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The map label for this gene is thrB

Identifier: 188585538

GI number: 188585538

Start: 964543

End: 965478

Strand: Direct

Name: thrB

Synonym: Nther_0910

Alternate gene names: 188585538

Gene position: 964543-965478 (Clockwise)

Preceding gene: 188585537

Following gene: 188585540

Centisome position: 30.47

GC content: 39.1

Gene sequence:

>936_bases
GTGGAAGAAAAAAATTTAGTAAAAGTTCAAGTACCGGGAACTTCGGCTAATTTAGGAGCGGGTTTTGATTCTATGGGAAT
TGCTCTAAATATTTATAATTATGTCAGCCTAAGACAGTTAGAACCTGGTTCTGGCGTAATAATAGAAGTCAAGGGCGAGG
GAGCGGATTTCATATCTAGAGACAAAGATAATCTTGTATATCAAGCTATTGCTGGAGTTTATCGCGAAATTTATGGTTCA
GATGTCCTAATACCTGATTTAGAAATAACCTTGGAAAATAATATACCACTGGCTAGAGGACTTGGTAGCAGTGCGGCAGC
CATAGTGGGTGGAGCAGTAGCTGCTAATGAGATGTTTAATGGTGAATTAACCAGGGACGAGTTGTTGAAACATGTGTTAG
AACTTGAGGGCCACCTTGATAATATAGCACCAGCTATGTATGGAGGATTAACCTGTAGTCTAATAACTCGGGAAAACGAA
TTAATGTTCAGAACAGTTGATGTAGTAGAAGATTGGAATTTCATCATAATTGTACCTGGTCAAGAACTATCAACTCAAAA
AGCCCGAGAAGCTTTACCAGAAAGAATTGCGTTTCAAGATGGTTTGTTTAATTTGAGTCGAGCTAATATGTTGATCTTAG
CCTTTCAACAGCGAGATTATGAATTGTTATGGCATAGTATGGATGACGAACTTCATGAGCCCTACCGGGCAAAATTAATA
CCCGGCTTGGATAGATTGTTGCAAGAAGTACGAGGGGCGGGTATTCCTGCTGCTATTAGTGGAGCAGGTCCTTCTATAGC
ATGTGTTTTAAGTGAGATTGAAGAAGAAAAAATTGTCCGTGAGCTCGGAAAAGAGAAATTTAGTGCTCACGGAATCGAGA
GCAATTTTTTCAAATTAAAACCCGATAACTCTGGAGCCAAGTCTATATTACATTAA

Upstream 100 bases:

>100_bases
GAGGATCAGGTTTTAGACGCGGTTTATTCATAAATTATTATTTATTGCGATATATTCATTAGTTAGTAATATAACGATTT
TGAAATAGGGTGGTGTTAAA

Downstream 100 bases:

>100_bases
AGGTGAAAATAGTCTTAAGATGTCTTCAATTATTTTTCTTATGGCACCTCTATTTTTAAACTCTTCCCAATAAAGAGGAG
AGGAGTTGTAAATATCTTGT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MEEKNLVKVQVPGTSANLGAGFDSMGIALNIYNYVSLRQLEPGSGVIIEVKGEGADFISRDKDNLVYQAIAGVYREIYGS
DVLIPDLEITLENNIPLARGLGSSAAAIVGGAVAANEMFNGELTRDELLKHVLELEGHLDNIAPAMYGGLTCSLITRENE
LMFRTVDVVEDWNFIIIVPGQELSTQKAREALPERIAFQDGLFNLSRANMLILAFQQRDYELLWHSMDDELHEPYRAKLI
PGLDRLLQEVRGAGIPAAISGAGPSIACVLSEIEEEKIVRELGKEKFSAHGIESNFFKLKPDNSGAKSILH

Sequences:

>Translated_311_residues
MEEKNLVKVQVPGTSANLGAGFDSMGIALNIYNYVSLRQLEPGSGVIIEVKGEGADFISRDKDNLVYQAIAGVYREIYGS
DVLIPDLEITLENNIPLARGLGSSAAAIVGGAVAANEMFNGELTRDELLKHVLELEGHLDNIAPAMYGGLTCSLITRENE
LMFRTVDVVEDWNFIIIVPGQELSTQKAREALPERIAFQDGLFNLSRANMLILAFQQRDYELLWHSMDDELHEPYRAKLI
PGLDRLLQEVRGAGIPAAISGAGPSIACVLSEIEEEKIVRELGKEKFSAHGIESNFFKLKPDNSGAKSILH
>Mature_311_residues
MEEKNLVKVQVPGTSANLGAGFDSMGIALNIYNYVSLRQLEPGSGVIIEVKGEGADFISRDKDNLVYQAIAGVYREIYGS
DVLIPDLEITLENNIPLARGLGSSAAAIVGGAVAANEMFNGELTRDELLKHVLELEGHLDNIAPAMYGGLTCSLITRENE
LMFRTVDVVEDWNFIIIVPGQELSTQKAREALPERIAFQDGLFNLSRANMLILAFQQRDYELLWHSMDDELHEPYRAKLI
PGLDRLLQEVRGAGIPAAISGAGPSIACVLSEIEEEKIVRELGKEKFSAHGIESNFFKLKPDNSGAKSILH

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=319, Percent_Identity=31.3479623824451, Blast_Score=130, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321814, Length=351, Percent_Identity=29.6296296296296, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_NATTJ (B2A8C9)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917083.1
- ProteinModelPortal:   B2A8C9
- GeneID:   6314962
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_0910
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 34093; Mature: 34093

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEKNLVKVQVPGTSANLGAGFDSMGIALNIYNYVSLRQLEPGSGVIIEVKGEGADFISR
CCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCEEEEECCCCCCHHCC
DKDNLVYQAIAGVYREIYGSDVLIPDLEITLENNIPLARGLGSSAAAIVGGAVAANEMFN
CCCHHHHHHHHHHHHHHHCCCEEECCEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHCC
GELTRDELLKHVLELEGHLDNIAPAMYGGLTCSLITRENELMFRTVDVVEDWNFIIIVPG
CCCCHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEEECCCCEEEEEEEHHCCCCEEEEECC
QELSTQKAREALPERIAFQDGLFNLSRANMLILAFQQRDYELLWHSMDDELHEPYRAKLI
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHCCHHHCCCHHHHHC
PGLDRLLQEVRGAGIPAAISGAGPSIACVLSEIEEEKIVRELGKEKFSAHGIESNFFKLK
CCHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
PDNSGAKSILH
CCCCCHHHHCC
>Mature Secondary Structure
MEEKNLVKVQVPGTSANLGAGFDSMGIALNIYNYVSLRQLEPGSGVIIEVKGEGADFISR
CCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEECCCCCEEEEECCCCCCHHCC
DKDNLVYQAIAGVYREIYGSDVLIPDLEITLENNIPLARGLGSSAAAIVGGAVAANEMFN
CCCHHHHHHHHHHHHHHHCCCEEECCEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHCC
GELTRDELLKHVLELEGHLDNIAPAMYGGLTCSLITRENELMFRTVDVVEDWNFIIIVPG
CCCCHHHHHHHHHHHHCCHHHHHHHHHCCEEEEEEECCCCEEEEEEEHHCCCCEEEEECC
QELSTQKAREALPERIAFQDGLFNLSRANMLILAFQQRDYELLWHSMDDELHEPYRAKLI
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHCCHHHCCCHHHHHC
PGLDRLLQEVRGAGIPAAISGAGPSIACVLSEIEEEKIVRELGKEKFSAHGIESNFFKLK
CCHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEC
PDNSGAKSILH
CCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA