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The map label for this gene is srrA [H]

Identifier: 188585846

GI number: 188585846

Start: 1295017

End: 1295718

Strand: Direct

Name: srrA [H]

Synonym: Nther_1220

Alternate gene names: 188585846

Gene position: 1295017-1295718 (Clockwise)

Preceding gene: 188585844

Following gene: 188585847

Centisome position: 40.91

GC content: 34.05

Gene sequence:

>702_bases
ATGCCTGATCAACAAGTACTAATAGTAGACGATGATAAAGATTTATGTAATATGGTTAAACTGACCCTGGAACACGAAGG
GTTTTCTGTTGATATGGCTTATGATGGTAAGACAGGTTATGAATATGTTGAAAAATATAACTATAATACTGTGATTTTAG
ATATTATGCTACCGGAAATGGATGGCTGGGAAGTTTGCCATAAAATAAGAAATTCAATAAACAATAGTAAGGTACCAATC
ATAATGTTAACTGCCAAAGTAGAAGAAGATGATAAAATTATGGGACTAAAACTGGGAGCTGATGATTATGTTATAAAACC
TTTCAGTCCACGTGAATTAGTAGCCCGGGTACGTGCTCTGATAAGAAGAGATCAGGATTTCAAGGATAAAGATAAAATTC
TTGAAAAAGGCGATCTAACTGTAGATGCACACAGTTATAAAGTCTTTGTTAAAGATAATGAAGTTGATTTACCACCAAAA
GAATTTGAATTATTATATTTACTCATTAAAAATCCCGAACGAGTATTTACCAGAGAAGAAATTCTGGAGAAAATTTGGGG
ATTTTCTTTTGCTGGTGGGACACGGACAGTAGATGAACATGTAAAACGAATTAGAAAAAAGCTAGAACCTGAAAGTGGTT
TTGATAGTTTGATCCAGACGGTTTGGGGCGTTGGCTACAAATTTGAGGTGAAAAATGAATGA

Upstream 100 bases:

>100_bases
ATGAAAATTTGCCTATTAGCAGGAAATTATTTATTAAGAGCAAAATATTAGATTAGACTTAGATAATGTTTAATTTTGAA
TTAAATTGGAGGTGGGTTTG

Downstream 100 bases:

>100_bases
TTAAAAAATTTAAGCCCAAGACCTTATTTTTAAAACTGATGCTGAGTTATTTGGTTGTCATACTAGTAACTTTGCTAGTA
TTAAGTGGCATTATGTCCTA

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MPDQQVLIVDDDKDLCNMVKLTLEHEGFSVDMAYDGKTGYEYVEKYNYNTVILDIMLPEMDGWEVCHKIRNSINNSKVPI
IMLTAKVEEDDKIMGLKLGADDYVIKPFSPRELVARVRALIRRDQDFKDKDKILEKGDLTVDAHSYKVFVKDNEVDLPPK
EFELLYLLIKNPERVFTREEILEKIWGFSFAGGTRTVDEHVKRIRKKLEPESGFDSLIQTVWGVGYKFEVKNE

Sequences:

>Translated_233_residues
MPDQQVLIVDDDKDLCNMVKLTLEHEGFSVDMAYDGKTGYEYVEKYNYNTVILDIMLPEMDGWEVCHKIRNSINNSKVPI
IMLTAKVEEDDKIMGLKLGADDYVIKPFSPRELVARVRALIRRDQDFKDKDKILEKGDLTVDAHSYKVFVKDNEVDLPPK
EFELLYLLIKNPERVFTREEILEKIWGFSFAGGTRTVDEHVKRIRKKLEPESGFDSLIQTVWGVGYKFEVKNE
>Mature_232_residues
PDQQVLIVDDDKDLCNMVKLTLEHEGFSVDMAYDGKTGYEYVEKYNYNTVILDIMLPEMDGWEVCHKIRNSINNSKVPII
MLTAKVEEDDKIMGLKLGADDYVIKPFSPRELVARVRALIRRDQDFKDKDKILEKGDLTVDAHSYKVFVKDNEVDLPPKE
FELLYLLIKNPERVFTREEILEKIWGFSFAGGTRTVDEHVKRIRKKLEPESGFDSLIQTVWGVGYKFEVKNE

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=36.8421052631579, Blast_Score=173, Evalue=8e-45,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=35.8407079646018, Blast_Score=157, Evalue=4e-40,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=33.1877729257642, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786784, Length=230, Percent_Identity=38.695652173913, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=37.0044052863436, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=34.2105263157895, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=34.468085106383, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=35.2678571428571, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=34.0807174887892, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=33.6244541484716, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=29.9559471365639, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=29.1845493562232, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787229, Length=235, Percent_Identity=30.2127659574468, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=33.9449541284404, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790437, Length=103, Percent_Identity=32.0388349514563, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788191, Length=116, Percent_Identity=33.6206896551724, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=105, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27099; Mature: 26968

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDQQVLIVDDDKDLCNMVKLTLEHEGFSVDMAYDGKTGYEYVEKYNYNTVILDIMLPEM
CCCCEEEEEECCHHHHHHHHHEEECCCEEEEEEECCCCHHHHHHHCCCCEEEEEEEECCC
DGWEVCHKIRNSINNSKVPIIMLTAKVEEDDKIMGLKLGADDYVIKPFSPRELVARVRAL
CCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEEEEEECCCCEEECCCCHHHHHHHHHHH
IRRDQDFKDKDKILEKGDLTVDAHSYKVFVKDNEVDLPPKEFELLYLLIKNPERVFTREE
HHCCCCCCCHHHHHHCCCEEEEECEEEEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHH
ILEKIWGFSFAGGTRTVDEHVKRIRKKLEPESGFDSLIQTVWGVGYKFEVKNE
HHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure 
PDQQVLIVDDDKDLCNMVKLTLEHEGFSVDMAYDGKTGYEYVEKYNYNTVILDIMLPEM
CCCEEEEEECCHHHHHHHHHEEECCCEEEEEEECCCCHHHHHHHCCCCEEEEEEEECCC
DGWEVCHKIRNSINNSKVPIIMLTAKVEEDDKIMGLKLGADDYVIKPFSPRELVARVRAL
CCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCEEEEEECCCCEEECCCCHHHHHHHHHHH
IRRDQDFKDKDKILEKGDLTVDAHSYKVFVKDNEVDLPPKEFELLYLLIKNPERVFTREE
HHCCCCCCCHHHHHHCCCEEEEECEEEEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHH
ILEKIWGFSFAGGTRTVDEHVKRIRKKLEPESGFDSLIQTVWGVGYKFEVKNE
HHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA