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The map label for this gene is map [H]

Identifier: 188584858

GI number: 188584858

Start: 230887

End: 231636

Strand: Direct

Name: map [H]

Synonym: Nther_0216

Alternate gene names: 188584858

Gene position: 230887-231636 (Clockwise)

Preceding gene: 188584857

Following gene: 188584859

Centisome position: 7.29

GC content: 39.33

Gene sequence:

>750_bases
ATGATTATTAAAAAAAGTAACCAAGAGCTAGAATTGATGAGAGTAGCAGGAAGAATCGTAGCAGAAACCCATCAAAAAGT
TGCTGAAGCAATTACTCCAGGCATAACCACTGTAGAATTGGATAAAATAGCGGAAGACTATATAAAAAGGCAAAATGCTC
ATCCCTCTTTTAAAGGCTACCACGGGTTTCCGGCGAGCATATGTGCTTCAATAAATCATGAAGTTGTGCACGGAATTCCT
GCCATTAAAAAATTGCAGGAAGGAGATATCATCAGTATAGATATTGGTGCTAATTATAAAGGTTATCATGGTGATGCAGC
AAAAACTTACAAAGTGGGAGCCGTCGATGGTCAACTAGAAGAGCTCATAGACGTAACAGAGCAATCACTGTTTAAGGGTA
TTGAGCAGGCGGTTCCTGGCAATAGATTGAGTGATATCTCCCATGCTGTAGAAAAACATGTAAACAATCATAATTTCTAT
GTAGTAAAAAAATATGTAGGACACGGAATAGGTAGTGCTATGCATGAAGCACCTGAAATACCTAACTTTGGGCCTCCTGG
AAAAGGACCTCGACTAAAAGCAGGGATGGTATTTGCCATCGAACCTATGGTAAATATAGGTACTTCTGAAGTTAAAACTT
TGGATGATCACTGGACGGTTATAACAGCGGATGAAAGCGCTTCGGCTCACTTTGAACATACAGTGGCCATAACTGATTCA
GAACCAGAAATTTTAACAAAACTGACCTAA

Upstream 100 bases:

>100_bases
TGGAGTATTACCAGGATCGAGGGATTTTAAAGAAAATTGACGGTACTAAGTCGCCTGAAGAGGTCTTCCGCGATATACTA
AAGGCAGTGCAAGCAAAACA

Downstream 100 bases:

>100_bases
CAAGTGTAAGGGATCAGGGATTATTAATAGCGAGGGGACTTTCTCTCCAAATTGTTTAAGAAAGGAGAGGAATACTTTGC
AGAAATTACAGGTGGGCCAG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MIIKKSNQELELMRVAGRIVAETHQKVAEAITPGITTVELDKIAEDYIKRQNAHPSFKGYHGFPASICASINHEVVHGIP
AIKKLQEGDIISIDIGANYKGYHGDAAKTYKVGAVDGQLEELIDVTEQSLFKGIEQAVPGNRLSDISHAVEKHVNNHNFY
VVKKYVGHGIGSAMHEAPEIPNFGPPGKGPRLKAGMVFAIEPMVNIGTSEVKTLDDHWTVITADESASAHFEHTVAITDS
EPEILTKLT

Sequences:

>Translated_249_residues
MIIKKSNQELELMRVAGRIVAETHQKVAEAITPGITTVELDKIAEDYIKRQNAHPSFKGYHGFPASICASINHEVVHGIP
AIKKLQEGDIISIDIGANYKGYHGDAAKTYKVGAVDGQLEELIDVTEQSLFKGIEQAVPGNRLSDISHAVEKHVNNHNFY
VVKKYVGHGIGSAMHEAPEIPNFGPPGKGPRLKAGMVFAIEPMVNIGTSEVKTLDDHWTVITADESASAHFEHTVAITDS
EPEILTKLT
>Mature_249_residues
MIIKKSNQELELMRVAGRIVAETHQKVAEAITPGITTVELDKIAEDYIKRQNAHPSFKGYHGFPASICASINHEVVHGIP
AIKKLQEGDIISIDIGANYKGYHGDAAKTYKVGAVDGQLEELIDVTEQSLFKGIEQAVPGNRLSDISHAVEKHVNNHNFY
VVKKYVGHGIGSAMHEAPEIPNFGPPGKGPRLKAGMVFAIEPMVNIGTSEVKTLDDHWTVITADESASAHFEHTVAITDS
EPEILTKLT

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=242, Percent_Identity=38.8429752066116, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI40385867, Length=244, Percent_Identity=37.7049180327869, Blast_Score=170, Evalue=1e-42,
Organism=Escherichia coli, GI1786364, Length=244, Percent_Identity=43.8524590163934, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1789275, Length=152, Percent_Identity=26.9736842105263, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=243, Percent_Identity=38.2716049382716, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6323273, Length=241, Percent_Identity=38.1742738589212, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21355531, Length=241, Percent_Identity=39.4190871369295, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24583427, Length=245, Percent_Identity=38.7755102040816, Blast_Score=191, Evalue=5e-49,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27118; Mature: 27118

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKKSNQELELMRVAGRIVAETHQKVAEAITPGITTVELDKIAEDYIKRQNAHPSFKGY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCCCC
HGFPASICASINHEVVHGIPAIKKLQEGDIISIDIGANYKGYHGDAAKTYKVGAVDGQLE
CCCHHHHHHHCCHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCCHHHH
ELIDVTEQSLFKGIEQAVPGNRLSDISHAVEKHVNNHNFYVVKKYVGHGIGSAMHEAPEI
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHHHCCCHHHHHHHCCCC
PNFGPPGKGPRLKAGMVFAIEPMVNIGTSEVKTLDDHWTVITADESASAHFEHTVAITDS
CCCCCCCCCCCCCCCEEEEECCHHHCCCHHHEEECCCEEEEEECCCCCCCEEEEEEEECC
EPEILTKLT
CCHHHCCCC
>Mature Secondary Structure
MIIKKSNQELELMRVAGRIVAETHQKVAEAITPGITTVELDKIAEDYIKRQNAHPSFKGY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCCCC
HGFPASICASINHEVVHGIPAIKKLQEGDIISIDIGANYKGYHGDAAKTYKVGAVDGQLE
CCCHHHHHHHCCHHHHHCCHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCCHHHH
ELIDVTEQSLFKGIEQAVPGNRLSDISHAVEKHVNNHNFYVVKKYVGHGIGSAMHEAPEI
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEHHHHCCCHHHHHHHCCCC
PNFGPPGKGPRLKAGMVFAIEPMVNIGTSEVKTLDDHWTVITADESASAHFEHTVAITDS
CCCCCCCCCCCCCCCEEEEECCHHHCCCHHHEEECCCEEEEEECCCCCCCEEEEEEEECC
EPEILTKLT
CCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]