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The map label for this gene is plsC [H]

Identifier: 188528136

GI number: 188528136

Start: 1352683

End: 1353405

Strand: Reverse

Name: plsC [H]

Synonym: HPSH_06975

Alternate gene names: 188528136

Gene position: 1353405-1352683 (Counterclockwise)

Preceding gene: 188528137

Following gene: 188528135

Centisome position: 84.14

GC content: 40.53

Gene sequence:

>723_bases
ATGAAGTCAAATAAAAAATCCAATCGTTTAAGAGCGATTTATAGAGCTTTAGTGATCGCTATAGGCTTAGCCGTTATCAT
TGTTTTCAATTATTTTAACCGCAAAAACAATAACGCCCGCTCTAGCCGTAGGGCTTGTTCGTGCTTTTTTCCCCTTACCG
GGGTTACTTTAGAAAAAATAGGCGCTTTTGATACGGACGCTAAACTCATTGTCCTAAACCACCAAAGCTTACTAGACATC
ATTTATTTAGAGGCCTACCACCCTAGCAATATTTGCTGGATCGCTAAAAAAGAGTTGGGCGAAATCCCTTTTTATGGGCA
TGCCCTAACGGATACGGGAATGATTTTAATTGACAGAGAGGATAAAAAGGGGATTGTGAGCCTTTTGAAAGCGTGTAAAG
AAAAATTAGATCAAAACCGCCCTTTAGTGATTTTCCCTGAAGGCACTAGAGGCAAAGGAGGGGAAAAATTCCTCCCTTTC
AAGCAAGGGGCTAAAATCATCGCCGAAAAATTCCAGCTCAAAATCCAGCCCATGGTGTTAATCAATTCCATTAAAATCTT
TAATTCCAAACCCCTAGAAGCCTATAAAGCCCGCACCCGTTTAGTCATGCTAGAAAGCTATACGCCCAATTTTAGCTCGC
CCACCTGGTATGAAGAATTACAAGAACGCATGCAAAAAGAGTATTTAAAACACTACCATGAATTAAACCCTAGCGAACCA
TGA

Upstream 100 bases:

>100_bases
GGGCTTTCTAAAAATGAAATGCCGATTAAAATTTTAGGTTCGCATGATGATTATTATAAAATCCTAACGCCGCATGAACA
AATAGGGTGGGTCAAAAAAG

Downstream 100 bases:

>100_bases
AACTTTTTGACTGCGCTCCTTTAAGTTTGGCTTGGCGGGAGTTTTTGCAAAGCGAATTTAAAAAGCCTTATTTTTTAGAA
ATAGAAAAACGTTACTTAGA

Product: 1-acyl-glycerol-3-phosphate acyltransferase (plsC)

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MKSNKKSNRLRAIYRALVIAIGLAVIIVFNYFNRKNNNARSSRRACSCFFPLTGVTLEKIGAFDTDAKLIVLNHQSLLDI
IYLEAYHPSNICWIAKKELGEIPFYGHALTDTGMILIDREDKKGIVSLLKACKEKLDQNRPLVIFPEGTRGKGGEKFLPF
KQGAKIIAEKFQLKIQPMVLINSIKIFNSKPLEAYKARTRLVMLESYTPNFSSPTWYEELQERMQKEYLKHYHELNPSEP

Sequences:

>Translated_240_residues
MKSNKKSNRLRAIYRALVIAIGLAVIIVFNYFNRKNNNARSSRRACSCFFPLTGVTLEKIGAFDTDAKLIVLNHQSLLDI
IYLEAYHPSNICWIAKKELGEIPFYGHALTDTGMILIDREDKKGIVSLLKACKEKLDQNRPLVIFPEGTRGKGGEKFLPF
KQGAKIIAEKFQLKIQPMVLINSIKIFNSKPLEAYKARTRLVMLESYTPNFSSPTWYEELQERMQKEYLKHYHELNPSEP
>Mature_240_residues
MKSNKKSNRLRAIYRALVIAIGLAVIIVFNYFNRKNNNARSSRRACSCFFPLTGVTLEKIGAFDTDAKLIVLNHQSLLDI
IYLEAYHPSNICWIAKKELGEIPFYGHALTDTGMILIDREDKKGIVSLLKACKEKLDQNRPLVIFPEGTRGKGGEKFLPF
KQGAKIIAEKFQLKIQPMVLINSIKIFNSKPLEAYKARTRLVMLESYTPNFSSPTWYEELQERMQKEYLKHYHELNPSEP

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=229, Percent_Identity=26.2008733624454, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI15100175, Length=229, Percent_Identity=26.2008733624454, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17564032, Length=136, Percent_Identity=33.0882352941176, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320151, Length=151, Percent_Identity=31.7880794701987, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281364648, Length=168, Percent_Identity=31.547619047619, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582856, Length=168, Percent_Identity=31.547619047619, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582854, Length=168, Percent_Identity=31.547619047619, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 27585; Mature: 27585

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNKKSNRLRAIYRALVIAIGLAVIIVFNYFNRKNNNARSSRRACSCFFPLTGVTLEKI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHEEEECCCCCCHHHHH
GAFDTDAKLIVLNHQSLLDIIYLEAYHPSNICWIAKKELGEIPFYGHALTDTGMILIDRE
CCCCCCCEEEEEECHHHEEEHEEEEECCCCEEEEEHHHCCCCCCCCEEECCCCEEEEECC
DKKGIVSLLKACKEKLDQNRPLVIFPEGTRGKGGEKFLPFKQGAKIIAEKFQLKIQPMVL
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEECEEEE
INSIKIFNSKPLEAYKARTRLVMLESYTPNFSSPTWYEELQERMQKEYLKHYHELNPSEP
EEEEEECCCCCHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKSNKKSNRLRAIYRALVIAIGLAVIIVFNYFNRKNNNARSSRRACSCFFPLTGVTLEKI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHEEEECCCCCCHHHHH
GAFDTDAKLIVLNHQSLLDIIYLEAYHPSNICWIAKKELGEIPFYGHALTDTGMILIDRE
CCCCCCCEEEEEECHHHEEEHEEEEECCCCEEEEEHHHCCCCCCCCEEECCCCEEEEECC
DKKGIVSLLKACKEKLDQNRPLVIFPEGTRGKGGEKFLPFKQGAKIIAEKFQLKIQPMVL
CCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEECEEEE
INSIKIFNSKPLEAYKARTRLVMLESYTPNFSSPTWYEELQERMQKEYLKHYHELNPSEP
EEEEEECCCCCHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]