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The map label for this gene is lldP [H]

Identifier: 188526945

GI number: 188526945

Start: 137046

End: 138701

Strand: Direct

Name: lldP [H]

Synonym: HPSH_00710

Alternate gene names: 188526945

Gene position: 137046-138701 (Clockwise)

Preceding gene: 188526944

Following gene: 188526948

Centisome position: 8.52

GC content: 43.42

Gene sequence:

>1656_bases
GTGTCAGAATTTCATCAAGTTTATGACCCTTTGGGTAATATTTGGCTGAGCGCTCTTGTGGCCTTATTACCGATTTTGTT
ATTTTTCTTATCTTTAATGGTTTTTAAACTCAAAGGTTATGCGGCGGCCTTTTTGAGCGTGGTTCTGTCAGCCGTTATTG
CGGTTTTAGTGTATAAAATGCCTGTTAGCATGGCGGGTTCAAGCTTTCTTTATGGCTTCCTCTATGGCTTATGGCCGATC
GCTTGGATCATTATTGCGGCGATTTTTTTATACAAACTCAGCGTTAAATCCGGCTATTTTGAAATTTTAAAAGAAAGCGT
TCAGTCCATCACTTTAGATCACAGGATTTTAGTGATTTTGATTGGCTTTTGTTTTGGCTCGTTTTTAGAAGGAGCGATCG
GCTTTGGAGGGCCTATTGCCATTACAGCGGCGATTTTAGTGGGCTTAGGGTTAAGCCCCTTATACGCTGCCGGGTTATGT
TTGATTGCTAACACCGCTCCTGTAGCCTTTGGCGCAGTGGGTATCCCTATAAGCGCGATGGCGAGTGCGGTAGGGGTGCC
AGCGATTTTGATTTCAGCCATGACGGGTAAAATCCTCTTTTTTGTGAGCTTGTTCGTGCCGTTTTTCATTGTGTTTTTAA
TGGATGGCTTTAAGGGGATTAAAGAAACTTTTCCGGCCGTTTTTATCGCGGCTTTTTCTTTCGCTGGCGCGCAATTTTTA
AGCTCTAATTACTTGGGGCCAGAATTGCCTGGCATTATTTCAGCCCTTGTTTCACTCGTTGCAACGGCGCTTTTTTTGAA
ATTTTGGCAACCTAAAGTGATTTTTAGAAGCGACGGCAAAGCGGCTTCATTCACTAAGAGTAACCATCATATTTGTAAGA
TTTATGTCGCTTGGTCTCCTTTTGTGATTTTGGTTTTAGTGATTGTGTTATGGATACAGCCTTTTTTTAAGGCTTTATTT
GAAAAAGACGGCTTGTTAGCTTTTTCTAATTTTTATTTTGAATTCAATAACATCAGTAACCACATCTTTAAAAGCCCGCC
TTTTGTAGAATCCGATCAAAGTGCGAGTTTTCCGGTGGTGTTTAAATTTTTCTTAATCAACACGGTTGGCACTTCCATTT
TTTTGGCCGCTCTCATTAGCATGCTCGTTTTAAGGGTGCGAGTGAGCGATGCGCTGAGCGTTTTTGGCGAAACTCTAAAA
GAAATGCGCTACCCCATTCTTACCATCGGTTTAGTCTTAAGCTTTGCCTATGTGTCTAATTACAGCGGGATTTCTTCCAC
CCTGGCCTTAGCGCTCACCCATACGGGCTTAGCTTTCACCTTTTTCTCGCCCTTGATCGGGTGGGTGGGCGTGTTTTTAA
CCGGGAGCGATACGAGTTCTAATCTTTTATTTGGCTCTTTACAGCAACTCACCGCCCAACGATTGCACCTCCCTGAGATT
TTAACCCTAACGGCTAATACCGTGGGTGGCACTTTAGGCAAGATGATAAGCCCTCAAAGCATCGCTATCGCTTGCGCGGC
AGTGGGATTGGTCGGGAAAGAGAGCGATTTATTCAAATTCACGGTCAAATACTCCCTTATTTTTGTAGCGATCATGGGAG
TCGTGATTAGCGCGATTGCGTATTTGATCCCTGAAGTGGTGCCTGCGATAAAGTAG

Upstream 100 bases:

>100_bases
CACTCTTATTGCTTATGTCTTCCCCTTTATTATCCCGGTTACTCCTACTTAATGGAGGGGGTTTAGGGGAGTAAGAGAAT
ATTTTTTAAAGGGATTTTTA

Downstream 100 bases:

>100_bases
AGCCATTTTAGATTTGGCAGGGTTTAACCCCCAAATAAATTTTTTTGTTTTAAAAAATTCAAAATTTTAAGCGTCATAGA
GCTTATGGGTAAGGTTTCTA

Product: L-lactate permease (lctP)

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MSEFHQVYDPLGNIWLSALVALLPILLFFLSLMVFKLKGYAAAFLSVVLSAVIAVLVYKMPVSMAGSSFLYGFLYGLWPI
AWIIIAAIFLYKLSVKSGYFEILKESVQSITLDHRILVILIGFCFGSFLEGAIGFGGPIAITAAILVGLGLSPLYAAGLC
LIANTAPVAFGAVGIPISAMASAVGVPAILISAMTGKILFFVSLFVPFFIVFLMDGFKGIKETFPAVFIAAFSFAGAQFL
SSNYLGPELPGIISALVSLVATALFLKFWQPKVIFRSDGKAASFTKSNHHICKIYVAWSPFVILVLVIVLWIQPFFKALF
EKDGLLAFSNFYFEFNNISNHIFKSPPFVESDQSASFPVVFKFFLINTVGTSIFLAALISMLVLRVRVSDALSVFGETLK
EMRYPILTIGLVLSFAYVSNYSGISSTLALALTHTGLAFTFFSPLIGWVGVFLTGSDTSSNLLFGSLQQLTAQRLHLPEI
LTLTANTVGGTLGKMISPQSIAIACAAVGLVGKESDLFKFTVKYSLIFVAIMGVVISAIAYLIPEVVPAIK

Sequences:

>Translated_551_residues
MSEFHQVYDPLGNIWLSALVALLPILLFFLSLMVFKLKGYAAAFLSVVLSAVIAVLVYKMPVSMAGSSFLYGFLYGLWPI
AWIIIAAIFLYKLSVKSGYFEILKESVQSITLDHRILVILIGFCFGSFLEGAIGFGGPIAITAAILVGLGLSPLYAAGLC
LIANTAPVAFGAVGIPISAMASAVGVPAILISAMTGKILFFVSLFVPFFIVFLMDGFKGIKETFPAVFIAAFSFAGAQFL
SSNYLGPELPGIISALVSLVATALFLKFWQPKVIFRSDGKAASFTKSNHHICKIYVAWSPFVILVLVIVLWIQPFFKALF
EKDGLLAFSNFYFEFNNISNHIFKSPPFVESDQSASFPVVFKFFLINTVGTSIFLAALISMLVLRVRVSDALSVFGETLK
EMRYPILTIGLVLSFAYVSNYSGISSTLALALTHTGLAFTFFSPLIGWVGVFLTGSDTSSNLLFGSLQQLTAQRLHLPEI
LTLTANTVGGTLGKMISPQSIAIACAAVGLVGKESDLFKFTVKYSLIFVAIMGVVISAIAYLIPEVVPAIK
>Mature_550_residues
SEFHQVYDPLGNIWLSALVALLPILLFFLSLMVFKLKGYAAAFLSVVLSAVIAVLVYKMPVSMAGSSFLYGFLYGLWPIA
WIIIAAIFLYKLSVKSGYFEILKESVQSITLDHRILVILIGFCFGSFLEGAIGFGGPIAITAAILVGLGLSPLYAAGLCL
IANTAPVAFGAVGIPISAMASAVGVPAILISAMTGKILFFVSLFVPFFIVFLMDGFKGIKETFPAVFIAAFSFAGAQFLS
SNYLGPELPGIISALVSLVATALFLKFWQPKVIFRSDGKAASFTKSNHHICKIYVAWSPFVILVLVIVLWIQPFFKALFE
KDGLLAFSNFYFEFNNISNHIFKSPPFVESDQSASFPVVFKFFLINTVGTSIFLAALISMLVLRVRVSDALSVFGETLKE
MRYPILTIGLVLSFAYVSNYSGISSTLALALTHTGLAFTFFSPLIGWVGVFLTGSDTSSNLLFGSLQQLTAQRLHLPEIL
TLTANTVGGTLGKMISPQSIAIACAAVGLVGKESDLFKFTVKYSLIFVAIMGVVISAIAYLIPEVVPAIK

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=553, Percent_Identity=55.1537070524412, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1789347, Length=555, Percent_Identity=52.4324324324324, Blast_Score=545, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 59464; Mature: 59332

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCC
>Mature Secondary Structure 
SEFHQVYDPLGNIWLSALVALLPILLFFLSLMVFKLKGYAAAFLSVVLSAVIAVLVYKM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PVSMAGSSFLYGFLYGLWPIAWIIIAAIFLYKLSVKSGYFEILKESVQSITLDHRILVIL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IGFCFGSFLEGAIGFGGPIAITAAILVGLGLSPLYAAGLCLIANTAPVAFGAVGIPISAM
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHCCHHHEECCCCHHHCCCCCCHHHH
ASAVGVPAILISAMTGKILFFVSLFVPFFIVFLMDGFKGIKETFPAVFIAAFSFAGAQFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSNYLGPELPGIISALVSLVATALFLKFWQPKVIFRSDGKAASFTKSNHHICKIYVAWSP
HCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEECCCCCEEEEEECHHH
FVILVLVIVLWIQPFFKALFEKDGLLAFSNFYFEFNNISNHIFKSPPFVESDQSASFPVV
HHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHEEEECCCCHHHCCCCCCCCCCCCCCCHHH
FKFFLINTVGTSIFLAALISMLVLRVRVSDALSVFGETLKEMRYPILTIGLVLSFAYVSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHC
YSGISSTLALALTHTGLAFTFFSPLIGWVGVFLTGSDTSSNLLFGSLQQLTAQRLHLPEI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHCCCHH
LTLTANTVGGTLGKMISPQSIAIACAAVGLVGKESDLFKFTVKYSLIFVAIMGVVISAIA
HHEECHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YLIPEVVPAIK
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]