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The map label for this gene is algA [H]

Identifier: 188526852

GI number: 188526852

Start: 38530

End: 39942

Strand: Direct

Name: algA [H]

Synonym: HPSH_00210

Alternate gene names: 188526852

Gene position: 38530-39942 (Clockwise)

Preceding gene: 188526851

Following gene: 188526853

Centisome position: 2.4

GC content: 39.84

Gene sequence:

>1413_bases
ATGAAAATTAAAAATATCTTACTGAGTGGGGGGAGTGGAAAACGCCTATGGCCTTTAAGCCGTAGCCTATACCCTAAGCA
ATTTTTAAAGCTTTTTGGCAATGAAAGCTTGTTTGAATTGAGTTTTAAAAGAAACGCTTCCTTAGTGGATGAAACGCTCA
TTGTGTGCAACGAAAAGCATTATTTTTTAGCCCTAGAAGAAATAGAGAGTGAAATCAAAAACAAAAGCGTGGGTTTTTTA
TTAGAGAGCTTGAGTAAAAACACCGCTAACGCCATCGCTTTGAGCGCTTTAATGAGCGAGAGAGAAGATTTGCTCATCGT
TACGCCAAGCGATCATTTGATTAAAGACATTCAAGCGTATGAAAATGCAATGAAAAAAGCGATTGATTTAGCCCAAAAAG
GCTTTTTAGTCACTTTTGGGATCAATATTGAAAAGCCCAACACGGAGTTTGGGTATATTGAAAGCCCTAATGGTTTAGAT
GTCAAGCGATTCATTGAAAAGCCAAGCCTAGAAAAAGCGATAGAGTTTCAAAAAAGCGGGGGTTTTTATTTCAATAGCGG
CATGTTTGTTTTCCAAGCGGGCGTTTTTTTAGACGAATTGAAAAAGCATGCCCCTACTATTTTAAAGGGGTGCGAAAGAG
CGTTTGAATCTTTGGAGAGGGCGTCTTTTTTTGAAAAAAAGATCGTTCGTTTGAGCGAAAAGAGCATGCAAGATTTAGAA
GATGTGAGCGTGGATATAGCTTTAATGCAACAAAGTCATAAAATCAAAATGGTAGGATTAAACGCCAAGTGGAGCGATTT
AGGGAATTTTAACGCTCTTTTTGAAGAAGTGGCTAACGATCCTAAAGAAAATGTCAGCCTGAATCAAACGCCTGTTTTTG
CCAAAGAGAGCCAGAATAATTTGGTGTTTTCCCATAAAGTGAGCGCTCTTTTAGGGGTTGAGAATTTAGCCATCATTGAC
ACCAAAGACGCTCTTTTAATCGCTCATAAAGACAAGGCTAAAGATTTAAAAGCTTTAGTGAGCGAGGTAGAAGCAAACAA
CCAAGAATTGTTGCAAACGCACACTAAAGTGTATCGCCCTTGGGGGAGCTATGAAGTCTTGCATGAGAGCGGGTGTTACA
AGGTTAAGATTTTAGAAGTCAAACCTAACGCAAGGCTTTCTTTGCAAAAGCATTTCCACAGGAGCGAACACTGGGTGGTG
ATTAGCGGGATGGCGAGCGTGGAGTTGGATCGCCAATCGTTTGAATTACAAGCTAACGAATCCACTTATATCCCTAAAAA
CACCTTACACCGCCTGGCTAATTACGGCAAAATCCCTTTAACCATCATAGAAGTTCAAGTGGGCGAGTATGTCGGTGAAG
ACGATATTGTAAGGGTTGATGATGATTTTAACAGACAAAATCAAAACGCCTAA

Upstream 100 bases:

>100_bases
AATGAAGTCATCGCTGAGTTTTTGAAGTAACTCAAAAAACGCCCGATTAAAAACGCTATAATAACCCTAAAAAACAAAAG
AGAGCCTGACAAGGAAACTC

Downstream 100 bases:

>100_bases
TAAAGAAAATTCAATAAAGGAAAAATAATGAAAGAAAAAATCGCTTTAATCACCGGGGTTACCGGGCAAGATGGGAGCTA
TCTGGCTGAATACTTGCTGA

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MKIKNILLSGGSGKRLWPLSRSLYPKQFLKLFGNESLFELSFKRNASLVDETLIVCNEKHYFLALEEIESEIKNKSVGFL
LESLSKNTANAIALSALMSEREDLLIVTPSDHLIKDIQAYENAMKKAIDLAQKGFLVTFGINIEKPNTEFGYIESPNGLD
VKRFIEKPSLEKAIEFQKSGGFYFNSGMFVFQAGVFLDELKKHAPTILKGCERAFESLERASFFEKKIVRLSEKSMQDLE
DVSVDIALMQQSHKIKMVGLNAKWSDLGNFNALFEEVANDPKENVSLNQTPVFAKESQNNLVFSHKVSALLGVENLAIID
TKDALLIAHKDKAKDLKALVSEVEANNQELLQTHTKVYRPWGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVV
ISGMASVELDRQSFELQANESTYIPKNTLHRLANYGKIPLTIIEVQVGEYVGEDDIVRVDDDFNRQNQNA

Sequences:

>Translated_470_residues
MKIKNILLSGGSGKRLWPLSRSLYPKQFLKLFGNESLFELSFKRNASLVDETLIVCNEKHYFLALEEIESEIKNKSVGFL
LESLSKNTANAIALSALMSEREDLLIVTPSDHLIKDIQAYENAMKKAIDLAQKGFLVTFGINIEKPNTEFGYIESPNGLD
VKRFIEKPSLEKAIEFQKSGGFYFNSGMFVFQAGVFLDELKKHAPTILKGCERAFESLERASFFEKKIVRLSEKSMQDLE
DVSVDIALMQQSHKIKMVGLNAKWSDLGNFNALFEEVANDPKENVSLNQTPVFAKESQNNLVFSHKVSALLGVENLAIID
TKDALLIAHKDKAKDLKALVSEVEANNQELLQTHTKVYRPWGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVV
ISGMASVELDRQSFELQANESTYIPKNTLHRLANYGKIPLTIIEVQVGEYVGEDDIVRVDDDFNRQNQNA
>Mature_470_residues
MKIKNILLSGGSGKRLWPLSRSLYPKQFLKLFGNESLFELSFKRNASLVDETLIVCNEKHYFLALEEIESEIKNKSVGFL
LESLSKNTANAIALSALMSEREDLLIVTPSDHLIKDIQAYENAMKKAIDLAQKGFLVTFGINIEKPNTEFGYIESPNGLD
VKRFIEKPSLEKAIEFQKSGGFYFNSGMFVFQAGVFLDELKKHAPTILKGCERAFESLERASFFEKKIVRLSEKSMQDLE
DVSVDIALMQQSHKIKMVGLNAKWSDLGNFNALFEEVANDPKENVSLNQTPVFAKESQNNLVFSHKVSALLGVENLAIID
TKDALLIAHKDKAKDLKALVSEVEANNQELLQTHTKVYRPWGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVV
ISGMASVELDRQSFELQANESTYIPKNTLHRLANYGKIPLTIIEVQVGEYVGEDDIVRVDDDFNRQNQNA

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=480, Percent_Identity=38.5416666666667, Blast_Score=340, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 53207; Mature: 53207

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKNILLSGGSGKRLWPLSRSLYPKQFLKLFGNESLFELSFKRNASLVDETLIVCNEKH
CCCCEEEEECCCCCEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHCEEEEECCCC
YFLALEEIESEIKNKSVGFLLESLSKNTANAIALSALMSEREDLLIVTPSDHLIKDIQAY
EEEEHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
ENAMKKAIDLAQKGFLVTFGINIEKPNTEFGYIESPNGLDVKRFIEKPSLEKAIEFQKSG
HHHHHHHHHHHHCCEEEEEEEEECCCCCCCCEEECCCCCCHHHHHCCCCHHHHHHHHHCC
GFYFNSGMFVFQAGVFLDELKKHAPTILKGCERAFESLERASFFEKKIVRLSEKSMQDLE
CEEEECCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVSVDIALMQQSHKIKMVGLNAKWSDLGNFNALFEEVANDPKENVSLNQTPVFAKESQNN
HCCEEHEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCHHCCCCCCCCEEEECCCCC
LVFSHKVSALLGVENLAIIDTKDALLIAHKDKAKDLKALVSEVEANNQELLQTHTKVYRP
EEEEEHHHHHHCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
WGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVVISGMASVELDRQSFELQANE
CCCEEHHCCCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCEEEEECCCCEEEECCC
STYIPKNTLHRLANYGKIPLTIIEVQVGEYVGEDDIVRVDDDFNRQNQNA
CCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure
MKIKNILLSGGSGKRLWPLSRSLYPKQFLKLFGNESLFELSFKRNASLVDETLIVCNEKH
CCCCEEEEECCCCCEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHCEEEEECCCC
YFLALEEIESEIKNKSVGFLLESLSKNTANAIALSALMSEREDLLIVTPSDHLIKDIQAY
EEEEHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHH
ENAMKKAIDLAQKGFLVTFGINIEKPNTEFGYIESPNGLDVKRFIEKPSLEKAIEFQKSG
HHHHHHHHHHHHCCEEEEEEEEECCCCCCCCEEECCCCCCHHHHHCCCCHHHHHHHHHCC
GFYFNSGMFVFQAGVFLDELKKHAPTILKGCERAFESLERASFFEKKIVRLSEKSMQDLE
CEEEECCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVSVDIALMQQSHKIKMVGLNAKWSDLGNFNALFEEVANDPKENVSLNQTPVFAKESQNN
HCCEEHEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCHHCCCCCCCCEEEECCCCC
LVFSHKVSALLGVENLAIIDTKDALLIAHKDKAKDLKALVSEVEANNQELLQTHTKVYRP
EEEEEHHHHHHCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
WGSYEVLHESGCYKVKILEVKPNARLSLQKHFHRSEHWVVISGMASVELDRQSFELQANE
CCCEEHHCCCCCEEEEEEEECCCCCCHHHHHHCCCCCEEEEECCEEEEECCCCEEEECCC
STYIPKNTLHRLANYGKIPLTIIEVQVGEYVGEDDIVRVDDDFNRQNQNA
CCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]