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The map label for this gene is ung [H]

Identifier: 188528135

GI number: 188528135

Start: 1351985

End: 1352686

Strand: Reverse

Name: ung [H]

Synonym: HPSH_06970

Alternate gene names: 188528135

Gene position: 1352686-1351985 (Counterclockwise)

Preceding gene: 188528136

Following gene: 188528134

Centisome position: 84.09

GC content: 42.59

Gene sequence:

>702_bases
ATGAAACTTTTTGACTGCGCTCCTTTAAGTTTGGCTTGGCGGGAGTTTTTGCAAAGCGAATTTAAAAAGCCTTATTTTTT
AGAAATAGAAAAACGTTACTTAGAAGCTCTAAAAAGCCCTAAAACCATTTTCCCTAAAAGCTCTAATCTGTTTTATGCAC
TCAATCTAACGCCCCCTAGTGCGGTTAAAATCATCCTTTTAGGGCAAGATCCCTACCATTCCACCTACCTAAAAAATCAG
CAAGAATTGCCTGTGGCGATGGGTTTAAGCTTTAGCGTGGGAAAAAACGCCCCCATCCCCCCAAGCTTAAAAAATATTTT
TAAAGAATTGCATGCGAATTTAGGCGTGTCTGTGCCTTGTTGTGGGGATTTGAGCGCATGGGCTAAAAGGGGCATGCTGT
TGTTGAACGCCATTTTAAGCGTGGAAAAAAACCAAGCCGCTTCGCACAAACGCATCGGCTGGGAAGCTTTTAGCGATCAA
ATATTGATGCGCCTTTTTGAAGCCAACGCCCCCTTGATCGTGGTGTTATTAGGAAAGATCGCACAAAAAAAGATCGCTCT
AATCCCCAAAAACAAGCACATCATCATCACCGCCCCTCACCCTAGCCCCTTATCTAGGGGGTTTTTAGGGAGTGGGGTTT
TTACAAGCATCCAAAACGCCCACAGAGAGATTTATCATAAGGATTTTGATTTTAGTTTATGA

Upstream 100 bases:

>100_bases
ATACGCCCAATTTTAGCTCGCCCACCTGGTATGAAGAATTACAAGAACGCATGCAAAAAGAGTATTTAAAACACTACCAT
GAATTAAACCCTAGCGAACC

Downstream 100 bases:

>100_bases
TTGATGCTTAATGAGACAGAACCCCTTAAGAATACCTTTATTTAAGAGCGTTTGTGATAAAATGGTGATTTTTAAATAAA
GGGAAAACATGCCAATTAGA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKLFDCAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFYALNLTPPSAVKIILLGQDPYHSTYLKNQ
QELPVAMGLSFSVGKNAPIPPSLKNIFKELHANLGVSVPCCGDLSAWAKRGMLLLNAILSVEKNQAASHKRIGWEAFSDQ
ILMRLFEANAPLIVVLLGKIAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSIQNAHREIYHKDFDFSL

Sequences:

>Translated_233_residues
MKLFDCAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFYALNLTPPSAVKIILLGQDPYHSTYLKNQ
QELPVAMGLSFSVGKNAPIPPSLKNIFKELHANLGVSVPCCGDLSAWAKRGMLLLNAILSVEKNQAASHKRIGWEAFSDQ
ILMRLFEANAPLIVVLLGKIAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSIQNAHREIYHKDFDFSL
>Mature_233_residues
MKLFDCAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFYALNLTPPSAVKIILLGQDPYHSTYLKNQ
QELPVAMGLSFSVGKNAPIPPSLKNIFKELHANLGVSVPCCGDLSAWAKRGMLLLNAILSVEKNQAASHKRIGWEAFSDQ
ILMRLFEANAPLIVVLLGKIAQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSIQNAHREIYHKDFDFSL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=207, Percent_Identity=42.512077294686, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI6224979, Length=223, Percent_Identity=40.3587443946188, Blast_Score=155, Evalue=3e-38,
Organism=Escherichia coli, GI1788934, Length=208, Percent_Identity=40.3846153846154, Blast_Score=156, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17556304, Length=218, Percent_Identity=38.9908256880734, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323620, Length=226, Percent_Identity=37.6106194690265, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26084; Mature: 26084

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFDCAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFYALNLTPPS
CCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCC
AVKIILLGQDPYHSTYLKNQQELPVAMGLSFSVGKNAPIPPSLKNIFKELHANLGVSVPC
CEEEEEECCCCCCHHHHCCCCCCCEEECCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
CGDLSAWAKRGMLLLNAILSVEKNQAASHKRIGWEAFSDQILMRLFEANAPLIVVLLGKI
CCCHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEHHHH
AQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSIQNAHREIYHKDFDFSL
HHHHEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKLFDCAPLSLAWREFLQSEFKKPYFLEIEKRYLEALKSPKTIFPKSSNLFYALNLTPPS
CCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCCEECCCCCCEEEEEECCCCC
AVKIILLGQDPYHSTYLKNQQELPVAMGLSFSVGKNAPIPPSLKNIFKELHANLGVSVPC
CEEEEEECCCCCCHHHHCCCCCCCEEECCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
CGDLSAWAKRGMLLLNAILSVEKNQAASHKRIGWEAFSDQILMRLFEANAPLIVVLLGKI
CCCHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEHHHH
AQKKIALIPKNKHIIITAPHPSPLSRGFLGSGVFTSIQNAHREIYHKDFDFSL
HHHHEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA