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The map label for this gene is norM [H]

Identifier: 188585618

GI number: 188585618

Start: 1054987

End: 1056414

Strand: Direct

Name: norM [H]

Synonym: Nther_0991

Alternate gene names: 188585618

Gene position: 1054987-1056414 (Clockwise)

Preceding gene: 188585617

Following gene: 188585619

Centisome position: 33.33

GC content: 40.62

Gene sequence:

>1428_bases
ATGAGTAGTGAGCAAAATTCAAATCAACAATCCAATTCAATACTATTAGAAGGAGAAAATCTTACTAATAGTGAAATCCG
CAAAAAAGTAATTTTCCTGGCATGGCCAGCCATTATTGAAATGTTTTTGATGACATTTAAGCAAATCGTTGATAATGCCA
TGGTAGGAAGGCTAGGAGAAGCGTCAATTGCTGCCGTTGGCTTATCAATGTCTCCCATGATGTTTTTTATGGGATTGTTC
GCAGCATTAGGTGTAGGCACTACAGCAGTAGTTGCTAGACATATAGGGGCAAAGGAACATAATCAAGCGAACCTGGCGGG
ACGACAGGCTATTATTATGAGCGTGGCAACAGCCTTGTTAGTAACTTCAATAGTTTTTCCTCTTGCTCCAACTATAATTA
ACTTGATGGGTGCCGAACCGGAAGTGGTCCCCTTAGGTACAGATTATTTGAGAATTATCAGTGCAGGTATTTTATTTATT
TCATCTTCTTTTATATTAAGCGGTGTCTTAAGAGGTGCAGGCGACACTAGGACCCCTATGCGGGTTAATGCTGTTGCCAA
TGTTGTTAATATCATATTGAACTTTTTATTGATTTTTGAAACTCGAGAGATGTCATTCTTAGGAATAGAATTCCTGATGC
CAGGCGCTGGAATAGGAGTACAAGGGGCAGCATTAGGGACTAGTATTTCCCGGGCAATAGCCTCTTTATTAGTTGTTAAA
ACCTTATTAAAGGGAAAATCCGTGATAAAGATTAATTTGTCAGATTCCTTTCGGCCTGATTTTACTATGATAAAAAGGAT
AGTTAAAGTAGGGATTCCGACAGCAATTGAGCGGATGGCCATGAGTTCAGGCCAGGTGTTATTTACTAGGATAGTTGCAA
GTTTGGGAACCACAGCTACTGCCGCTCATCATATGGCCATTAACGCAGAATCCTTGTCTTTTATGCCCGGTTTTGGGTTT
TCCATGGCTGCTACAACTTTGGTTGGTCAAGGCCTTGGAGCCAAAGATCCTAAACTTTCAGAGCGTTGTGGACTAGAAAC
CTGGCGTTTGGGTGCCGGTGTAATGAGTTTCATGGGATTAATATTCTTTTTCTTTCCCCATGTACTGATGAACTTCCTAA
CTAATGAGCCTGAGGTTATAGATCTTGGTGTGATGTGTCTTAGAATAGTAGCCCTGGCACAGCCTCCCTTTGCGACTGCT
ATTATACTGTCAGGAGGTCTTAGAGGGGCAGGAGATACTACTTTCCCAGCTGTAACAACGGCAATCGGAATGTTGGGAGT
AAGATTGATTTTAGCTGTTTTATTTGCCTTTGTGTTTAACTGGGGATTATTTGGAGCATGGTTGGCAATGGCTAGTGATC
TGTATGTTCGAGGAATTTTAGTATTTTTAAGATTTAAATCCGGTAAATGGAAGGAAATAAAAGTTTAA

Upstream 100 bases:

>100_bases
CAAAGAAGAAAAAACACCATAAAATTATATTGACACTTAAATATAAATCGTAATAAACTAATATTTAGTGAGGCGAAATA
TTGAAAAAGGGGAAAATTTT

Downstream 100 bases:

>100_bases
TGAAGAACTCATGTTTCGACTACAATAATGTGATAGGGTAAATAGAATAAATAATTTGTTGCAATAAAAAAGATCGTAGT
GTACTATGTTGAATATGCTG

Product: MATE efflux family protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MSSEQNSNQQSNSILLEGENLTNSEIRKKVIFLAWPAIIEMFLMTFKQIVDNAMVGRLGEASIAAVGLSMSPMMFFMGLF
AALGVGTTAVVARHIGAKEHNQANLAGRQAIIMSVATALLVTSIVFPLAPTIINLMGAEPEVVPLGTDYLRIISAGILFI
SSSFILSGVLRGAGDTRTPMRVNAVANVVNIILNFLLIFETREMSFLGIEFLMPGAGIGVQGAALGTSISRAIASLLVVK
TLLKGKSVIKINLSDSFRPDFTMIKRIVKVGIPTAIERMAMSSGQVLFTRIVASLGTTATAAHHMAINAESLSFMPGFGF
SMAATTLVGQGLGAKDPKLSERCGLETWRLGAGVMSFMGLIFFFFPHVLMNFLTNEPEVIDLGVMCLRIVALAQPPFATA
IILSGGLRGAGDTTFPAVTTAIGMLGVRLILAVLFAFVFNWGLFGAWLAMASDLYVRGILVFLRFKSGKWKEIKV

Sequences:

>Translated_475_residues
MSSEQNSNQQSNSILLEGENLTNSEIRKKVIFLAWPAIIEMFLMTFKQIVDNAMVGRLGEASIAAVGLSMSPMMFFMGLF
AALGVGTTAVVARHIGAKEHNQANLAGRQAIIMSVATALLVTSIVFPLAPTIINLMGAEPEVVPLGTDYLRIISAGILFI
SSSFILSGVLRGAGDTRTPMRVNAVANVVNIILNFLLIFETREMSFLGIEFLMPGAGIGVQGAALGTSISRAIASLLVVK
TLLKGKSVIKINLSDSFRPDFTMIKRIVKVGIPTAIERMAMSSGQVLFTRIVASLGTTATAAHHMAINAESLSFMPGFGF
SMAATTLVGQGLGAKDPKLSERCGLETWRLGAGVMSFMGLIFFFFPHVLMNFLTNEPEVIDLGVMCLRIVALAQPPFATA
IILSGGLRGAGDTTFPAVTTAIGMLGVRLILAVLFAFVFNWGLFGAWLAMASDLYVRGILVFLRFKSGKWKEIKV
>Mature_474_residues
SSEQNSNQQSNSILLEGENLTNSEIRKKVIFLAWPAIIEMFLMTFKQIVDNAMVGRLGEASIAAVGLSMSPMMFFMGLFA
ALGVGTTAVVARHIGAKEHNQANLAGRQAIIMSVATALLVTSIVFPLAPTIINLMGAEPEVVPLGTDYLRIISAGILFIS
SSFILSGVLRGAGDTRTPMRVNAVANVVNIILNFLLIFETREMSFLGIEFLMPGAGIGVQGAALGTSISRAIASLLVVKT
LLKGKSVIKINLSDSFRPDFTMIKRIVKVGIPTAIERMAMSSGQVLFTRIVASLGTTATAAHHMAINAESLSFMPGFGFS
MAATTLVGQGLGAKDPKLSERCGLETWRLGAGVMSFMGLIFFFFPHVLMNFLTNEPEVIDLGVMCLRIVALAQPPFATAI
ILSGGLRGAGDTTFPAVTTAIGMLGVRLILAVLFAFVFNWGLFGAWLAMASDLYVRGILVFLRFKSGKWKEIKV

Specific function: Multidrug efflux pump [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=466, Percent_Identity=28.1115879828326, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI48994890, Length=451, Percent_Identity=26.3858093126386, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50838; Mature: 50707

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEQNSNQQSNSILLEGENLTNSEIRKKVIFLAWPAIIEMFLMTFKQIVDNAMVGRLGE
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ASIAAVGLSMSPMMFFMGLFAALGVGTTAVVARHIGAKEHNQANLAGRQAIIMSVATALL
CHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VTSIVFPLAPTIINLMGAEPEVVPLGTDYLRIISAGILFISSSFILSGVLRGAGDTRTPM
HHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RVNAVANVVNIILNFLLIFETREMSFLGIEFLMPGAGIGVQGAALGTSISRAIASLLVVK
HHHHHHHHHHHHHHHHHHHHCCCCHHEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TLLKGKSVIKINLSDSFRPDFTMIKRIVKVGIPTAIERMAMSSGQVLFTRIVASLGTTAT
HHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCHHH
AAHHMAINAESLSFMPGFGFSMAATTLVGQGLGAKDPKLSERCGLETWRLGAGVMSFMGL
HHHHEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHH
IFFFFPHVLMNFLTNEPEVIDLGVMCLRIVALAQPPFATAIILSGGLRGAGDTTFPAVTT
HHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEEHEEECCCCCCCCCCHHHHHH
AIGMLGVRLILAVLFAFVFNWGLFGAWLAMASDLYVRGILVFLRFKSGKWKEIKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCC
>Mature Secondary Structure 
SSEQNSNQQSNSILLEGENLTNSEIRKKVIFLAWPAIIEMFLMTFKQIVDNAMVGRLGE
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ASIAAVGLSMSPMMFFMGLFAALGVGTTAVVARHIGAKEHNQANLAGRQAIIMSVATALL
CHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VTSIVFPLAPTIINLMGAEPEVVPLGTDYLRIISAGILFISSSFILSGVLRGAGDTRTPM
HHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RVNAVANVVNIILNFLLIFETREMSFLGIEFLMPGAGIGVQGAALGTSISRAIASLLVVK
HHHHHHHHHHHHHHHHHHHHCCCCHHEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
TLLKGKSVIKINLSDSFRPDFTMIKRIVKVGIPTAIERMAMSSGQVLFTRIVASLGTTAT
HHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHCCHHH
AAHHMAINAESLSFMPGFGFSMAATTLVGQGLGAKDPKLSERCGLETWRLGAGVMSFMGL
HHHHEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHH
IFFFFPHVLMNFLTNEPEVIDLGVMCLRIVALAQPPFATAIILSGGLRGAGDTTFPAVTT
HHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCEEHEEECCCCCCCCCCHHHHHH
AIGMLGVRLILAVLFAFVFNWGLFGAWLAMASDLYVRGILVFLRFKSGKWKEIKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]