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The map label for this gene is lldP [H]

Identifier: 188526944

GI number: 188526944

Start: 135348

End: 136997

Strand: Direct

Name: lldP [H]

Synonym: HPSH_00705

Alternate gene names: 188526944

Gene position: 135348-136997 (Clockwise)

Preceding gene: 188526939

Following gene: 188526945

Centisome position: 8.41

GC content: 43.52

Gene sequence:

>1650_bases
ATGGAATTTTATCAAGTCTATGACCCATTAGGCCATATTTGGCTGAGCGCTTTAGTGGCGCTATCGCCTATTGCGCTCTT
TTTTATTTCTCTTATTGTCTTTAAACTTAAAGGGTATAGCGCTGGGTTTTTAAGCTTAGTGCTTTCAATCATTATTGCGT
TATTTGTGTATAAAATGCCTGCTCAAATGGTGAGCGCGAGTTTTTTCTATGGCTTTCTTTATGGCTTGTGGCCGATCGCT
TGGATTGTGATCGCTGCGATTTTTCTTTACAACCTTTCAGTGAAATCCGGGTATTTTGAGATTTTAAAAGAAAGCATTTT
AACCCTAACGCCGGATCACCGGATTTTGGTGATTTTGATTGGCTTTTGTTTTGGCTCGTTTTTAGAAGGAGCGATCGGCT
TTGGAGGCCCGGTAGCGATCACAGCGGCGATTTTAGTCGGCCTTGGGCTAAACCCCTTATACGCTGCCGGATTATGCCTA
ATCGCTAACACCGCTCCTGTAGCTTTTGGCGCGGTGGGTATTCCTATTACGGCAATGGCTAGCGTGGTGGGTATCCCTGA
ATTAGAGATTTCTCAAATGGTGGGCAGGGTGTTACCCATTTTTTCCATTGGTATTCCTTTTTTCATCGTGTTTTTAATGG
ATGGTTTTAAAGGGATTAGAGAGACTTTTCCTGCAGTGGCCGTTACCGGGTTTAGTTTCGCTATCGCGCAATTTTTAAGC
TCTAATTATCTAGGGCCGCAACTCCCGGATATTATTTCAGCCTTAGTGTCATTGATCGCTACCACTTTGTTTTTAAAATT
CTGGCAGCCCAAACGCATTTTCACCAGCAATGGCAAAGAGCCCGCAATCAGCACAGAAAAACACCATATTTGTAAAGTGA
TTGTGGCGTGGATGCCTTTTGTGTTGCTCACTATTACGATTATCATATGGACGCAACCCTGGTTTAAAGCGCTCTTTAAA
GAAGGCGGGGCTTTGGCGTTTTCTAGCTTTGCGTTTGAATTCAATTCTATCAGTCAAAAGGTTTTTAAAACCGTTCCCAT
TGTTACTGAAGCGACCAATTTTCCTGTCGTGTTCAAATTCCCTCTAATTCTAACGACAGGCACTTCCATTTTTTTAGCCG
CTCTTTTAAGCGTGTTTTTGTTGCGCGTGAAAATCAGCGATGCGATAGGGGTGTTTGGGGCTACTTTAAAAGAAATGCGT
TTGCCGATTTTAACCATTGGCGTGGTTTTAGCGTTTGCGTATGTGGCTAATTATAGCGGCATGAGCGCCACGCTCGCTTT
AGCGTTAGCGGATACTGGGCATGTTTTCACTTTCTTTTCGCCTGTTGTAGGCTGGCTTGGGGTGTTTTTAACCGGAAGTG
ATACGAGTTCTAATCTTTTATTTGGCTCTTTGCAAATGCTCATCGCTACACAGCTTGGCTTGCCTGAAGTGCTTTTCTTA
GCGGCAAACACTTCAGGGGGTGTTGTGGGTAAAATGATAAGCCCTCAAAGTATCGCTATCGCTTGCGCGGCGGTGGGGTT
AGTGGGGAAAGAGAGCGAATTGTTCAGATTTACAGTAAAATATTCTATCGCTTTGGCGATCATTATGGGGATTGTCTTCA
CTCTTATTGCTTATGTCTTCCCCTTTATTATCCCGGTTACTCCTACTTAA

Upstream 100 bases:

>100_bases
ACAAACCCATTAAATTTGACTTAATATTAAATGCTACTTAAAATTAGTTTTTTCTTTTAAGTAAGATAAAAAAATACTTT
TAATTATTCAAGGAAAATTT

Downstream 100 bases:

>100_bases
TGGAGGGGGTTTAGGGGAGTAAGAGAATATTTTTTAAAGGGATTTTTAGTGTCAGAATTTCATCAAGTTTATGACCCTTT
GGGTAATATTTGGCTGAGCG

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MEFYQVYDPLGHIWLSALVALSPIALFFISLIVFKLKGYSAGFLSLVLSIIIALFVYKMPAQMVSASFFYGFLYGLWPIA
WIVIAAIFLYNLSVKSGYFEILKESILTLTPDHRILVILIGFCFGSFLEGAIGFGGPVAITAAILVGLGLNPLYAAGLCL
IANTAPVAFGAVGIPITAMASVVGIPELEISQMVGRVLPIFSIGIPFFIVFLMDGFKGIRETFPAVAVTGFSFAIAQFLS
SNYLGPQLPDIISALVSLIATTLFLKFWQPKRIFTSNGKEPAISTEKHHICKVIVAWMPFVLLTITIIIWTQPWFKALFK
EGGALAFSSFAFEFNSISQKVFKTVPIVTEATNFPVVFKFPLILTTGTSIFLAALLSVFLLRVKISDAIGVFGATLKEMR
LPILTIGVVLAFAYVANYSGMSATLALALADTGHVFTFFSPVVGWLGVFLTGSDTSSNLLFGSLQMLIATQLGLPEVLFL
AANTSGGVVGKMISPQSIAIACAAVGLVGKESELFRFTVKYSIALAIIMGIVFTLIAYVFPFIIPVTPT

Sequences:

>Translated_549_residues
MEFYQVYDPLGHIWLSALVALSPIALFFISLIVFKLKGYSAGFLSLVLSIIIALFVYKMPAQMVSASFFYGFLYGLWPIA
WIVIAAIFLYNLSVKSGYFEILKESILTLTPDHRILVILIGFCFGSFLEGAIGFGGPVAITAAILVGLGLNPLYAAGLCL
IANTAPVAFGAVGIPITAMASVVGIPELEISQMVGRVLPIFSIGIPFFIVFLMDGFKGIRETFPAVAVTGFSFAIAQFLS
SNYLGPQLPDIISALVSLIATTLFLKFWQPKRIFTSNGKEPAISTEKHHICKVIVAWMPFVLLTITIIIWTQPWFKALFK
EGGALAFSSFAFEFNSISQKVFKTVPIVTEATNFPVVFKFPLILTTGTSIFLAALLSVFLLRVKISDAIGVFGATLKEMR
LPILTIGVVLAFAYVANYSGMSATLALALADTGHVFTFFSPVVGWLGVFLTGSDTSSNLLFGSLQMLIATQLGLPEVLFL
AANTSGGVVGKMISPQSIAIACAAVGLVGKESELFRFTVKYSIALAIIMGIVFTLIAYVFPFIIPVTPT
>Mature_549_residues
MEFYQVYDPLGHIWLSALVALSPIALFFISLIVFKLKGYSAGFLSLVLSIIIALFVYKMPAQMVSASFFYGFLYGLWPIA
WIVIAAIFLYNLSVKSGYFEILKESILTLTPDHRILVILIGFCFGSFLEGAIGFGGPVAITAAILVGLGLNPLYAAGLCL
IANTAPVAFGAVGIPITAMASVVGIPELEISQMVGRVLPIFSIGIPFFIVFLMDGFKGIRETFPAVAVTGFSFAIAQFLS
SNYLGPQLPDIISALVSLIATTLFLKFWQPKRIFTSNGKEPAISTEKHHICKVIVAWMPFVLLTITIIIWTQPWFKALFK
EGGALAFSSFAFEFNSISQKVFKTVPIVTEATNFPVVFKFPLILTTGTSIFLAALLSVFLLRVKISDAIGVFGATLKEMR
LPILTIGVVLAFAYVANYSGMSATLALALADTGHVFTFFSPVVGWLGVFLTGSDTSSNLLFGSLQMLIATQLGLPEVLFL
AANTSGGVVGKMISPQSIAIACAAVGLVGKESELFRFTVKYSIALAIIMGIVFTLIAYVFPFIIPVTPT

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=548, Percent_Identity=58.2116788321168, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1789347, Length=553, Percent_Identity=55.5153707052441, Blast_Score=573, Evalue=1e-165,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 59190; Mature: 59190

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCCC
>Mature Secondary Structure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HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]