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The map label for this gene is moeA [C]

Identifier: 188585085

GI number: 188585085

Start: 469414

End: 470655

Strand: Direct

Name: moeA [C]

Synonym: Nther_0446

Alternate gene names: 188585085

Gene position: 469414-470655 (Clockwise)

Preceding gene: 188585084

Following gene: 188585086

Centisome position: 14.83

GC content: 39.05

Gene sequence:

>1242_bases
TTGTTCCAGGTCATATCAGTAGAAGAAGCTATTTCGAAAGTCACTGCAAATATAGATAAGTATTTTGAAGGTCTTGAGTC
AGAGCAAATCAAGTCAGAAAATGCCTTAGGAAGGGTGTTAGCTCAAGATATAAAAGCTCCCAGTGACTTACCTCCTTTTT
CTAGGTCCACCGTAGATGGTTATGTAGTCAAGGCTAAAGATACCTTTGGTGTTTCGGAATCTTTACCTGCGGTGTTATTT
AATAAAGGTAAGATAGAAATGGGAGAAGAGCCCCATAAAACTTTGAATCAAGATGAAACTATGGAAATTTCTACAGGAGG
TATGCTTCCTTCAGGTGGAGATGCTGTAGTTATGCTTGAGGATGTGGAGACCTTCGATGATAATTCTATCATTGTTAACA
AATCCGTAGCTAGAGGCGAAAATGTCATCGAAAAAGGGGAAGATACTCAAGAAGGTGTCACTGTATTACGAAAAGGGCAT
AGACTAAGATCTCAAGATATAGGTGCTTTAGCTGCCTTAGGAATTTTAGAAATATCTGTTTATCATCAACCTGTAATAGG
AATAATCTCAACGGGGGATGAATTAATACCACCTGAAAAACCTCTATCTGGCGGTAAAATTAGAGATATCAATTCCTGGG
CTTTAAGTGCTGCTGTCACAAAACTAGGTGGAAAACCTATACAGTACGGAATAATACAAGATGAGCCACAATATTTTCGA
GAAAGCTTTGACAAGGCAGTTACTCAATGTGATATGGTGATTTTATCTGGGGGCAGTTCTGTTGGCACTCGTGATCTGAC
AGCTAAGACCATAGACTTGGGAGAACCAGGCATTATTTTTCATGGTGTTTCAGTTAAACCTGGTAAGCCAACTATATTTG
GAATCGTTGATAATGTCCCTGTATTTGGCTTATCGGGAAATCCCGTCAGCGCTATGGTTACCTTTGATTTATTTGTTAAA
CCTGCCATTTATGGAATATCGGGTGTTGCTAATTTTGGTAGAGACTGGTTTGAAAATATAACTAAGGCCAGATTGGCTCG
TAATATATCTTCAAAAGGTGGTAGAGAAGACTTTGTCAGAGTTTCATTAAAAGGTGAACCAGGAGAGTTTCCGGAAGCTT
TCCCAGTGTTAGGAGAATCGGGTTTAATTTTTACACTTGTCGAAGCTGATGGATTGGTGCGCATTCCCCAAAACACTGAA
GGTTATTCTCAAGGTGAAATAATAGAAGTGATCAAGTGTTAA

Upstream 100 bases:

>100_bases
GGGAAGTTGCTGATGAATTAAAATTAAAAATTGTTAAATGTCAGCTAGGTTGTTTTTAATAACAAGTAGTTAATGGATTA
AGTTTAAGGAGTGGATACAA

Downstream 100 bases:

>100_bases
TGAGAGGTGATGAACATGAAAAAAAATAAAAAAAGGAAAGTTTATCTAGATAACACCCCTTTAGATGAGGCCTTAGAGAC
TTTTTTCAATGCTCTTTCTG

Product: molybdenum cofactor synthesis domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MFQVISVEEAISKVTANIDKYFEGLESEQIKSENALGRVLAQDIKAPSDLPPFSRSTVDGYVVKAKDTFGVSESLPAVLF
NKGKIEMGEEPHKTLNQDETMEISTGGMLPSGGDAVVMLEDVETFDDNSIIVNKSVARGENVIEKGEDTQEGVTVLRKGH
RLRSQDIGALAALGILEISVYHQPVIGIISTGDELIPPEKPLSGGKIRDINSWALSAAVTKLGGKPIQYGIIQDEPQYFR
ESFDKAVTQCDMVILSGGSSVGTRDLTAKTIDLGEPGIIFHGVSVKPGKPTIFGIVDNVPVFGLSGNPVSAMVTFDLFVK
PAIYGISGVANFGRDWFENITKARLARNISSKGGREDFVRVSLKGEPGEFPEAFPVLGESGLIFTLVEADGLVRIPQNTE
GYSQGEIIEVIKC

Sequences:

>Translated_413_residues
MFQVISVEEAISKVTANIDKYFEGLESEQIKSENALGRVLAQDIKAPSDLPPFSRSTVDGYVVKAKDTFGVSESLPAVLF
NKGKIEMGEEPHKTLNQDETMEISTGGMLPSGGDAVVMLEDVETFDDNSIIVNKSVARGENVIEKGEDTQEGVTVLRKGH
RLRSQDIGALAALGILEISVYHQPVIGIISTGDELIPPEKPLSGGKIRDINSWALSAAVTKLGGKPIQYGIIQDEPQYFR
ESFDKAVTQCDMVILSGGSSVGTRDLTAKTIDLGEPGIIFHGVSVKPGKPTIFGIVDNVPVFGLSGNPVSAMVTFDLFVK
PAIYGISGVANFGRDWFENITKARLARNISSKGGREDFVRVSLKGEPGEFPEAFPVLGESGLIFTLVEADGLVRIPQNTE
GYSQGEIIEVIKC
>Mature_413_residues
MFQVISVEEAISKVTANIDKYFEGLESEQIKSENALGRVLAQDIKAPSDLPPFSRSTVDGYVVKAKDTFGVSESLPAVLF
NKGKIEMGEEPHKTLNQDETMEISTGGMLPSGGDAVVMLEDVETFDDNSIIVNKSVARGENVIEKGEDTQEGVTVLRKGH
RLRSQDIGALAALGILEISVYHQPVIGIISTGDELIPPEKPLSGGKIRDINSWALSAAVTKLGGKPIQYGIIQDEPQYFR
ESFDKAVTQCDMVILSGGSSVGTRDLTAKTIDLGEPGIIFHGVSVKPGKPTIFGIVDNVPVFGLSGNPVSAMVTFDLFVK
PAIYGISGVANFGRDWFENITKARLARNISSKGGREDFVRVSLKGEPGEFPEAFPVLGESGLIFTLVEADGLVRIPQNTE
GYSQGEIIEVIKC

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=407, Percent_Identity=35.3808353808354, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI66932975, Length=407, Percent_Identity=35.3808353808354, Blast_Score=204, Evalue=9e-53,
Organism=Escherichia coli, GI1787049, Length=363, Percent_Identity=35.8126721763085, Blast_Score=194, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI25147659, Length=374, Percent_Identity=32.3529411764706, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=367, Percent_Identity=26.9754768392371, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136978, Length=386, Percent_Identity=30.3108808290155, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24638841, Length=386, Percent_Identity=30.3108808290155, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44419; Mature: 44419

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQVISVEEAISKVTANIDKYFEGLESEQIKSENALGRVLAQDIKAPSDLPPFSRSTVDG
CEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
YVVKAKDTFGVSESLPAVLFNKGKIEMGEEPHKTLNQDETMEISTGGMLPSGGDAVVMLE
EEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCEEEEEE
DVETFDDNSIIVNKSVARGENVIEKGEDTQEGVTVLRKGHRLRSQDIGALAALGILEISV
CCCCCCCCCEEEECCHHCCCHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEE
YHQPVIGIISTGDELIPPEKPLSGGKIRDINSWALSAAVTKLGGKPIQYGIIQDEPQYFR
ECCCEEEEEECCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCEEEEEECCCHHHHH
ESFDKAVTQCDMVILSGGSSVGTRDLTAKTIDLGEPGIIFHGVSVKPGKPTIFGIVDNVP
HHHHHHHHHEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCEEEEEECCCE
VFGLSGNPVSAMVTFDLFVKPAIYGISGVANFGRDWFENITKARLARNISSKGGREDFVR
EEEECCCCEEEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
VSLKGEPGEFPEAFPVLGESGLIFTLVEADGLVRIPQNTEGYSQGEIIEVIKC
EEECCCCCCCCCHHHCCCCCCCEEEEEECCCEEECCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MFQVISVEEAISKVTANIDKYFEGLESEQIKSENALGRVLAQDIKAPSDLPPFSRSTVDG
CEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
YVVKAKDTFGVSESLPAVLFNKGKIEMGEEPHKTLNQDETMEISTGGMLPSGGDAVVMLE
EEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCEEEEEE
DVETFDDNSIIVNKSVARGENVIEKGEDTQEGVTVLRKGHRLRSQDIGALAALGILEISV
CCCCCCCCCEEEECCHHCCCHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHEEEE
YHQPVIGIISTGDELIPPEKPLSGGKIRDINSWALSAAVTKLGGKPIQYGIIQDEPQYFR
ECCCEEEEEECCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHCCCCEEEEEECCCHHHHH
ESFDKAVTQCDMVILSGGSSVGTRDLTAKTIDLGEPGIIFHGVSVKPGKPTIFGIVDNVP
HHHHHHHHHEEEEEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCEEEEEECCCE
VFGLSGNPVSAMVTFDLFVKPAIYGISGVANFGRDWFENITKARLARNISSKGGREDFVR
EEEECCCCEEEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
VSLKGEPGEFPEAFPVLGESGLIFTLVEADGLVRIPQNTEGYSQGEIIEVIKC
EEECCCCCCCCCHHHCCCCCCCEEEEEECCCEEECCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]