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The map label for this gene is 188585621

Identifier: 188585621

GI number: 188585621

Start: 1058972

End: 1059787

Strand: Reverse

Name: 188585621

Synonym: Nther_0994

Alternate gene names: NA

Gene position: 1059787-1058972 (Counterclockwise)

Preceding gene: 188585622

Following gene: 188585620

Centisome position: 33.48

GC content: 39.34

Gene sequence:

>816_bases
ATGAAAATTGTATTTCATGAAGATTTTTTCAAAACCTATAGTTTTGATCCAGCGGCATCCAAAGGAAGATTAGATCATGC
TGCAGCATTGTTAACAAACCACTACCCCGTAGTCACTCCTTATCTAGCCTCAGAAAAACAAATCAAAATAATTCATACTG
ATTCTCACGTCCAAGAGATTCAAAACTCAAGTCAGATATATCACATGGCACGCCTGGCAGCAGGTTCAGCCATCAAAGCT
GCTGATCTCGCCTATTCTGGTACAGCAGCTTTCTCCCTGGCCAGGCCTCCAGGCCATCATGCAGGTCCGTCTACATATTG
GGGTTTTTGTTATTTTAATAATATAGCCATCGCAGTAAAACAGTTGATATTAGAAGAAAAAATCAATTCCGCTGTAATCG
TAGATTTTGACCTTCATCTAGGTGATGGCACTATTGATTCCTTTGCTGATACTCCCGAAGTTCATTATTATCATCTTGAA
AACGGAATTGATTTAATTGGTCTCAACAATGGAAATAAGGACTTTAGAAATCACCCGGTAACTCAATTAAGAGAATACTT
AAAGAAATTCTATAATATACCAGAAGATACACCTGATATCCTTGCTGTGTCTGCAGGCTTTGATCGACACATACATGATT
GGGGTGGCAGCTTGGATACTAAAGAGTACCAGGAAATAGGTGAAGAGTTGGGAAAATTTGCCAAAGAGCAATGTCAAGGT
AAGATTTTTTCCGTACTGGAAGGTGGTTATAATCCCGAATCTTTGGGAGAAAGTGCCTTGGCCTTTTGTCAGGGAATTGA
AAAAGGAGTTAACTAG

Upstream 100 bases:

>100_bases
CTTGTTGAAATAACTCCAAATAACATTCGATTAAGAAAGAAAACATTAAAAAAACAGTTTAGAAAATAGCTTTAAAGAAT
TAATTACAGGGGTGTTATTC

Downstream 100 bases:

>100_bases
TGTGCTTTAACTAGTGTACTTTTTGGTTACATCCAAACTAAAAAGGGAGTGTCAAAATGATTTCTCAAGTTTTTTCCCAT
ATAGAGGATAATAAAGAGAA

Product: histone deacetylase superfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MKIVFHEDFFKTYSFDPAASKGRLDHAAALLTNHYPVVTPYLASEKQIKIIHTDSHVQEIQNSSQIYHMARLAAGSAIKA
ADLAYSGTAAFSLARPPGHHAGPSTYWGFCYFNNIAIAVKQLILEEKINSAVIVDFDLHLGDGTIDSFADTPEVHYYHLE
NGIDLIGLNNGNKDFRNHPVTQLREYLKKFYNIPEDTPDILAVSAGFDRHIHDWGGSLDTKEYQEIGEELGKFAKEQCQG
KIFSVLEGGYNPESLGESALAFCQGIEKGVN

Sequences:

>Translated_271_residues
MKIVFHEDFFKTYSFDPAASKGRLDHAAALLTNHYPVVTPYLASEKQIKIIHTDSHVQEIQNSSQIYHMARLAAGSAIKA
ADLAYSGTAAFSLARPPGHHAGPSTYWGFCYFNNIAIAVKQLILEEKINSAVIVDFDLHLGDGTIDSFADTPEVHYYHLE
NGIDLIGLNNGNKDFRNHPVTQLREYLKKFYNIPEDTPDILAVSAGFDRHIHDWGGSLDTKEYQEIGEELGKFAKEQCQG
KIFSVLEGGYNPESLGESALAFCQGIEKGVN
>Mature_271_residues
MKIVFHEDFFKTYSFDPAASKGRLDHAAALLTNHYPVVTPYLASEKQIKIIHTDSHVQEIQNSSQIYHMARLAAGSAIKA
ADLAYSGTAAFSLARPPGHHAGPSTYWGFCYFNNIAIAVKQLILEEKINSAVIVDFDLHLGDGTIDSFADTPEVHYYHLE
NGIDLIGLNNGNKDFRNHPVTQLREYLKKFYNIPEDTPDILAVSAGFDRHIHDWGGSLDTKEYQEIGEELGKFAKEQCQG
KIFSVLEGGYNPESLGESALAFCQGIEKGVN

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=319, Percent_Identity=28.8401253918495, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI169234807, Length=243, Percent_Identity=31.6872427983539, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI148539870, Length=243, Percent_Identity=31.6872427983539, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI62750347, Length=241, Percent_Identity=29.4605809128631, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI62750349, Length=241, Percent_Identity=29.4605809128631, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI30795202, Length=250, Percent_Identity=31.6, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI30795204, Length=250, Percent_Identity=31.6, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI17158039, Length=250, Percent_Identity=31.6, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI226529806, Length=314, Percent_Identity=26.1146496815287, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI153085395, Length=221, Percent_Identity=31.6742081447964, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI13128864, Length=265, Percent_Identity=30.188679245283, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25154020, Length=221, Percent_Identity=30.316742081448, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25154022, Length=221, Percent_Identity=30.316742081448, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193209491, Length=235, Percent_Identity=32.7659574468085, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17540334, Length=277, Percent_Identity=26.7148014440433, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17540332, Length=277, Percent_Identity=26.7148014440433, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193206283, Length=277, Percent_Identity=26.7148014440433, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537347, Length=220, Percent_Identity=31.8181818181818, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI193207430, Length=311, Percent_Identity=23.7942122186495, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6324307, Length=271, Percent_Identity=29.520295202952, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24642142, Length=273, Percent_Identity=30.4029304029304, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24642144, Length=273, Percent_Identity=30.4029304029304, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI281360899, Length=273, Percent_Identity=30.4029304029304, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24642146, Length=273, Percent_Identity=30.4029304029304, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24641720, Length=222, Percent_Identity=31.5315315315315, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI281360799, Length=222, Percent_Identity=31.5315315315315, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI281360801, Length=222, Percent_Identity=31.5315315315315, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 30064; Mature: 30064

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVFHEDFFKTYSFDPAASKGRLDHAAALLTNHYPVVTPYLASEKQIKIIHTDSHVQEI
CEEEEECHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCEEEEEECCHHHHHH
QNSSQIYHMARLAAGSAIKAADLAYSGTAAFSLARPPGHHAGPSTYWGFCYFNNIAIAVK
HHHHHHHHHHHHHCCCCCHHHHHEECCCCEEEECCCCCCCCCCCCEEEEEEEHHHHHHHH
QLILEEKINSAVIVDFDLHLGDGTIDSFADTPEVHYYHLENGIDLIGLNNGNKDFRNHPV
HHHHHHHCCCEEEEEEEEECCCCCCHHCCCCCCEEEEEECCCEEEEEECCCCCCHHCCCH
TQLREYLKKFYNIPEDTPDILAVSAGFDRHIHDWGGSLDTKEYQEIGEELGKFAKEQCQG
HHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
KIFSVLEGGYNPESLGESALAFCQGIEKGVN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIVFHEDFFKTYSFDPAASKGRLDHAAALLTNHYPVVTPYLASEKQIKIIHTDSHVQEI
CEEEEECHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCEEEEEECCHHHHHH
QNSSQIYHMARLAAGSAIKAADLAYSGTAAFSLARPPGHHAGPSTYWGFCYFNNIAIAVK
HHHHHHHHHHHHHCCCCCHHHHHEECCCCEEEECCCCCCCCCCCCEEEEEEEHHHHHHHH
QLILEEKINSAVIVDFDLHLGDGTIDSFADTPEVHYYHLENGIDLIGLNNGNKDFRNHPV
HHHHHHHCCCEEEEEEEEECCCCCCHHCCCCCCEEEEEECCCEEEEEECCCCCCHHCCCH
TQLREYLKKFYNIPEDTPDILAVSAGFDRHIHDWGGSLDTKEYQEIGEELGKFAKEQCQG
HHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
KIFSVLEGGYNPESLGESALAFCQGIEKGVN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]