Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 188585537

GI number: 188585537

Start: 963426

End: 964475

Strand: Direct

Name: thrC [H]

Synonym: Nther_0909

Alternate gene names: 188585537

Gene position: 963426-964475 (Clockwise)

Preceding gene: 188585536

Following gene: 188585538

Centisome position: 30.43

GC content: 41.62

Gene sequence:

>1050_bases
ATGTGGAAAGGAATAGTGAATTATTATCGTGAGTTTTTACCCGTGGATGAAGATTTTCCTCAATGCTCTTTGCAAGAAGG
AAATACCCCCCTATATTATGCTGGGGAAATTTCCAATAGAGTTGGAGCTGAAGTTTATCTGAAATTTGAAGGTTTGAATC
CCACGGGATCATTTAAAGATAGAGGCATGGTAATGGCCGTTACCAAGGCCATTGAAGATGGATCAGATACTATAATGTGT
GCTTCAACAGGTAATACTTCTGCTTCAGCTGCGGCATACGCTGCGAAAAATGGTTTGACATGTGCAGTTCTAGTTCCCCA
TGGCAATATTGCCATGGGGAAATTATCCCAGGCATTAATGCATGGTGCTAAAATTATAGAAATCGAAGGGAATTTTGATG
AAGCTCTGACTATAGTACGTGATATCACCAGTAAACATCCAATTAGCTTGGTAAACTCTTTGAATCCGTATAGACTAGAA
GGACAAAAGACAGCAGCTTTTGAAGTTTGTGATCAATTACAAAGTGCTCCTAACTACTTAGCTATACCTGTTGGGAATGC
CGGTAATATTACAGCCTACTGGAAAGGATTTCAAGAATATAGAGACTACAACATGATTGAAAATTTACCCCGAATGCTCG
GTTTTCAAGCTCAAGGGGCTGCACCTATATTATCAGGAGAACCGGTACAGAAACCGGAGACCCTTGCTACTGCTATCAGA
ATTGGCAATCCCGCCAGCTGGCAAGGGGCGTTAACTGCTGTAGAACAATCAAAAGGGGAAGTCGGCTCAGTATCTGACCA
AGAAATTATCCATGCATATCAGACTTTAGCTAAATACGAAGGGGTTTTTGTGGAACCAGCTTCTGCAGCTTCAGTGGCAG
GCATAATGAAGTTGGGTCAACAGGGTTGGTTTAAACCTGAAGATAAAATAGTGTGTGTCAATACGGGTCATGGTTTAAAA
GACCCTGACTGTGCCATTAATTCCATGGAATATCAACCTCAGGTGATTCCGCCCTTAGAGGATCAGGTTTTAGACGCGGT
TTATTCATAA

Upstream 100 bases:

>100_bases
AACTAAGTGAAATTTTAAAAGAACTAGAGGAGAGACTAGATACAACCATAGAAGATGAAGACAGTGATGATCAATAAACC
ACTATTATGAGGTGAATATT

Downstream 100 bases:

>100_bases
ATTATTATTTATTGCGATATATTCATTAGTTAGTAATATAACGATTTTGAAATAGGGTGGTGTTAAAGTGGAAGAAAAAA
ATTTAGTAAAAGTTCAAGTA

Product: L-threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MWKGIVNYYREFLPVDEDFPQCSLQEGNTPLYYAGEISNRVGAEVYLKFEGLNPTGSFKDRGMVMAVTKAIEDGSDTIMC
ASTGNTSASAAAYAAKNGLTCAVLVPHGNIAMGKLSQALMHGAKIIEIEGNFDEALTIVRDITSKHPISLVNSLNPYRLE
GQKTAAFEVCDQLQSAPNYLAIPVGNAGNITAYWKGFQEYRDYNMIENLPRMLGFQAQGAAPILSGEPVQKPETLATAIR
IGNPASWQGALTAVEQSKGEVGSVSDQEIIHAYQTLAKYEGVFVEPASAASVAGIMKLGQQGWFKPEDKIVCVNTGHGLK
DPDCAINSMEYQPQVIPPLEDQVLDAVYS

Sequences:

>Translated_349_residues
MWKGIVNYYREFLPVDEDFPQCSLQEGNTPLYYAGEISNRVGAEVYLKFEGLNPTGSFKDRGMVMAVTKAIEDGSDTIMC
ASTGNTSASAAAYAAKNGLTCAVLVPHGNIAMGKLSQALMHGAKIIEIEGNFDEALTIVRDITSKHPISLVNSLNPYRLE
GQKTAAFEVCDQLQSAPNYLAIPVGNAGNITAYWKGFQEYRDYNMIENLPRMLGFQAQGAAPILSGEPVQKPETLATAIR
IGNPASWQGALTAVEQSKGEVGSVSDQEIIHAYQTLAKYEGVFVEPASAASVAGIMKLGQQGWFKPEDKIVCVNTGHGLK
DPDCAINSMEYQPQVIPPLEDQVLDAVYS
>Mature_349_residues
MWKGIVNYYREFLPVDEDFPQCSLQEGNTPLYYAGEISNRVGAEVYLKFEGLNPTGSFKDRGMVMAVTKAIEDGSDTIMC
ASTGNTSASAAAYAAKNGLTCAVLVPHGNIAMGKLSQALMHGAKIIEIEGNFDEALTIVRDITSKHPISLVNSLNPYRLE
GQKTAAFEVCDQLQSAPNYLAIPVGNAGNITAYWKGFQEYRDYNMIENLPRMLGFQAQGAAPILSGEPVQKPETLATAIR
IGNPASWQGALTAVEQSKGEVGSVSDQEIIHAYQTLAKYEGVFVEPASAASVAGIMKLGQQGWFKPEDKIVCVNTGHGLK
DPDCAINSMEYQPQVIPPLEDQVLDAVYS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI2367138, Length=284, Percent_Identity=26.056338028169, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322631, Length=271, Percent_Identity=23.9852398523985, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 37710; Mature: 37710

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWKGIVNYYREFLPVDEDFPQCSLQEGNTPLYYAGEISNRVGAEVYLKFEGLNPTGSFKD
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCCCCCCC
RGMVMAVTKAIEDGSDTIMCASTGNTSASAAAYAAKNGLTCAVLVPHGNIAMGKLSQALM
CCEEEEEEHHHCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
HGAKIIEIEGNFDEALTIVRDITSKHPISLVNSLNPYRLEGQKTAAFEVCDQLQSAPNYL
CCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCEE
AIPVGNAGNITAYWKGFQEYRDYNMIENLPRMLGFQAQGAAPILSGEPVQKPETLATAIR
EEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHC
IGNPASWQGALTAVEQSKGEVGSVSDQEIIHAYQTLAKYEGVFVEPASAASVAGIMKLGQ
CCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHH
QGWFKPEDKIVCVNTGHGLKDPDCAINSMEYQPQVIPPLEDQVLDAVYS
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MWKGIVNYYREFLPVDEDFPQCSLQEGNTPLYYAGEISNRVGAEVYLKFEGLNPTGSFKD
CCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEECCCCCCCCCC
RGMVMAVTKAIEDGSDTIMCASTGNTSASAAAYAAKNGLTCAVLVPHGNIAMGKLSQALM
CCEEEEEEHHHCCCCCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
HGAKIIEIEGNFDEALTIVRDITSKHPISLVNSLNPYRLEGQKTAAFEVCDQLQSAPNYL
CCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCEE
AIPVGNAGNITAYWKGFQEYRDYNMIENLPRMLGFQAQGAAPILSGEPVQKPETLATAIR
EEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHC
IGNPASWQGALTAVEQSKGEVGSVSDQEIIHAYQTLAKYEGVFVEPASAASVAGIMKLGQ
CCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHH
QGWFKPEDKIVCVNTGHGLKDPDCAINSMEYQPQVIPPLEDQVLDAVYS
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3098560; 9384377; 3139660 [H]