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The map label for this gene is fadA [H]

Identifier: 187929700

GI number: 187929700

Start: 2742273

End: 2743454

Strand: Reverse

Name: fadA [H]

Synonym: Rpic_2629

Alternate gene names: 187929700

Gene position: 2743454-2742273 (Counterclockwise)

Preceding gene: 187929701

Following gene: 187929699

Centisome position: 69.59

GC content: 67.77

Gene sequence:

>1182_bases
ATGAATGACCATGAACCCGTCATCGTCGGTGCGTTGCGCACCCCCGTGGGCAAGCGCGGCGGGCGCCTGCAGAAATGGCA
CCCCGTCGATCTGCTGGGCGAGACGCTGCGCCAGCTGGTCGAGCGCTCCGGCATCAACCCCGCCGATCTGGACGATGTGA
TCGTCGGCTGCGTGCTGCAATGGGACCAACAGCACGGCAACCTGGGCCGTCATGCCGTATTGGCGGCGGGGCTGCCCGAA
TCCGTCCCGGCGGTGACGGTTGACCGGCAATGCGGCTCCGGCCAGCAGGCGGTGAGCTTTGCCGTGCATGGCATCCAGGC
GGGCGCTTACCAACTGGTCATCGGCGCCGGGGTGGAATCGATGTCGCAGGCCCCCATGCCGCCGTCATTCAAACCCGGCG
CGCCGCTGGGCTCGCAATACAGCCCGCGCGAACTGGCGCGCTACCAGGACAACCCGCTGCTGGCGCAAGGCGCTTCGTCG
GAGTTGATGAACAAGCGCTTCGGCCTCACGCGCGAGGCCCTGGACGCTTTCGCCGTGCGCAGCCATCGGCGCGCCACCGA
GGCTTTGCAGGCTGGCCGAGTCCAAGACCAACTGGTGCGACTGAACGAAGACCCAGCCGACCCAGACAGCCCGCTCGTCA
CTGCCGACGAAGGCGTGCGTGCCGACCCGAACCCCGAGAAGATGGCCACGCTCAAGCCCGTGTTTGCCGCCGACGGTGCC
ACCACGGCCGCCAACTCGTCGCAGATCAGCGATGGCGCCGCCGCGCTGCTGATCGCCAGCCGCGCCTATGCCAAGCAGCA
TGGCCTGAAGCCGCGCGCGCGCTTCGTCAGCACCGCCGTGGCGGCAGCCGACCCGGTGATCCAGTTCACCGCTGTTCTCG
ATGCCACCCGCAAGGCGCTGACGGAATCGGGTCTGACCCCGGCCGACATTGACCTGTTTGAAGTCAACGAGGCCTTTGGC
GGCGTGCCGCTGATGTTCCAGCAGGAATTCGGCATTCCGGACGATCGCCTCAACGTCAACGGCGGCTCGGTGGCCATCGG
CCATCCGCTGGGTTCCACCGGCGCGCGCATGCTCACCGACCTGCTGTGCGAGCTGGAGCGGCGGGGCGGCCGCTATGGCC
TGCAGACCATCTGCGAGGCTTCGGGCACGGCCAATACCACCATCATCGAGCGGCTTGGATGA

Upstream 100 bases:

>100_bases
CCCAAGACCAGCGTCGGCAAGCTCGACAAGAAGCGCATCCGCGCCGAGCATGCGGGCCGCTACGCCGAGTGAGCCAACCT
TTTTGCACCAGGAGAAGAAC

Downstream 100 bases:

>100_bases
GCGGAGCCACCATGAGCGAAGCCAGCGAAGTGCTCGTCAGCCGCGATGGCGCCATCGCCACCTTGACCATCAACCGCCCG
CGCGCGAAGAACAGCTTGAA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNDHEPVIVGALRTPVGKRGGRLQKWHPVDLLGETLRQLVERSGINPADLDDVIVGCVLQWDQQHGNLGRHAVLAAGLPE
SVPAVTVDRQCGSGQQAVSFAVHGIQAGAYQLVIGAGVESMSQAPMPPSFKPGAPLGSQYSPRELARYQDNPLLAQGASS
ELMNKRFGLTREALDAFAVRSHRRATEALQAGRVQDQLVRLNEDPADPDSPLVTADEGVRADPNPEKMATLKPVFAADGA
TTAANSSQISDGAAALLIASRAYAKQHGLKPRARFVSTAVAAADPVIQFTAVLDATRKALTESGLTPADIDLFEVNEAFG
GVPLMFQQEFGIPDDRLNVNGGSVAIGHPLGSTGARMLTDLLCELERRGGRYGLQTICEASGTANTTIIERLG

Sequences:

>Translated_393_residues
MNDHEPVIVGALRTPVGKRGGRLQKWHPVDLLGETLRQLVERSGINPADLDDVIVGCVLQWDQQHGNLGRHAVLAAGLPE
SVPAVTVDRQCGSGQQAVSFAVHGIQAGAYQLVIGAGVESMSQAPMPPSFKPGAPLGSQYSPRELARYQDNPLLAQGASS
ELMNKRFGLTREALDAFAVRSHRRATEALQAGRVQDQLVRLNEDPADPDSPLVTADEGVRADPNPEKMATLKPVFAADGA
TTAANSSQISDGAAALLIASRAYAKQHGLKPRARFVSTAVAAADPVIQFTAVLDATRKALTESGLTPADIDLFEVNEAFG
GVPLMFQQEFGIPDDRLNVNGGSVAIGHPLGSTGARMLTDLLCELERRGGRYGLQTICEASGTANTTIIERLG
>Mature_393_residues
MNDHEPVIVGALRTPVGKRGGRLQKWHPVDLLGETLRQLVERSGINPADLDDVIVGCVLQWDQQHGNLGRHAVLAAGLPE
SVPAVTVDRQCGSGQQAVSFAVHGIQAGAYQLVIGAGVESMSQAPMPPSFKPGAPLGSQYSPRELARYQDNPLLAQGASS
ELMNKRFGLTREALDAFAVRSHRRATEALQAGRVQDQLVRLNEDPADPDSPLVTADEGVRADPNPEKMATLKPVFAADGA
TTAANSSQISDGAAALLIASRAYAKQHGLKPRARFVSTAVAAADPVIQFTAVLDATRKALTESGLTPADIDLFEVNEAFG
GVPLMFQQEFGIPDDRLNVNGGSVAIGHPLGSTGARMLTDLLCELERRGGRYGLQTICEASGTANTTIIERLG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=393, Percent_Identity=38.4223918575064, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI167614485, Length=387, Percent_Identity=34.1085271317829, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=35.1145038167939, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=33.1645569620253, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4504327, Length=429, Percent_Identity=32.1678321678322, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=27.2493573264781, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI19923233, Length=398, Percent_Identity=23.1155778894472, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI48994986, Length=394, Percent_Identity=39.0862944162437, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=37.9052369077307, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=36.2244897959184, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=36.6412213740458, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=32.6241134751773, Blast_Score=161, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=37.5321336760925, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17535921, Length=399, Percent_Identity=34.3358395989975, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25147385, Length=395, Percent_Identity=32.1518987341772, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=432, Percent_Identity=32.4074074074074, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17535917, Length=413, Percent_Identity=28.0871670702179, Blast_Score=134, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=32.8320802005013, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=32.9974811083123, Blast_Score=179, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=33.3333333333333, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=30.5128205128205, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=31.7865429234339, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24640423, Length=397, Percent_Identity=31.4861460957179, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41585; Mature: 41585

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDHEPVIVGALRTPVGKRGGRLQKWHPVDLLGETLRQLVERSGINPADLDDVIVGCVLQ
CCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
WDQQHGNLGRHAVLAAGLPESVPAVTVDRQCGSGQQAVSFAVHGIQAGAYQLVIGAGVES
CCHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCHHH
MSQAPMPPSFKPGAPLGSQYSPRELARYQDNPLLAQGASSELMNKRFGLTREALDAFAVR
HHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEECCCHHHHHHHHHCCCHHHHHHHHHH
SHRRATEALQAGRVQDQLVRLNEDPADPDSPLVTADEGVRADPNPEKMATLKPVFAADGA
HHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHCCHHCCCCC
TTAANSSQISDGAAALLIASRAYAKQHGLKPRARFVSTAVAAADPVIQFTAVLDATRKAL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
TESGLTPADIDLFEVNEAFGGVPLMFQQEFGIPDDRLNVNGGSVAIGHPLGSTGARMLTD
HHCCCCCCCCEEEEEHHHHCCCCEEEECCCCCCCCCEECCCCCEEECCCCCCHHHHHHHH
LLCELERRGGRYGLQTICEASGTANTTIIERLG
HHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHCC
>Mature Secondary Structure
MNDHEPVIVGALRTPVGKRGGRLQKWHPVDLLGETLRQLVERSGINPADLDDVIVGCVLQ
CCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
WDQQHGNLGRHAVLAAGLPESVPAVTVDRQCGSGQQAVSFAVHGIQAGAYQLVIGAGVES
CCHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCHHH
MSQAPMPPSFKPGAPLGSQYSPRELARYQDNPLLAQGASSELMNKRFGLTREALDAFAVR
HHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEECCCHHHHHHHHHCCCHHHHHHHHHH
SHRRATEALQAGRVQDQLVRLNEDPADPDSPLVTADEGVRADPNPEKMATLKPVFAADGA
HHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHCCHHCCCCC
TTAANSSQISDGAAALLIASRAYAKQHGLKPRARFVSTAVAAADPVIQFTAVLDATRKAL
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
TESGLTPADIDLFEVNEAFGGVPLMFQQEFGIPDDRLNVNGGSVAIGHPLGSTGARMLTD
HHCCCCCCCCEEEEEHHHHCCCCEEEECCCCCCCCCEECCCCCEEECCCCCCHHHHHHHH
LLCELERRGGRYGLQTICEASGTANTTIIERLG
HHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]