Click here to switch to the map view.

The map label for this gene is tkt1 [H]

Identifier: 187930057

GI number: 187930057

Start: 3115417

End: 3117432

Strand: Reverse

Name: tkt1 [H]

Synonym: Rpic_2989

Alternate gene names: 187930057

Gene position: 3117432-3115417 (Counterclockwise)

Preceding gene: 187930058

Following gene: 187930056

Centisome position: 79.07

GC content: 65.53

Gene sequence:

>2016_bases
ATGACCGCCCCCGCCCTCCACTCGAACACCACCCAGCCTACCCAGTTGATGGCCAACGCCATTCGCGTGCTCGCCATGGA
CGCCGTCCAGCAAGCCAATTCGGGCCACCCTGGCGCGCCGATGGGCATGGCGGATATCGCCGTGGCACTGTGGAGCCGCC
ACCTGCGCCACAACCCGCTGAACCCGCGCTGGCCTGATCGTGACCGTTTCGTGCTGTCCAACGGCCACGGCTCGATGCTG
ATCTACGCGCTGCTGCACCTCACCGGCTACGACCTGCCGATGTCGGAACTGAAGAATTTCCGCCAGTTGCACAGCAAGAC
CGCCGGCCACCCGGAATACGGCATCACCCCGGGCGTGGAAACCACCACCGGCCCGCTCGGCCAAGGCATCACCAACGCCG
TCGGCATGGCCCTGGCTGAACGTCTGCTGGGTCAGGAATTCAATCGCCCGGGCTTTGACATCGTCAACCATCACACCTAT
GTCTTCCTGGGCGACGGCTGCCTGATGGAAGGCATCAGCCACGAAGCCTGCTCGCTGGCCGGCACGCTCAAGCTGAACAA
GCTGATCGCGCTGTGGGACGACAACGGCATCTCGATCGACGGCGACGTCGTCCACTGGTTCAACGACGACACCCCGAAGC
GCTTCGAAGCCTACGGCTGGAACGTGATCCGCGCCGTGGACGGCCACAACGTTGACGCCGTGGACGCCGCCATTGCCGAG
GCCAAGAAGTCCGACAAGCCGACCCTGATCTGCTGCCGCACGCTCATCGGCAAGGGTGCGCCCAACAAGGAAGGCGGCCA
CGACGTGCATGGCGCCCCGCTGGGCGGCGTTGAAATCGCCGCTGCGCGCGAAGCGCTGGCTTGGCCGCACGCCCCGTTCG
AAGTCCCGCAAGCCGTGTACGACGCCTGGGATGCCAAAGGGCAGGGCCAGGCGCTGGAAAAGGCCTGGAACGCGCTGTTC
GATGCATATTCCGACCGCTACCCCGCCGAAGCCGAACAATTCGAGCGCCGCATGCGCGGCGAACTGCCCGCCAGCTTCGA
GAAGGCCGTCGACGAGTTCATCGAGAAATGCGAACTCAAGGCTGAGACCATCGCCACCCGCAAGGCCAGCCAGAACACGC
TTGAAGCCTACGCCCCGGTCCTGGGCGAGCTGCTGGGCGGCTCGGCCGATCTGACCGGTTCGAACCTGACCAACTGGAGC
GGCAGCAAGGCCGTGCGCGTGGAAGCCTGGGGCAACCACATCAACTACGGCGTGCGTGAGTTCGGCATGAGCGCCATCAT
GAACGGCATCGCGCTGCACGGCGGCTACATTCCGTACGGCGGCACGTTCCTCACGTTCTCCGACTACAGCCGCAACGCGC
TGCGCATGGCCGCGCTGATGAAGATCCGCTCGATCTTCGTCTTCACGCACGATTCCATCGGCCTGGGCGAAGACGGCCCG
ACGCACCAGTCCATCGAGCACGTTGCCAGCCTGCGCCTGATCCCGAACATGGATGTCTGGCGCACCGCCGACACGACCGA
AACCGCCGTTGCCTGGGCCGCTGCCATCGAGCGCCAGAACGGCCCGAGCTGCCTGATCTTCAGCCGCCAGAACCTGCCGT
TCCAGGCGCGCAACCCGGCCACGCGCGAAGCCATCGCGCGCGGCGGCTATGTGCTGCGCGATGCGGCCAACGGCAAGCCG
GACGTGGTCATCATCGCCACCGGCTCGGAAGTTGGCCTGGCGGTCGGTGCAGCAGACCAGCTCGCCGCCGAGGGAATCCA
CGCGCGCGTGGTTTCCGTGCCCGCCACCACCGTGTTCGATAAACAGGATTCGGCCTACAAGGCGAGCGTGCTGCCGGCCG
GCGTGCCGCGCATCGCCGTGGAAGCGGGCGTGACCGATTTCTGGTGGAAGTACCAGGTACAAGCCGTGGTCGGTATCGAC
ACGTTCGGTGAATCCGCCCCGGCAGGTGTGCTGTTCAAGCACTTCGGCTTCACCGTCGAGAACGTGGTGAACACCGCCAA
GAGCGTCATTGCTTAA

Upstream 100 bases:

>100_bases
GGACGTCGTAGCACGTTTTACTGACCGCGATCACCCCAGCCGGGTCATCCCCGTCTGGTAAAATCGCGGTTTTCCCGCCT
ATCTCCTGCCGCAGGTTCGC

Downstream 100 bases:

>100_bases
CTGAATTTGCGCACGCGGCACCTACGAGGTGCCGCGCTGGTTTTTATCGCATCGTCGATTTCTTTTCTGCTATCAGGAGA
CTGACCATGACCATCAAGAT

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MTAPALHSNTTQPTQLMANAIRVLAMDAVQQANSGHPGAPMGMADIAVALWSRHLRHNPLNPRWPDRDRFVLSNGHGSML
IYALLHLTGYDLPMSELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGITNAVGMALAERLLGQEFNRPGFDIVNHHTY
VFLGDGCLMEGISHEACSLAGTLKLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRAVDGHNVDAVDAAIAE
AKKSDKPTLICCRTLIGKGAPNKEGGHDVHGAPLGGVEIAAAREALAWPHAPFEVPQAVYDAWDAKGQGQALEKAWNALF
DAYSDRYPAEAEQFERRMRGELPASFEKAVDEFIEKCELKAETIATRKASQNTLEAYAPVLGELLGGSADLTGSNLTNWS
GSKAVRVEAWGNHINYGVREFGMSAIMNGIALHGGYIPYGGTFLTFSDYSRNALRMAALMKIRSIFVFTHDSIGLGEDGP
THQSIEHVASLRLIPNMDVWRTADTTETAVAWAAAIERQNGPSCLIFSRQNLPFQARNPATREAIARGGYVLRDAANGKP
DVVIIATGSEVGLAVGAADQLAAEGIHARVVSVPATTVFDKQDSAYKASVLPAGVPRIAVEAGVTDFWWKYQVQAVVGID
TFGESAPAGVLFKHFGFTVENVVNTAKSVIA

Sequences:

>Translated_671_residues
MTAPALHSNTTQPTQLMANAIRVLAMDAVQQANSGHPGAPMGMADIAVALWSRHLRHNPLNPRWPDRDRFVLSNGHGSML
IYALLHLTGYDLPMSELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGITNAVGMALAERLLGQEFNRPGFDIVNHHTY
VFLGDGCLMEGISHEACSLAGTLKLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRAVDGHNVDAVDAAIAE
AKKSDKPTLICCRTLIGKGAPNKEGGHDVHGAPLGGVEIAAAREALAWPHAPFEVPQAVYDAWDAKGQGQALEKAWNALF
DAYSDRYPAEAEQFERRMRGELPASFEKAVDEFIEKCELKAETIATRKASQNTLEAYAPVLGELLGGSADLTGSNLTNWS
GSKAVRVEAWGNHINYGVREFGMSAIMNGIALHGGYIPYGGTFLTFSDYSRNALRMAALMKIRSIFVFTHDSIGLGEDGP
THQSIEHVASLRLIPNMDVWRTADTTETAVAWAAAIERQNGPSCLIFSRQNLPFQARNPATREAIARGGYVLRDAANGKP
DVVIIATGSEVGLAVGAADQLAAEGIHARVVSVPATTVFDKQDSAYKASVLPAGVPRIAVEAGVTDFWWKYQVQAVVGID
TFGESAPAGVLFKHFGFTVENVVNTAKSVIA
>Mature_670_residues
TAPALHSNTTQPTQLMANAIRVLAMDAVQQANSGHPGAPMGMADIAVALWSRHLRHNPLNPRWPDRDRFVLSNGHGSMLI
YALLHLTGYDLPMSELKNFRQLHSKTAGHPEYGITPGVETTTGPLGQGITNAVGMALAERLLGQEFNRPGFDIVNHHTYV
FLGDGCLMEGISHEACSLAGTLKLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRAVDGHNVDAVDAAIAEA
KKSDKPTLICCRTLIGKGAPNKEGGHDVHGAPLGGVEIAAAREALAWPHAPFEVPQAVYDAWDAKGQGQALEKAWNALFD
AYSDRYPAEAEQFERRMRGELPASFEKAVDEFIEKCELKAETIATRKASQNTLEAYAPVLGELLGGSADLTGSNLTNWSG
SKAVRVEAWGNHINYGVREFGMSAIMNGIALHGGYIPYGGTFLTFSDYSRNALRMAALMKIRSIFVFTHDSIGLGEDGPT
HQSIEHVASLRLIPNMDVWRTADTTETAVAWAAAIERQNGPSCLIFSRQNLPFQARNPATREAIARGGYVLRDAANGKPD
VVIIATGSEVGLAVGAADQLAAEGIHARVVSVPATTVFDKQDSAYKASVLPAGVPRIAVEAGVTDFWWKYQVQAVVGIDT
FGESAPAGVLFKHFGFTVENVVNTAKSVIA

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=592, Percent_Identity=28.8851351351351, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI4507521, Length=592, Percent_Identity=28.8851351351351, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI133778974, Length=588, Percent_Identity=27.5510204081633, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI225637459, Length=268, Percent_Identity=27.6119402985075, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI225637461, Length=268, Percent_Identity=26.4925373134328, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI225637463, Length=159, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI48994911, Length=658, Percent_Identity=65.1975683890577, Blast_Score=900, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=658, Percent_Identity=61.7021276595745, Blast_Score=847, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=588, Percent_Identity=26.3605442176871, Blast_Score=161, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=669, Percent_Identity=49.626307922272, Blast_Score=605, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6319593, Length=669, Percent_Identity=45.440956651719, Blast_Score=556, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45551847, Length=274, Percent_Identity=35.036496350365, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI45550715, Length=274, Percent_Identity=35.036496350365, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24666278, Length=278, Percent_Identity=33.8129496402878, Blast_Score=140, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24645119, Length=232, Percent_Identity=36.2068965517241, Blast_Score=119, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72363; Mature: 72232

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPALHSNTTQPTQLMANAIRVLAMDAVQQANSGHPGAPMGMADIAVALWSRHLRHNPL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
NPRWPDRDRFVLSNGHGSMLIYALLHLTGYDLPMSELKNFRQLHSKTAGHPEYGITPGVE
CCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
TTTGPLGQGITNAVGMALAERLLGQEFNRPGFDIVNHHTYVFLGDGCLMEGISHEACSLA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHCCCHHHHHHH
GTLKLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRAVDGHNVDAVDAAIAE
HHEEEEEEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCEEEEEECCCCCHHHHHHHHH
AKKSDKPTLICCRTLIGKGAPNKEGGHDVHGAPLGGVEIAAAREALAWPHAPFEVPQAVY
HHCCCCCCEEEHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
DAWDAKGQGQALEKAWNALFDAYSDRYPAEAEQFERRMRGELPASFEKAVDEFIEKCELK
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCH
AETIATRKASQNTLEAYAPVLGELLGGSADLTGSNLTNWSGSKAVRVEAWGNHINYGVRE
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHH
FGMSAIMNGIALHGGYIPYGGTFLTFSDYSRNALRMAALMKIRSIFVFTHDSIGLGEDGP
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCC
THQSIEHVASLRLIPNMDVWRTADTTETAVAWAAAIERQNGPSCLIFSRQNLPFQARNPA
CHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCH
TREAIARGGYVLRDAANGKPDVVIIATGSEVGLAVGAADQLAAEGIHARVVSVPATTVFD
HHHHHHHCCEEEEECCCCCCCEEEEECCCCCCEEECCHHHHHHCCCEEEEEECCCCEEEC
KQDSAYKASVLPAGVPRIAVEAGVTDFWWKYQVQAVVGIDTFGESAPAGVLFKHFGFTVE
CCCCCEEEECCCCCCCCEEHHCCCCHHEEEEEEEEEEEEECCCCCCCCHHHHHHHCCCHH
NVVNTAKSVIA
HHHHHHHHHCC
>Mature Secondary Structure 
TAPALHSNTTQPTQLMANAIRVLAMDAVQQANSGHPGAPMGMADIAVALWSRHLRHNPL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
NPRWPDRDRFVLSNGHGSMLIYALLHLTGYDLPMSELKNFRQLHSKTAGHPEYGITPGVE
CCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
TTTGPLGQGITNAVGMALAERLLGQEFNRPGFDIVNHHTYVFLGDGCLMEGISHEACSLA
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCCHHHHCCCHHHHHHH
GTLKLNKLIALWDDNGISIDGDVVHWFNDDTPKRFEAYGWNVIRAVDGHNVDAVDAAIAE
HHEEEEEEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCEEEEEECCCCCHHHHHHHHH
AKKSDKPTLICCRTLIGKGAPNKEGGHDVHGAPLGGVEIAAAREALAWPHAPFEVPQAVY
HHCCCCCCEEEHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
DAWDAKGQGQALEKAWNALFDAYSDRYPAEAEQFERRMRGELPASFEKAVDEFIEKCELK
HHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCH
AETIATRKASQNTLEAYAPVLGELLGGSADLTGSNLTNWSGSKAVRVEAWGNHINYGVRE
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHH
FGMSAIMNGIALHGGYIPYGGTFLTFSDYSRNALRMAALMKIRSIFVFTHDSIGLGEDGP
HHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCC
THQSIEHVASLRLIPNMDVWRTADTTETAVAWAAAIERQNGPSCLIFSRQNLPFQARNPA
CHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCH
TREAIARGGYVLRDAANGKPDVVIIATGSEVGLAVGAADQLAAEGIHARVVSVPATTVFD
HHHHHHHCCEEEEECCCCCCCEEEEECCCCCCEEECCHHHHHHCCCEEEEEECCCCEEEC
KQDSAYKASVLPAGVPRIAVEAGVTDFWWKYQVQAVVGIDTFGESAPAGVLFKHFGFTVE
CCCCCEEEECCCCCCCCEEHHCCCCHHEEEEEEEEEEEEECCCCCCCCHHHHHHHCCCHH
NVVNTAKSVIA
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]