDDQNEE
HHCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCHH
EQKEVIGVVSLNVPLAGIEDTLANISRLTLISGGIAILVASAFALSLSKNITRPLSSINE
HHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SAQALAKGEFTQKIGREVLEETDDELGKVSRTFHLAAQEIENNIEEQKRLAVFRKNLVDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ASHEFRAPLSAIRGYSELIIDGIVPEQDQTHYLNLIWKHAVELNEMVDTLLDLSSLETGT
CCHHHHCHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
INLNKEKMTAKEVLIDAMDMVLPDAEKKNQTITIDKSESKTFFKGDPPRVKQIIVNLLKN
EECCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
AIQYTSEKGTIRLRAFDTEQYVALQVVDNGIGIPKSELDSIFQRFYKVDKARNQNKKSGS
HHHHCCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
SGLGLAIVNELVKIHNGKIEVDSEEGKGSTFTVYFPRSYNVDGTE
CCCHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]