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The map label for this gene is typA [H]

Identifier: 188585622

GI number: 188585622

Start: 1059819

End: 1061657

Strand: Reverse

Name: typA [H]

Synonym: Nther_0995

Alternate gene names: 188585622

Gene position: 1061657-1059819 (Counterclockwise)

Preceding gene: 188585627

Following gene: 188585621

Centisome position: 33.54

GC content: 35.89

Gene sequence:

>1839_bases
ATGACTACACAAAAAATCAGAAACATAGCTTTAATTGCCCACGTAGACCATGGAAAAACGACCTTGGTAGATAGCTTGTT
AAAGCAAAGTGGAGTTTTTCATGAAAAAGAACAAGTAAAAGAAAGGGTTATGGATTCAAATGATCAGGAGAGGGAAAGAG
GTATTACAATACTTTCAAAAAATACTGCTATCAAATACAATGACACAAAAATCAACATAGTAGACACTCCGGGTCATGCA
GATTTTGGTGGAGAAGTGGAACGGATAATAAATATGGTAGAAGGTGGATTACTATTAGTTGATGCTGTTGAAGGACCTAT
GCCCCAAACTAAGTTTGTCTTAGAGAAGGCCTTATCAATGGGATTAGTCCCCATTGTTGTCATAAATAAAATTGATAGAC
CACAAGCAAGACCGCAAGAGGTTGCCGATGAAATCCTTGATTTATTTTTTGACTTAGAAGCCAACGAAGATCAACTGGAA
TTCCCTATTTTGTATACAGATGCACTTAAAGGAATTGCCAGCCATCAACTAGAAGATTTTCAATCAGATAACCAAAGTAT
TGAAAATGGGTCCTTAAAACCATTGTTTGATACCATCTTAGAAGTAATACCAAGCCCAAAAGTCGATCCTAATGCTCCTT
TCCAAATGCTTGTATCCAGCACGGATTATGACAGTTATCTTGGAAAATACGCAGTGGGCAAAATCATGCAAGGAACTATT
TCAAAGCACGATCAAGTTTTAATTTTAGAAAAACAGGAAACGGAAGACCAAGAGCCTAAAAAAGATAAGCAAACTGCGGG
ACAAATTTTCACATATCAAAACCTTGAAAAAATTGAAGTCCCAAAGGCAGAGGCTGGAGACATTGCCGCAATTTCTGGGC
TTAATGATATTAATATTGGTGCCACTATTACTGATCCCAACTATCCAGAACCTTTACCAAGCCCTACTATTGAAGCACCA
ACAATTAGCATGACCTTTTCAATTAATAATAGTCCCTTCGCAGGACAAGAAGGTAAATATCTAACATCAAGAAAGTTAAA
AGAACGTTTATTTACAGAGCAAGAATCTAATATCAGTTTAAAAGTAGAAGAAACTGATAACCCAGAGCTTTTCCAGGTTT
CAGGTCGTGGTGAACTCCATCTTTCTACGGTAATTGAAAAACTGAGAAGAGAAGGATATGAATTTCAGGTATCAAAACCT
CAGGTGATTTATAAGGAAATTGATGGAAAGAAATGTGAACCTATTGAAGAAGTTGTAGTGACTTTACCTGATGAATATTC
AGGAACAGTAATTGAAGAAATAAATCAGCGAAAAGGCGAACTATTAGAATACAAAAATTTATCCAGTGGAAATACCCGAT
TAAAATTCAAAGTACCATCTAGAGGATTAATTGGTTTCAGATCAGAATTTTTAACATTAACTAGAGGGACTGGATTATTT
TATCACAATTTCCTTAACTACGAGCCATATAAAGGAGATTTCTCAACGAGAGTGAATGGAGCCCTTGTGGCACATCAAGC
CGGTGAAGCTACTTTCTATAGTATTCAAGCAATGGAAGATCGAGGCGAATTTTTCATATCCCCAGGAGTTAAAGTTTATG
AAGGAATGATTGTAGGCCAAAGGAATCGTGAAGGTGATCTAGATATCAATGTATGCAAGCAAAAACAATTGACCAATGTA
AGGGCAGCAGGTTCCGACAATACTGAAAAAATTGCGCCTCCTAAATTATTATCACTTGAAGAAGCTCTAGAATTTATCAA
TCAGGATGAACTTGTTGAAATAACTCCAAATAACATTCGATTAAGAAAGAAAACATTAAAAAAACAGTTTAGAAAATAG

Upstream 100 bases:

>100_bases
TGGTTATTATTATATTCTCATTTGTGTAAAAAGTCAATACTTGCTTTAATTAATCGCCACAATCTGCTATACTGTAAAAG
TTGAGAAGGAGGAATTCAAA

Downstream 100 bases:

>100_bases
CTTTAAAGAATTAATTACAGGGGTGTTATTCATGAAAATTGTATTTCATGAAGATTTTTTCAAAACCTATAGTTTTGATC
CAGCGGCATCCAAAGGAAGA

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 612; Mature: 611

Protein sequence:

>612_residues
MTTQKIRNIALIAHVDHGKTTLVDSLLKQSGVFHEKEQVKERVMDSNDQERERGITILSKNTAIKYNDTKINIVDTPGHA
DFGGEVERIINMVEGGLLLVDAVEGPMPQTKFVLEKALSMGLVPIVVINKIDRPQARPQEVADEILDLFFDLEANEDQLE
FPILYTDALKGIASHQLEDFQSDNQSIENGSLKPLFDTILEVIPSPKVDPNAPFQMLVSSTDYDSYLGKYAVGKIMQGTI
SKHDQVLILEKQETEDQEPKKDKQTAGQIFTYQNLEKIEVPKAEAGDIAAISGLNDINIGATITDPNYPEPLPSPTIEAP
TISMTFSINNSPFAGQEGKYLTSRKLKERLFTEQESNISLKVEETDNPELFQVSGRGELHLSTVIEKLRREGYEFQVSKP
QVIYKEIDGKKCEPIEEVVVTLPDEYSGTVIEEINQRKGELLEYKNLSSGNTRLKFKVPSRGLIGFRSEFLTLTRGTGLF
YHNFLNYEPYKGDFSTRVNGALVAHQAGEATFYSIQAMEDRGEFFISPGVKVYEGMIVGQRNREGDLDINVCKQKQLTNV
RAAGSDNTEKIAPPKLLSLEEALEFINQDELVEITPNNIRLRKKTLKKQFRK

Sequences:

>Translated_612_residues
MTTQKIRNIALIAHVDHGKTTLVDSLLKQSGVFHEKEQVKERVMDSNDQERERGITILSKNTAIKYNDTKINIVDTPGHA
DFGGEVERIINMVEGGLLLVDAVEGPMPQTKFVLEKALSMGLVPIVVINKIDRPQARPQEVADEILDLFFDLEANEDQLE
FPILYTDALKGIASHQLEDFQSDNQSIENGSLKPLFDTILEVIPSPKVDPNAPFQMLVSSTDYDSYLGKYAVGKIMQGTI
SKHDQVLILEKQETEDQEPKKDKQTAGQIFTYQNLEKIEVPKAEAGDIAAISGLNDINIGATITDPNYPEPLPSPTIEAP
TISMTFSINNSPFAGQEGKYLTSRKLKERLFTEQESNISLKVEETDNPELFQVSGRGELHLSTVIEKLRREGYEFQVSKP
QVIYKEIDGKKCEPIEEVVVTLPDEYSGTVIEEINQRKGELLEYKNLSSGNTRLKFKVPSRGLIGFRSEFLTLTRGTGLF
YHNFLNYEPYKGDFSTRVNGALVAHQAGEATFYSIQAMEDRGEFFISPGVKVYEGMIVGQRNREGDLDINVCKQKQLTNV
RAAGSDNTEKIAPPKLLSLEEALEFINQDELVEITPNNIRLRKKTLKKQFRK
>Mature_611_residues
TTQKIRNIALIAHVDHGKTTLVDSLLKQSGVFHEKEQVKERVMDSNDQERERGITILSKNTAIKYNDTKINIVDTPGHAD
FGGEVERIINMVEGGLLLVDAVEGPMPQTKFVLEKALSMGLVPIVVINKIDRPQARPQEVADEILDLFFDLEANEDQLEF
PILYTDALKGIASHQLEDFQSDNQSIENGSLKPLFDTILEVIPSPKVDPNAPFQMLVSSTDYDSYLGKYAVGKIMQGTIS
KHDQVLILEKQETEDQEPKKDKQTAGQIFTYQNLEKIEVPKAEAGDIAAISGLNDINIGATITDPNYPEPLPSPTIEAPT
ISMTFSINNSPFAGQEGKYLTSRKLKERLFTEQESNISLKVEETDNPELFQVSGRGELHLSTVIEKLRREGYEFQVSKPQ
VIYKEIDGKKCEPIEEVVVTLPDEYSGTVIEEINQRKGELLEYKNLSSGNTRLKFKVPSRGLIGFRSEFLTLTRGTGLFY
HNFLNYEPYKGDFSTRVNGALVAHQAGEATFYSIQAMEDRGEFFISPGVKVYEGMIVGQRNREGDLDINVCKQKQLTNVR
AAGSDNTEKIAPPKLLSLEEALEFINQDELVEITPNNIRLRKKTLKKQFRK

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=540, Percent_Identity=26.4814814814815, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI94966754, Length=135, Percent_Identity=45.1851851851852, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI18390331, Length=174, Percent_Identity=37.9310344827586, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=38.1944444444444, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI310132016, Length=113, Percent_Identity=41.5929203539823, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI310110807, Length=113, Percent_Identity=41.5929203539823, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI310123363, Length=113, Percent_Identity=41.5929203539823, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI25306287, Length=472, Percent_Identity=25.4237288135593, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI25306283, Length=170, Percent_Identity=34.7058823529412, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI19923640, Length=170, Percent_Identity=34.7058823529412, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI217272894, Length=142, Percent_Identity=35.9154929577465, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI217272892, Length=142, Percent_Identity=35.9154929577465, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI34147630, Length=316, Percent_Identity=27.8481012658228, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI94966752, Length=131, Percent_Identity=32.0610687022901, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI5729864, Length=347, Percent_Identity=27.3775216138329, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI223555963, Length=347, Percent_Identity=27.3775216138329, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI48994988, Length=610, Percent_Identity=50.1639344262295, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=521, Percent_Identity=28.5988483685221, Blast_Score=159, Evalue=6e-40,
Organism=Escherichia coli, GI1789738, Length=150, Percent_Identity=39.3333333333333, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1790835, Length=174, Percent_Identity=28.1609195402299, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790412, Length=259, Percent_Identity=27.7992277992278, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789737, Length=259, Percent_Identity=27.7992277992278, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17557151, Length=522, Percent_Identity=25.095785440613, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71988811, Length=131, Percent_Identity=41.9847328244275, Blast_Score=115, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71988819, Length=131, Percent_Identity=41.9847328244275, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17533571, Length=175, Percent_Identity=37.1428571428571, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17506493, Length=176, Percent_Identity=35.2272727272727, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17556745, Length=471, Percent_Identity=25.9023354564756, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=35.0746268656716, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=251, Percent_Identity=29.0836653386454, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25141371, Length=248, Percent_Identity=28.6290322580645, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=519, Percent_Identity=30.4431599229287, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6324707, Length=146, Percent_Identity=41.0958904109589, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6320593, Length=146, Percent_Identity=41.0958904109589, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324761, Length=299, Percent_Identity=30.4347826086957, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=36.6666666666667, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322359, Length=150, Percent_Identity=36, Blast_Score=94, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6323098, Length=179, Percent_Identity=33.5195530726257, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322937, Length=341, Percent_Identity=22.8739002932551, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI78706572, Length=533, Percent_Identity=24.577861163227, Blast_Score=139, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24582462, Length=174, Percent_Identity=37.3563218390805, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI28574573, Length=139, Percent_Identity=41.0071942446043, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24585711, Length=168, Percent_Identity=36.3095238095238, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585713, Length=168, Percent_Identity=36.3095238095238, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585709, Length=168, Percent_Identity=36.3095238095238, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221458488, Length=172, Percent_Identity=36.6279069767442, Blast_Score=97, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=39.5522388059701, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19921738, Length=306, Percent_Identity=26.1437908496732, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI281363316, Length=314, Percent_Identity=28.343949044586, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17864358, Length=314, Percent_Identity=28.343949044586, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI45550900, Length=344, Percent_Identity=26.453488372093, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28572034, Length=240, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 68733; Mature: 68602

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQKIRNIALIAHVDHGKTTLVDSLLKQSGVFHEKEQVKERVMDSNDQERERGITILSK
CCCHHHCCEEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHCCCEEEEC
NTAIKYNDTKINIVDTPGHADFGGEVERIINMVEGGLLLVDAVEGPMPQTKFVLEKALSM
CEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC
GLVPIVVINKIDRPQARPQEVADEILDLFFDLEANEDQLEFPILYTDALKGIASHQLEDF
CCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHH
QSDNQSIENGSLKPLFDTILEVIPSPKVDPNAPFQMLVSSTDYDSYLGKYAVGKIMQGTI
HCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHC
SKHDQVLILEKQETEDQEPKKDKQTAGQIFTYQNLEKIEVPKAEAGDIAAISGLNDINIG
CCCCCEEEEECCCCCCCCCCHHHHHHCCEEEECCCCCEECCCCCCCCEEEECCCCCCCCC
ATITDPNYPEPLPSPTIEAPTISMTFSINNSPFAGQEGKYLTSRKLKERLFTEQESNISL
EEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEE
KVEETDNPELFQVSGRGELHLSTVIEKLRREGYEFQVSKPQVIYKEIDGKKCEPIEEVVV
EEECCCCCCEEEECCCCCEEHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCHHHHHE
TLPDEYSGTVIEEINQRKGELLEYKNLSSGNTRLKFKVPSRGLIGFRSEFLTLTRGTGLF
ECCCCCCCHHHHHHHHHCCCEEHCCCCCCCCCEEEEECCCCCCCHHHHHEEEEECCCCEE
YHNFLNYEPYKGDFSTRVNGALVAHQAGEATFYSIQAMEDRGEFFISPGVKVYEGMIVGQ
EECCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCEEECCCCEEEEEEEEEC
RNREGDLDINVCKQKQLTNVRAAGSDNTEKIAPPKLLSLEEALEFINQDELVEITPNNIR
CCCCCCCEEEECCHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEE
LRKKTLKKQFRK
EHHHHHHHHHCC
>Mature Secondary Structure 
TTQKIRNIALIAHVDHGKTTLVDSLLKQSGVFHEKEQVKERVMDSNDQERERGITILSK
CCHHHCCEEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHCCCEEEEC
NTAIKYNDTKINIVDTPGHADFGGEVERIINMVEGGLLLVDAVEGPMPQTKFVLEKALSM
CEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHC
GLVPIVVINKIDRPQARPQEVADEILDLFFDLEANEDQLEFPILYTDALKGIASHQLEDF
CCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHH
QSDNQSIENGSLKPLFDTILEVIPSPKVDPNAPFQMLVSSTDYDSYLGKYAVGKIMQGTI
HCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHC
SKHDQVLILEKQETEDQEPKKDKQTAGQIFTYQNLEKIEVPKAEAGDIAAISGLNDINIG
CCCCCEEEEECCCCCCCCCCHHHHHHCCEEEECCCCCEECCCCCCCCEEEECCCCCCCCC
ATITDPNYPEPLPSPTIEAPTISMTFSINNSPFAGQEGKYLTSRKLKERLFTEQESNISL
EEECCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEE
KVEETDNPELFQVSGRGELHLSTVIEKLRREGYEFQVSKPQVIYKEIDGKKCEPIEEVVV
EEECCCCCCEEEECCCCCEEHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCHHHHHE
TLPDEYSGTVIEEINQRKGELLEYKNLSSGNTRLKFKVPSRGLIGFRSEFLTLTRGTGLF
ECCCCCCCHHHHHHHHHCCCEEHCCCCCCCCCEEEEECCCCCCCHHHHHEEEEECCCCEE
YHNFLNYEPYKGDFSTRVNGALVAHQAGEATFYSIQAMEDRGEFFISPGVKVYEGMIVGQ
EECCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCEEECCCCEEEEEEEEEC
RNREGDLDINVCKQKQLTNVRAAGSDNTEKIAPPKLLSLEEALEFINQDELVEITPNNIR
CCCCCCCEEEECCHHHHCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCEE
LRKKTLKKQFRK
EHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]