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The map label for this gene is moeA [C]

Identifier: 188585086

GI number: 188585086

Start: 470671

End: 472599

Strand: Direct

Name: moeA [C]

Synonym: Nther_0447

Alternate gene names: 188585086

Gene position: 470671-472599 (Clockwise)

Preceding gene: 188585085

Following gene: 188585087

Centisome position: 14.87

GC content: 40.28

Gene sequence:

>1929_bases
ATGAAAAAAAATAAAAAAAGGAAAGTTTATCTAGATAACACCCCTTTAGATGAGGCCTTAGAGACTTTTTTCAATGCTCT
TTCTGAGGTGGAAGCGGATACTTTAGCAGGAGAAACTATTCTAACTGAGAATGCCCATGGACGAATTACAAAAGAACCTG
TCTTTGCAAAGGTTTCTTCACCCCATTATCATGCTTCAGCTATGGATGGAATAGCCGTTGATTCTAAAAAAACTCAAGGG
GCTTCATTGAGAAACCCAAAGATATTAACAACCCCTCAAGATGCAGAATTAGTTGATACTGGATCACCTATACCTCATGA
TAAAAATGCTGTCATTATGATCGAGGACGTTGACTGGGCTGGCAGGAATGAGGTGGAAATTGTCGAGTCGGTGGCGCCTT
GGCAGCATGTTAGGACTATAGGGGAAGATCTGGTAGCTACCGAATTAATTGTTCCGGCTGGGCAAAAACTTCGTCCTGTT
GATATTGGGGCGATACTGGCTGGAGGTGTGACAGAAGTAACTGTTGAACCTAAACCTCGAGTTGCTGTAGTACCTACTGG
TACTGAACTTGTTGAACCAGGAGAAAGATTAAAACCAGGGGATGTAGTTGAATTTAACTCTCGAGTTTTATCAGGTTTAG
TTTCTCAATGGGGTGGTAAACCTTCTAAGGAAGATAAACTACCCGATGATTACGATTTAATTGTGGAAACAATAAAAAGT
TTATTACCGCAGAATGATTTGATTATAGTAAATGCAGGCTCTTCAGCGGGGGCACAAGATTATACCTATCAAGCTATTAA
AGATATGGGAGAAGTGATTTCCCATGGTGTGGCGATAAAACCAGGAAAACCAGTGATTCTTGGTATCATTGATAAAACTC
CTGTCATCGGTATTCCCGGCTATCCGGTATCTGCTGTGCTTGCCATGGAGTTATTCGTTAAACCTTTGCTGTATAAATGG
CAAAACAAATCGGTACCCAAACAGGAAGAAATAACGGCTAAAATATCTAGGAGGGTAGTATCTTCTTTTAATGCCCAAGA
GTACCTCAGAGTGAAAGTTGGAAAAGTAGGGGATAAGTTTGTAGCGACTCCTTTAGGAAGAGGAGCTAGTATGATCATGT
CTCTGGTTAAATCCGATGGTATGATTGTAATTCCCCAGATGCGAGAAGGTTTGGAAAAAGGTGAAGAGATAGATGTCAAG
CTCCACAGGTCAAAAGAAAATATCGAAAGTACAATTGTAGGAATAGGAAGTCATGATATCTCCTTAGACATTTTATCCAA
TGAACTGTCCAAAAGGTACCCGCCTTATACTTTATCTTCAGCCCATGTCGGTAGCATGGGTGGGCTTATGGCTTTAAAAC
GTGGTGAGGCTCATATGGCAGGAGTACACCTGTTAGACCCAGAAACTGGAGAATACAATATCCCTCATATAAAAAAATAC
CTGTCCGATCAAGATATTATACTGGTTAATTTAGCTTATAGAGAACAAGGATTATTGGTAGCTAAGGATAATCCCAAGAA
CATTTACGGCCTGGAGGATTTAAAAAGAGAAGATGTAAAAATGGTTAATCGTCAAAAAGGGGCAGGCACTAGAATATTAC
TTGATTATAAGTTAGAGGAACTAGGCATCTCTTCTGAACAACTTACAGGTTATGATAGAGAGGAAGTTAATCACCTATCT
GTGGCAGCTGCTGTCAATGGAGGTACTGCGGATTGCGGTCTAGGAATTAGAGCAGCTGCAGAAGCTTTAGATTTGGACTT
TATACCTGTATCCAAAGAACGTTATGACATCGCAATTCCTCGTGATTTTTGGGATTGGGAAGGTATCCAACATATACTGA
AGGTGATTAGAAGTGAGGAGTTCAAGCACTCTATTGATGAATTGTCGGGATATGATCTATCTGCAAGTGGTGAGATATTA
CACTGTTAA

Upstream 100 bases:

>100_bases
TGTCGAAGCTGATGGATTGGTGCGCATTCCCCAAAACACTGAAGGTTATTCTCAAGGTGAAATAATAGAAGTGATCAAGT
GTTAATGAGAGGTGATGAAC

Downstream 100 bases:

>100_bases
GTGAGGTGAATGGGATGACTTTGTATAAAGCAGGGATAATTACTGCTAGTGATAGTGGTGCTCAAGGAAAACGCGTTGAT
GAGAGTGGCAAGCTATTAAA

Product: molybdenum cofactor synthesis domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MKKNKKRKVYLDNTPLDEALETFFNALSEVEADTLAGETILTENAHGRITKEPVFAKVSSPHYHASAMDGIAVDSKKTQG
ASLRNPKILTTPQDAELVDTGSPIPHDKNAVIMIEDVDWAGRNEVEIVESVAPWQHVRTIGEDLVATELIVPAGQKLRPV
DIGAILAGGVTEVTVEPKPRVAVVPTGTELVEPGERLKPGDVVEFNSRVLSGLVSQWGGKPSKEDKLPDDYDLIVETIKS
LLPQNDLIIVNAGSSAGAQDYTYQAIKDMGEVISHGVAIKPGKPVILGIIDKTPVIGIPGYPVSAVLAMELFVKPLLYKW
QNKSVPKQEEITAKISRRVVSSFNAQEYLRVKVGKVGDKFVATPLGRGASMIMSLVKSDGMIVIPQMREGLEKGEEIDVK
LHRSKENIESTIVGIGSHDISLDILSNELSKRYPPYTLSSAHVGSMGGLMALKRGEAHMAGVHLLDPETGEYNIPHIKKY
LSDQDIILVNLAYREQGLLVAKDNPKNIYGLEDLKREDVKMVNRQKGAGTRILLDYKLEELGISSEQLTGYDREEVNHLS
VAAAVNGGTADCGLGIRAAAEALDLDFIPVSKERYDIAIPRDFWDWEGIQHILKVIRSEEFKHSIDELSGYDLSASGEIL
HC

Sequences:

>Translated_642_residues
MKKNKKRKVYLDNTPLDEALETFFNALSEVEADTLAGETILTENAHGRITKEPVFAKVSSPHYHASAMDGIAVDSKKTQG
ASLRNPKILTTPQDAELVDTGSPIPHDKNAVIMIEDVDWAGRNEVEIVESVAPWQHVRTIGEDLVATELIVPAGQKLRPV
DIGAILAGGVTEVTVEPKPRVAVVPTGTELVEPGERLKPGDVVEFNSRVLSGLVSQWGGKPSKEDKLPDDYDLIVETIKS
LLPQNDLIIVNAGSSAGAQDYTYQAIKDMGEVISHGVAIKPGKPVILGIIDKTPVIGIPGYPVSAVLAMELFVKPLLYKW
QNKSVPKQEEITAKISRRVVSSFNAQEYLRVKVGKVGDKFVATPLGRGASMIMSLVKSDGMIVIPQMREGLEKGEEIDVK
LHRSKENIESTIVGIGSHDISLDILSNELSKRYPPYTLSSAHVGSMGGLMALKRGEAHMAGVHLLDPETGEYNIPHIKKY
LSDQDIILVNLAYREQGLLVAKDNPKNIYGLEDLKREDVKMVNRQKGAGTRILLDYKLEELGISSEQLTGYDREEVNHLS
VAAAVNGGTADCGLGIRAAAEALDLDFIPVSKERYDIAIPRDFWDWEGIQHILKVIRSEEFKHSIDELSGYDLSASGEIL
HC
>Mature_642_residues
MKKNKKRKVYLDNTPLDEALETFFNALSEVEADTLAGETILTENAHGRITKEPVFAKVSSPHYHASAMDGIAVDSKKTQG
ASLRNPKILTTPQDAELVDTGSPIPHDKNAVIMIEDVDWAGRNEVEIVESVAPWQHVRTIGEDLVATELIVPAGQKLRPV
DIGAILAGGVTEVTVEPKPRVAVVPTGTELVEPGERLKPGDVVEFNSRVLSGLVSQWGGKPSKEDKLPDDYDLIVETIKS
LLPQNDLIIVNAGSSAGAQDYTYQAIKDMGEVISHGVAIKPGKPVILGIIDKTPVIGIPGYPVSAVLAMELFVKPLLYKW
QNKSVPKQEEITAKISRRVVSSFNAQEYLRVKVGKVGDKFVATPLGRGASMIMSLVKSDGMIVIPQMREGLEKGEEIDVK
LHRSKENIESTIVGIGSHDISLDILSNELSKRYPPYTLSSAHVGSMGGLMALKRGEAHMAGVHLLDPETGEYNIPHIKKY
LSDQDIILVNLAYREQGLLVAKDNPKNIYGLEDLKREDVKMVNRQKGAGTRILLDYKLEELGISSEQLTGYDREEVNHLS
VAAAVNGGTADCGLGIRAAAEALDLDFIPVSKERYDIAIPRDFWDWEGIQHILKVIRSEEFKHSIDELSGYDLSASGEIL
HC

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=428, Percent_Identity=28.7383177570093, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI66932975, Length=428, Percent_Identity=28.7383177570093, Blast_Score=144, Evalue=3e-34,
Organism=Escherichia coli, GI1787049, Length=319, Percent_Identity=30.7210031347962, Blast_Score=132, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI25147659, Length=338, Percent_Identity=28.1065088757396, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17136978, Length=353, Percent_Identity=27.7620396600567, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24638841, Length=353, Percent_Identity=27.7620396600567, Blast_Score=114, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 70210; Mature: 70210

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNKKRKVYLDNTPLDEALETFFNALSEVEADTLAGETILTENAHGRITKEPVFAKVSS
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEECCCEEEEECC
PHYHASAMDGIAVDSKKTQGASLRNPKILTTPQDAELVDTGSPIPHDKNAVIMIEDVDWA
CCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCCCCCEEEEECCCCC
GRNEVEIVESVAPWQHVRTIGEDLVATELIVPAGQKLRPVDIGAILAGGVTEVTVEPKPR
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHEEECCCEEEEECCCCC
VAVVPTGTELVEPGERLKPGDVVEFNSRVLSGLVSQWGGKPSKEDKLPDDYDLIVETIKS
EEEEECCHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
LLPQNDLIIVNAGSSAGAQDYTYQAIKDMGEVISHGVAIKPGKPVILGIIDKTPVIGIPG
HCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECCCCEEECCC
YPVSAVLAMELFVKPLLYKWQNKSVPKQEEITAKISRRVVSSFNAQEYLRVKVGKVGDKF
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCE
VATPLGRGASMIMSLVKSDGMIVIPQMREGLEKGEEIDVKLHRSKENIESTIVGIGSHDI
EECCCCCCHHHHHHHHHCCCEEEEHHHHHHHCCCCEEEEEEECCHHCCHHEEEECCCCCE
SLDILSNELSKRYPPYTLSSAHVGSMGGLMALKRGEAHMAGVHLLDPETGEYNIPHIKKY
EEHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEECEEEEECCCCCCCCCHHHHHH
LSDQDIILVNLAYREQGLLVAKDNPKNIYGLEDLKREDVKMVNRQKGAGTRILLDYKLEE
CCCCCEEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEHHH
LGISSEQLTGYDREEVNHLSVAAAVNGGTADCGLGIRAAAEALDLDFIPVSKERYDIAIP
HCCCHHHHCCCCHHHCCEEEEEEEECCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEECC
RDFWDWEGIQHILKVIRSEEFKHSIDELSGYDLSASGEILHC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEC
>Mature Secondary Structure
MKKNKKRKVYLDNTPLDEALETFFNALSEVEADTLAGETILTENAHGRITKEPVFAKVSS
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEECCCEEEEECC
PHYHASAMDGIAVDSKKTQGASLRNPKILTTPQDAELVDTGSPIPHDKNAVIMIEDVDWA
CCCCCCCCCCEEECCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCCCCCEEEEECCCCC
GRNEVEIVESVAPWQHVRTIGEDLVATELIVPAGQKLRPVDIGAILAGGVTEVTVEPKPR
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHEEECCCEEEEECCCCC
VAVVPTGTELVEPGERLKPGDVVEFNSRVLSGLVSQWGGKPSKEDKLPDDYDLIVETIKS
EEEEECCHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
LLPQNDLIIVNAGSSAGAQDYTYQAIKDMGEVISHGVAIKPGKPVILGIIDKTPVIGIPG
HCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECCCCEEECCC
YPVSAVLAMELFVKPLLYKWQNKSVPKQEEITAKISRRVVSSFNAQEYLRVKVGKVGDKF
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCE
VATPLGRGASMIMSLVKSDGMIVIPQMREGLEKGEEIDVKLHRSKENIESTIVGIGSHDI
EECCCCCCHHHHHHHHHCCCEEEEHHHHHHHCCCCEEEEEEECCHHCCHHEEEECCCCCE
SLDILSNELSKRYPPYTLSSAHVGSMGGLMALKRGEAHMAGVHLLDPETGEYNIPHIKKY
EEHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCEECEEEEECCCCCCCCCHHHHHH
LSDQDIILVNLAYREQGLLVAKDNPKNIYGLEDLKREDVKMVNRQKGAGTRILLDYKLEE
CCCCCEEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEHHH
LGISSEQLTGYDREEVNHLSVAAAVNGGTADCGLGIRAAAEALDLDFIPVSKERYDIAIP
HCCCHHHHCCCCHHHCCEEEEEEEECCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEECC
RDFWDWEGIQHILKVIRSEEFKHSIDELSGYDLSASGEILHC
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]