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The map label for this gene is thyX [H]

Identifier: 188584815

GI number: 188584815

Start: 197201

End: 197893

Strand: Direct

Name: thyX [H]

Synonym: Nther_0173

Alternate gene names: 188584815

Gene position: 197201-197893 (Clockwise)

Preceding gene: 188584814

Following gene: 188584816

Centisome position: 6.23

GC content: 34.05

Gene sequence:

>693_bases
ATGAAAGTTATTGATCCACAAGTTCTAATACCAGAGAAAGAAATGGATGAAGCCAAATTGAAAAAAATCGAAAGATATGC
CAGGGTTTGTTATAAATCCGAAGACAAAATGAAAGGGAATTATAATCAGAGCTTATTAGAGTTTTTGGTAGAACAGGGCC
ACGAATCAGTTATTGAACATGAAAAGGTTACTGTTATGATGATTATTGACAGGGGTTTATCCCATGAAATTGTGCGTCAC
CGCCTAGCTAGTTATAGTCAAGAATCCACAAGATACTGCAACTATCAAAAAGATAAGTTTGGAAATGAGATCACACTTAT
AAGACCGTATTTCTATTCTCATAGAGATAAAGAGTATCAGTTGTGGGAATCAAGCTGTCAAGAAATAGAACAAAAGTACT
TTGAATTACTTGAAACAGGTTCAACACCTCAGGAAGCCCGTTCAATTTTACCTAACTCACTTAAGACGGAAATTGTAGTT
ACTTTTAATATGAGGGAATGGAGACATTTCTTTAAATTAAGATGTGATAAGGCGGCCCACCCACAAGCTAGGCAAATTGC
TATTCCTGTGTTAAAAGAGTTTAAAAATAAATTCCCTGTCCTGTTTCAGGATATAGACTATGATAAATCTTTTGATCAAG
AACATTATGCTAGTGTAATATATACTGATGAAATGTTTCAACCTTTAAAGTAA

Upstream 100 bases:

>100_bases
GAATAGAAGAGCTGCTAATAAATGAAGTTAACAGGGAACTGTCAAATGAAGAATGTAAATAAAAACACCAAATATCTTTT
AAAGGGGAGGAGTTGATATA

Downstream 100 bases:

>100_bases
AGATTGTGAAATTTTTGTGCTAGACAAATGTTTGCCTGTTTTCAAAACAGTTTGTCAATGGCTTGTTATAACTTTAAATA
CTACGATTAACAGTAATTTT

Product: thymidylate synthase, flavin-dependent

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKVIDPQVLIPEKEMDEAKLKKIERYARVCYKSEDKMKGNYNQSLLEFLVEQGHESVIEHEKVTVMMIIDRGLSHEIVRH
RLASYSQESTRYCNYQKDKFGNEITLIRPYFYSHRDKEYQLWESSCQEIEQKYFELLETGSTPQEARSILPNSLKTEIVV
TFNMREWRHFFKLRCDKAAHPQARQIAIPVLKEFKNKFPVLFQDIDYDKSFDQEHYASVIYTDEMFQPLK

Sequences:

>Translated_230_residues
MKVIDPQVLIPEKEMDEAKLKKIERYARVCYKSEDKMKGNYNQSLLEFLVEQGHESVIEHEKVTVMMIIDRGLSHEIVRH
RLASYSQESTRYCNYQKDKFGNEITLIRPYFYSHRDKEYQLWESSCQEIEQKYFELLETGSTPQEARSILPNSLKTEIVV
TFNMREWRHFFKLRCDKAAHPQARQIAIPVLKEFKNKFPVLFQDIDYDKSFDQEHYASVIYTDEMFQPLK
>Mature_230_residues
MKVIDPQVLIPEKEMDEAKLKKIERYARVCYKSEDKMKGNYNQSLLEFLVEQGHESVIEHEKVTVMMIIDRGLSHEIVRH
RLASYSQESTRYCNYQKDKFGNEITLIRPYFYSHRDKEYQLWESSCQEIEQKYFELLETGSTPQEARSILPNSLKTEIVV
TFNMREWRHFFKLRCDKAAHPQARQIAIPVLKEFKNKFPVLFQDIDYDKSFDQEHYASVIYTDEMFQPLK

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 27567; Mature: 27567

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIDPQVLIPEKEMDEAKLKKIERYARVCYKSEDKMKGNYNQSLLEFLVEQGHESVIEH
CCCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHCCHHHHHHH
EKVTVMMIIDRGLSHEIVRHRLASYSQESTRYCNYQKDKFGNEITLIRPYFYSHRDKEYQ
CCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCHHHHCCCEEEEEECHHHCCCCCHHH
LWESSCQEIEQKYFELLETGSTPQEARSILPNSLKTEIVVTFNMREWRHFFKLRCDKAAH
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHCCCCCC
PQARQIAIPVLKEFKNKFPVLFQDIDYDKSFDQEHYASVIYTDEMFQPLK
CCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHEECHHHHCCCC
>Mature Secondary Structure
MKVIDPQVLIPEKEMDEAKLKKIERYARVCYKSEDKMKGNYNQSLLEFLVEQGHESVIEH
CCCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHCCHHHHHHH
EKVTVMMIIDRGLSHEIVRHRLASYSQESTRYCNYQKDKFGNEITLIRPYFYSHRDKEYQ
CCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCHHHHCCCEEEEEECHHHCCCCCHHH
LWESSCQEIEQKYFELLETGSTPQEARSILPNSLKTEIVVTFNMREWRHFFKLRCDKAAH
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHCCCCCC
PQARQIAIPVLKEFKNKFPVLFQDIDYDKSFDQEHYASVIYTDEMFQPLK
CCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHEECHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA