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The map label for this gene is ispD [H]

Identifier: 188584808

GI number: 188584808

Start: 189880

End: 190638

Strand: Direct

Name: ispD [H]

Synonym: Nther_0166

Alternate gene names: 188584808

Gene position: 189880-190638 (Clockwise)

Preceding gene: 188584807

Following gene: 188584809

Centisome position: 6.0

GC content: 37.55

Gene sequence:

>759_bases
TTGTGTAATTCAAACTTAAATGTTTCAGTGATTTTACCAGCAGGCGGTCAAGGGTCGAGAATGGGTCAGTCTATAAATAA
ACAGTACCTTAATTTGAGAGGTCAACCGATTTTGGCAAGAACATGGCGGGTGTTTACCCGCCTTCCTTGTGTTAAGGAAA
TTTTTTTAGTTGTAGCATCGGGAGAAGAAAGATTCTGTTGGGAAAATGTAGTCTACCCCTATAAAGATCTTGAAAATACT
GTTAATATCCAGGTCCTTTCAGGGGGTAAAGAACGTCAAGACTCTGTTTATGAAGGATTGAAACGGGTTTCTGAAGAAAG
CGACTATACAATAATTCATGATGGGGCTAGGCCTTTAATTACACAACAAAATATTGAAAACAGTCTGATTCAAGCTAAAG
AGTCAGGTGCCTCTATTGTCGCGGTCCCTGTAAAAAATACTATTAAAAGCTTGCAGTACCCATTAAAAGTCAAGAGTTTA
AGTAACGGAGATGAAGTTCCTAAAGTTAAAGAAACTCTTCCCAGAAATACCTTGATAGAAGTTCAAACTCCTCAAACCTT
TAAATCTACTTTGATTAAAGATGCATATCAGTGGGCGCTTCGACAAAACATTACAGCTACAGACGATTCTTCTTTAGTAG
AAAAAATGGGTCATCAGGTGTCTGTAGTTCAAGGAAGTTTTGAAAACATTAAAGTAACAACTCCAGAAGACCTGTTTATG
GCAGAAGAGATATTGAAAAAACGGGAGGAGCAAATATGA

Upstream 100 bases:

>100_bases
AAGTTATGGTAACAAGTGTACTACAAACAGCTGCAGGAAGAATGATATTTGCAAAGCCTAAATATCAATTGGATAAAAGT
CATGCATGAGGTGAAAAAGC

Downstream 100 bases:

>100_bases
GAATAGGACATGGAGTAGATGTACATAAATTGGTTAAAGGTGAAGACTTAGTTTTAGGTGGAGTTCAGATTCCATCAGAC
CTTGGCTTGAAAGGTCATTC

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MCNSNLNVSVILPAGGQGSRMGQSINKQYLNLRGQPILARTWRVFTRLPCVKEIFLVVASGEERFCWENVVYPYKDLENT
VNIQVLSGGKERQDSVYEGLKRVSEESDYTIIHDGARPLITQQNIENSLIQAKESGASIVAVPVKNTIKSLQYPLKVKSL
SNGDEVPKVKETLPRNTLIEVQTPQTFKSTLIKDAYQWALRQNITATDDSSLVEKMGHQVSVVQGSFENIKVTTPEDLFM
AEEILKKREEQI

Sequences:

>Translated_252_residues
MCNSNLNVSVILPAGGQGSRMGQSINKQYLNLRGQPILARTWRVFTRLPCVKEIFLVVASGEERFCWENVVYPYKDLENT
VNIQVLSGGKERQDSVYEGLKRVSEESDYTIIHDGARPLITQQNIENSLIQAKESGASIVAVPVKNTIKSLQYPLKVKSL
SNGDEVPKVKETLPRNTLIEVQTPQTFKSTLIKDAYQWALRQNITATDDSSLVEKMGHQVSVVQGSFENIKVTTPEDLFM
AEEILKKREEQI
>Mature_252_residues
MCNSNLNVSVILPAGGQGSRMGQSINKQYLNLRGQPILARTWRVFTRLPCVKEIFLVVASGEERFCWENVVYPYKDLENT
VNIQVLSGGKERQDSVYEGLKRVSEESDYTIIHDGARPLITQQNIENSLIQAKESGASIVAVPVKNTIKSLQYPLKVKSL
SNGDEVPKVKETLPRNTLIEVQTPQTFKSTLIKDAYQWALRQNITATDDSSLVEKMGHQVSVVQGSFENIKVTTPEDLFM
AEEILKKREEQI

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=254, Percent_Identity=27.5590551181102, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI157671913, Length=139, Percent_Identity=28.7769784172662, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789104, Length=252, Percent_Identity=33.3333333333333, Blast_Score=134, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 28342; Mature: 28342

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCNSNLNVSVILPAGGQGSRMGQSINKQYLNLRGQPILARTWRVFTRLPCVKEIFLVVAS
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHEEEEEC
GEERFCWENVVYPYKDLENTVNIQVLSGGKERQDSVYEGLKRVSEESDYTIIHDGARPLI
CCCCHHHHCCCCCHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCE
TQQNIENSLIQAKESGASIVAVPVKNTIKSLQYPLKVKSLSNGDEVPKVKETLPRNTLIE
EHHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCEEEECCCCCCCCCHHHHHCCCCCEEE
VQTPQTFKSTLIKDAYQWALRQNITATDDSSLVEKMGHQVSVVQGSFENIKVTTPEDLFM
EECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCCCEEEECCHHHHH
AEEILKKREEQI
HHHHHHHHHHCC
>Mature Secondary Structure
MCNSNLNVSVILPAGGQGSRMGQSINKQYLNLRGQPILARTWRVFTRLPCVKEIFLVVAS
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHEEEEEC
GEERFCWENVVYPYKDLENTVNIQVLSGGKERQDSVYEGLKRVSEESDYTIIHDGARPLI
CCCCHHHHCCCCCHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCE
TQQNIENSLIQAKESGASIVAVPVKNTIKSLQYPLKVKSLSNGDEVPKVKETLPRNTLIE
EHHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCEEEECCCCCCCCCHHHHHCCCCCEEE
VQTPQTFKSTLIKDAYQWALRQNITATDDSSLVEKMGHQVSVVQGSFENIKVTTPEDLFM
EECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEEECCCCCEEEECCHHHHH
AEEILKKREEQI
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA