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The map label for this gene is purE [H]

Identifier: 188585093

GI number: 188585093

Start: 479275

End: 479799

Strand: Direct

Name: purE [H]

Synonym: Nther_0454

Alternate gene names: 188585093

Gene position: 479275-479799 (Clockwise)

Preceding gene: 188585092

Following gene: 188585094

Centisome position: 15.14

GC content: 40.95

Gene sequence:

>525_bases
ATGAATTATAAAGTTGGAGTGATAATGGGAAGTGATTCTGATCTACCTGTTTTACAAGATGCCTGTGATGTTTTGGAAGA
ATTTCAAATTCCCTACGAGGTAGATATAGTTTCCGCTCACAGGACCCCGGAAAAAATGTATCAATACGCACAAGAAGCCA
AGAATAGAGGAATCAAAGTTATTATAGCCGGAGCTGGAGGTGCTGCTCACTTACCCGGGATGGTAGCTTCTTTGACGGAA
CTTCCTGTTATAGGTGTTCCGATTAAGACTCGTTCCTTGAGTGGAATGGATTCACTATATTCCATTGTTCAAATGCCAGC
AGGAGTTCCAGTGGCAACAGTGGCTATTAACGGTGCTAAAAATGCTGCCCTATTAGCTGCAAGAATGATAGGAAGTTATG
AAGAGAGGGTGTCCCAGGCCTTGAATGATTATCAAGAACAAAATCGTCAAAAGGTTTTAGAGAAGGGGCAAGAGTTACAA
AAAATAGGTCACGAACAATATTTGAAAAGAAAGGAAGAAAGCTGA

Upstream 100 bases:

>100_bases
GGAAGGAAAATGGGTCATATCACAATTACTGGACAAAATGAACAGGACCTTGTATCTAAAGTCAATAACTTGGAAATTAT
TGATAAAAGGGGGATCTTGG

Downstream 100 bases:

>100_bases
TGATAGAGCGTTATCAAAGGCCGGAAATGAAGCAGTTATGGAGCTTGGAAAATAAATTTAAGAAATGGTTGCAGGTGGAG
ATCTATTCATGTGAAGCCTT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MNYKVGVIMGSDSDLPVLQDACDVLEEFQIPYEVDIVSAHRTPEKMYQYAQEAKNRGIKVIIAGAGGAAHLPGMVASLTE
LPVIGVPIKTRSLSGMDSLYSIVQMPAGVPVATVAINGAKNAALLAARMIGSYEERVSQALNDYQEQNRQKVLEKGQELQ
KIGHEQYLKRKEES

Sequences:

>Translated_174_residues
MNYKVGVIMGSDSDLPVLQDACDVLEEFQIPYEVDIVSAHRTPEKMYQYAQEAKNRGIKVIIAGAGGAAHLPGMVASLTE
LPVIGVPIKTRSLSGMDSLYSIVQMPAGVPVATVAINGAKNAALLAARMIGSYEERVSQALNDYQEQNRQKVLEKGQELQ
KIGHEQYLKRKEES
>Mature_174_residues
MNYKVGVIMGSDSDLPVLQDACDVLEEFQIPYEVDIVSAHRTPEKMYQYAQEAKNRGIKVIIAGAGGAAHLPGMVASLTE
LPVIGVPIKTRSLSGMDSLYSIVQMPAGVPVATVAINGAKNAALLAARMIGSYEERVSQALNDYQEQNRQKVLEKGQELQ
KIGHEQYLKRKEES

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=50, Blast_Score=148, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324702, Length=167, Percent_Identity=60.4790419161677, Blast_Score=214, Evalue=6e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18988; Mature: 18988

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYKVGVIMGSDSDLPVLQDACDVLEEFQIPYEVDIVSAHRTPEKMYQYAQEAKNRGIKV
CCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEE
IIAGAGGAAHLPGMVASLTELPVIGVPIKTRSLSGMDSLYSIVQMPAGVPVATVAINGAK
EEECCCCCHHHHHHHHHHHHCCEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCC
NAALLAARMIGSYEERVSQALNDYQEQNRQKVLEKGQELQKIGHEQYLKRKEES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNYKVGVIMGSDSDLPVLQDACDVLEEFQIPYEVDIVSAHRTPEKMYQYAQEAKNRGIKV
CCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEE
IIAGAGGAAHLPGMVASLTELPVIGVPIKTRSLSGMDSLYSIVQMPAGVPVATVAINGAK
EEECCCCCHHHHHHHHHHHHCCEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCC
NAALLAARMIGSYEERVSQALNDYQEQNRQKVLEKGQELQKIGHEQYLKRKEES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]