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The map label for this gene is adk

Identifier: 188584857

GI number: 188584857

Start: 230246

End: 230890

Strand: Direct

Name: adk

Synonym: Nther_0215

Alternate gene names: 188584857

Gene position: 230246-230890 (Clockwise)

Preceding gene: 188584856

Following gene: 188584858

Centisome position: 7.27

GC content: 40.93

Gene sequence:

>645_bases
ATGCGCATAATTTTAATGGGACCTCCAGGAGCAGGAAAAGGAACACAAGCTGAAAAACTATCAAAAGAATTGGATGTACC
ACACATTGCAACAGGTGACATTTTTCGAAAAGCTGTATCCGAAGGAACTGAACTTGGCAAAGAAGCTAAATCTTACATGG
ATGCTGGACAGTTGGTTCCTGACGATGTTGTAATAGGAATTGTTGAAGAAAGATTAAAAAAGCCGGATTGTCATGAAGGT
TTTATATTAGATGGTTTCCCTCGTACAGTGACTCAGGCTGAAGCCCTTGATAAAGTGTTGAGTGACAACCCCTTGACAGC
GGCAGTATATATCGATGTATCAAAGGATGAATTGATAGATAGACTTTCAGGTCGTAGGATTTGTAGAAAATGCGGTAAAA
GTTATCATATTAAGTTTAATCCTCCTCAAGTTCGGGGAGTCTGTGATGAGGACGAAGGCGAACTATATCAGAGAGACGAC
GATAATGAGGAAACGGCAAAAGAGCGACTGGAAGTTTATTTAGAAAATACCCAACCCCTGGTGGAGTATTACCAGGATCG
AGGGATTTTAAAGAAAATTGACGGTACTAAGTCGCCTGAAGAGGTCTTCCGCGATATACTAAAGGCAGTGCAAGCAAAAC
AATGA

Upstream 100 bases:

>100_bases
GTAGGTGTGGCTTTGGAGACAATGAAGCAAATCGAGAGCCAGATGTTGATGAGACACTATCAAGGCTTTATGAAGAAGTG
ATATTTTAGGGGGGTAAGAA

Downstream 100 bases:

>100_bases
TTATTAAAAAAAGTAACCAAGAGCTAGAATTGATGAGAGTAGCAGGAAGAATCGTAGCAGAAACCCATCAAAAAGTTGCT
GAAGCAATTACTCCAGGCAT

Product: Adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIILMGPPGAGKGTQAEKLSKELDVPHIATGDIFRKAVSEGTELGKEAKSYMDAGQLVPDDVVIGIVEERLKKPDCHEG
FILDGFPRTVTQAEALDKVLSDNPLTAAVYIDVSKDELIDRLSGRRICRKCGKSYHIKFNPPQVRGVCDEDEGELYQRDD
DNEETAKERLEVYLENTQPLVEYYQDRGILKKIDGTKSPEEVFRDILKAVQAKQ

Sequences:

>Translated_214_residues
MRIILMGPPGAGKGTQAEKLSKELDVPHIATGDIFRKAVSEGTELGKEAKSYMDAGQLVPDDVVIGIVEERLKKPDCHEG
FILDGFPRTVTQAEALDKVLSDNPLTAAVYIDVSKDELIDRLSGRRICRKCGKSYHIKFNPPQVRGVCDEDEGELYQRDD
DNEETAKERLEVYLENTQPLVEYYQDRGILKKIDGTKSPEEVFRDILKAVQAKQ
>Mature_214_residues
MRIILMGPPGAGKGTQAEKLSKELDVPHIATGDIFRKAVSEGTELGKEAKSYMDAGQLVPDDVVIGIVEERLKKPDCHEG
FILDGFPRTVTQAEALDKVLSDNPLTAAVYIDVSKDELIDRLSGRRICRKCGKSYHIKFNPPQVRGVCDEDEGELYQRDD
DNEETAKERLEVYLENTQPLVEYYQDRGILKKIDGTKSPEEVFRDILKAVQAKQ

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=47.196261682243, Blast_Score=197, Evalue=5e-51,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=47.196261682243, Blast_Score=197, Evalue=6e-51,
Organism=Homo sapiens, GI19923437, Length=213, Percent_Identity=36.150234741784, Blast_Score=157, Evalue=7e-39,
Organism=Homo sapiens, GI310110345, Length=220, Percent_Identity=33.1818181818182, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI53832003, Length=220, Percent_Identity=33.1818181818182, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI8051579, Length=220, Percent_Identity=33.1818181818182, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI53832001, Length=220, Percent_Identity=33.1818181818182, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI4502011, Length=211, Percent_Identity=32.7014218009479, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI22749187, Length=206, Percent_Identity=29.6116504854369, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI28144897, Length=211, Percent_Identity=28.436018957346, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI28144899, Length=211, Percent_Identity=28.436018957346, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI7706497, Length=212, Percent_Identity=25, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=47.4178403755869, Blast_Score=189, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17552384, Length=205, Percent_Identity=46.3414634146341, Blast_Score=185, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17537943, Length=214, Percent_Identity=33.6448598130841, Blast_Score=113, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17567503, Length=203, Percent_Identity=30.0492610837438, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=212, Percent_Identity=26.4150943396226, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320432, Length=211, Percent_Identity=45.0236966824645, Blast_Score=191, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6321018, Length=207, Percent_Identity=37.1980676328502, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322828, Length=213, Percent_Identity=26.7605633802817, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=45.7943925233645, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI17737899, Length=200, Percent_Identity=37.5, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24645822, Length=200, Percent_Identity=37.5, Blast_Score=140, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24663208, Length=209, Percent_Identity=25.3588516746411, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17647141, Length=209, Percent_Identity=25.3588516746411, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=26.7605633802817, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=26.7605633802817, Blast_Score=94, Evalue=5e-20,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_NATTJ (B2A4G2)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001916402.1
- ProteinModelPortal:   B2A4G2
- SMR:   B2A4G2
- GeneID:   6315962
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_0215
- HOGENOM:   HBG630208
- OMA:   APLLEFY
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- InterPro:   IPR001878
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- SMART:   SM00343
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23978; Mature: 23978

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILMGPPGAGKGTQAEKLSKELDVPHIATGDIFRKAVSEGTELGKEAKSYMDAGQLVP
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DDVVIGIVEERLKKPDCHEGFILDGFPRTVTQAEALDKVLSDNPLTAAVYIDVSKDELID
HHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHH
RLSGRRICRKCGKSYHIKFNPPQVRGVCDEDEGELYQRDDDNEETAKERLEVYLENTQPL
HHHHHHHHHHCCCCEEEEECCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHH
VEYYQDRGILKKIDGTKSPEEVFRDILKAVQAKQ
HHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIILMGPPGAGKGTQAEKLSKELDVPHIATGDIFRKAVSEGTELGKEAKSYMDAGQLVP
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DDVVIGIVEERLKKPDCHEGFILDGFPRTVTQAEALDKVLSDNPLTAAVYIDVSKDELID
HHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHH
RLSGRRICRKCGKSYHIKFNPPQVRGVCDEDEGELYQRDDDNEETAKERLEVYLENTQPL
HHHHHHHHHHCCCCEEEEECCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHH
VEYYQDRGILKKIDGTKSPEEVFRDILKAVQAKQ
HHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA